scholarly journals Possible Relation between Lack of Posterior Vitreous Detachment and Severe Endogenous Endophthalmitis

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Kazuhiko Umazume ◽  
Jun Suzuki ◽  
Yoshihiko Usui ◽  
Yoshihiro Wakabayashi ◽  
Hiroshi Goto
Keyword(s):  
Posterior Vitreous Detachment ◽  
The Body ◽  
University Hospital ◽  
Endogenous Endophthalmitis ◽  
Systemic Complications ◽  
Vitreous Detachment ◽  
Corrected Visual Acuity ◽  
The Mean ◽  
Tokyo Medical ◽  
Medical University

Purpose. Endogenous endophthalmitis (EE) is a rare ocular disease caused by bacterial or fungal infection of intraocular spaces by hematogenous spread of pathogens from distant infectious loci in the body. We investigated the clinical characteristics and management of eyes with EE in ten consecutive patients. Methods. Ten patients (10 eyes) with EE treated at Tokyo Medical University Hospital in 2014 were reviewed. We retrospectively studied the causative organisms, systemic complications, pre/postoperative mean best-corrected visual acuity (BCVA), and status of posterior vitreous detachment (PVD). Results. The 10 patients comprised 8 males and 2 females, with mean age of 71.2 years. The causative organisms were bacteria in 6 eyes and fungi in 4 eyes. Systemic complications included septicemia or disseminated intravascular coagulation in 5 patients and diabetes mellitus in 4 patients. Postoperative BCVA was improved by 0.2log⁡MAR or greater in 4 eyes and decreased in 4 eyes. Vitrectomy was performed in all eyes, and 4 required multiple surgeries. During vitrectomy, PVD was absent in 8 eyes, 4 of which showed retinal necrosis. The mean age of patients with no PVD was 71.2 years. Conclusion. Despite an advanced age, PVD was absent in the majority of patients with EE. PVD may be related to the pathogenesis and aggravation of EE.

scholarly journals Status of microsatellite instability in different histomorphological patterns of colorectal carcinoma among a group of Bangladeshi people

2021 ◽  
Vol 8 (12) ◽  
pp. 1799
Author(s):  
Momammed Mustafizur Rahman ◽  
Shabnam Imam ◽  
Sayedatun Nessa ◽  
A. K. M. Maruf Raza ◽  
Farida Arjuman ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Observational Study ◽  
Microsatellite Instability ◽  
University Hospital ◽  
Biological Behavior ◽  
Cancer Tissue ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Medical University

Background: This cross- sectional observational study was carried out with an aim to look for microsatellite instability (MSI) status in colorectal carcinoma and their association with different histomorphological patterns and biological behavior of colorectal carcinoma.Methods: This cross-sectional observational study was done in the Department of Pathology, Bangabandhu Sheikh Mujib Medical University Hospital (BSMMU), Dhaka, Bangladesh during September 2014 to October 2015. A total of 39 surgically resected sample of colorectal carcinoma were included. Consent from each patient was taken. The samples were histopathologically evaluated according to the standard protocol. The statistical analyses were done using Statistical packages for social sciences (SPSS 15) for Windows.Results: A total of 39 cases of colorectal carcinoma were included in this study. Majority of the patients (55.5%) was in 6th decade in MSI and 29.1% were MSI absent group. The mean age was found 47.67±10.97 years in present group and 47.84±14.26 years in absent group. The difference was not statistically significant (p>0.05). TNM stage with MSI was observed. The mean CEA level was 100.74±103.66 and 60.43±91.72. The mean Hb was 9.72±1.99 % and 9.92±2.17, the range was 7.2-12.2 and 4.6-13.4 among the groups. The mean difference was not statistically significant (p>0.05). Ulcerated was 3 (33.3%) and 19 (64.5%). Stage 3 tumor was 4 (44.4%) and 16 (51.6%). Grade 2 tumor was 5 (55.6%) and 17 (58.0%).Conclusions: For the first time in Bangladesh, this study was undertaken to evaluate the microsatellite instability (MSI) status in colorectal cancer tissue and their association with different histomorphological patterns of colorectal carcinoma.   

scholarly journals Surgical treatment for secondary aortoesophageal fistula

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Kayo Sugiyama ◽  
Toru Iwahashi ◽  
Nobusato Koizumi ◽  
Toshiya Nishibe ◽  
Toshiki Fujiyoshi ◽  
...  
Keyword(s):  
Open Repair ◽  
Rare Condition ◽  
Aortic Aneurysms ◽  
Total Arch Replacement ◽  
University Hospital ◽  
Aortoesophageal Fistula ◽  
Thoracic Aortic Aneurysms ◽  
Life Threatening ◽  
Tokyo Medical ◽  
Medical University

Abstract Background Aortoesophageal fistula (AEF) is a relatively rare condition that is often life-threatening. Secondary AEF is a complication of previous surgery, which can be more critical and challenging than primary AEF. The number of secondary AEF is increasing due to increase in the number of thoracic endovascular aortic repair (TEVAR). Although TEVAR has become a successful alternative surgical strategy for thoracic aortic aneurysms, secondary AEF after TEVAR might be critical than other secondary AEF because of severe adhesion between the esophagus and residual thoracic aortic wall. Methods This study analyzed six patients with secondary AEF who were treated at Tokyo Medical University Hospital between 2011 and 2016. These participants included four patients who had undergone TEVAR and two who had undergone total arch replacement. Results Although they were subsequently hospitalized for a long period, open surgical repair was completed in two patients who had undergone total arch replacement. TEVAR alone was performed in two patients who had undergone TEVAR and they were discharged without major complications shortly. Combined repair of TEVAR as a bridge to open surgery was planned for two patients who had undergone TEVAR. However, reconstruction of the aorta and esophagus could not be completed in these patients due to severe adhesions, and they died during hospitalization. Conclusions Definitive open repair was successfully performed in patients with secondary AEF after total arch replacement. However, in the patients with secondary AEF after TEVAR, severe adhesion between the aorta and esophagus led to difficulty in performing a successful definitive open repair. The strategy for secondary AEF should, therefore, be decided considering the etiology of secondary AEF. In secondary AEF after TEVAR, definitive open repair is difficult to complete because of catastrophic complication, and palliative treatment using TEVAR without reconstruction of aorta and esophagus can be an alternative.

scholarly journals Association of foveal avascular zone with the metamorphopsia in epiretinal membrane

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hideki Shiihara ◽  
Hiroto Terasaki ◽  
Shozo Sonoda ◽  
Naoko Kakiuchi ◽  
Hidetaka Yamaji ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Superficial Layer ◽  
University Hospital ◽  
Foveal Avascular Zone ◽  
Service Unit ◽  
Corrected Visual Acuity ◽  
Avascular Zone ◽  
The Mean ◽  
The Relationship ◽  
Best Corrected Visual Acuity

Abstract This study was to investigate the relationship between the metamorphopsia and foveal avascular zone (FAZ) parameter in eyes with epiratinal membrane (ERM). We studied patients with an ERM visited retinal service unit at the Kagoshima University Hospital or Shirai Hospital. The best-corrected visual acuity (BCVA), and the degree of metamorphopsia by M -CHARTS™ were evaluated. The 3 × 3 mm optical coherence tomography angiography (OCTA) images of the superficial layer were obtained. Area (mm2), the circularity, eigen value were calculated using ImageJ software. The relationship between visual function, such as best corrected visual acuity (BCVA) and metamorphopsia, and FAZ parameters were studied by Pearson’s correlational coefficient. Fifty-four eyes of 51 patients (24 men and 27 women) with an ERM were studied. The mean age of the patients was 69.6 ± 8.20 years. The mean BCVA and metamorphopsia score was 0.31 ± 0.29 logMAR units and 0.49 ± 0.42. There was no significant relationship between BCVA and FAZ parameters. While, metamorphopsia score was significantly and negatively correlated with all of FAZ parameters (area R = − 0.491, P < 0.001; circularity R = − 0.385, P = 0.004; eigenvalue ratio R = − 0.341; P = 0.012). Multiple regression analysis showed the FAZ area was solely and significantly correlated with metamorphopsia score (β − 0.479, P < 0.001). The size but not the shape of the FAZ was significantly correlated with the degree of metamorphopsia suggesting that it could be an objective parameter of metamorphopsia in ERM patients.

Clinical Treatment to a Child with Profound Hearing Impairment-Attempt of Auditory and Cochlear Implant Center of Tokyo Medical University Hospital (ACICTMU)-

2009 ◽  
Vol 102 (6) ◽  
pp. 415-422
Author(s):  
Atsushi Kawano ◽  
Michio Hazama ◽  
Akira Hagiwara ◽  
Nobuhiro Nishiyama ◽  
Sachie Kawaguchi ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Hearing Impairment ◽  
Clinical Treatment ◽  
University Hospital ◽  
Tokyo Medical ◽  
Medical University

Composição Corporal de Adultos Com Síndrome de Down e Excesso de Peso Atendidos em Hospital Universitário

2018 ◽  
Vol 22 (1) ◽  
pp. 47
Author(s):  
Leiliane Cruz Reis ◽  
Livia Maria Machado Nunes ◽  
Maria Edilma Da Silva Bezerra ◽  
Rosilene Reis Della Noce
Keyword(s):  
Body Composition ◽  
Down Syndrome ◽  
Overweight And Obesity ◽  
The Body ◽  
Fat Free Mass ◽  
University Hospital ◽  
Normal Range ◽  
Cross Sectional ◽  
The Mean ◽  
The City

Pessoas com Síndrome de Down podem, frequentemente, apresentar doença cardíaca congênita, hipotireoidismo, distúrbios gastrointestinais e tendência ao sobrepeso e obesidade, comprometendo gravemente a saúde. O objetivo deste trabalho foi descrever a composição corporal de adultos com Síndrome de Down - SD e excesso de peso, atendidos em um Hospital Universitário. Trata-se de um estudo transversal e descritivo realizado na cidade de Belém do Pará, no ano de 2017, onde os participantes com SD, foram avaliados para determinação da composição corporal com a utilização do aparelho de bioimpedância elétrica InBody230. Foram avaliados 13 indivíduos de ambos os sexos com idades variando entre 20 e 40 anos. A média de peso dos indivíduos do sexo masculino e feminino foi de 71,8 kg e 69,2 kg respectivamente, a média de Índice de Massa Corporal - IMC foi de 31,27 kg/m² para os homens e 34,08 kg/m² para as mulheres, classificada em obesidade. A maioria dos indivíduos apresenta Massa Muscular Esquelética - MME e Massa Livre de Gordura - MLG dentro da faixa de normalidade, porém os valores de Massa de Gordura (MG), assim como a Relação Cintura Quadril - RCQ de todos os indivíduos estão elevados. O acompanhamento individualizado da composição corporal, por meio da bioimpedância elétrica, mostrou ser um instrumento eficaz para avaliação do estado nutricional dessa população.Palavras-chave: Síndrome de Down. Composição Corporal. Bioimpedância Elétrica.AbstractPeople with Down Syndrome can often have congenital heart disease, hypothyroidism, gastrointestinal disorders, and tendency to overweight and obesity severely compromising health. The objective of this study was to describe the body composition in adults with Down Syndrome and overweight treated in a University Hospital. This is a cross-sectional and descriptive study carried out in the city of Belém do Pará in 2017, where the participants with DS, were evaluated to determine the body composition with the use of InBody 230 electric bioimpedance device. Eight individuals of both sexes with ages varying between 20 and 40 years were evaluated. The mean weight of the male and female subjects was 71.8 kg and 69.2 kg respectively, the mean Body Mass Index (BMI) was 31.27 kg / m² for men and 34.08 kg / m² for women, classified as obesity. The majority of individuals had a Skeletal Muscle Mass (MME) and Fat Free Mass (MLG) within the normal range, but the values of Mass of Fat (MG), as well as the Hip Waist Ratio (WHR) of all individuals are high. The individualized monitoring of body composition through electric bioimpedance proved to be an effective tool for assessing the nutritional status of this population.Keywords: Down Syndrome. Body composition. Electric impedance.

Photodynamic therapy using Laserphyrin for centrally located early stage lung cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 7229-7229 ◽  
Author(s):  
J. Usuda ◽  
H. Kato ◽  
T. Okunaka ◽  
K. Furukawa ◽  
H. Honda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Early Stage ◽  
Stage I ◽  
University Hospital ◽  
Early Stage Lung Cancer ◽  
Endobronchial Ultrasonography ◽  
Tokyo Medical ◽  
Medical University ◽  
Stage Lung Cancer

7229 Background: In central type early stage lung cancer, the tumor must be located only as far as the segmental bronchi and be carcinoma in situ or with only limited invasion into the bronchial wall. Laserphyrin (mono-L-aspartyl chlorine e6, NPe6) is a second generation photosensitize and approved by the Japanese government and has been on sale from June 2004. Methods: Four h after the administration of Laserphyrin 40 mg/m2, we irradiated using diode laser (100 mJ/cm2). Before PDT, we evaluated the tumor lesions and tumor depth using autofluorescence bronchoscopy and endobronchial ultrasonography (EBUS), and we confirmed the area of laser irradiation. Results: From February 1980 to December 2005, a total number of 204 patients with 264 lesions of centrally located early stage lung cancer underwent photodynamic therapy (PDT) in the Department of Thoracic Surgery, Tokyo Medical University Hospital. There were 185 clinical stage 0 lesions and 79 stage I lesions. CRs and PRs were obtained in 224 lesions (84.8%) and 40 lesions (15.2%) out of 264 lesions. From July 2004 to December 2005, we performed Laserphyrin-PDT for 28 lesions of centrally located early stage lung cancer in Tokyo Medical University Hospital. The rate of CR was 92.9% (26 lesions) in 28 lesions. For Laserphyrin-PDT, Skin photosensitivity was very low and the clean-up bronchoscopies were not frequently needed, and the period of hospitalization was shorter compared to that for Photofrin-PDT. Conclusions: We conclude that PDT using Laserphyrin will be a standard option for stage 0 (TisN0M0) and stage I (T1N0M0) centrally located early stage lung cancer. No significant financial relationships to disclose.

scholarly journals Differences in age and topographic distribution of the different histological subtypes of basal cell carcinoma, Taubaté (SP), Brazil

2013 ◽  
Vol 88 (5) ◽  
pp. 726-730 ◽  
Author(s):  
Flavia Regina Ferreira ◽  
Bruna da Costa Pevide ◽  
Rafaela Fabri Rodrigues ◽  
Luiz Fernando Costa Nascimento ◽  
Marcia Lanzoni de Alvarenga Lira
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Skin Color ◽  
Age Of Onset ◽  
The Body ◽  
University Hospital ◽  
Histological Subtype ◽  
Histological Subtypes ◽  
The Mean

BACKGROUND: Basal cell carcinoma is the most common form of cancer in humans. OBJECTIVES: To identify the epidemiology of basal cell carcinoma in Taubaté-SP and verify a possible association between topography and the different histological subtypes of this tumor. METHODS: This was a cross-sectional study conducted at The University Hospital of Taubaté between 01/01/08 and 12/31/09. The study included patients with a confirmed diagnosis of basal cell carcinoma, of both genders, without age restrictions. The variables studied were incidence of basal cell carcinoma, topography, histological subtype, skin color, age and gender. We employed the chi-square test to identify the association between histological subtype and topography, and the student's t test to compare the mean age of onset for the different histological subtypes. RESULTS: The study included 239 individuals. The mean age of the sample was 68.0 years. Male subjects (57.7%) and whites (87.1%) predominated in the study. The predominant histological subtype was nodular (34.7%), followed by the superficial subtype. The most frequent sites of involvement were the head and neck (areas exposed to light), with predominance of the nasal region. The superficial subtype was an exception, as it showed a strong association with unexposed areas like the trunk. The mean age of onset of superficial basal cell carcinoma also differed from that of the other histological subtypes, 63.0 and 69.0 years, respectively. CONCLUSION: The results of this study suggest an association of the superficial histological subtype with younger patients and unexposed areas of the body, linking this type of tumor with a pattern of intermittent sun exposure, more similar to the standard photocarcinogenesis of melanoma.

scholarly journals Questionnaire Survey on Driving among Patients with Age-Related Macular Degeneration in Japan

2021 ◽  
Vol 10 (21) ◽  
pp. 4845
Author(s):  
Chikako Hara ◽  
Miki Sawa ◽  
Fumi Gomi ◽  
Kohji Nishida
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
University Hospital ◽  
Corrected Visual Acuity ◽  
Age Related ◽  
Paracentral Scotoma ◽  
The Mean ◽  
The Right ◽  
The Relationship ◽  
Car Driving

Purpose: This study aimed to assess driving capabilities in patients with exudative age-related macular degeneration (AMD) causing unilateral blindness or paracentral scotoma without vision deterioration. Methods: Of the 275 patients with AMD who responded to a questionnaire regarding car driving at Osaka University Hospital, we excluded 78 patients who answered that they had never driven. Finally, 197 patients were included (50 with bilateral and 142 with unilateral AMD). We investigated the relationship between the questionnaire findings and best-corrected visual acuity (BCVA). Results: The mean age was 74.8 ± 6.9 years, and the mean BCVA in the right and left eyes were 0.48 and 0.47, respectively. A negative correlation was observed between the proportion of patients who stopped driving due to AMD and the vision in the worse eye (p < 0.0001); however, 66% of participants were still driving. Regardless of the BCVA, 84% of them wished to continue driving. Concerning perceived dangerous situations, all patients reported an oversight of people or signals and night driving; further, patients with unilateral and bilateral vision deterioration reported vision narrowness and difficulty with discerning signal colours, respectively. Conclusion: Despite the associated danger, patients with AMD continued driving. Close attention should be paid to the driving activities among patients with AMD, even if they have passed the relevant driving tests.

scholarly journals Role of Optical Coherence Tomography Angiography in Following-up Choroidal Neovascular Membranes during the Course of Aflibercept Therapy

2021 ◽  
pp. 89-96
Author(s):  
Ahmad R. Ziada ◽  
Mostafa Abd El Latif Abo El Einen ◽  
Hamdy Abd El Azim El Koumy ◽  
El Said Ibraheem El Dessouky
Keyword(s):  
Choroidal Neovascularization ◽  
Optical Coherence Tomography Angiography ◽  
University Hospital ◽  
P Value ◽  
Interventional Study ◽  
Flow Area ◽  
Corrected Visual Acuity ◽  
The Mean ◽  
Automated Software

Aims: To evaluate the mean area of choroidal neovascularization (CNV) and the flow area within the CNV and determine their value in monitoring the effect of aflibercept therapy. Study Design: prospective, interventional study. Place and Duration of Study: Tanta University Hospital in the period between March 2017 and March 2019. Methodology: OCT angiography images were obtained using the AngioVue (Optovue Inc., CA, USA). For quantitative analysis of the mean area of CNV and the flow area within the CNV, the CNV was manually delineated with the help of the manufacturer’s automated software, and the parameters of interest were automatically calculated and generated. Results: The study included forty eyes of 40 patients, 14 females and 26 males, the mean age of patients was 69 ± 5 years. The mean baseline best-corrected visual acuity (BCVA) was 51.29 ± 14.80 ETDRS letters, which significantly increased to 63.41 ± 5.03 at week 36; p-value < 0.05. The mean area of choroidal neovascularization decreased significantly from baseline (2.72 ± 4.29 mm2) to week 36 (1.53 ± 1.07 mm2); p-value < 0.05. The the flow area within the measured CNV decreased significantly from baseline (2.28 ± 2.08 mm2) to week 36 (0.91 ± 0.63 mm2); p-value < 0.05. Conclusion: The mean area of CNV and the flow area within the measured CNV are valuable biomarkers for following up CNV during treatment with aflibercept.

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