scholarly journals Effects of Bufei Yishen Granules Combined with Acupoint Sticking Therapy on Pulmonary Surfactant Proteins in Chronic Obstructive Pulmonary Disease Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yange Tian ◽  
Jiansheng Li ◽  
Ya Li ◽  
Yuqiong Dong ◽  
Fengjia Yao ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Surfactant ◽  
Surfactant Proteins ◽  
Acupoint Sticking Therapy ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects ◽  
Integrated Therapy ◽  
Pulmonary Surfactant Proteins ◽  
Better Than

Our previous studies have demonstrated the beneficial effects of Bufei Yishen granules combined with acupoint sticking therapy (the integrated therapy) in chronic obstructive pulmonary disease (COPD), but the underlying mechanism remains unclear. Dysfunction of pulmonary surfactant proteins (SPs, including SP-A, SP-B, SP-C, and SP-D) may be included in pathophysiology of COPD. This study aimed to explore the mechanism of the integrated therapy on SPs. COPD rat models were established. The treatment groups received Bufei Yishen granules or acupoint sticking or their combination. Using aminophylline as a positive control drug. The levels of SPs in serum, BALF, and lung were measured. The results showed that the integrated therapy markedly reduced the levels of SPs in serum and increased these indicators in the lung. The integrated therapy was better than aminophylline in reducing the levels of SPs and was better than Bufei Yishen granules in reducing SP-A, SP-C, and SP-D in serum. The integrated therapy was better than aminophylline and Bufei Yishen granules in increasing SP-A, SP-B, and SP-D mRNA in the lung. SP-A and SP-D in BALF were positively correlated with PEF and EF50. The levels of SPs are associated with airway limitation. The beneficial effects of the integrated therapy may be involved in regulating pulmonary surfactant proteins.

scholarly journals Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Hyojung Lee ◽  
Youngeun Kim ◽  
Hye Jin Kim ◽  
Soojin Park ◽  
Young Pyo Jang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Murine Model ◽  
Lung Inflammation ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Chronic Obstructive ◽  
Herbal Formula ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects

Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema. This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD. Balb/c mice were treated once with each herb extract in PM014 or PM014 mixture via an oral injection. Lipopolysaccharide (LPS) or elastase/LPS were administrated to the mice to induce a disease that resembles COPD. PM014 treatment significantly attenuated the increased accumulation of immune cells in bronchoalveolar lavage fluid (BALF) compared to control mice. In addition, the TNF-αand IL-6 levels in BALF were decreased in the PM014 mice. Furthermore, histological analysis demonstrated that PM014 attenuated the hazardous effects of lung inflammation. These data suggest that PM014 exerts beneficial effects against forms of COPD such as lung inflammation.

scholarly journals Kinesiotherapeutic interventions in diaphragmatic mobility of patients with chronic obstructive lung disease: systematic review

2020 ◽  
Vol 19 (2) ◽  
pp. 141
Author(s):  
Gilson Rosa De Jesus ◽  
Milena Santos Peixoto ◽  
Sidney De Souza Oliveira
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive Lung Disease ◽  
Intervention Programs ◽  
Chronic Obstructive ◽  
Diaphragmatic Dysfunction ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects ◽  
Risk Of Mortality ◽  
Respiratory Rehabilitation

This study analyzed the pathophysiological impacts of Chronic Obstructive Pulmonary Disease (COPD) on the respiratory system and the benefits of kinesiotherapeutic interventions on diaphragmatic mobility in patients affected by COPD. Systematic literature review carried out in the Scielo, Medline, VHL, Lilacs and PEDro databases, using the following keywords: Chronic Obstructive Pulmonary Disease, Respiratory Rehabilitation, Kinesitherapeutic Interventions and Diaphragmatic Dysfunction. Only original articles published between 2009 and 2019, about the benefits of different respiratory physical therapy intervention programs were included. Two examiners analyzed the qualities and evidence of the articles using the PEDro scale. Twelve manuscripts make up the discussion of this work. The present study confirms the beneficial effects of different Kinesiotherapy Intervention programs on physical health and quality of life, reduction of respiratory symptoms and risk of mortality, increased mobility of the rib cage, diaphragmatic functionality, functional capacity and respiratory muscle strength of patients affected by COPD.Keywords: chronic obstructive pulmonary disease, respiratory rehabilitation, kinesiotherapeutic interventions, diaphragmatic dysfunction.

Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease

2015 ◽  
Vol 26 (5) ◽  
Author(s):  
Dushyant Lal ◽  
Sachin Manocha ◽  
Arunabha Ray ◽  
V.K. Vijayan ◽  
Raj Kumar
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Comparative Study ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Clinical Symptoms ◽  
Chronic Obstructive ◽  
Efficacy And Safety ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects ◽  
Copd Patients

AbstractBronchial asthma and chronic obstructive pulmonary disease (COPD) are the major obstructive disorders that may contribute to the severity in individual patients. The present study was designed to compare the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and COPD.A total of 60 patients, 30 each with bronchial asthma and COPD, were enrolled for the study. Each group of 30 patients received standard treatment for asthma and COPD. Each group was again subdivided into two with 15 patients each, who received theophylline or doxofylline in addition to standard therapy, for a period of 2 months. Each patient was followed up fortnightly for the assessment of efficacy parameters using a pulmonary function test (PFT), clinical symptoms and emergency drug use, and safety was assessed by recording adverse drug reactions.Both theophylline and doxofylline produced enhancements in PFT at different time intervals in both asthma and COPD patients. The maximum beneficial effects were seen at 6 weeks for asthma patients and at 8 weeks for COPD patients for both theophylline and doxofylline.The comparative study showed that doxofylline was more effective as evidenced by improvement in PFT as well as clinical symptoms, and reduced incidence of adverse effects and emergency bronchodilator use.

Low-Dose Dopamine in Severe Right Heart Failure and Chronic Obstructive Pulmonary Disease

1995 ◽  
Vol 29 (5) ◽  
pp. 493-496 ◽  
Author(s):  
Thomas YK Chan
Keyword(s):  
Heart Failure ◽  
Chronic Obstructive Pulmonary Disease ◽  
Cardiac Output ◽  
Low Dose ◽  
Cor Pulmonale ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Dopamine Infusion ◽  
Beneficial Effects ◽  
Diuretic Response

Objective: To describe the beneficial effects of low-dose dopamine infusion (2-5 μg/kg/min) in a patient with severe cor pulmonale complicating chronic obstructive pulmonary disease (COPD). Case Summary: A 53-year-old woman with severe cor pulmonale and generalized edema complicating COPD received low-dose dopamine to stabilize blood pressure and, perhaps, improve cardiac output. Low-dose dopamine also improved her renal function and enhanced the diuretic response to furosemide therapy. Discussion: Previous studies of dopamine in such patients were reviewed. Both dopamine infusion (4 μg/kg/min) and oral administration of its precursor, l-dopa, can increase the cardiac output, decrease pulmonary vascular resistance, and enhance oxygen delivery in patients who are stable with cor pulmonale secondary to COPD. In patients with COPD during acute respiratory failure, high-dose dopamine (10 μg/kg/min) has been shown to increase the diaphragmatic blood flow and contraction. Low-dose dopamine also has been reported to be useful in patients with congestive heart failure or cirrhosis of the liver. Conclusions: Low-dose dopamine is useful in the acute management of patients with severe cor pulmonale complicating COPD because of the drug's beneficial effects on blood pressure, cardiac output, renal perfusion, natriuresis, and diuresis. Low-dose dopamine also may enhance the natriuretic and diuretic response to loop diuretics, decrease pulmonary vascular resistance, and enhance oxygen delivery.

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