scholarly journals Posttraumatic Skin and Soft-Tissue Infection due toPseudomonas fulva

2016 ◽  
Vol 2016 ◽  
pp. 1-2 ◽  
Author(s):  
Fernando Cobo ◽  
Gemma Jiménez ◽  
Javier Rodríguez-Granger ◽  
Antonio Sampedro
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Soft Tissue Infection ◽  
Traffic Accident ◽  
Left Thigh ◽  
Species Level ◽  
Tissue Infection ◽  
Intravenous Antibiotic ◽  
Injured Area

We report a case of posttraumatic skin and soft-tissue infection in a patient with a left thigh wound after a traffic accident.Pseudomonas fulvawas isolated from a wound aspirate and was identified to the species level by Maldi-tof. The patient responded to drainage, debridement of wound, and two weeks of intravenous antibiotic therapy. Follow-up after 3 weeks was satisfactory with healthy cover of the injured area.

scholarly journals Real-world experience with dalbavancin therapy in gram-positive skin and soft tissue infection, bone and joint infection

Infection ◽  
2019 ◽  
Vol 47 (6) ◽  
pp. 1013-1020 ◽  
Author(s):  
Selma Tobudic ◽  
Christina Forstner ◽  
Heinz Burgmann ◽  
Heimo Lagler ◽  
Christoph Steininger ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Septic Arthritis ◽  
Clinical Improvement ◽  
Soft Tissue Infection ◽  
Joint Infection ◽  
Tissue Infection ◽  
Oral Drug ◽  
Gram Positive ◽  
Positive Skin

Abstract Purpose Dalbavancin is a novel lipoglycopeptide with potent activity against several gram-positive pathogens, an excellent safety profile and a long elimination half-life. Methods In this case series observed at the University Hospital of Vienna between 2015 and 2017, all adult patients with gram-positive infections who received at least one dosage of dalbavancin were screened (n = 118). A total of 72 patients were included in the final analysis. The number of included patients stratified by the source of infection was: skin and soft tissue infection (SSTI) (n = 26), osteomyelitis (n = 20), spondylodiscitis (n = 14), acute septic arthritis (n = 4) and prosthetic joint infection (n = 8). Results In 46 patients (64%), clinical cure was detected at the end of dalbavancin therapy without additional antibiotic therapy. Of the 26 patients who received additional antibiotic therapy other than dalbavancin, 15 patients (21%) showed no clinical improvement under dalbavancin therapy, four patients (5%) had side effects (nausea n = 1, exanthema n = 2, hyperglycemia n = 1), and in seven patients (10%) clinical improvement under dalbavancin therapy was detected but antibiotic therapy was de-escalated to an oral drug. Conclusion We demonstrated high clinical effectiveness of dalbavancin for acute gram-positive infections primarily acute SSTI, acute septic arthritis, acute osteomyelitis and spondylodiscitis. In patients with biofilm-associated infection (chronic infection or joint prosthesis), source control was absolutely necessary for treatment success.

Soft Tissue Infection after Missile Injuries to the Extremities–A Non-Randomized, Prospective Study in Gaza City

2007 ◽  
Vol 22 (2) ◽  
pp. 106-108 ◽  
Author(s):  
Hazem M. Hamouda ◽  
Eivind Witsø ◽  
Nedal K.E. Moghani ◽  
Ahmed Shahwan ◽  
Øystein P. Nygaard
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Damage ◽  
Soft Tissue Injuries ◽  
Tissue Infection ◽  
Soft Tissue Damage ◽  
Safe Procedure ◽  
Infected Wound ◽  
Severe Soft Tissue

AbstractIntroduction:Patients with soft tissue injuries caused by missile attacks during wartime have been treated with radical debridement and delayed closure. In a study in Gaza City, the rate of infection of missile injuries to the extremities when treated with minimal surgical intervention, was measured.Methods:Patients with severe soft tissue damage, compound fractures, and injuries to major blood vessels and/or nerves were excluded from the study. One hundred fourteen patients were treated according to a standardized regime that included a superficial, minor surgery revision of the inlet and the outlet opening, and antibiotic treatment. Local soft tissue infection was defined as the presence of at least two signs of local infection.Results:A total of 109 out of 114 patients attended the first follow-up visit. Eleven (10%) of these patients had an infected wound. A total of 105 of the patients (92%) attended a second follow-up. None of these patients had an infected wound.Conclusions:Under conditions with a high number of causalities, minimal surgical treatment followed by the administration of antibiotics is a safe procedure for patients with penetrating missile injuries and less severe soft tissue damage.

scholarly journals The Lectin Complement Pathway in Patients with Necrotizing Soft Tissue Infection

2016 ◽  
Vol 8 (5) ◽  
pp. 507-516 ◽  
Author(s):  
Marco B. Hansen ◽  
Lars S. Rasmussen ◽  
Katrine Pilely ◽  
Dorthe Hellemann ◽  
Estrid Hein ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Confidence Interval ◽  
Soft Tissue Infection ◽  
Simplified Acute Physiology Score ◽  
Hazard Ratio ◽  
Tissue Infection ◽  
Complement Pathway ◽  
Necrotizing Soft Tissue Infection ◽  
Short And Long Term

Background: Mannose-binding lectin (MBL) and ficolins are pattern recognition molecules (PRMs) that play an important role during infection through activation of the lectin complement pathway. We assessed whether plasma PRM levels were associated with mortality in patients with necrotizing soft tissue infection (NSTI). Methods: We conducted a prospective, observational study over 25 months involving 135 NSTI patients with a maximum follow-up of 2.7 years. Blood samples were taken upon admission. Non-infected patients served as controls. Results: PRM levels were significantly lower compared with controls. A baseline Ficolin-2 level below the median was associated with mortality at the end of follow-up (p = 0.007). No significant association was found for MBL, Ficolin-1 and Ficolin-3. A Ficolin-2 level below the median had a negative predictive value of 0.94 for 28-day mortality, and a level below the optimal cut-off was independently associated with 28-day mortality when adjusted for age, sex and chronicity [hazard ratio 6.27 (95% confidence interval 2.28-17.21), p < 0.0001], also when Simplified Acute Physiology Score II was included in the analysis [hazard ratio 3.16 (95% confidence interval 1.03-9.73), p = 0.045]. Conclusions: All PRMs were significantly lower in patients with NSTI than in controls. Only baseline Ficolin-2 was associated with short- and long-term mortality. A high baseline Ficolin-2 level indicated a 94% chance of surviving the first 28 days after admission.

Admission Time Deep Swab Specimens Compared With Surgical Bone Sampling in Hospitalized Individuals With Diabetic Foot Osteomyelitis and Soft Tissue Infection

2020 ◽  
pp. 153473462091638 ◽  
Author(s):  
Ana Belen Manas ◽  
Surabhi Taori ◽  
Raju Ahluwalia ◽  
Hani Slim ◽  
C. Manu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Soft Tissue Infection ◽  
Diabetic Foot ◽  
Tissue Infection ◽  
Surgical Debridement ◽  
Deep Wound ◽  
Negative Growth ◽  
Diabetic Foot Osteomyelitis ◽  
Prior Antibiotic Therapy

Whether deep swab cultures taken at admission reliably identify pathogens compared to surgical bone specimens in hospitalized individuals with diabetic foot osteomyelitis and soft tissue infection is unclear. Comparison of microbiological isolates between a deep wound swab (DWS) taken at the time of admission through the actively infected, discharging ulcer probing to the bone and the subsequent surgical bone sample (SBS) taken during surgical debridement was made. A total of 63 subjects (age 60.8 ± 13.5 years, 75% male, 80% Type 2 diabetes, HbA1C 8.9%±2.2%) were included. The proportion of Gram-positive (DWS 49% v SBS 52%) and Gram-negative (DWS 60% v SBS 60%) isolates was similar between the techniques. However, the overall concordance of isolates between the two techniques was only fair (κ=0.302). The best concordance was observed for Staphylococcus aureus (κ=0.571) and MRSA (κ=0.644). There was a correlation between number of isolates in SBS with prior antibiotic therapy of any duration (r= -0.358, p=0.005) and with the duration of ulceration (r=0.296, p=0.045); no clinical correlations were found for DWS. Prior antibiotic therapy (p=0.03) and duration of ulceration <8 weeks (p=0.025) were predictive of negative growth on SBS. In conclusion, we found only a fair concordance between deep wound swabs acquired at admission and surgical bone specimens in those presenting with a severe diabetic foot infection and features of osteomyelitis. Ensuring early surgical debridement of all infected tissue and obtaining bone specimens should be considered a clinical priority, which may also reduce the likelihood of negative growth on SBS.

Managing skin and soft-tissue infection and nosocomial pneumonia caused by MRSA: a 2014 follow-up survey

2015 ◽  
Vol 45 ◽  
pp. S1-S14 ◽  
Author(s):  
Matthew Dryden ◽  
Arjana Tambic Andrasevic ◽  
Matteo Bassetti ◽  
Emilio Bouza ◽  
Jean Chastre ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Nosocomial Pneumonia ◽  
Soft Tissue Infection ◽  
Tissue Infection
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