scholarly journals Association between Serum Cystatin C and Diabetic Foot Ulceration in Patients with Type 2 Diabetes: A Cross-Sectional Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Jie Zhao ◽  
Wuquan Deng ◽  
Yuping Zhang ◽  
Yanling Zheng ◽  
Lina Zhou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Serum Cystatin C ◽  
Cross Sectional ◽  
Serum Cystatin ◽  
Foot Ulceration ◽  
Artery Disease

Serum cystatin C (CysC) has been identified as a possible potential biomarker in a variety of diabetic complications, including diabetic peripheral neuropathy and peripheral artery disease. We aimed to examine the association between CysC and diabetic foot ulceration (DFU) in patients with type 2 diabetes (T2D). 411 patients with T2D were enrolled in this cross-sectional study at a university hospital. Clinical manifestations and biochemical parameters were compared between DFU group and non-DFU group. The association between serum CysC and DFU was explored by binary logistic regression analysis. The cut point of CysC for DFU was also evaluated by receiver operating characteristic (ROC) curve. The prevalence of coronary artery disease, diabetic nephropathy (DN), and DFU dramatically increased with CysC (P<0.01) in CysC quartiles. Multivariate logistic regression analysis indicated that the significant risk factors for DFU were serum CysC, coronary artery disease, hypertension, insulin use, the differences between supine and sitting TcPO2, and hypertension. ROC curve analysis revealed that the cut point of CysC for DFU was 0.735 mg/L. Serum CysC levels correlated with DFU and severity of tissue loss. Our study results indicated that serum CysC was associated with a high prevalence of DFU in Chinese T2D subjects.

scholarly journals Association between serum cystatin C and diabetic peripheral neuropathy: a cross-sectional study of a Chinese type 2 diabetic population

2014 ◽  
Vol 171 (5) ◽  
pp. 641-648 ◽  
Author(s):  
Yanyun Hu ◽  
Fang Liu ◽  
Jing Shen ◽  
Hui Zeng ◽  
Lianxi Li ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
High Serum ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Serum Cystatin C ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Serum Cystatin ◽  
Type 2 Diabetic

ObjectiveSerum cystatin C (CysC) is a sensitive marker of kidney function and recent studies have shown that CysC plays a critical role in degenerative diseases in both the central and the peripheral nervous systems. The aim of this study was to explore the relationship between serum CysC and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes.MethodsIn total, 937 type 2 diabetic patients were enrolled in this cross-sectional study. Serum CysC concentration was measured by immunoturbidimetry. DPN was evaluated by neurological symptoms, neurological signs, neurothesiometer, and electromyogram.ResultsSerum CysC levels were significantly higher in DPN patients (1.3 (1.1–1.5) mg/l) compared with patients with signs of DPN (1.1 (0.9–1.3) mg/l, P<0.001) and non-DPN patients (1.0 (0.9–1.3) mg/l, P<0.001). Multiple regression analysis revealed that DPN was associated with age, diabetes duration, HbA1c, and serum CysC. Spearman's correlation analysis showed that serum CysC was closely related with age, sex, diabetes duration, hypertension, glomerular infiltration rate, and serum creatinine (Cr) level. The patients were divided into quartiles according to the serum CysC levels. Compared with quartile 1 (referent), the risk of DPN was significantly higher in quartile 2 (odds ratio (OR), 1.753; 95% CI, 1.055–2.912; P<0.05), quartile 3 (OR, 2.463; 95% CI, 1.445–4.917; P<0.01), and quartile 4 (OR, 5.867; 95% CI, 2.075–16.589; P<0.01). Receiver-operating characteristic analysis revealed that the optimal cutoff point of serum CysC to indicate DPN was 1.25 mg/l in male patients and 1.05 mg/l in female patients. High serum CysC level indicated a onefold higher risk of DPN.ConclusionsHigh serum CysC level is closely associated with DPN and may be a potential biomarker for DPN in type 2 diabetic patients.

scholarly journals Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Qin-Fen Chen ◽  
Dan Cao ◽  
Ting-Ting Ye ◽  
Hui-Hui Deng ◽  
Hong Zhu
Keyword(s):  
Type 2 Diabetes ◽  
Arterial Disease ◽  
Cross Sectional Study ◽  
Fibrinogen Concentration ◽  
Sectional Study ◽  
Cross Sectional ◽  
Noninvasive Measurements ◽  
Artery Disease ◽  
Peripheral Arterial

Background. The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods. We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Furthermore, the univariate and multiple logistic analyses were performed to explore the correlation between PAD and fibrinogen levels, individual components in the cross-sectional study. Results. Finally, 887 (80.9%) T2DM patients meet the diagnostic criteria of PAD and these patients had considerably higher serum fibrinogen concentration than non-PAD group (P<0.001). Multiple logistic analyses revealed that higher fibrinogen quartiles were positively related with the development of PAD in the adjusted model. After adjusting for known confounding parameters, the ORs for PAD were 1.993 (95% CI: 1.322-3.005, P<0.001), 2.469 (95% CI: 1.591-3.831, P<0.001), and 2.942 (95% CI, 1.838-4.711, P<0.001) for Q2, Q3, and Q4, respectively (all P values <0.05). Conclusions. Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients.

scholarly journals Carotid arterial wall inflammation in peripheral artery disease is augmented by type 2 diabetes: a cross-sectional study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Sophie J. Bernelot Moens ◽  
Robert M. Stoekenbroek ◽  
Fleur M. van der Valk ◽  
Simone L. Verweij ◽  
Mark J. W. Koelemay ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Artery Disease ◽  
Arterial Wall ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Peripheral Artery ◽  
Cross Sectional ◽  
Artery Disease ◽  
Carotid Arterial
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