scholarly journals A Low-Grade Fibromyxoid Sarcoma of the Internal Abdominal Oblique Muscle

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Masakazu Hashimoto ◽  
Kei Koide ◽  
Michinori Arita ◽  
Koji Kawaguchi ◽  
Yoshihiro Mikuriya ◽  
...  
Keyword(s):  
Radical Resection ◽  
Oblique Muscle ◽  
Low Grade ◽  
First Case ◽  
Positron Emission ◽  
Muc4 Expression ◽  
Highly Sensitive ◽  
Fibromyxoid Sarcoma ◽  
Fluorine 18 Fluorodeoxyglucose

A low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor, with a benign histologic appearance but malignant behavior. This report describes a 74-year-old man with an internal abdominal oblique muscle mass. The tumor appeared as a well-defined ovoid mass on computed tomography, with mild uptake on fluorine-18-fluorodeoxyglucose positron-emission tomography images. Radical resection with wide safe margins was performed. Histologically, the tumor was composed of spindle-shaped cells in a whorled growth pattern, with alternating fibrous and myxoid stroma. MUC4 expression, a highly sensitive and specific immunohistochemical marker for LGFMS, was detected. Therefore, we diagnosed the tumor as LGFMS. At the 3-month follow-up, there was no sign of recurrence or metastasis. We report the first case of LGFMS arising from the internal abdominal oblique muscle.

Low-Grade Mucosa-Associated Lymphoid Tissue Lymphoma Involving the Kidney: Report of 3 Cases and Review of the Literature

2006 ◽  
Vol 130 (1) ◽  
pp. 86-89 ◽  
Author(s):  
Libo Qiu ◽  
Pamela D. Unger ◽  
Robert W. Dillon ◽  
James A. Strauchen
Keyword(s):  
Lymphoid Tissue ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoid Cells ◽  
Low Grade ◽  
The Third ◽  
First Case ◽  
Abundant Cytoplasm ◽  
History Of

Abstract Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue involving the kidney is rare. We report a series of 3 cases. The first case occurred in an 83-year-old woman who presented with back pain. The second case was a 53-year-old man with a history of sarcoidosis who was found, in the course of evaluation of sarcoidosis, to have a right renal mass. The third case occurred in a 72-year-old man who had a history of periorbital mucosa–associated lymphoid tissue lymphoma and had been treated with surgery and radiation 1 year prior to this presentation. Histologically, all 3 patients showed infiltrate of uniform small-to-medium–sized lymphocytes with irregular nuclear contours and abundant cytoplasm resembling centrocytes or monocytoid lymphoid cells. The first patient received chemotherapy without complications. The second patient underwent a partial nephrectomy and was asymptomatic at the subsequent follow-up. The third patient developed a pulmonary embolism following nephrectomy, and further follow-up is not available.

scholarly journals Low-Grade Fibromyxoid Sarcoma of the Lateral Skull Base: Presentation of Two Cases

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Evgenia Chetverikova ◽  
Priit Kasenõmm
Keyword(s):  
Malignant Tumour ◽  
Low Grade ◽  
Loss Of Consciousness ◽  
First Case ◽  
Clinical Presentations ◽  
Lateral Skull Base ◽  
Fibromyxoid Sarcoma ◽  
Gag Reflex ◽  
The Right ◽  
Slow Growing

Low-grade fibromyxoid sarcoma (LGFMS) is a rare slow-growing malignant tumour with a deceptively benign histologic appearance. Herein, we report two cases of LGFMS with variable clinical presentations. The first case was a 17-year-old female who referred to our department due to deaf ear on the right together with ipsilateral gag reflex impairment and globus sensation in the pharynx. The second case was a 35-year-old female with recurrent LGFMS, suffering from headaches, vertigo, and episodes of loss of consciousness. LGFMS of the temporal bone is a rare pathology, and to the best of our knowledge, no such cases have been reported before.

Low-grade fibromyxoid sarcoma of the parapharyngeal space: an unusual location

2021 ◽  
Vol 14 (5) ◽  
pp. e237083
Author(s):  
Muhammad Hammad Deewani ◽  
Muhammad Hassan Danish ◽  
Muhammad Sohail Awan ◽  
Nasir Ud Din
Keyword(s):  
Head And Neck ◽  
Parapharyngeal Space ◽  
Neck Region ◽  
Low Grade ◽  
Head And Neck Region ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Fibromyxoid Sarcoma ◽  
Established Treatment

Low-grade fibromyxoid sarcoma (LGFMS) is an uncommon soft-tissue malignancy. LGFMS preferentially affects trunks and extremities of young adults; however, occasional cases have been reported in different sites of head and neck region including oral cavity, larynx and oropharynx. LGFMS usually exhibit areas of collagenised and myxoid stroma with appearance of spindle cells in whorling pattern. It is a challenge to diagnose it accurately as most of the time it is misdiagnosed as benign neoplastic entity of spindle cells. There have been only few isolated cases of LGFMS reported in head and neck region and LGFMS originating from the parapharyngeal space has never been reported before. We recently experienced a case of low grade fibomyxoid sarcoma in parapharyngeal space of neck. LGFMS have the propensity to locally recur and to metastasise. Due to its rarity in head and neck region, there are no well-established treatment and follow-up guidelines.

scholarly journals RARE-07. HOW TO TREAT THE INCIDENTAL THALAMIC PRESUMED LOW-GRADE GLIOMAS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi222-vi222
Author(s):  
Toshihiro Kumabe ◽  
Ichiyo Shibahara ◽  
Masayuki Kanamori ◽  
Ryuta Saito ◽  
Takuichiro Hide ◽  
...  
Keyword(s):  
Stereotactic Biopsy ◽  
Tumor Volume ◽  
Radical Resection ◽  
Histological Diagnosis ◽  
The Other ◽  
Low Grade ◽  
Diffuse Astrocytoma ◽  
Low Grade Gliomas ◽  
Tumor Dissemination

Abstract Medical intervention for patients with incidentally found presumed low grade gliomas (iLGGs) is controversial. We experienced 5 consecutive thalamic iLGGs, and discuss the follow-up methods and the timing of the intervention. Age at the initial MRI was 19, 57, 58, 70, 70, respectively. Only the bilateral thalamic iLGG of 19-year-old male was radically resected soon after the initial MRI, because of the large tumor size. The histological diagnosis was a diffuse astrocytoma, IDH-wildtype, without H3K27M mutation. This patient was treated by chemoradiation, still alive for 24 months with KPS of 90%. The other four cases were strictly followed by MRI. One case of 70-year-old female is followed for 38 months without increasing the tumor volume. The other 3 cases had been followed by MRI for 15, 91, 154 months, respectively. Stereotactic biopsy or ventriculo-peritoneal shunting (VPS) was performed after that because of the tumor progression. The histological diagnosis of 57-year-old male followed for 15 months was a diffuse astrocytoma, IDH-wildtype. This patient selected further follow-up, although volume of the tumor increased exponentially. Radical resection was performed 11 months after the stereotactic biopsy, disclosed malignant transformation. This patient was treated by chemoradiation, finally died of tumor dissemination 15 months after the radical resection. Long-term followed patients, such as 91 and 154 months, showed slow linear tumor volume increasing. The latter patient with bilateral iLGG was treated by VPS followed by radiation therapy. This patient could keep KPS of 100% for 13 years after the initial MRI and live for 20 years. Our case series suggests that conservative management and close follow-up of thalamic iLGGs is a safe and effective strategy. However, volumetric analysis must be performed for every follow-up MRI. Once the steep volume increasing is detected, surgical intervention and/or chemoradiation should be considered without delay.

MUC4 Is a Highly Sensitive and Specific Marker for Low-grade Fibromyxoid Sarcoma

2011 ◽  
Vol 35 (5) ◽  
pp. 733-741 ◽  
Author(s):  
Leona A. Doyle ◽  
Emely Möller ◽  
Paola Dal Cin ◽  
Christopher D.M. Fletcher ◽  
Fredrik Mertens ◽  
...  
Keyword(s):  
Specific Marker ◽  
Low Grade ◽  
Highly Sensitive ◽  
Fibromyxoid Sarcoma

scholarly journals Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor

2012 ◽  
Vol 166 (1) ◽  
pp. 131-135 ◽  
Author(s):  
Charlotte Lepoutre-Lussey ◽  
Audrey Rousseau ◽  
Abir Al Ghuzlan ◽  
Laurence Amar ◽  
Chantal Hignette ◽  
...  
Keyword(s):  
Adrenocortical Adenoma ◽  
Primary Tumor Site ◽  
Positron Emission Tomography Scanning ◽  
Primary Angiosarcoma ◽  
First Case ◽  
Positron Emission ◽  
Hypokalemic Hypertension ◽  
Cell Proliferations ◽  
Tomography Scanning

ContextPrimary adrenal angiosarcoma is an extremely rare neoplasm, as are combined tumors within a given adrenal lesion.Clinical presentation and interventionA 35-year-old man presented with hypokalemic hypertension leading to the discovery of a 6 cm diameter malignant-appearing right adrenal tumor. The lesion displayed marked 18F-fluorodeoxyglucose uptake on positron emission tomography scanning. Endocrine investigations revealed secretion of both cortisol and aldosterone by the neoplasm. The entire right adrenal gland along with the periadrenal fat tissue was removed during laparoscopic surgery.ResultsHistological examination revealed two intermingled tumor cell proliferations, namely an angiosarcoma and an adrenocortical adenoma. An extensive post-operative search revealed no other primary tumor site, nor metastases. The lesion was then considered to be a primary adrenal angiosarcoma combined with a secreting adrenocortical adenoma. The patient received four cycles of chemotherapy (adriamycin/ifosfamide). At 2-year follow-up, he is alive and well, with no sign of relapse.ConclusionTo the best of our knowledge, this is the first case of an adrenal neoplasm combining a primary angiosarcoma and a functioning adrenocortical adenoma.

scholarly journals Case Report: An extremely rare occurrence of recurrent inguinal low-grade fibromyxoid sarcoma involving the scrotum

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 789
Author(s):  
Samy Chitayat ◽  
Rodrigo Barros ◽  
José Genilson Ribeiro ◽  
Heleno Augusto Moreira Silva ◽  
Flávio Rondinelli Sá ◽  
...  
Keyword(s):  
Tumor Resection ◽  
Muscle Flap ◽  
Inguinal Region ◽  
Purulent Discharge ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
Patient Reported ◽  
Fibromyxoid Sarcoma ◽  
Left Inguinal Region

Low-grade fibromyxoid sarcoma (LGFMS) is a rare sarcoma subtype. The most common tumor locations are the deep soft tissue of extremities or trunks. We report a rare case of recurrent LGFMS in the inguinal region involving the scrotum and both testicles. A 38-year-old male patient reported a history of multiple nodular lesions in the left inguinal region accompanied by local inflammation. The patient was submitted for local resection of the lesion at our institution, with histopathological diagnosis of LGFMS. He missed his follow-up, returning with a large bulge in the left inguinal region involving the scrotum with signs of tissue necrosis and local purulent discharge. Surgical exploration was performed and the patient underwent tumor resection in the left inguinal region and the entire scrotum, with bilateral orchiectomy, with the margins enlarged to the right inguinal region and proximal surface of the penis. Local reconstruction was performed with a left fascia lata tensor muscle flap and ipsilateral thigh coverage using partial skin graft. On microscopic examination, the tumor showed spindle cells arranged in bundles, with abundant collagen and myxoid stroma with interspersed prominent vessels. The immunohistochemical study carried out showed immunoreactivity with Ki67 (<5%), immunonegativity with desmin and S100, confirming the diagnosis of LGFMS. Postoperative recovery was good and no recurrence was seen after two years. The patient is in good health, realizing multidisciplinary outpatient follow-up and performing continuous testosterone replacement. Surgical resection with negative margins for localized disease remains the standard treatment for LGFMS.

scholarly journals Giant Low-Grade Fibromyxoid Sarcoma in the Neck

2020 ◽  
Vol 63 (9) ◽  
pp. 432-435
Author(s):  
Jong Min Park ◽  
Hye Rin Lim ◽  
Jo Heon Kim ◽  
Dong Hoon Lee
Keyword(s):  
Neck Region ◽  
Surgical Excision ◽  
Late Recurrence ◽  
Low Grade ◽  
Head And Neck Region ◽  
Long Term Follow Up ◽  
Fibromyxoid Sarcoma ◽  
Middle Aged Adults

Low-grade fibromyxoid sarcoma (LGFS) is a soft tissue tumor that rarely occurs in the head and neck region. It occurs mainly in the proximal extremities and the trunk and is prevalent in the young and middle-aged adults. In the present case, LGFS was present at an atypical location and at an unusual age. The treatment of choice for LGFS is radical wide surgical excision with a clear margin. Long-term follow-up is essential for all patients with LGFS, as it has the potential for late recurrence or metastasis.

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