scholarly journals Symptomatic Acute Hepatitis C Infection Following a Single Episode of Unprotected Sexual Intercourse

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Benjamin Butler ◽  
Bhaskar Narayan ◽  
Jonathan Potts ◽  
Julian Emmanuel
Keyword(s):  
Hepatitis C ◽  
Sexual Intercourse ◽  
Pegylated Interferon ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Unprotected Sexual Intercourse ◽  
Single Episode ◽  
Acute Hcv ◽  
Symptomatic Acute Hepatitis ◽  
Elevated Transaminases

A previously healthy 23-year-old MSM presented with jaundice, systemic upset, and rash 2 months after a single episode of unprotected sexual intercourse. Liver biochemistry was grossly deranged, with markedly elevated transaminases and hyperbilirubinaemia. Serology was positive for genotype 1a hepatitis C virus (HCV) and in the absence of other causes, acute HCV infection was suspected. He was subsequently successfully treated with pegylated interferon and ribavirin for 24 weeks and made a full clinical and biochemical recovery.

scholarly journals Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: The HEP-NET acute-HCV-II study

Hepatology ◽  
2006 ◽  
Vol 43 (2) ◽  
pp. 250-256 ◽  
Author(s):  
Johannes Wiegand ◽  
Peter Buggisch ◽  
Wulf Boecher ◽  
Stefan Zeuzem ◽  
Cornelia M. Gelbmann ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Interferon Alpha ◽  
Pegylated Interferon ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Pegylated Interferon Alpha ◽  
Interferon Alpha 2B ◽  
Acute Hcv

Long-lasting Imprint in the Soluble Inflammatory Milieu despite Early Treatment of Acute Symptomatic Hepatitis C

2021 ◽  
Author(s):  
Tanvi Khera ◽  
Yanqin Du ◽  
Daniel Todt ◽  
Katja Deterding ◽  
Benedikt Strunz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Partial Restoration ◽  
Acute Hcv ◽  
Direct Acting ◽  
Inflammatory Milieu

Abstract Background Treatment with direct acting antivirals (DAAs) in patients with chronic hepatitis C infection leads to partial restoration of soluble inflammatory mediators (SIMs). In contrast, we hypothesized that early DAA treatment of acute hepatitis C with DAAs may normalize most SIMs. Methods In this study, we made use of a unique cohort of acute symptomatic hepatitis C who cleared HCV with a 6-week course of ledipasvir/sofosbuvir. Plasma samples were used for proximity extension assay (PEA) measuring 92 proteins. Results Profound SIM alterations were observed in acute HCV patients, with marked upregulation of IL-6 and CXCL10 while certain mediators were down-regulated (e.g. MCP-4, IL-7). During treatment and follow-up, the majority of SIMs decreased but not all normalized (e.g. CDCP1, IL-18). Of note, SIMs that were down-regulated before DAA treatment remained suppressed while others that were initially unchanged, declined to lower values during treatment and follow-up (e.g.CD244). Conclusions Acute hepatitis C was associated with marked changes in the soluble inflammatory milieu as compared to both chronic hepatitis patients and healthy controls. Whereas early DAA treatment partly normalized this altered signature, long-lasting imprints of HCV remained. Thus, acute HCV-induced changes in the immune system may persist even after a short duration of viremia.

scholarly journals Acute hepatitis C infection among adults with HIV in the Netherlands between 2003 and 2016: a capture–recapture analysis for the 2013 to 2016 period

2020 ◽  
Vol 25 (7) ◽  
Author(s):  
T. Sonia Boender ◽  
Eline Op de Coul ◽  
Joop Arends ◽  
Maria Prins ◽  
Marc van der Valk ◽  
...  
Keyword(s):  
Hepatitis C ◽  
The Netherlands ◽  
Global Strategy ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Acute Hcv ◽  
Hiv Serostatus ◽  
Capture Recapture ◽  
Acute Hcv Infection

Background With regards to the global strategy towards eliminating viral hepatitis, reliable surveillance systems are essential to assess the national response for eliminating hepatitis C virus (HCV). Aim We aimed to assess the completeness of the two national registries with data on acute HCV infection in people with HIV, and estimated the number of acute HCV infections among adults (aged ≥ 18 years) with HIV in the Netherlands. Methods In this observational study, cases of HCV infection and reinfection among adults with a positive or unknown HIV-serostatus were identified from 2003 to 2016 in two national registries: the ATHENA cohort and the National Registry for Notifiable Diseases. For 2013–2016, cases were linked, and two-way capture–recapture analysis was carried out. Results During 2013–2016, there were an estimated 282 (95% confidence interval (CI): 264–301) acute HCV infections among adults with HIV. The addition of cases with an unknown HIV-serostatus increased the matches (from n = 107 to n = 129), and subsequently increased the estimated total: 330 (95%CI: 309–351). Under-reporting was estimated at 14–20%. Conclusion Under-reporting of acute HCV infection among people with HIV could partially be explained by an unknown HIV-serostatus, or by differences in HCV stage (acute or chronic) at first diagnosis. Surveillance data should ideally include both acute and chronic HCV infections, and enable to distinguish these as well as initial- and re-infections. National surveillance of acute HCV can be improved by increased notification of infections.

Efficacy of early treatment of acute hepatitis C infection with pegylated interferon and ribavirin in HIV-infected patients

AIDS ◽  
2006 ◽  
Vol 20 (8) ◽  
pp. 1157-1161 ◽  
Author(s):  
Stéphanie Dominguez ◽  
Jade Ghosn ◽  
Marc-Antoine Valantin ◽  
Aurélie Schruniger ◽  
Anne Simon ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Early Treatment ◽  
Pegylated Interferon ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection

Histology of Symptomatic Acute Hepatitis C Infection in Immunocompetent Adults

2007 ◽  
Vol 31 (11) ◽  
pp. 1754-1758 ◽  
Author(s):  
Kathyrn Johnson ◽  
Ayman Kotiesh ◽  
John K. Boitnott ◽  
Michael Torbenson
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Symptomatic Acute Hepatitis ◽  
Immunocompetent Adults

scholarly journals Acute hepatitis C infection among adults with HIV in the Netherlands: a capture-recapture analysis

2019 ◽  
Author(s):  
Tamara Sonia Boender ◽  
Eline Op de Coul ◽  
Joop Arends ◽  
Maria Prins ◽  
Marc van der Valk ◽  
...  
Keyword(s):  
Hepatitis C ◽  
The Netherlands ◽  
Global Strategy ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Acute Hcv ◽  
Hiv Serostatus ◽  
Capture Recapture ◽  
Acute Hcv Infection

AbstractBackgroundReliable surveillance systems are essential to assess the national response to eliminating hepatitis C virus (HCV), in the context of the global strategy towards eliminating viral hepatitis.AimWe aimed to assess the completeness of the two national registries of acute HCV infection in people with HIV, and estimated the number of acute HCV infections among adults with HIV in the Netherlands.MethodsFor 2003-2016, cases of HCV infection and reinfection among adults with a positive or unknown HIV-serostatus were identified in two national registries: the ATHENA cohort, and the National Registry for Notifiable Diseases. For 2013-2016, cases were linked, and two-way capture-recapture analysis was carried out.ResultsDuring 2013-2016, there were an estimated 282 (95%CI: 264-301) acute HCV infections among adults with HIV. The addition of cases with an unknown HIV-serostatus increased the matches (from N=104 to N=129), and a subsequently increased the estimated total: 330 (95%CI: 309-351). Underreporting was estimated at 14-20%.ConclusionIn 2013-2016, up to 330 cases of acute HCV infection were estimated to have occurred among adults with HIV. National surveillance of acute HCV can be improved by increased notification of infections. Surveillance data should ideally include both acute and chronic HCV infections, and be able to distinguish between acute and chronic infections, and initial and reinfections.ClassificationsThe Netherlands; sexually transmitted infections; hepatitis C; HIV infection; Surveillance; epidemiology

Sign in / Sign up

Export Citation Format

Share Document