scholarly journals Neural Correlates of Dual-Task Walking: Effects of Cognitive versus Motor Interference in Young Adults

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Rainer Beurskens ◽  
Fabian Steinberg ◽  
Franziska Antoniewicz ◽  
Wanja Wolff ◽  
Urs Granacher
Keyword(s):  
Young Adults ◽  
Dual Task ◽  
Motor Performance ◽  
Human Locomotion ◽  
Neural Correlates ◽  
Brain Regions ◽  
Gait Velocity ◽  
Neural Activation ◽  
Activation Patterns ◽  
Behavioral Studies

Walking while concurrently performing cognitive and/or motor interference tasks is the norm rather than the exception during everyday life and there is evidence from behavioral studies that it negatively affects human locomotion. However, there is hardly any information available regarding the underlying neural correlates of single- and dual-task walking. We had 12 young adults (23.8 ± 2.8 years) walk while concurrently performing a cognitive interference (CI) or a motor interference (MI) task. Simultaneously, neural activation in frontal, central, and parietal brain areas was registered using a mobile EEG system. Results showed that the MI task but not the CI task affected walking performance in terms of significantly decreased gait velocity and stride length and significantly increased stride time and tempo-spatial variability. Average activity in alpha and beta frequencies was significantly modulated during both CI and MI walking conditions in frontal and central brain regions, indicating an increased cognitive load during dual-task walking. Our results suggest that impaired motor performance during dual-task walking is mirrored in neural activation patterns of the brain. This finding is in line with established cognitive theories arguing that dual-task situations overstrain cognitive capabilities resulting in motor performance decrements.

scholarly journals Mapping the common and distinct neural correlates of visual, rule and motor conflict

2020 ◽  
Author(s):  
Bryony Goulding Mew ◽  
Darije Custovic ◽  
Eyal Soreq ◽  
Romy Lorenz ◽  
Ines Violante ◽  
...  
Keyword(s):  
Region Of Interest ◽  
Neural Correlates ◽  
Brain Regions ◽  
Control Mechanisms ◽  
Activation Patterns ◽  
The Common ◽  
Full Factorial ◽  
The Brain ◽  
Categorical Scale ◽  
Conflict Types

AbstractFlexible behaviour requires cognitive-control mechanisms to efficiently resolve conflict between competing information and alternative actions. Whether a global neural resource mediates all forms of conflict or this is achieved within domainspecific systems remains debated. We use a novel fMRI paradigm to orthogonally manipulate rule, response and stimulus-based conflict within a full-factorial design. Whole-brain voxelwise analyses show that activation patterns associated with these conflict types are distinct but partially overlapping within Multiple Demand Cortex (MDC), the brain regions that are most commonly active during cognitive tasks. Region of interest analysis shows that most MDC sub-regions are activated for all conflict types, but to significantly varying levels. We propose that conflict resolution is an emergent property of distributed brain networks, the functional-anatomical components of which place on a continuous, not categorical, scale from domain-specialised to domain general. MDC brain regions place towards one end of that scale but display considerable functional heterogeneity.

Multisensory Integration of Emotion in Schizophrenic Patients

2020 ◽  
Vol 33 (8) ◽  
pp. 865-901
Author(s):  
Yi Lin ◽  
Hongwei Ding ◽  
Yang Zhang
Keyword(s):  
Multisensory Integration ◽  
Cognitive Abilities ◽  
Emotion Processing ◽  
Essential Element ◽  
Brain Regions ◽  
Event Related Potential ◽  
Activation Patterns ◽  
Behavioral Studies ◽  
Schizophrenic Patients ◽  
Neurological Research

Abstract Multisensory integration (MSI) of emotion has been increasingly recognized as an essential element of schizophrenic patients’ impairments, leading to the breakdown of their interpersonal functioning. The present review provides an updated synopsis of schizophrenics’ MSI abilities in emotion processing by examining relevant behavioral and neurological research. Existing behavioral studies have adopted well-established experimental paradigms to investigate how participants understand multisensory emotion stimuli, and interpret their reciprocal interactions. Yet it remains controversial with regard to congruence-induced facilitation effects, modality dominance effects, and generalized vs specific impairment hypotheses. Such inconsistencies are likely due to differences and variations in experimental manipulations, participants’ clinical symptomatology, and cognitive abilities. Recent electrophysiological and neuroimaging research has revealed aberrant indices in event-related potential (ERP) and brain activation patterns, further suggesting impaired temporal processing and dysfunctional brain regions, connectivity and circuities at different stages of MSI in emotion processing. The limitations of existing studies and implications for future MSI work are discussed in light of research designs and techniques, study samples and stimuli, and clinical applications.

Differences in Chemo-signaling Compound-Evoked Brain Activity in Male and Female Young Adults: A Pilot Study in the Role of Sexual Dimorphism in Olfactory Chemo-Signaling

2020 ◽  
Author(s):  
Taylor D. Ottesen ◽  
Kevin C. Davis ◽  
Landon K. Hobbs ◽  
Nathan M. Muncy ◽  
Nicholas M. Stevens ◽  
...  
Keyword(s):  
Young Adults ◽  
Pilot Study ◽  
Neural Development ◽  
Brain Activity ◽  
Block Design ◽  
Inferior Frontal Gyrus ◽  
Multivariate Model ◽  
Neural Activation ◽  
Whole Brain ◽  
Activation Patterns

AbstractIntroductionPrevious studies have shown that putative pheromones 4,16-androstadien-3-one (AND) and estra-1,3,5(10),16-tetraen-3-ol (EST) cause activation in the preoptic area/anterior hypothalamus in men and women. Sex differences in neural activation patterns have been demonstrated when participants are subject to pheromone stimulation; however, whether other compounds give rise to similar neural activity has not been completely investigated.MethodsTwenty-nine young adults [16 female (21.3+/−0.54; mean yrs+/−SE), 13 male (22.85+/−0.42)] participated in a 3-block design, where participants were exposed to a scent (lavender), a synthetic male pheromone (4,16-androstadien-3b-ol; ALD), and a synthetic female pheromone (1,3,5(10),16-Estratetraen-3-ol; EST) via an automated olfactometer. Whole-brain, high-resolution (1.8mm3) functional MRI data from a Siemens Trio 3T MRI scanner were collected during all blocks. Five adults were excluded due to excessive movement. MANOVA analysis, a 2 × 3 multivariate model and analysis of 2×2 effects between sex and subsets of stimuli was done for activation over the whole brain and small volumes involved in olfaction.ResultsExploratory analysis of 2×2 effects between sex and subsets of stimuli exhibited significant interactions when assessing activations over the whole brain, and small volumes involved in olfaction. The left and right frontal poles (LFP, RFP) shows significant interaction when assessing sex with lavender and EST for whole brain analysis. For small volume analysis, the right orbitofrontal cortex (ROFC) exhibited a sex with lavender and ALD interaction, and a sex with lavender and EST interaction was observed in the left inferior frontal gyrus (LIFG). Main effects of sex, stimulus, or interaction show no differences analyzed using a 2 × 3 multivariate model.ConclusionThe study shows there is a sexually dimorphic response in the olfactory system to pheromones not previously studied. Scents like lavender do not have this same response. These distinct functional differences in activation patterns may be a result of neural development and maturation differences between sexes. Future studies should expand this pilot study and involve a younger demographic to accurately determine the age at which the olfactory response differentiates between males and females.

scholarly journals I am happy for us: Neural processing of vicarious joy when winning for parents versus strangers

2020 ◽  
Vol 20 (6) ◽  
pp. 1309-1322
Author(s):  
Philip Brandner ◽  
Berna Güroğlu ◽  
Eveline A. Crone
Keyword(s):  
Family Relationships ◽  
Neural Correlates ◽  
Brain Regions ◽  
Neural Mechanisms ◽  
Self Report ◽  
Future Research ◽  
Neural Activation ◽  
New Paradigm ◽  
Emotional Closeness ◽  
Neural Processes

AbstractThis study investigated the neural processes underlying vicarious joy and their dependence on emotional closeness. Prior studies revealed that the nucleus accumbens (NAcc) is a target brain region for processing rewards for self, but the neural mechanisms of processing rewards for others are not yet well understood. A functional magnetic resonance imaging (fMRI) paradigm was employed in young adults (N = 30), in combination with a self-report questionnaire on the perceived emotional closeness to the target. We examined the neural correlates of vicarious rewards when winning money for oneself or one of three other targets. To examine family relationships, two of the targets were the mother and father of the participants, and the third target was an unknown stranger. We found an increase in activation in the NAcc when playing for family members compared with a stranger. We further observed a difference in neural activation when winning for the father compared with the mother in an extended network involving the medial prefrontal cortex and precuneus, brain regions involved in mentalizing. These findings were not related to reports of emotional closeness. This new paradigm has considerable value for future research into the fundamental neural processes underlying empathy and vicarious joy.

scholarly journals Changes to Neural Activation Patterns (c-fos Labeling) in Chinchilla Auditory Midbrain following Neonatal Exposure to an Enhanced Sound Environment

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Lisa M. D’Alessandro ◽  
Robert V. Harrison
Keyword(s):  
Brain Regions ◽  
Central Nucleus ◽  
Neural Activation ◽  
Auditory Midbrain ◽  
Sound Stimulation ◽  
Activation Patterns ◽  
Acoustic Environment ◽  
Sound Exposure ◽  
Sound Environment ◽  
Subcortical Regions

Sensory brain regions show neuroplastic changes following deficits or experimental augmentation of peripheral input during a neonatal period. We have previously shown reorganization of cortical tonotopic maps after neonatal cochlear lesions or exposure to an enhanced acoustic environment. Such experiments probe the cortex and show reorganization, but it is unclear if such changes are intrinsically cortical or reflect projections from modified subcortical regions. Here, we ask whether an enhanced neonatal acoustic environment can induce midbrain (inferior colliculus (IC)) changes. Neonatal chinchillas were chronically exposed to a 70 dB SPL narrowband (2 ± 0.25 kHz) sound stimulus for 4 weeks. In line with previous studies, we hypothesized that such exposure would induce widening of the 2 kHz tonotopic map region in IC. To probe c-fos expression in IC (central nucleus), sound-exposed and nonexposed animals were stimulated with a 2 kHz stimulus for 90 minutes. In sound-exposed subjects, we find no change in the width of the 2 kHz tonotopic region; thus, our hypothesis is not supported. However, we observed a significant increase in the number of c-fos-labeled neurons over a broad region of best frequencies. These data suggest that neonatal sound exposure can modify midbrain regions and thus change the way neurons in IC respond to sound stimulation.

scholarly journals Functional magnetic resonance imaging in primary hyperparathyroidism

2020 ◽  
Vol 183 (1) ◽  
pp. 21-30
Author(s):  
Yunglin Gazes ◽  
Minghao Liu ◽  
Melissa Sum ◽  
Elaine Cong ◽  
Jennifer Kuo ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Verbal Memory ◽  
Cognitive Task ◽  
Brain Regions ◽  
Neural Activation ◽  
Precentral Gyrus ◽  
Left Frontal Lobe ◽  
Activation Patterns ◽  
Paired Associates ◽  
Matrix Reasoning

Objective The neurophysiological mechanisms underlying cognitive dysfunction in primary hyperparathyroidism (PHPT) and the brain regions affected are not clear. We assessed neural activation during cognitive testing (matrix reasoning, paired associates, and logical memory) using functional MRI (fMRI) in 23 patients with PHPT and 23 healthy controls. A subset with PHPT was re-assessed 6 months post-parathyroidectomy (PTX). Design This is an observational study comparing neural activation by fMRI in patients with PHPT to normative controls. Postmenopausal women were studied at a tertiary referral center. Results There were no between-group differences in cognitive task performance. Patients with PHPT had lower neural activation vs controls (max Z = 4.02, all P < 0.01) during matrix reasoning in brain regions involved in executive function (left frontal lobe (k = 57) and right medial frontal gyrus (k = 72)) and motor function (right precentral gyrus (k = 51)). During paired associates (verbal memory), those with PHPT had greater activation in the right inferior parietal lobule (language/mathematical operations; k = 65, P < 0.01). Greater activation in this region bilaterally correlated with higher PTH (k = 96, P < 0.01). Post-PTX, activation decreased during matrix reasoning, but in different regions than those affected pre-PTX. Conclusions PHPT is associated with differences in task-related neural activation patterns, but no difference in cognitive performance. While this may indicate compensation to maintain the same cognitive function, there was no clear improvement in neural activation after PTX. Larger, longitudinal studies that include PHPT patients followed without surgery are needed to determine if PTX could prevent worsening of altered neural activation patterns in PHPT.

Intact Recollection Memory in High-performing Older Adults: ERP and Behavioral Evidence

2006 ◽  
Vol 18 (1) ◽  
pp. 33-47 ◽  
Author(s):  
Audrey Duarte ◽  
Charan Ranganath ◽  
Celina Trujillo ◽  
Robert T. Knight
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Memory Performance ◽  
Event Related Potentials ◽  
Neural Correlates ◽  
Normal Aging ◽  
Behavioral Studies ◽  
Related Potentials ◽  
Young Subjects ◽  
Effects Of Aging

Numerous behavioral studies have suggested that normal aging has deleterious effects on episodic memory and that recollection is disproportionately impaired relative to familiarity-based recognition. However, there is a wide degree of variability in memory performance within the aging population and this generalization may not apply to all elderly adults. Here we investigated these issues by using event-related potentials (ERPs) to measure the effects of aging on the neural correlates of recollection and familiarity in older adults with recognition memory performance that was equivalent to (old-high) or lower than (old-low) that of young adults. Results showed that, behaviorally, old-high subjects exhibited intact recollection but reduced familiarity, whereas old-low subjects had impairments in both recollection and familiarity, relative to the young. Consistent with behavioral results, old-high subjects exhibited ERP correlates of recollection that were topographically similar to those observed in young subjects. However, unlike the young adults, old-high subjects did not demonstrate any neural correlates of familiarity-based recognition. In contrast to the old-high group, the old-low group exhibited neural correlates of recollection that were topographically distinct from those of the young. Our results suggest that the effects of aging on the underlying brain processes related to recollection and familiarity are dependent on individual memory performance and highlight the importance of examining performance variability in normal aging.

Inefficient Encoding as an Explanation for Age-Related Deficits in Recollection-Based Processing

2014 ◽  
Vol 28 (3) ◽  
pp. 148-161 ◽  
Author(s):  
David Friedman ◽  
Ray Johnson
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Cognitive Processes ◽  
Brain Activity ◽  
Memory Performance ◽  
Brain Regions ◽  
Semantic Retrieval ◽  
Age Related ◽  
The Face ◽  
Episodic Memories

A cardinal feature of aging is a decline in episodic memory (EM). Nevertheless, there is evidence that some older adults may be able to “compensate” for failures in recollection-based processing by recruiting brain regions and cognitive processes not normally recruited by the young. We review the evidence suggesting that age-related declines in EM performance and recollection-related brain activity (left-parietal EM effect; LPEM) are due to altered processing at encoding. We describe results from our laboratory on differences in encoding- and retrieval-related activity between young and older adults. We then show that, relative to the young, in older adults brain activity at encoding is reduced over a brain region believed to be crucial for successful semantic elaboration in a 400–1,400-ms interval (left inferior prefrontal cortex, LIPFC; Johnson, Nessler, & Friedman, 2013 ; Nessler, Friedman, Johnson, & Bersick, 2007 ; Nessler, Johnson, Bersick, & Friedman, 2006 ). This reduced brain activity is associated with diminished subsequent recognition-memory performance and the LPEM at retrieval. We provide evidence for this premise by demonstrating that disrupting encoding-related processes during this 400–1,400-ms interval in young adults affords causal support for the hypothesis that the reduction over LIPFC during encoding produces the hallmarks of an age-related EM deficit: normal semantic retrieval at encoding, reduced subsequent episodic recognition accuracy, free recall, and the LPEM. Finally, we show that the reduced LPEM in young adults is associated with “additional” brain activity over similar brain areas as those activated when older adults show deficient retrieval. Hence, rather than supporting the compensation hypothesis, these data are more consistent with the scaffolding hypothesis, in which the recruitment of additional cognitive processes is an adaptive response across the life span in the face of momentary increases in task demand due to poorly-encoded episodic memories.

THE RELIABILITY OF CLINICAL BALANCE TESTS UNDER SINGLE-TASK AND DUAL-TASK TESTING PARADIGMS IN UNINJURED ACTIVE YOUTH AND YOUNG ADULTS

2020 ◽  
Vol 15 (4) ◽  
pp. 487-500
Author(s):  
Thaer S. Manaseer ◽  
Jackie L. Whittaker ◽  
Codi Isaac ◽  
Kathryn Schneider ◽  
Mary Roduta Roberts ◽  
...  
Keyword(s):  
Young Adults ◽  
Dual Task ◽  
Single Task ◽  
Balance Tests ◽  
Youth And Young Adults

scholarly journals Pairwise maximum entropy model explains the role of white matter structure in shaping emergent co-activation states

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Arian Ashourvan ◽  
Preya Shah ◽  
Adam Pines ◽  
Shi Gu ◽  
Christopher W. Lynn ◽  
...  
Keyword(s):  
White Matter ◽  
Maximum Entropy ◽  
Large Scale ◽  
Structural Connectivity ◽  
Quantitative Relationship ◽  
Brain Regions ◽  
Maximum Entropy Model ◽  
Entropy Model ◽  
Activation Patterns ◽  
Co Activation

AbstractA major challenge in neuroscience is determining a quantitative relationship between the brain’s white matter structural connectivity and emergent activity. We seek to uncover the intrinsic relationship among brain regions fundamental to their functional activity by constructing a pairwise maximum entropy model (MEM) of the inter-ictal activation patterns of five patients with medically refractory epilepsy over an average of ~14 hours of band-passed intracranial EEG (iEEG) recordings per patient. We find that the pairwise MEM accurately predicts iEEG electrodes’ activation patterns’ probability and their pairwise correlations. We demonstrate that the estimated pairwise MEM’s interaction weights predict structural connectivity and its strength over several frequencies significantly beyond what is expected based solely on sampled regions’ distance in most patients. Together, the pairwise MEM offers a framework for explaining iEEG functional connectivity and provides insight into how the brain’s structural connectome gives rise to large-scale activation patterns by promoting co-activation between connected structures.

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