scholarly journals Immune Signatures in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Xin Li ◽  
Qing-qing Xiao ◽  
Fu-lun Li ◽  
Rong Xu ◽  
Bin Fan ◽  
...  
Keyword(s):  
Psoriasis Vulgaris ◽  
Meta Analysis ◽  
Serum Marker ◽  
Serum Markers ◽  
Quality Data ◽  
Healthy Controls ◽  
High Quality Data ◽  
The Past ◽  
Before And After ◽  
Heat Syndrome

Objective. To determine whether immunological serum markers IFN-γ, IL-4, IL-17, IL-23, IL-6, TNF-α, and IL-10 are elevated or decreased in patients compared with healthy controls.Methods. A complete search of the literature on this topic within the past 30 years was conducted across seven databases. Seventeen studies including 768 individuals were identified. Differences in serum marker levels between subjects and controls were pooled as MDs using the random-effects model.Results. The pooled MDs were higher in patients than in healthy controls for IFN-γ(MD 24.9, 95% CI 12.36–37.43), IL-17 (MD 28.92, 95% CI 17.44–40.40), IL-23 (MD 310.60, 95% CI 4.96–616.24), and TNF-α(MD 19.84, 95% CI 13.80–25.87). Pooled IL-4 (MD −13.5, 95% CI −17.74–−9.26) and IL-10 (MD −10.33, 95% CI −12.03–−8.63) levels were lower in patients.Conclusion. The pooled analyses suggest that levels of IFN-γ, IL-17, IL-23, and TNF-αare significantly elevated and that levels of IL-4 and IL-10 are significantly decreased in sera of patients with psoriasis vulgaris of blood-heat syndrome. Measuring progression of blood-heat syndrome of psoriasis vulgaris will require additional high-quality data, with a low risk of bias and adequate sample sizes, before and after antipsoriatic therapy.

Decreased Flow-Mediated Dilatation in Children With Type 1 Diabetes: A Systematic Review and Meta-Analysis

Angiology ◽  
2021 ◽  
pp. 000331972110100
Author(s):  
Lei Cao ◽  
Miao Hou ◽  
Wanping Zhou ◽  
Ling Sun ◽  
Jie Shen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Endothelial Function ◽  
Meta Analysis ◽  
Quality Data ◽  
Cochrane Library ◽  
Healthy Children ◽  
Healthy Controls ◽  
Flow Mediated Dilatation

Type 1 diabetes (T1DM) is a strong risk factor for the development of cardiovascular disease. Flow-mediated dilatation (FMD) is an early noninvasive marker of endothelial function and it predicts future cardiovascular disease. However, the changes in FMD among T1DM children are still controversial. The present meta-analysis aimed to investigate whether FMD is impaired in children with T1DM. PubMed, EMBASE, Cochrane library, and Web of Science were searched for studies comparing FMD in children with T1DM and healthy controls. The Newcastle-Ottawa quality assessment scale for case–control studies was used to assess study quality. Data were pooled using a random effects models to obtain the weighted mean differences (WMD) in FMD and 95% CIs. Overall, 19 studies with 1245 patients and 872 healthy controls were included in this meta-analysis. Children with T1DM had significantly lower FMDs compared with healthy controls (WMD: −2.58; 95% CI: −3.36 to −1.81; P < .001). Meta-regression analysis revealed that low-density lipoprotein cholesterol levels impacted the observed difference in FMD between T1DM and healthy children. This meta-analysis showed that T1DM children have impaired endothelial function, which indicates they are at higher risk of developing cardiovascular disease in later life.

Lessons Learned from Modal Testing of Aerospace Structures

1993 ◽  
Vol 36 (1) ◽  
pp. 49-56
Author(s):  
David Hunt ◽  
Ralph Brillhart
Keyword(s):  
Data Acquisition ◽  
Lessons Learned ◽  
Modal Testing ◽  
Quality Data ◽  
High Quality Data ◽  
Modal Data ◽  
Analysis Techniques ◽  
Rapid Acquisition ◽  
The Past ◽  
Multiple Input

A wide variety of challenges have been encountered during the past 10 years of aerospace modal testing. New excitation methods have evolved, including single and multiple input random. Enhancements to traditional single and multiple input sine methods have been developed. Data analysis techniques that allow more consistent modal models to be extracted in less time than previously required have also been developed. New data acquisition hardware allows more rapid acquisition of modal data. As a result of these new excitation methods, data acquisition hardware and analysis tools, more high-quality data can be collected in considerably less time than was possible in the past. Modal surveys with 200 to 400 channels of response are becoming more commonplace. During the development and implementation of these new capabilities, many lessons have been learned about how to manage the increased amount of data collected and how to ensure that the quality remains high.

scholarly journals A Demonstration of the Collaborative Replication and Education Project: Replication Attempts of the Red-Romance Effect

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Jordan R. Wagge ◽  
Cristina Baciu ◽  
Kasia Banas ◽  
Joel T. Nadler ◽  
Sascha Schwarz ◽  
...  
Keyword(s):  
Undergraduate Students ◽  
Meta Analysis ◽  
Quality Data ◽  
High Quality ◽  
High Quality Data ◽  
Total N ◽  
Education Project ◽  
Null Results ◽  
Null Result ◽  
Student Projects

The present article reports the results of a meta-analysis of nine student replication projects of Elliot et al.’s (2010) findings from Experiment 3, that women were more attracted to photographs of men with red borders (total n = 640). The eight student projects were part of the Collaborative Replication and Education Project (CREP; https://osf.io/wfc6u/), a research crowdsourcing project for undergraduate students. All replications were reviewed by experts to ensure high quality data, and were pre-registered prior to data collection. Results of this meta-analysis showed no effect of red on attractiveness ratings for either perceived attractiveness (mean ratings difference = –0.07, 95% CI [–0.31, 0.16]) or sexual attractiveness (mean ratings difference = –0.06, 95% CI [–0.36, 0.24]); this null result held with and without Elliot et al.’s (2010) data included in analyses. Exploratory analyses examining whether being in a relationship moderated the effect of color on attractiveness ratings also produced null results.

A seminal paper on the epidemiology of cancer pain

2018 ◽  
Author(s):  
Paul Farquhar-Smith
Keyword(s):  
Cancer Pain ◽  
Quality Data ◽  
High Quality ◽  
High Quality Data ◽  
Seminal Paper ◽  
Patients With Cancer ◽  
The Past ◽  
Pain Prevalence ◽  
Prevalence Of Pain ◽  
Interest In Research

The landmark paper discussed in this chapter is ‘Prevalence of pain in patients with cancer: A systematic review of the past 40 years’, published by van den Beuken et al. in 2007. It is not surprising that this definitive study on cancer pain prevalence is one of the most cited papers in cancer pain. Despite the extent of cancer pain literature, this paper’s 2007 publication is surprisingly recent for the first methodologically sound and major study of cancer pain prevalence. Many previous estimates lacked accuracy, and were prone to bias. What was known was that, despite apparent increasing interest in, research in, and recognition of pain in cancer patients, the prevalence of such pain was still high, even after treatment. This paper attempted to accurately quantify just how high by statistically pooling available high-quality data while avoiding the pitfalls of combining heterogeneous studies, as had plagued previous reports.

scholarly journals Excitation of Polar Motion

2000 ◽  
Vol 178 ◽  
pp. 411-420 ◽  
Author(s):  
Clark R. Wilson
Keyword(s):  
Polar Motion ◽  
Conceptual Models ◽  
Numerical Models ◽  
Broad Band ◽  
Quality Data ◽  
Past Century ◽  
High Quality Data ◽  
The Past ◽  
Continuum Concept ◽  
The Continuum

AbstractConceptual models of polar motion have evolved over the past century, as improved data revealed signals over progressively wider frequency bands. In the 1890s, Chandler represented polar motion as a sum of discrete components, 14 month and annual terms, and this component model effectively summarized the observations, but did not provide a physical explanation for them. Over time both the search for a physical understanding of polar motion, and the ability to observe the broad band continuum outside the Chandler and annual bands have led to an understanding of polar motion as a continuum of variations, not adequately described by a few discrete components. The continuum concept is now the working model in most studies of polar motion. The transition from component to continuum conceptual models preceded the arrival of high quality data by several decades, and reflected significant contributions from Harold Jeffreys. With modern space geodetic observations and good global numerical models of the atmosphere, oceans, and other climate processes, it is clear that air and water motion and redistribution are the dominant contributors to the excitation continuum.

scholarly journals Non-invasive brain stimulation effectiveness in anxiety disorder treatment: a meta-analysis on sham/behavior-controlled studies

2021 ◽  
Author(s):  
Alessandra Vergallito ◽  
Alessia Gallucci ◽  
Alberto Pisoni ◽  
Gabriele Caselli ◽  
Giovanni M. Ruggiero ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Brain Stimulation ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Anxiety And Depression ◽  
Non Invasive ◽  
The Past ◽  
Before And After ◽  
Disorder Treatment ◽  
Meta Analyses

AbstractOver the past decades, the possibility of using non-invasive brain stimulation (NIBS) to treat mental disorders received considerable attention. To date, no recommendation is available for anxiety disorders, suggesting that evidence is still limited. Here, we systematically revised the existing literature, and quantitively analyzed the effectiveness of transcranial magnetic stimulation and transcranial direct current stimulation in anxiety disorders treatment.Following PRISMA guidelines, three electronic databases were screened to the end of February 2020 to select English-written peer-reviewed articles, including a clinical anxiety sample, a NIBS technique, and a control condition. Overall, ten papers met the inclusion criteria.TheHedge g for scores at the specific and generic anxiety questionnaires before and after the treatment was computed as effect size and analyzed in two independent random-effects meta-analyses. Moreover, considering the well-known comorbidity between anxiety and depression, a third meta-analysis was run, analyzing depression scores’ outcomes. Albeit preliminary, our findings highlighted that real stimulation significantly reduced anxiety and depression scores compared to the control condition, suggesting that NIBS can alleviate clinical symptoms.

scholarly journals Selective Editing: A Quest for Efficiency and Data Quality

2013 ◽  
Vol 29 (4) ◽  
pp. 473-488 ◽  
Author(s):  
Ton de Waal
Keyword(s):  
Statistical Data ◽  
Quality Data ◽  
Future Research ◽  
High Quality ◽  
High Quality Data ◽  
The Past ◽  
Usual Form ◽  
Data Editing ◽  
Data Record ◽  
Editing Process

Abstract National statistical institutes are responsible for publishing high quality statistical information on many different aspects of society. This task is complicated considerably by the fact that data collected by statistical offices often contain errors. The process of correcting errors is referred to as statistical data editing. For many years this has been a purely manual process, with people checking the collected data record by record and correcting them if necessary. For this reason the data editing process has been both expensive and time-consuming. This article sketches some of the important methodological developments aiming to improve the efficiency of the data editing process that have occurred during the past few decades. The article focuses on selective editing, which is based on an idea rather shocking for people working in the production of high-quality data: that it is not necessary to find and correct all errors. Instead of trying to correct all errors, it generally suffices to correct only those errors where data editing has substantial influence on publication figures. This overview article sketches the background of selective editing, describes the most usual form of selective editing up to now, and discusses the contributions to this special issue of the Journal of Official Statistics on selective editing. The article concludes with describing some possible directions for future research on selective editing and statistical data editing in general.

Golgi protein 73(GP73), a useful serum marker in liver diseases

2011 ◽  
Vol 49 (8) ◽  
Author(s):  
Xiangyi Liu ◽  
Xiaohua Wan ◽  
Zhongwu Li ◽  
Changqing Lin ◽  
Yutao Zhan ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Liver Diseases ◽  
Serum Marker ◽  
Serum Markers ◽  
Healthy Controls ◽  
B Virus ◽  
Different Types ◽  
Golgi Protein

AbstractThis study was performed to quantify the expression of Golgi protein-73 (GP73) in healthy controls and in patients with liver disease, and to evaluate the correlations between GP73 and other serum markers in different liver diseases.Serum GP73 was measured in 478 healthy controls and 296 patients with different types of liver disease. Quantitative hepatitis B virus (HBV) DNA was determined in two chronic hepatitis B (CHB) groups. Other serum liver fibrosis markers were measured in the liver fibrosis group and α-fetoprotein (AFP) was measured in hepatocellular carcinoma (HCC) group. The correlations between GP73 and these markers were evaluated.The GP73 value in hepatitis B e antigen (HBeAg)-positive CHB group, HBeAg-negative CHB group, liver fibrosis group and HCC group was significantly higher (p<0.001) than that in healthy controls. GP73 showed significant correlation with other markers in the liver fibrosis group and with AFP in the HCC group.Compared with healthy controls, GP73 in patients with liver disease was significantly increased. With the progression of liver disease, GP73 showed a significantly increasing trend. These results suggest that GP73 might be used as a serum marker for the diagnosis of liver diseases and for monitoring disease progression.

scholarly journals Epidemiology, Natural History, and Clinical Presentation of Large Vessel Ischemic Stroke

Neurosurgery ◽  
2019 ◽  
Vol 85 (suppl_1) ◽  
pp. S4-S8 ◽  
Author(s):  
Robert C Rennert ◽  
Arvin R Wali ◽  
Jeffrey A Steinberg ◽  
David R Santiago-Dieppa ◽  
Scott E Olson ◽  
...  
Keyword(s):  
Natural History ◽  
Clinical Presentation ◽  
Treatment Algorithm ◽  
Large Vessel ◽  
Quality Data ◽  
High Quality Data ◽  
Endovascular Thrombectomy ◽  
The Past ◽  
Intravenous Tissue Plasminogen Activator ◽  
Tissue Plasminogen

Abstract Large vessel occlusions (LVOs), variably defined as blockages of the proximal intracranial anterior and posterior circulation, account for approximately 24% to 46% of acute ischemic strokes. Commonly refractory to intravenous tissue plasminogen activator (tPA), LVOs place large cerebral territories at ischemic risk and cause high rates of morbidity and mortality without further treatment. Over the past few years, an abundance of high-quality data has demonstrated the efficacy of endovascular thrombectomy for improving clinical outcomes in patients with LVOs, transforming the treatment algorithm for affected patients. In this review, we discuss the epidemiology, pathophysiology, natural history, and clinical presentation of LVOs as a framework for understanding the recent clinical strides of the endovascular era.

scholarly journals The state of the art in helioseismic ground-based experiments

1997 ◽  
Vol 181 ◽  
pp. 15-29
Author(s):  
Pere L. Pallé
Keyword(s):  
Solar Cycle ◽  
State Of The Art ◽  
Quality Data ◽  
Direct Impact ◽  
High Quality ◽  
High Quality Data ◽  
The Past ◽  
Long Time ◽  
Inversion Techniques ◽  
And Inversion

The new results obtained from the observation of solar oscillations over the past decade, have a direct impact on our knowledge of the Sun's interior. As a consequence, a great interest in helioseismology has arisen and is reflected in the development of new observational projects as well as new analyse and inversion techniques. In this review we will describe the present ground-based observational programmes, which, unlike the space ones, are mostly designed to produce high quality data over very long time spans (up to solar cycle time scales). The characteristics of the various observational programmes, single-site and network, will be described together with their performances, the main results obtained up to now, and some other logistical aspects.

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