scholarly journals Acupuncture Decreases NF-κB p65, miR-155, and miR-21 and Increases miR-146a Expression in Chronic Atrophic Gastritis Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Jialing Zhang ◽  
Kangbai Huang ◽  
Guoxin Zhong ◽  
Yong Huang ◽  
Suhe Li ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Nuclear Factor Kappa B ◽  
Acupuncture Treatment ◽  
Chronic Atrophic Gastritis ◽  
Nuclear Factor ◽  
Gastric Tissue ◽  
Model Group ◽  
Weight Changes ◽  
Gastric Glands ◽  
Histological Changes

Acupuncture has been used to treat chronic atrophic gastritis (CAG) in traditional Chinese medicine (TCM) for centuries. In this study, we evaluated the effect of acupuncture at Zusanli (ST36), Zhongwan (CV12), and Pishu (BL20) acupoints on weight changes of rats, histological changes of gastric glands, and expressions changes of nuclear factor-kappa B (NF-κB) p65, microRNA- (miR-) 155, miR-21, and miR-146a in CAG rats induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) combined with irregular diet. Consequently, we found that acupuncture treatment elevated body weight of rats significantly when compared to the model group. By observing histological changes, we found that the acupuncture group showed better improvement of gastric mucosa injury than the model group. Our results also demonstrated upregulation of NF-κB p65, miR-155, and miR-21 in gastric tissue of CAG rats and a positive correlation between miR-155 and miR-21. Relatively, expression of miR-146a was downregulated and negative correlation relationships between miR-146a and miR-155/miR-21 in CAG rats were observed. Additionally, expressions of NF-κB p65, miR-155, and miR-21 were downregulated and miR-146a was upregulated after acupuncture treatment. Taken together, our data imply that acupuncture can downregulate NF-κB p65, miR-155, and miR-21 and upregulate miR-146a expression in CAG rats. NF-κB p65, miR-155, miR-21, and miR-146a may play important roles in therapeutic effect of acupuncture in treating CAG.

Clinical observation on acupuncture treatment of 36 cases of chronic atrophic gastritis

2005 ◽  
Vol 3 (2) ◽  
pp. 23-25
Author(s):  
Li Jian-zhong ◽  
Zhou Lu ◽  
Liu Li-gong ◽  
Zhang De-hua ◽  
Zhang Rong ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Clinical Observation ◽  
Acupuncture Treatment ◽  
Chronic Atrophic Gastritis

scholarly journals Urine metabolomics of rats with chronic atrophic gastritis

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0236203
Author(s):  
Guo-Xiu Zu ◽  
Qian-Qian Sun ◽  
Jian Chen ◽  
Xi-Jian Liu ◽  
Ke-Yun Sun ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Metabolic Pathways ◽  
Wistar Rats ◽  
Acid Metabolism ◽  
Chronic Atrophic Gastritis ◽  
Control Group ◽  
Liquid Chromatography Mass Spectrometry ◽  
Model Group ◽  
Rat Urine ◽  
Pathological Model

Background/aim To use liquid chromatography-mass spectrometry (LC-MS) to identify endogenous differential metabolites in the urine of rats with chronic atrophic gastritis (CAG). Materials and methods Methylnitronitrosoguanidine (MNNG) was used to produce a CAG model in Wistar rats, and HE staining was used to determine the pathological model. LC-MS was used to detect the differential metabolic profiles in rat urine. Diversified analysis was performed by the statistical method. Results Compared with the control group, the model group had 68 differential metabolites, 25 that were upregulated and 43 that were downregulated. The main metabolic pathways were D-glutamine and D-glutamic acid metabolism, histidine metabolism and purine metabolism. Conclusion By searching for differential metabolites and metabolic pathways in the urine of CAG rats, this study provides effective experimental data for the pathogenesis and clinical diagnosis of CAG.

scholarly journals Urine metabolomics of rats with chronic atrophic gastritis

2020 ◽  
Author(s):  
Guo-Xiu Zu ◽  
Qian-Qian Sun ◽  
Jian Chen ◽  
Xi-Jian Liu ◽  
Ke-Yun Sun ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Metabolic Pathways ◽  
Wistar Rats ◽  
Acid Metabolism ◽  
Chronic Atrophic Gastritis ◽  
Control Group ◽  
Liquid Chromatography Mass Spectrometry ◽  
Model Group ◽  
Rat Urine ◽  
Pathological Model

AbstractBackground/Aim: To use liquid chromatography-mass spectrometry (LC-MS) to identify endogenous differential metabolites in the urine of rats with chronic atrophic gastritis (CAG). Materials and Methods: Methylnitronitrosoguanidine (MNNG) was used to produce a CAG model in Wistar rats, and HE staining was used to determine the pathological model. LC-MS was used to detect the differential metabolic profiles in rat urine. Diversified analysis was performed by the statistical method. Results: Compared with the control group, the model group had 68 differential metabolites, 25 that were upregulated and 43 that were downregulated. The main metabolic pathways were D-glutamine and D-glutamic acid metabolism, histidine metabolism and purine metabolism. Conclusion: By searching for differential metabolites and metabolic pathways in the urine of CAG rats, this study provides effective experimental data for the pathogenesis and clinical diagnosis of CAG.

scholarly journals Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Yuling Tong ◽  
Manyi Jing ◽  
Xu Zhao ◽  
Honghong Liu ◽  
Shizhang Wei ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Expression Level ◽  
Gastric Tissue ◽  
Metabolomic Analysis ◽  
Rt Pcr ◽  
Related Factors ◽  
First Time ◽  
Metabolomic Study ◽  
Proinflammatory Factors

The classic prescription Zuojin Pill (ZJP) shows a good therapeutic effect on chronic atrophic gastritis (CAG); it is of great significance to clarify its specific mechanism. Therefore, we explore the mechanism of ZJP on MNNG-induced CAG by integrating approaches. First of all, through the pathological changes of gastric tissue and the expression level of PGI and PGI/II in serum, the expression of inflammation-related factors was determined by RT-PCR to determine the efficacy. Then, UPLC-Q-TOF/MS was used for plasma and urine metabolomic analysis to screen the specific potential biomarkers and metabolic pathway of ZJP in ameliorating CAG and to explore its possible mechanism. ZJP significantly ameliorate the pathological injury of gastric tissue, increase levels of PGI and PGI/II, and reduce the expression level of proinflammatory factors. Through metabolomic analysis, 9 potential metabolic differences were identified and 6 related metabolic pathways were enriched. These findings indicate for the first time the potential mechanism of ZJP in improving CAG induced by MNNG and are of great significance to the clinical development and application of ZJP-related drugs.

The role of nuclear factor-[kappa ]B in the biology and treatment of multiple myeloma

2001 ◽  
Vol 28 (6) ◽  
pp. 626-633 ◽  
Author(s):  
James R. Berenson ◽  
Hongjin M. Ma ◽  
Robert Vescio
Keyword(s):  
Multiple Myeloma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

Chronic Atrophic Gastritis: A Review

2018 ◽  
Vol 37 (3) ◽  
pp. 241-259 ◽  
Author(s):  
Yifei Li ◽  
Ran Xia ◽  
Bo Zhang ◽  
Chunsheng Li
Keyword(s):  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis
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