scholarly journals Spectral Analysis of Chinese Medicinal Herbs Based on Delayed Luminescence

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Jingxiang Pang ◽  
Xiaoyan Zhu ◽  
Yanli Liu ◽  
Jialei Fu ◽  
Xiaolei Zhao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Probability Distribution ◽  
Spectral Distribution ◽  
Medicinal Herbs ◽  
Therapeutic Effects ◽  
Chinese Medicinal Herbs ◽  
Delayed Luminescence ◽  
Decay Probability ◽  
Chinese Herbal ◽  
Significant Difference

Traditional Chinese medicine (TCM) plays a critical role in healthcare; however, it lacks scientific evidence to support the multidimensional therapeutic effects. These effects are based on experience, and, to date, there is no advanced tool to evaluate these experience based effects. In the current study, Chinese herbal materials classified with different cold and heat therapeutic properties, based on Chinese medicine principles, were investigated using spectral distribution, as well as the decay probability distribution based on delayed luminescence (DL). A detection system based on ultraweak biophoton emission was developed to determine the DL decay kinetics of the cold and heat properties of Chinese herbal materials. We constructed a mathematical model to fit the experimental data and characterize the properties of Chinese medicinal herbs with different parameters. The results demonstrated that this method has good reproducibility. Moreover, there is a significant difference (p<0.05) in the spectral distribution and the decay probability distribution of Chinese herbal materials with cold and heat properties. This approach takes advantage of the comprehensive nature of DL compared with more reductionist approaches and is more consistent with TCM principles, in which the core comprises holistic views.

Acupuncture plus Herbal Medicine for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 45 (07) ◽  
pp. 1327-1344 ◽  
Author(s):  
Simin Zhou ◽  
Lanlan Dong ◽  
Yuan He ◽  
Hong Xiao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
World Population ◽  
Chinese Herbal ◽  
Significant Difference

Alzheimer’s disease (AD) is associated with the unprecedented aging tendency in our world population and has become a significant health issue. The use of Traditional Chinese Medicine to treat AD has been increasing in recent years. The objective of this meta-analysis is to evaluate the effectiveness of combining acupuncture with herbal medicine to treat AD. Randomized controlled trials (RCTs) of acupuncture plus herbals versus treatment with western drugs for AD were retrieved from 11 databases. The data were extracted by two authors; dichotomous data were expressed as odds ratio (ORs) and 95% confidence intervals (CIs), while continuous data were calculated by mean differences (MDs) with 95% CIs. Although the combined analysis of the score of Activity of Daily Life (ADL) scale MD was [Formula: see text]3.59 (95% CI [Formula: see text]7.18–0.01, [Formula: see text]), which indicates there was no statistically significant difference between the two treatments at reducing the ADL scale score, the pooled results of 12 trials indicated that acupuncture plus Chinese herbal medicine was better than western drugs at improving the effectiveness rate (OR 2.24, 95% CI 1.40–3.56), the combined evidence of 11 articles showed that acupuncture plus Chinese herbal medicine was more effective than western drugs at improving the scores for the Mini Mental State Examination (MMSE) scale (2.10, 95% CI 0.69–3.51, [Formula: see text]) and the traditional Chinese medicine symptom (MD 5.07, 95% CI 3.90–6.25, [Formula: see text]). From the current research results, acupuncture plus herbal medicine may have advantages over western drugs for treating AD. Nevertheless, well-designed RCTs with a larger sample size are required in the future.

scholarly journals Chinese Herbal Medicine Bushen Qinggan Formula for Blood Pressure Variability and Endothelial Injury in Hypertensive Patients: A Randomized Controlled Pilot Clinical Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chunxiao Wu ◽  
Jingchun Zhang ◽  
Yingke Zhao ◽  
Jing Chen ◽  
Yue Liu
Keyword(s):  
Blood Pressure ◽  
Herbal Medicine ◽  
Endothelial Function ◽  
Chinese Herbal Medicine ◽  
Blood Pressure Variability ◽  
Endothelial Injury ◽  
Control Group ◽  
Therapeutic Effects ◽  
Chinese Herbal ◽  
Significant Difference

Background.Blood pressure variability (BPV) independent of average blood pressure is related to cardiovascular damage. Meanwhile, BPV is also associated with measures of endothelial injury. Decoction, a traditional used form of Traditional Chinese Medicine (TCM), is inconvenient to prepare, carry, and store. Dispensing granules is now developing as an alternative to decoction, but the evidence supporting its clinical efficacy the same as decoction remains unclear.Objective.To examine the therapeutic effects on mean blood pressure (MBP), blood pressure variability, and endothelial function by giving Bushen Qinggan Formula, a compound Chinese Herbal Medicine and also to evaluate the difference in efficacy between decoction and granule.Methods.A total of 150 patients with hypertension were enrolled and randomly assigned to receive the placebo, Bushen Qinggan decoction, or Bushen Qinggan granule in addition to the standard medications (amlodipine-5 mg/d) for the treatment of essential hypertension (EH). The outcome was the reduction in the MBP and BPV and also included changes in the endothelial markers including endothelin-1 (ET-1) and nitric oxide (NO) after 8 weeks of treatment.Results.Compared with the control group, the Bushen Qinggan decoction and granule groups had significant improvement (P<0.01) in BPV and endothelial founction. The level of BPV and endothelial function between decoction and granule group had no significant difference (P>0.05).Conclusion.Based on the standard treatment, Bushen Qinggan Formula further improved BPV and endothelial function. The efficacy of Bushen Qinggan decoction and granule is similar in improving BPV and endothelial function. However, no significant antihypertensive effects could be demonstrated.

scholarly journals A comparison of the chemical compounds in single- and co-boiled Zhi-Zi-Da-Huang decoctions with UPLC-qTOF-MS/MS and UPLC-DAD

2020 ◽  
Author(s):  
Mengyu Xia ◽  
Xue Zhang ◽  
Hongwei Wu ◽  
Yun Wang ◽  
Cun Zhang
Keyword(s):  
Chinese Medicine ◽  
Chemical Compounds ◽  
Important Variable ◽  
Therapeutic Effects ◽  
Experimental Basis ◽  
Chemical Substances ◽  
Fragment Ions ◽  
Significant Difference ◽  
Characteristic Fragment ◽  
The Difference

Abstract Background Zhi-Zi-Da-Huang decoction (ZZDHD) is a famous Traditional Chinese Medicine decoction due to its therapeutic effects on clinical hepatobiliary disorders. ZZDHD is composed of Gardeniae Fructus, Rhei Radix et Rhizoma, Fructus Aurantii Immaturus, and Sojae Semen Praeparatum. With the development of current technology, dispensing granules have been widely used for convenience. However, limited research has been conducted to determine differences in the chemical compounds between dispensing granules and traditional decoction. Methods A strategy based on UPLC-qTOF-MS/MS and UPLC-DAD was established to quantitatively and qualitatively analyze the chemical compounds present in single- and co-boiled ZZDHD. First, we utilized UPLC-qTOF-MS/MS to identify the compounds in single- and co-boiled ZZDHD. Then, 15 compounds were quantitatively analyzed in ZZDHD by UPLC-DAD. Finally, fingerprint and chemometric analyses were adopted to evaluate the difference between single- and co-boiled ZZDHD. Results One hundred and forty-seven compounds were authenticated or determined according to their retention behaviors, mass mensuration, and characteristic fragment ions. In addition, 15 analytes of single- and co-boiled ZZDHD indicated a significant difference in the content of many compounds, including geniposide (G2), emodin, chrysophanol, daidzin, and crocin-I. The similarities of single and co-boiled ZZDHD were higher than 0.99, as evaluated by fingerprinting; 30 common peaks were evaluated by the chemometric analysis, which found 13 important variable values (VIP > 1) including C3, A3, crocetin, daidzin, C5, physcion, G2, genipin-1-O-β-D-gentiobioside (G1), chrysophanol, emodin, A2, A5, and C6. Conclusions This study provided an experimental basis for explaining the rationality of single-and co-boiled ZZDHD, and a study model for comparing the chemical substances between traditional decoctions and dispensing granules.

scholarly journals Therapeutic Effects and Molecular Mechanisms of Bioactive Compounds Against Respiratory Diseases: Traditional Chinese Medicine Theory and High-Frequency Use

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Wang ◽  
Qibiao Wu ◽  
Lu Ding ◽  
Siyu Song ◽  
Yaxin Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Application ◽  
Bioactive Compounds ◽  
High Frequency ◽  
Lung Diseases ◽  
Respiratory Diseases ◽  
Molecular Mechanisms ◽  
Therapeutic Effects ◽  
Chinese Herbal

Respiratory diseases, especially the pandemic of respiratory infectious diseases and refractory chronic lung diseases, remain a key clinical issue and research hot spot due to their high prevalence rates and poor prognosis. In this review, we aimed to summarize the recent advances in the therapeutic effects and molecular mechanisms of key common bioactive compounds from Chinese herbal medicine. Based on the theories of traditional Chinese medicine related to lung diseases, we searched several electronic databases to determine the high-frequency Chinese medicines in clinical application. The active compounds and metabolites from the selected medicines were identified using the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) by analyzing oral bioavailability and drug similarity index. Then, the pharmacological effects and molecular mechanisms of the selected bioactive compounds in the viral and bacterial infections, inflammation, acute lung injury (ALI), chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, asthma, and lung cancer were summarized. We found that 31 bioactive compounds from the selected 10 common Chinese herbs, such as epigallocatechin-3-gallate (EGCG), kaempferol, isorhamnetin, quercetin, and β-sitosterol, can mainly regulate NF-κB, Nrf2/HO-1, NLRP3, TGF-β/Smad, MAPK, and PI3K/Akt/mTOR pathways to inhibit infection, inflammation, extracellular matrix deposition, and tumor growth in a series of lung-related diseases. This review provides novel perspectives on the preclinical study and clinical application of Chinese herbal medicines and their bioactive compounds against respiratory diseases.

scholarly journals A Randomized, Controlled Clinical Trial of Combining Therapy with Traditional Chinese Medicine-Based Psychotherapy and Chinese Herbal Medicine for Menopausal Women with Moderate to Serious Mood Disorder

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Yuyan Zeng ◽  
Xuchun Huang ◽  
Changqian Chen ◽  
Guangning Nie ◽  
Xiaojing Cao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Mood Disorder ◽  
Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Self Rating ◽  
Menopausal Women ◽  
Significant Difference

Objective. To comparatively examine the effectiveness and safety of the combination therapy of traditional Chinese medicine formula Bushen-Shugan granule and psychotherapy (BSSG-P) and Chinese herbal medicine Bushen-Shugan granule (BSSG) alone in the treatment of moderate to serious mood disorder in menopausal women. Methods. In our previous clinical studies, BSSG-P had been proved to be superior to BSSG, psychological treatment, and placebo in improving mild mood disorder in menopausal women. In this study, we analyzed the efficacy of BSSG-P and BSSG in the treatment of moderate to serious mood disorder. Eighty-five eligible participants, who were diagnosed as menopausal women with moderate to serious mood disorder and categorized as kidney deficiency and liver-qi stagnation pattern, were randomly assigned into two groups and treated with BSSG-P or BSSG. They were subjected to an 8-week treatment period and a 4-week follow-up study. The primary outcome instrument was the Greene Climacteric Scale, Self-Rating Depression Scale (SDS), and Self-Rating Anxiety Scale (SAS), respectively. Results. When comparing all time points with baseline, both BSSG-P and BSSG markedly decreased the total score of Greene, SDS, and SAS and the score of each dimension, in which BSSG-P exerted superior effect after 8-week treatment and 4-week follow-up (P<0.05). Furthermore, BSSG-P also showed great advantage in reducing the score of Greene, SDS, and SAS for menopausal women with moderate mood disorder at the end of the 8th and 12th week when compared with BSSG (P < 0.05), whereas there was no significant difference between groups at any time point for patients with serious mood disorder (P>0.05). No serious event occurred in both groups, and no significant difference was found between groups in adverse event proportion. Conclusions. BSSG-P was superior to BSSG in improving the physical and psychological symptoms of menopausal women with mood disorder. For patients with moderate mood disorder, BSSG-P showed obvious advantages; however, no superiority was observed for serious mood disorder.

Correlation between the different therapeutic properties of Chinese medicinal herbs and delayed luminescence

Luminescence ◽  
2015 ◽  
Vol 31 (2) ◽  
pp. 323-327 ◽  
Author(s):  
Jingxiang Pang ◽  
Jialei Fu ◽  
Meina Yang ◽  
Xiaolei Zhao ◽  
Eduard van Wijk ◽  
...  
Keyword(s):  
Medicinal Herbs ◽  
Chinese Medicinal Herbs ◽  
Delayed Luminescence ◽  
Therapeutic Properties

scholarly journals How can traditional Chinese medicine contribute to the therapeutic approach in coronavirus disease 2019 (COVID-19)? A review of the registered clinical trials

2020 ◽  
Author(s):  
Hui Luo ◽  
Ming Yang ◽  
Qiao-ling Tang ◽  
Xiao-yang Hu ◽  
Merlin L. Willcox ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Tai Chi ◽  
Relevant Information ◽  
Current Status ◽  
Therapeutic Effects ◽  
Global Management ◽  
Chinese Herbal ◽  
Chinese Patent

Abstract Background: Since the outbreak of coronavirus disease 2019 (COVID-19) in January 2020, Traditional Chinese Medicine (TCM) has been fully and deeply involved in the treatment of COVID-19 in China. An increasing number of clinical trials has been registered to evaluate the effects of TCM in the prevention and therapeutic management of COVID-19.Objective: This study aims to review the existing TCM registered trials, identify promising and available TCM therapies, in order to provide reference for the global management of COVID-19. Methods: All clinical trials on TCM for COVID-19 registered in eight registry platforms worldwide were searched up to May 14, 2020. The data of registration trend, design, objective, interventions, current status, and relevant information were reviewed and summarized. Supportive information on the progress, results and potential value of the included registered trials were searched and reviewed from databases and official websites. Results: 161 TCM trials registered in three registries from January 26 to May 14 were included. 94 (58.4%) were randomized controlled trials, followed by controlled clinical trials (25, 15.5%), single-arm clinical studies (18, 11.2%) and others (24, 14.9%). 114 trials (70.8%) assessed therapeutic effects; while the remaining were for prevention, rehabilitation, and TCM syndrome epidemiology. The three most evaluated TCM interventions were Chinese herbal medicine (CHM) in the preparation forms of formulae decoction/granule (41.7%), Chinese patent medicine (24.8%) and Chinese herbal-derived injections (8.1%). The common outcomes in therapeutic trials were symptoms and signs (65.8%), time to viral clearance on PCR (50.9%), and improvement in CT images (43.9%). 78 trials (48.4%) had started recruiting and six trials (3.7%) had completed recruiting. Among the TCM interventions identified from the registered trials, the following are worthy of attention and may have the potential feasibility of being evaluated and then used worldwide due to their rigorous design, previous evidence and availability: for prevention in high-risk populations or suspected cases, moxibustion, Huoxiang Zhengqi pill and Jinye Baidu granule could be considered; for treatment, Qingfei Paidu decoction or granules in mild, moderate and severe cases, Huashi Baidu decoction, Lianhua Qingwen caplsule, Toujie Quwen granule and Xiyanping injection in mild and moderate cases, and Xuebijing injection in severe cases could be considered. For rehabilitation of cured patients, the effect of Tai Chi and Liuzijue on the patients’ lung function and quality of life deserves attention.Conclusion: A series of promising potentially effective TCM interventions including CHM formulae, Chinese patent medicines, herbal-derived injections and non-drug therapies have been identified in clinical practice and are being evaluated by registered clinical trials. Available and applicable interventions within relevant trials are worthy of worldwide attention and application, in order to contribute to the global management of COVID-19 epidemic.

Therapeutic potential of DCB-SLE1, an extract of a mixture of Chinese medicinal herbs, for severe lupus nephritis

2011 ◽  
Vol 301 (4) ◽  
pp. F751-F764 ◽  
Author(s):  
Pei-Yi Tsai ◽  
Shuk-Man Ka ◽  
Jia-Ming Chang ◽  
Wen-Liang Chang ◽  
Yuan-Jen Huang ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
B Cell ◽  
Cell Activation ◽  
Acute Onset ◽  
Medicinal Herbs ◽  
Autoimmune Response ◽  
Therapeutic Effects ◽  
Chinese Medicinal Herbs ◽  
Autoantibody Production ◽  
Severe Lupus Nephritis

The pathogenesis of lupus nephritis is mainly attributable to a complex interaction between the innate and adaptive immune systems, including T and B cell function abnormalities. In addition to autoantibody production and immune complex deposition, Th1 and Th17 cytokines may play key roles in the development and progression of lupus nephritis. Acute onset of severe lupus nephritis remains a challenge in terms of prevention and treatment. In the present study, we evaluated the therapeutic effects of DCB-SLE1, an extract of a mixture of four traditional Chinese medicinal herbs ( Atractylodis macrocephalae Rhizoma, Eucommiae cortex , Lonicerae caulis , and Hedyotidis diffusae Herba), on an accelerated severe lupus nephritis model, characterized by acute onset of proteinuria, azotemia, autoantibody production, and development of severe nephritis, induced by twice weekly injection of New Zealand black/white F1 mice with Salmonella -type lipopolysaccharide. DCB-SLE1 was administered daily by gavage starting 2 days after the first dose of induction of lipopolysaccharide, and the mice were euthanized at week 1 or week 5. The results showed that DCB-SLE1 significantly ameliorated the hematuria, proteinuria, renal dysfunction, and severe renal lesions by 1) suppression of B cell activation and decreased autoantibody production; 2) negative regulation of T cell activation/proliferation and natural killer cell activity; 3) suppression of IL-18, IL-6, and IL-17 production and blocking of NF-κB activation in the kidney; and 4) prevention of lymphoid and renal apoptosis. These results show that DCB-SLE1 can protect the kidney from autoimmune response-mediated acute and severe damage through systemic immune modulation and anti-inflammation pathways.

scholarly journals Chinese Medicinal Herbs in the Treatment of Diabetic Cognitive Impairment: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Bin Yan ◽  
Jingbo Wang ◽  
Zhigang Xue ◽  
Guoqing Tian
Keyword(s):  
Cognitive Impairment ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Memory Function ◽  
Effective Rate ◽  
Medicinal Herbs ◽  
Controlled Trials ◽  
Chinese Medicinal Herbs ◽  
Randomized Controlled ◽  
Significant Difference

Background. Diabetic cognitive impairment (DCI), a serious complication of diabetes mellitus (DM), is gaining more acceptance and attention. The learning and memory function of diabetics always decreases. Traditional Chinese medicine (TCM) has been demonstrated to be effective in treating the symptoms in China, and thereinto Chinese medicinal herbs (CMH) are the most widely used. The objective of the present study was to review and analyze the existing data about reducing the symptoms in CMH treatment for DCI. Methods. Electronic literature databases (PubMed, EMBASE, CNKI, SinoMed, and Wan fang) were searched for randomized controlled trials conducted in China, comparing CMH with western medicines in the treatment of DCI, up to April 1, 2018. We applied standard meta-analytic techniques to analyze data from papers that reached acceptable criteria. Result. Nine randomized controlled trials (n = 576) on CMH were included. We found moderate evidence that CMH used alone or in combination with western medicines was more effective than western medicines alone in reliving the symptoms for DCI (total effective rate, odds radio (OR) = 4.64 (2.60, 8.29), and 95% confidence interval, P<0.00001). Besides, CMH along or in combination with western medicines showed more beneficial effects on Montreal Cognitive Assessment (MoCA) scale (mean difference (MD) = 1.31(0.75, 1.87), P<0.00001), Mini-Mental State Examination (MMSE) scale (MD = 2.07 (0.86, 3.28), P<0.00001, and TCM symptom score (TCMSS) (MD = -4.89 (-8.44, -1.34), P = 0.007). Most of the included studies showed that there was not a significant difference in the adverse events. Conclusions. These findings demonstrated that CMH used alone or in combination with western medicines were apparently better than western medicines alone in the treatment of DCI. Because of the poor quality of the studies that were available for the present meta-analysis, further researches are still needed to support these early findings.

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