scholarly journals Preparation and Loading with Rifampicin of Sub-50 nm Poly(ethyl cyanoacrylate) Nanoparticles by Semicontinuous Heterophase Polymerization

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
H. Saade ◽  
C. Barrera ◽  
R. Guerrero ◽  
E. Mendizábal ◽  
J. E. Puig ◽  
...  
Keyword(s):  
Drug Release ◽  
Aqueous Dispersions ◽  
Molecular Weights ◽  
Heterophase Polymerization ◽  
Release Times ◽  
Addition Rate ◽  
Nanoparticle Structure ◽  
Ethyl Cyanoacrylate ◽  
Two Populations ◽  
Semicontinuous Heterophase Polymerization

We report the preparation of poly(ethyl cyanoacrylate) (PECA) nanoparticles by semicontinuous heterophase polymerization carried out at monomer starved conditions at three monomer addition rates. Particles in the nanometer range were obtained, the size of which diminishes with decreasing monomer addition rate as shown by the fact that particles with mean diameters of ca. 42 and 30 nm were obtained at the faster and intermediate dosing rates, respectively, whereas two populations of particles, one of 15.5 and the other of 36 nm in mean diameters, were produced at the slower dosing rate. The obtained molecular weights were from 2,200 to 3,500 g/mol, depending on the addition rate, which are typical of the anionic polymerizations of cyanoacrylates in aqueous dispersions at low pHs. The rifampicin (RIF) loading into the nanoparticles was successful since the entire drug added was incorporated. The drug release study carried out at pH of 7.2 indicated a faster release from the free RIF at intermediate and larger release times as expected since, in the nanoparticles, first the drug has to diffuse through the nanoparticle structure. The comparison of several drug release models indicates that the RIF release from PECA nanoparticles follows that of Higuchi.

scholarly journals Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
J. A. Balleño ◽  
A. P. Mendizábal-Ruiz ◽  
H. Saade ◽  
R. Díaz de León-Gómez ◽  
E. Mendizábal ◽  
...  
Keyword(s):  
Surfactant Concentration ◽  
Uv Spectroscopy ◽  
Drug Loading ◽  
Weibull Model ◽  
Heterophase Polymerization ◽  
Transmission Electron ◽  
Ethyl Cyanoacrylate ◽  
Release Data ◽  
Ibuprofen Release ◽  
Semicontinuous Heterophase Polymerization

Ibuprofen-loaded poly(ethyl cyanoacrylate) nanoparticles were prepared by semicontinuous heterophase polymerization of ethyl cyanoacrylate in the presence of ibuprofen; different surfactant concentration, pH, and temperature were used. Particle size was measured by quasi-light scattering and transmission electron microscopy, while the amount of drug released was determined by UV spectroscopy. Nanoparticles with diameters between 10 and 58 nm, loaded with ibuprofen, were obtained. The smallest particles and the higher drug loading were obtained at the highest pH tested. The analysis of the release data showed that the drug release profiles correspond to the Weibull model. Moreover, it was found that most of the ibuprofen is released within the first 80–120 min; initially the release rate is slow, but then it increases to finally decrease. This behavior contrasts with the reported burst of drug concentration in the plasma after oral administration of IB.

scholarly journals Effect of Monomer Dosing Rate in the Preparation of Mesoporous Polystyrene Nanoparticles by Semicontinuous Heterophase Polymerization

Molecules ◽  
2014 ◽  
Vol 20 (1) ◽  
pp. 52-69 ◽  
Author(s):  
Dalia Sosa ◽  
Lourdes Guillén ◽  
Hened Saade ◽  
Eduardo Mendizábal ◽  
Jorge Puig ◽  
...  
Keyword(s):  
Polystyrene Nanoparticles ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

scholarly journals Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yixiang Shi ◽  
Ajun Wan ◽  
Yifei Shi ◽  
Yueyue Zhang ◽  
Yupeng Chen
Keyword(s):  
Drug Release ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Solid Material ◽  
Loading Capacity ◽  
Simulation Studies ◽  
Release Behavior ◽  
Molecular Weights ◽  
Drug Release Behavior ◽  
Positively Charged

The study of drug release dynamic is aiming at understanding the process that drugs release in human body and its dynamic characteristics. It is of great significance since these characteristics are closely related to the dose, dosage form, and effect of the drugs. The Noyes-Whitney function is used to represent how the solid material is dissolved into solution, and it is well used in study of drug dynamic. In this research, aspirin (acetylsalicylic acid (ASA)) has been encapsulated with different grades of chitosan (CS) varying in molecular weight (Mw) for the purpose of controlled release. The encapsulation was accomplished by ionic gelation technology based on assembly of positively charged chitosan and negatively charged sodium tripolyphosphate (TPP). The encapsulation efficiency, loading capacity, and drug release behavior of aspirin loaded chitosan nanoparticles (CS-NPs) were studied. It was found that the concentration of TPP and Aspirin, molecular weights of chitosan have important effect on the drug release patterns from chitosan nanoparticles. The results for simulation studies show that the Noyes-Whitney equation can be successfully used to interpret the drug release characteristics reflected by our experimental data.

Modeling the Semicontinuous Heterophase Polymerization for Synthesizing Poly(n -butyl methacrylate) Nanoparticles

2013 ◽  
Vol 7 (9) ◽  
pp. 440-452 ◽  
Author(s):  
María G. Pérez-García ◽  
Lourdes A. Pérez-Carrillo ◽  
Eduardo Mendizábal ◽  
Jorge E. Puig ◽  
Francisco López-Serrano
Keyword(s):  
Butyl Methacrylate ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

In Situ Study of The Exposure of Polycarbonate to an Argon Plasma

1995 ◽  
Vol 385 ◽  
Author(s):  
S. Vallon ◽  
B. Drevillon ◽  
F. Poncin-Epaillard ◽  
J. C. Rostaing
Keyword(s):  
Structural Changes ◽  
Argon Plasma ◽  
Silica Layer ◽  
Molecular Weights ◽  
In Situ Study ◽  
Polar Groups ◽  
Unit Scale ◽  
Two Populations ◽  
Polymer Unit

ABSTRACTThe exposure of polycarbonate to an argon plasma is studied using in situ ellipsometry from the UV to the IR, nuclear magnetic resonance and light scattering measurements. An increase in the refractive index and the existence of two populations of different molecular weights show that structural changes occur in the polymer. They are correlated with modifications at the polymer unit scale, such as formation of new polar groups and decrease in dimethyl groups. Two simultaneous reaction mechanisms must be considered to account for these changes. The adhesion of a silica layer on treated polycarbonate is then discussed.

Controlling Burst and Final Drug Release Times from Porous Polylactide Devices Derived from Co-continuous Polymer Blends

2009 ◽  
Vol 10 (8) ◽  
pp. 2053-2066 ◽  
Author(s):  
Zhenyu Xiang ◽  
Pierre Sarazin ◽  
Basil D. Favis
Keyword(s):  
Drug Release ◽  
Polymer Blends ◽  
Release Times

Semicontinuous heterophase polymerization under monomer starved conditions to prepare nanoparticles with narrow size distribution

2007 ◽  
Vol 45 (8) ◽  
pp. 1463-1473 ◽  
Author(s):  
Raquel Ledezma ◽  
M. Esther Treviño ◽  
Luis E. Elizalde ◽  
Lourdes A. Pérez-Carrillo ◽  
Eduardo Mendizábal ◽  
...  
Keyword(s):  
Size Distribution ◽  
Narrow Size Distribution ◽  
Heterophase Polymerization ◽  
Semicontinuous Heterophase Polymerization

Drug release behavior from in situ gelatinized thermosensitive nanogel aqueous dispersions

2008 ◽  
Vol 361 (1-2) ◽  
pp. 189-193 ◽  
Author(s):  
Qin Wang ◽  
Huibi Xu ◽  
Xiangliang Yang ◽  
Yajiang Yang
Keyword(s):  
Drug Release ◽  
Release Behavior ◽  
Aqueous Dispersions ◽  
Drug Release Behavior

scholarly journals Characterization and optimization of pH-responsive polymer nanoparticles for drug delivery to oral biofilms

2016 ◽  
Vol 4 (18) ◽  
pp. 3075-3085 ◽  
Author(s):  
Jiayi Zhou ◽  
Benjamin Horev ◽  
Geelsu Hwang ◽  
Marlise I. Klein ◽  
Hyun Koo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Polymer Nanoparticles ◽  
Ph Responsive ◽  
Molecular Weights ◽  
Responsive Polymer ◽  
Oral Biofilms ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Corona and core molecular weights of p(DMAEMA)-b-p(DMAEMA-co-BMA-co-PAA) block copolymer micelles can be tuned to enhance drug release in response to acidic milieus consistent with oral biofilms.

Sign in / Sign up

Export Citation Format

Share Document