scholarly journals Angioimmunoblastic T Cell Lymphoma Mimicking Chronic Urticaria

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Mohleen Kang ◽  
Nitasha Bhatia ◽  
Adrienne Sauder ◽  
Mirela Feurdean
Keyword(s):  
T Cell ◽  
Primary Care Physicians ◽  
Cell Lymphoma ◽  
Distinct Type ◽  
Maculopapular Rash ◽  
Skin Lesions ◽  
T Cell Lymphoma ◽  
Cutaneous Manifestations ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
High Index Of Suspicion

Angioimmunoblastic T cell lymphoma (AITL) is a rare but distinct type of T cell lymphoma with an aggressive course and high mortality. Most patients are diagnosed late in the disease and usually present with generalized lymphadenopathy. A minority have skin lesions at the time of diagnosis, more commonly in the form of nonspecific maculopapular rash with or without pruritus. We report a rare case of AITL presenting with chronic, recurrent angioedema and urticaria-like lesions and no palpable peripheral adenopathy. Primary Care physicians, dermatologists, and allergists must maintain a high index of suspicion for cutaneous manifestations of lymphoma, especially if the skin lesions are refractory to standard treatment. Timely diagnosis is essential to improve survival.

scholarly journals Skin manifestation of angioimmunoblastic T-cell lymphoma mimicking Hansen’s disease on histology

2020 ◽  
Vol 6 (4) ◽  
pp. 570
Author(s):  
Anju Shukla ◽  
Sunil Sharad Dabadghao ◽  
Surbhi Gupta ◽  
Priyanka Jain
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Delayed Diagnosis ◽  
Maculopapular Rash ◽  
Lymph Node Biopsy ◽  
T Cell Lymphoma ◽  
Cutaneous Manifestations ◽  
Hansen's Disease ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Hansen’S Disease

<p>Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon form of peripheral T-cell lymphoma now put under the category of nodal T-cell lymphoma with follicular T helper phenotype. 50% cases of AITL have varied cutaneous manifestations including macules, papules, petechiae, purpura, nodules, non-specific rash and urticaria. Herein we present a case of AITL initially presented as maculopapular rash which on histology was mimicking as Hansen’s disease with perineural and perivascular inflammation; however, an infective organism could not be demonstrated. Later on, a delayed diagnosis was made on lymph node biopsy and immunohistochemistry and patient responded well with chemotherapy.</p>

scholarly journals Angioimmunoblastic T-cell lymphoma presenting with an acute serologic Epstein-Barr virus profile

2015 ◽  
Vol 7 (2) ◽  
Author(s):  
Timothy Beer ◽  
Patrick Dorion
Keyword(s):  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Lymph Node Biopsy ◽  
T Cell Lymphoma ◽  
High Endothelial Venules ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr ◽  
High Index Of Suspicion

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma typically characterized by prominent lymphadenopathy and B-symptoms at the time of presentation, polyclonal hypergammaglobulinemia, autoimmune hemolysis and frequent but highly variable involvement of Epstein- Barr virus (EBV). Lymph node biopsy findings typically include effacement of nodal architecture, polymorphic infiltrate, atypical T-cells (usually CD4+/CD10+/PD1+) and prominent proliferations of high endothelial venules and follicular dendritic cells. However, this classic constellation of pathologic findings is often initially obscured by a prominence of EBV+ B-immunoblasts with or without associated peripherally circulating EBV DNA. Here we document the first reported case of an acute serologic EBV profile (VCA-IgM) in a patient with AITL, and we recommend that clinicians maintain a high index of suspicion for AITL in the appropriate clinical scenario, irrespective of Epstein-Barr related findings.

Cutaneous Manifestations of Angioimmunoblastic T-Cell Lymphoma

2015 ◽  
Vol 37 (4) ◽  
pp. 274-283 ◽  
Author(s):  
Noha Botros ◽  
Lorenzo Cerroni ◽  
Allam Shawwa ◽  
Peter J. Green ◽  
Wenda Greer ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous Manifestations ◽  
Angioimmunoblastic T Cell Lymphoma

scholarly journals Angioimmunoblastic T-Cell Lymphoma Mimicking Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome)

2017 ◽  
Vol 9 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Joanna Mangana ◽  
Emmanuella Guenova ◽  
Katrin Kerl ◽  
Mirjana Urosevic-Maiwald ◽  
Valerie C. Amann ◽  
...  
Keyword(s):  
Drug Reaction ◽  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
High Dose ◽  
Dress Syndrome ◽  
Cutaneous Manifestations ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Drug Eruptions ◽  
Systemic Symptoms

Angioimmunoblastic T-cell lymphoma (AITCL) is a rare, aggressive lymphoma which derives from follicular helper T cells, commonly affecting the elderly population. It accounts for 2% of all non-Hodgkin lymphomas, with a reported 5-year overall survival rate of less than 30%. Very often, the clinical picture of AITCL encompasses systemic symptoms such as generalized lymphadenopathy, hepatosplenomegaly, skin rash, anemia, and polyclonal hypergammaglobulinemia. Here we report on the case of a female patient who presented with clinical features resembling drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) prior to the definitive diagnosis of AITCL. The index of suspicion for cutaneous manifestations of lymphoma, and especially AITCL, must be high, particularly in atypical clinical courses of drug eruptions or if skin lesions relapse and are refractory to standard high-dose systemic corticosteroids.

scholarly journals CUTANEOUS MANIFESTATIONS OF ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA

2018 ◽  
Vol 94 (2) ◽  
pp. 48-56
Author(s):  
N. G. Chernova ◽  
M. N. Sinitsyna ◽  
Yu. V. Sidorova ◽  
N. P. Soboleva ◽  
A. B. Sudarikov ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous Manifestations ◽  
Angioimmunoblastic T Cell Lymphoma

scholarly journals Cutaneous manifestations of angioimmunoblastic T-cell lymphoma

2019 ◽  
Vol 25 (7) ◽  
Author(s):  
Sidney Hoskins ◽  
Natalie Moriarty ◽  
Kevin White ◽  
Andrea Kalus ◽  
Andrei Shustov ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous Manifestations ◽  
Angioimmunoblastic T Cell Lymphoma

Cutaneous manifestations of angioimmunoblastic T-cell lymphoma

2013 ◽  
Vol 69 (1) ◽  
pp. e25-e26 ◽  
Author(s):  
Rebecca K. Jacobson ◽  
Kachiu C. Lee ◽  
Jennie J. Muglia ◽  
Leslie Robinson-Bostom
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous Manifestations ◽  
Angioimmunoblastic T Cell Lymphoma

scholarly journals Initial Report of a Cutaneous T-Cell Lymphoma Appearing on the Auricular Helix

2000 ◽  
Vol 79 (5) ◽  
pp. 391-396 ◽  
Author(s):  
Brian J. Baumgartner ◽  
Vincent Eusterman ◽  
Jerome Myers ◽  
Phillip Massengill
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Skin Lesions ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Initial Report ◽  
Delay In Diagnosis ◽  
Multiple Biopsies ◽  
Key Factor ◽  
High Index Of Suspicion

We report a case of cutaneous T-cell lymphoma in which the first sign of disease was involvement of the superior auricular helix. A review of the literature reveals that T-cell lymphoma often presents cutaneously, but it usually does not involve the ear, and an auricular lesion is rarely the first sign. The uncommon nature of this presentation, in addition to the potential need for multiple biopsies for a tissue diagnosis, can lead to a delay in diagnosis. When evaluating skin lesions in the head and neck, a high index of suspicion for cutaneous T-cell lymphoma is a key factor in its early diagnosis.

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