scholarly journals A Meta-Analysis for Association of Maternal Smoking with Childhood Refractive Error and Amblyopia

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Li Li ◽  
Ya Qi ◽  
Wei Shi ◽  
Yuan Wang ◽  
Wen Liu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Confidence Interval ◽  
Publication Bias ◽  
Refractive Error ◽  
Odds Ratio ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Significant Heterogeneity ◽  
Chi Square ◽  
The Difference

Background. We aimed to evaluate the association between maternal smoking and the occurrence of childhood refractive error and amblyopia.Methods. Relevant articles were identified from PubMed and EMBASE up to May 2015. Combined odds ratio (OR) corresponding with its 95% confidence interval (CI) was calculated to evaluate the influence of maternal smoking on childhood refractive error and amblyopia. The heterogeneity was evaluated with the Chi-square-basedQstatistic and theI2test. Potential publication bias was finally examined by Egger’s test.Results. A total of 9 articles were included in this meta-analysis. The pooled OR showed that there was no significant association between maternal smoking and childhood refractive error. However, children whose mother smoked during pregnancy were 1.47 (95% CI: 1.12–1.93) times and 1.43 (95% CI: 1.23-1.66) times more likely to suffer from amblyopia and hyperopia, respectively, compared with children whose mother did not smoke, and the difference was significant. Significant heterogeneity was only found among studies involving the influence of maternal smoking on children’s refractive error (P<0.05;I2=69.9%). No potential publication bias was detected by Egger’s test.Conclusion. The meta-analysis suggests that maternal smoking is a risk factor for childhood hyperopia and amblyopia.

Back pain and depressive symptoms: A systematic review and meta-analysis

2020 ◽  
pp. 009121742091300 ◽  
Author(s):  
Sohrab Amiri ◽  
Sepideh Behnezhad ◽  
Esfandiar Azad
Keyword(s):  
Back Pain ◽  
Depressive Symptoms ◽  
Confidence Interval ◽  
Publication Bias ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Depression Symptoms ◽  
Psychological Consequences ◽  
Cross Sectional ◽  
Effective Prevention

Background Low back pain is a common disorder that has many consequences. This study is an attempt to meta-analyze the risk of depression symptoms in back pain. Method Four databases were selected for review, and this search was conducted using key words. Eleven eligible articles were selected for review and meta-analysis was conducted. Subgroup analyses were continued with study design and the method of measuring depression. Also, the heterogeneity and publication bias were examined. Results Eleven cohort and cross-sectional articles are used in the meta-analysis between back pain and depressive symptoms. The odds ratio 2.07 was calculated for this relationship. In prospective-cohort studies, 1.71 (95% confidence interval = 1.24–2.36) results indicated that back pain is a risk factor for depression symptoms and in cross-sectional studies, pooled odds ratio (2.33; 95% confidence interval = 1.29–4.21) showed that back pain is associated with depression symptoms. Some degree of publication bias was not found in the study. Conclusions Back pain is an effective factor in increasing the likelihood of depression. Adoption of effective prevention and treatment approaches can play an important role in reducing the psychological consequences in these individuals.

scholarly journals The association between lithium in drinking water and neuropsychiatric outcomes: A systematic review and meta-analysis from across 2678 regions containing 113 million

2020 ◽  
pp. 000486742096374 ◽  
Author(s):  
Brenton Eyre-Watt ◽  
Eesharnan Mahendran ◽  
Shuichi Suetani ◽  
Joseph Firth ◽  
Steve Kisely ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drinking Water ◽  
Confidence Interval ◽  
Publication Bias ◽  
Hospital Admissions ◽  
Meta Analysis ◽  
Significant Heterogeneity ◽  
Suicide Rates ◽  
Registration Number ◽  
Trim And Fill

Background: Lithium in drinking water may have significant mental health benefits. We investigated the evidence on the association between lithium concentrations in drinking water and their neuropsychiatric outcomes. Methods: We conducted a systematic review and meta-analysis and searched Pubmed, Embase, Web of Science, PsycINFO and CINAHL up to 19 January 2020, for peer-reviewed research examining the association between lithium concentrations in drinking water and neuropsychiatric outcomes. We used a pairwise analysis and a random effects model to meta-analyse suicide rates and psychiatric hospital admissions. We assessed for publication bias using Egger’s test and Duval and Tweedie’s Trim and Fill analysis. Results: Twenty-seven studies including 113 million subjects were included in this systematic review. Meta-analysis of 14 studies including 94 million people found higher lithium concentrations were associated with reduced suicide rates ( r = −0.191, 95% confidence interval = [−0.287, −0.090], p < 0.001) and meta-analysis of two studies including 5 million people found higher lithium concentrations were associated with fewer hospital admissions ( r = −0.413, 95% confidence interval = [−0.689, −0.031], p = 0.035). We found significant heterogeneity between studies ( Q = 67.4, p < 0.001, I2 = 80.7%) and the presence of publication bias (Egger’s test; t value = 2.90, p = 0.013). Other included studies did not provide sufficient data to analyse other neuropsychiatric outcomes quantitatively. Conclusion: Higher lithium concentrations in drinking water may be associated with reduced suicide rates and inpatient psychiatric admissions. The relationship with other neuropsychiatric outcomes and complications remains unclear. Further research is required before any public health recommendations can be made. Trial registration number: The study was registered with PROSPERO, number CRD42018090145.

scholarly journals Predictive Value of D-dimer on Mortality in Patients with Acute Aortic Dissection

2020 ◽  
Author(s):  
Shuangshuang Li ◽  
Pengcheng Du ◽  
Jian Dong ◽  
Jian Zhou ◽  
Zaiping Jing
Keyword(s):  
Sensitivity Analysis ◽  
Aortic Dissection ◽  
Confidence Interval ◽  
Hospital Mortality ◽  
Publication Bias ◽  
Odds Ratio ◽  
Acute Aortic Dissection ◽  
Meta Analysis ◽  
Cutoff Value ◽  
D Dimer

Abstract ObjectiveTo clarify the relation between D-dimer and in-hospital mortality of acute aortic dissection, a meta-analysis was performed by summarizing all relevant studies.MethodsAll related studies were retrieved and identified in PubMed and Embase databases. Precise data was extracted from standard articles, such as sample size, odds ratio, and 95% confidence interval. Then pooled odds ratio (OR) accompanying 95% confidence interval (CI) were calculated using random model. Study heterogeneity examined by Q text and I2 statistic. Sensitivity analysis was performed to assess the stability of the results. Publication bias was assessed by Egger’s test. ResultsTen studies (1954 patients) that met the inclusion criteria were included in this review. The results suggested a link between D-dimer and in-hospital mortality of acute aortic dissection (OR=1.17 95%CI=1.08-1.27). With higher of cutoff value of D-dimer, the closer for the mortality of AAD, with ORs (95% CIs) ranging from 1.13(1.09–1.16) to 4.12 (1.56–10.93). The relationship was also found in six Type A AAD studies without heterogeneity (OR=1.13 95%CI=1.08-1.18). According to sensitivity analysis, the link was stable after exclusion of one study at a time. Publication bias was find among studies (P=0.02). ConclusionsThe result of this meta-analysis indicated that D-dimer maybe a predictor in-hospital mortality of acute aortic dissection patients. What’s more, the higher of cutoff value of D-dimer, the stronger for the predictive ability.

scholarly journals Greater Incidence of Emergence Agitation in Children after Sevoflurane Anesthesia as Compared with Halothane

2008 ◽  
Vol 109 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Norifumi Kuratani ◽  
Yumiko Oi
Keyword(s):  
Confidence Interval ◽  
Publication Bias ◽  
Odds Ratio ◽  
Pain Treatment ◽  
Meta Analysis ◽  
Fixed Effect Model ◽  
Sevoflurane Anesthesia ◽  
Emergence Agitation ◽  
Inclusion Criteria ◽  
Halothane Anesthesia

Background Sevoflurane is a popular inhalational anesthetic for general anesthesia in children. The higher incidence of emergence agitation has been suspected after sevoflurane anesthesia as compared with halothane, whereas some controlled studies showed conflicting results. In this report, the authors performed a meta-analysis of randomized controlled trials to compare the incidence of emergence agitation in children after sevoflurane or halothane anesthesia. Methods A comprehensive literature search was conducted to identify clinical trials that compared the incidence of emergence agitation in children anesthetized with sevoflurane versus halothane. Two reviewers independently assessed each report to meet the authors inclusion criteria and extracted data. The data from each trial were combined using the Mantel-Haenszel fixed-effect model to calculate the pooled odds ratio and 95% confidence interval. Funnel plots were used to assess publication bias. Subgroup analysis was used to clarify the effects of age, surgical procedure, pain treatment, and premedication on the incidence of emergence agitation. Results The authors identified 23 studies that met their inclusion criteria. Overall, 1,252 patients received sevoflurane and 1,111 had halothane. Heterogeneity of data was statistically refuted. The pooled odds ratio for all studies was 2.21, with a 95% confidence interval of 1.77-2.77 (P &lt; 0.0001). Publication bias was not apparent in a funnel plot. All subgroup analyses showed a higher incidence of agitation after sevoflurane anesthesia. Conclusions This meta-analysis revealed that emergence agitation occurred more frequently with sevoflurane than with halothane anesthesia in children.

scholarly journals Prevalence of depression among women with obstetric fistula: A systematic review and meta-analysis Berhanu Boru Bifftu [BBB] 1*and Yonas Deressa Guracho [YDG]2

2020 ◽  
Author(s):  
Berhanu Boru Biftu ◽  
Yonas Deressa Guracho
Keyword(s):  
Publication Bias ◽  
Obstetric Fistula ◽  
Meta Analysis ◽  
Sensitivity Test ◽  
Cochrane Library ◽  
Significant Heterogeneity ◽  
Chi Square ◽  
Pooled Prevalence ◽  
Prevalence Of Depression

Abstract Objective Obstetric fistula is one of the most devastating birth injuries, affecting up to 3.5 million women. Depression is the priority mental disorders affecting up to 98% the patient living with obstetric fistula and adversely affects their quality of life. Inconsistent reported prevalence of depression and dearth of comprehensive meta-analysis need an up to date evidence for decision makers. Thus, the purpose of this meta-analysis was to determine the pooled prevalence of depression among women with obstetric fistula. Methods Databases including PubMed, Cochrane Library and SCOPUS were searched. Heterogeneity across the studies was assessed by Cochrane chi-square (χ2) and quantified by I 2 statistics test. Funnel plots and Egger’s test were used to determine publication bias. Sensitivity test and subgroup analysis were also performed. The pooled prevalence of depression was calculated using random effects model and Dersimonian and Laird method. Results Fifteen eligible studies were included in the study. The pooled prevalence of depression was found to be 72% (95% CI; 60%-83%). We found evidence of significant heterogeneity (I 2 =95.64% and p < 0.001). Sensitivity test showed none of the point estimates was outside of the overall 95%CI. No evidence of publication bias egger’s test (p =0.654). Conclusion Around three fourth of women with obstetric fistula experienced depression. Thus, authors’ suggest the need of special attention to mange co-morbid depression among women with obstetric fistula, such as an integrated mental health care.

scholarly journals Isolated Tricuspid Valve Surgery – Repair Versus Replacement: a Meta-analysis

2021 ◽  
Author(s):  
Panagiotis Sarris-Michopoulos ◽  
Alejandro Macias ◽  
Constantine Sarris-Michopoulos ◽  
Palina Woodhouse ◽  
Daniel Buitrago ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Publication Bias ◽  
Tricuspid Valve ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Valve Surgery ◽  
Tricuspid Valve Repair ◽  
Tricuspid Valve Surgery ◽  
Significant Difference ◽  
Pacemaker Placement

Objective: There is paucity of data on outcomes after isolated tricuspid valve surgery. This meta-analysis aims to compile available data on isolated tricuspid valve surgery and compare isolated tricuspid valve repair (iTVr) with isolated tricuspid valve replacement (iTVR) to elucidate outcomes after tricuspid valve surgery. Methods: A literature search of 6 databases was performed. The primary outcomes was 30-day mortality. Secondary outcomes were early stroke, post-op pacemaker placement, and tricuspid reoperation within 5 years. Publication bias was explored using the funnel plot. Results: Ten retrospective studies involving 1407 patients (iTVr group = 779 patients and iTVR group = 628 patients) were included. A cumulative analysis demonstrated a significant difference favoring iTVr for 30-day mortality [odds ratio – 10 studies (95% confidence interval) 0.34 (0.18-0.66)]; 4.7% versus 12.6%, for iTVr and iTVR, respectively. Post-op pacemaker placement favored iTVr [odds ratio – 6 studies (95% confidence interval) 0.37 (0.18-0.77)]. Although stroke rates and TV reoperation favored iTVr, they did not reach statistical significance. No publication bias was identified. Conclusions: This meta-analysis demonstrates that iTVr has better 30-day mortality and fewer permanent pacemaker placements. Etiology and severity of TR, as well as careful patient selection remain the most important factors for optimal outcomes.

Association between diabetes and keratoconus—a systematic review and meta-analysis

2021 ◽  
pp. 112067212110531
Author(s):  
Prince K Akowuah ◽  
Christabel Arthur ◽  
Fredrick A Otabil ◽  
Collins A Ofori ◽  
Kofi Osei-Poku ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Publication Bias ◽  
Study Design ◽  
Odds Ratio ◽  
Literature Search ◽  
Meta Analysis ◽  
Case Control ◽  
Reference List ◽  
Significant Heterogeneity ◽  
Cross Sectional

Purpose To assess the association between diabetes mellitus and keratoconus. Methods PubMed, Google Scholar, Web of Science, and Scopus databases were searched for literature on the association between diabetes and keratoconus. The last literature search was conducted on April 4, 2021. A secondary form of the literature search was conducted by manually scanning the reference list of retrieved eligible articles. Included studies were cohort, case-control, or cross-sectional study design that used odds ratio or risk ratio to evaluate the relationship between keratoconus and diabetes. Egger's test was used to assess the presence of publication bias. The quality of eligible studies was assessed using the Newcastle-Ottawa Scale. Results Nine studies (six case-control and three cohort studies) published between 2000 and 2021 were included. The total number of keratoconus patients and controls were 27,311 and 53,732. respectively. Meta-analysis revealed no significant association between diabetes mellitus and keratoconus; the pooled odds ratio was 0.87 (95% confidence interval: 0.66–1.14; p = 0.314). There was significant heterogeneity ( Q (df = 7) = 33.36, p < 0.001; I 2  = 79.01, p < 0.001). Age of participants ( p < 0.0001), study design ( p < 0.001), and sample size ( p = 0.024) were significant sources of heterogeneity. There was no evidence of publication bias. Conclusion The current meta-analysis revealed no significant association between diabetes mellitus and keratoconus. Well-designed longitudinal prospective studies are, however, needed to investigate any association between diabetes mellitus and keratoconus.

A Method for Meta-Analysis of Epidemiological Studies

1988 ◽  
Vol 22 (10) ◽  
pp. 813-824 ◽  
Author(s):  
Thomas R. Einarson ◽  
J. Steven Leeder ◽  
Gideon Koren
Keyword(s):  
Confidence Interval ◽  
Odds Ratio ◽  
Meta Analysis ◽  
A Priori ◽  
Epidemiological Studies ◽  
Percent Confidence Interval ◽  
Case Control Studies ◽  
Chi Square ◽  
The Impact ◽  
Summary Odds Ratio

This article presents a stepwise approach for conducting a meta-analysis of epidemiological studies based on proposed guidelines. This systematic method is recommended for practitioners evaluating epidemiological studies in the literature to arrive at an overall quantitative estimate of the impact of a treatment. Bendectin is used as an illustrative example. Meta-analysts should establish a priori the purpose of the analysis and a complete protocol. This protocol should be adhered to, and all steps performed should be recorded in detail. To aid in developing such a protocol, we present methods the researcher can use to perform each of 22 steps in six major areas. The illustrative meta-analysis confirmed previous traditional narrative literature reviews that Bendectin is not related to teratogenic outcomes in humans. The overall summary odds ratio was 1.01 (χ2 = 0.05, p = 0.815) with a 95 percent confidence interval of 0.66–1.55. When the studies were separated according to study type, the summary odds ratio for cohort studies was 0.95 with a 95 percent confidence interval of 0.62–1.45. For case-control studies, the summary odds ratio was 1.27 with a 95 percent confidence interval of 0.83–1.94. The corresponding chi-square values were not statistically significant at the p = 0.05 level.

scholarly journals Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Jing Liu ◽  
Caiying Li ◽  
Wen Chen ◽  
Kuanrong He ◽  
Huijuan Ma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Publication Bias ◽  
Asymmetric Dimethylarginine ◽  
Meta Analysis ◽  
Microvascular Complications ◽  
Healthcare Research ◽  
Significant Heterogeneity ◽  
Statistical Heterogeneity ◽  
The Difference

Objective. The purpose of the meta-analysis was to evaluate the relationship between serum asymmetric dimethylarginine (ADMA) level and microvascular complications in diabetes mellitus (DM) including diabetic retinopathy (DR), diabetic neuropathy (DN), and diabetic nephropathy. Methods. Studies were comprehensively identified by searching Web of Science, Embase, and PubMed databases up to August 30, 2018. The meta-analysis was carried out to compare the difference of serum ADMA concentrations of DR, DN, and diabetic nephropathy patients with healthy controls. The Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality were applied to assess the methodological quality. Chi-squared Q test and I2 statistics were applied to evaluate statistical heterogeneity. Subgroup analyses were conducted and publication bias was assessed by Egger’s test. Result. Ten studies were finally entered in the meta-analysis. Statistically significant heterogeneity was observed across these studies (I2 = 77.0%, p < 0.001). Compared with DM without microvascular complications, circulating level of ADMA was significantly higher in DM with microvascular complications (all p < 0.05). Sensitivity analysis suggested that the results of this meta-analysis were shown to be stable. There was no significant publication bias (P=0.823). Conclusion. Elevated ADMA levels correlate with diabetic microangiopathies such as DR and diabetic nephropathy. ADMA may play an important role in the pathobiology of microvascular complications of diabetes.

scholarly journals Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

2021 ◽  
Author(s):  
Liting Wu ◽  
Ming Chu ◽  
Wenfang Zhuang
Keyword(s):  
Atrial Fibrillation ◽  
High Resolution ◽  
Confidence Interval ◽  
Publication Bias ◽  
Odds Ratio ◽  
Inverse Relationship ◽  
Meta Analysis ◽  
Healthy Controls ◽  
High Resolution Melt ◽  
Stratified Analysis

Abstract Background Atrial fibrillation (AF) is a common, sustained cardiac arrhythmia. Recent studies have reported an association between ZFHX3/PRRX1 polymorphisms and AF. In this study, a meta-analysis was conducted to confirm these associations. Methods The PubMed, Embase, and Wanfang databases were searched, covering all publications before July 20, 2020. Results Overall, seven articles including 3,674 cases and 8,990 healthy controls for ZFHX3 rs2106261 and 1045 cases and 1407 controls for PRRX1 rs3903239 were included. The odds ratio (OR) [95% confidence interval (CI)] was used to assess the associations. Publication bias was calculated using Egger’s and Begg’s tests. We found that the ZFHX3 rs2106261 polymorphism increased AF risk in Asians (for example, allelic contrast: OR [95% CI]: 1.39 [1.31–1.47], P < 0.001). Similarly, strong associations were detected through stratified analysis using source of control and genotype methods (for example, allelic contrast: OR [95% CI]: 1.51 [1.38–1.64], P < 0.001 for HB; OR [95% CI]: 1.31 [1.21–1.41], P < 0.001 for PB; OR [95% CI]: 1.55 [1.33–1.80], P < 0.001 for TaqMan; OR [95% CI]: 1.31 [1.21–1.41], P < 0.001 for high-resolution melt). In contrast, an inverse relationship was observed between the PRRX1 rs3903239 polymorphism and AF risk (C-allele vs. T-allele: OR [95% CI]: 0.83 [0.77–0.99], P = 0.036; CT vs. TT: OR [95% CI]: 0.79 [0.67–0.94], P = 0.006). No obvious evidence of publication bias was observed. Conclusion In summary, our study suggests that the ZFHX3 rs2106261 and PRRX1 rs3903239 polymorphisms are associated with AF risk, and larger case-controls must be carried out to confirm the above conclusions.

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