scholarly journals External Validation of the Cancer of the Prostate Risk Assessment Postsurgical Score for Prediction of Disease Recurrence after Radical Prostatectomy

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Taha Numan Yıkılmaz ◽  
Erdem Öztürk ◽  
Eşref Oğuz Güven ◽  
Halil Başar
Keyword(s):  
Risk Assessment ◽  
Lymph Node ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Seminal Vesicle ◽  
External Validation ◽  
Specific Antigen ◽  
Surgical Margin ◽  
Seminal Vesicle Invasion ◽  
Cancer Of The Prostate

Objective. The cancer of the prostate risk assessment (CAPRA-S) postsurgical score predicts recurrence, metastasis, and cancer-specific survival after radical prostatectomy (RP). We evaluated the relation between CAPRA-S score and biochemical recurrence (BCR) in prostate cancer after RP in our clinic.Materials and Methods. This study was performed on 203 patients with prostate carcinoma who underwent open RP and regional lymph node dissection in our clinic between 2008 and 2013. We calculated the CAPRA-S scores including prostate-specific antigen (PSA) at diagnosis, pathology Gleason score, surgical margin, seminal vesicle invasion, extracapsular extension, and lymph node involvement. The patients were divided into 3 risk groups (low, intermediate, and high risk) according to risk scores.Results. Recurrence occurred in 17.8% of the patients (36 patients out of 203 patients) with a median of 11.7-month follow-up. The average recurrence-free survival time is 44.6 months. Surgical margin invasion and seminal vesicle invasion significantly correlated with BCR especially in high risk group (11 and 13 of 15 patients,p<0.05, resp.).Conclusion. CAPRA-S score can be easily calculated and it is useful in clinical practice in order to timely propose adjuvant therapies after surgery.

scholarly journals Oncologic Outcome of Radical Prostatectomy as Monotherapy for Men with High-risk Prostate Cancer

2015 ◽  
Vol 9 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Junya Furukawa ◽  
Hideaki Miyake ◽  
Taka-aki Inoue ◽  
Takayoshi Ogawa ◽  
Hirokazu Tanaka ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Seminal Vesicle ◽  
Specific Antigen ◽  
Surgical Margin ◽  
Capsular Invasion ◽  
Seminal Vesicle Invasion ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

Background: The objective of this study was to review our experience with radical prostatectomy (RP) as monotherapy for men with high-risk prostate cancer (PCa). Patients and Methods: This study included 382 consecutive patients who were diagnosed with high-risk PCa according to the D'Amico definition and subsequently underwent RP without neoadjuvant therapy. Biochemical recurrence (BR) was defined as a serum prostate-specific antigen (PSA) level ≥ 0.2 ng/ml on two consecutive measurements, and none of the patients received any adjuvant therapies until their serum PSA levels reached ≥ 0.4 ng/ml. Results: The median preoperative serum PSA level in these 382 patients was 15.9 ng/ml. Pathological stages ≥ pT2c and Gleason scores ≥ 8 were observed in 288 and 194 patients, respectively. During the observation period (median, 48.0 months), BR occurred in 134 patients, and the 5-year BR-free survival rate was 60.1%; however, no patient died of cancer progression. Multivariate analysis identified capsular invasion, seminal vesicle invasion, and surgical margin status as independent predictors of BR. Conclusions: Comparatively favorable cancer control could be achieved using RP as monotherapy for men with high-risk PCa; however, RP alone may be insufficient for patients with capsular invasion, seminal vesicle invasion, and/or surgical margin positivity.

scholarly journals Factors affecting surgical margin positivity in robotic assisted radical prostatectomy

2017 ◽  
Vol 89 (1) ◽  
pp. 71 ◽  
Author(s):  
Mustafa Yuksel ◽  
Kaan Karamık ◽  
Hakan Anıl ◽  
Ekrem Islamoglu ◽  
Mutlu Ates ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Seminal Vesicle ◽  
Gleason Score ◽  
Surgical Margin ◽  
Factors Affecting ◽  
Seminal Vesicle Invasion ◽  
Positive Biopsy ◽  
Biopsy Core ◽  
Robotic Assisted Radical Prostatectomy ◽  
Extraprostatic Extension

Objectives: After radical prostatectomy, surgical margin positivity is an important indicator of biochemical recurrence and progression. In our study we want to compare the surgical margin positivity rates for retropubic radical prostatectomy (RRP) and robotic assisted radical prostatectomy (RALP) and investigate the factors affecting surgical margin positivity in RALP. Materials and methods: Data from 78 RRP and 62 RALP patients operated from 2011 May to 2016 March were retrospectively screened. Patients in both groups were compared in terms of age, postop hematocrit reduction, hospital stay, duration of follow-up, surgical margin positivity, biochemical recurrence and oncologic parameters. In RALP group it was searched the relationship between the surgical margin positivity and prostate specific antigen (PSA), positive biopsy core, biopsy Gleason scoring, pathologic stage and Gleason scoring, lymph node positivity, lymphovascular and perineural invasion, extracapsular extension, seminal vesicle invasion, prostate weight. Results: Patients in the RALP group had lower postop hematocrit reduction and shorter hospital stay (p &lt; 0.001). There was no difference in surgical margin positivity between RALP and RRP groups (37.1% vs. 29.5%, p = 0.341). In RALP group there was a correlation between surgical margin positivity and positive biopsy core number (p = 0.011), pathologic stage (p &lt; 0.001) and Gleason score (p &lt; 0.001), EAU risk classification (p = 0.001), seminal vesicle invasion (p = 0.045), extraprostatic extension (p &lt; 0.001). There was no correlation between prostate weight (p = 0.896), PSA (p = 0.220), biopsy Gleason score (p = 0.266), lymph node positivity (p = 0.140), perineural (p = 0.103) and lymphovascular invasion (p = 0.92) with surgical margin positivity. Conclusions: Positive biopsy core number, pathological stage and Gleason score, EAU risk classification, seminal vesicle invasion and extraprostatic extension are correlated with surgical margin positivity in RALP.

scholarly journals Predictors of prostate-specific antigen progression among men with seminal vesicle invasion at the time of radical prostatectomy

Cancer ◽  
2004 ◽  
Vol 100 (8) ◽  
pp. 1633-1638 ◽  
Author(s):  
Stephen J. Freedland ◽  
William J. Aronson ◽  
Joseph C. Presti ◽  
Christopher L. Amling ◽  
Martha K. Terris ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Seminal Vesicle ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Seminal Vesicle Invasion

scholarly journals Cancer-specific survival and predictors of prostate-specific antigen recurrence and survival in patients with seminal vesicle invasion after radical prostatectomy

Cancer ◽  
2006 ◽  
Vol 106 (11) ◽  
pp. 2369-2375 ◽  
Author(s):  
Fernando P. Secin ◽  
Fernando J. Bianco ◽  
Andrew J. Vickers ◽  
Victor Reuter ◽  
Thomas Wheeler ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Seminal Vesicle ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Cancer Specific Survival ◽  
Seminal Vesicle Invasion

Benefit on Biochemical Control of Adjuvant Radiation Therapy in Patients with Pathologically Involved Seminal Vesicles after Radical Prostatectomy

2007 ◽  
Vol 93 (5) ◽  
pp. 445-451 ◽  
Author(s):  
Carlo Greco ◽  
Simona Castiglioni ◽  
Andrei Fodor ◽  
Ottavio De Cobelli ◽  
Nadia Longaretti ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Radical Prostatectomy ◽  
Seminal Vesicle ◽  
Biochemical Recurrence ◽  
Specific Antigen ◽  
Biochemical Failure ◽  
Adjuvant Radiation ◽  
Biochemical Control ◽  
Adjuvant Radiation Therapy ◽  
Seminal Vesicle Invasion

Aims and Background To determine whether there is a benefit for biochemical control with adjuvant radiation therapy to the surgical bed following radical prostatectomy in patients with seminal vesicle invasion and pathologically negative pelvic lymph nodes (pT3b-pT4 pN0). Methods We retrospectively reviewed the clinical records of radical prostatectomy patients treated between 1995 and 2002. A total of 66 patients with seminal vesicle invasion were identified: 45 of these patients received adjuvant radiation therapy and 21 were observed. Radiation therapy was initiated within 4 months of prostatectomy. Median dose was 66 Gy (range, 60–70 Gy). Median follow-up from the day of surgery was 40.6 months (mean, 41.5; range, 12–99). Biochemical recurrence was defined as the first value ≥0.2 ng/ml. Results At two years, the proportion of patients free from biochemical recurrence was 80% in patients who received adjuvant radiation therapy versus 54% for those not given radiation therapy (P = 0.036). Actuarial biochemical recurrence at 5 years was 59% vs 41% for the radiation therapy and no radiation therapy groups, respectively. On univariate Cox regression model, the hazard of biochemical failure was also associated with a detectable (≥0.2 ng/ml) postsurgical prostate-specific antigen (P = 0.02) prior to radiation therapy. Pathological T stage (pT3b vs pT4), Gleason score, primary Gleason pattern and positive surgical margins were not significantly associated with biochemical recurrence. The hazard of biochemical failure was around 85% lower in the radiation therapy group than in the observation group (P = 0.002). Conclusions Data from the present series suggest that adjuvant radiation therapy for patients with seminal vesicle invasion and undetectable (≤0.2 ng/ml) postoperative prostate-specific antigen significantly reduces the likelihood of biochemical failure.

1147: Favorable Long-Term Outcomes in Patients with Seminal Vesicle Invasion or Lymph Node Invasion at Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 378-379
Author(s):  
Andrea Gallina ◽  
Jochen Walz ◽  
Miriam Traumann ◽  
Georg C. Hutterer ◽  
Thorsten Schlomm ◽  
...  
Keyword(s):  
Lymph Node ◽  
Radical Prostatectomy ◽  
Seminal Vesicle ◽  
Long Term Outcomes ◽  
Seminal Vesicle Invasion
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