scholarly journals Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: AnIn VitroStudy Using a Clinical Device

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Lu-Yan Zhao ◽  
Jian-Zhong Zou ◽  
Zong-Gui Chen ◽  
Shan Liu ◽  
Jiao Jiao ◽  
...  
Keyword(s):  
Phase Shift ◽  
Focused Ultrasound ◽  
Continuous Wave ◽  
Acoustic Cavitation ◽  
High Intensity Focused Ultrasound ◽  
Inertial Cavitation ◽  
Hifu Ablation ◽  
Duty Cycles ◽  
Ultrasound Ablation ◽  
Phosphate Buffered Saline

Purpose.To investigate whether acoustic cavitation could increase the evaporation of a phase-shift inorganic perfluorohexane (PFH) nanoemulsion and enhance high intensity focused ultrasound (HIFU) ablation.Materials and Methods.PFH was encapsulated by mesoporous silica nanocapsule (MSNC) to form a nanometer-sized droplet (MSNC-PFH). It was added to a tissue-mimicking phantom, whereas phosphate buffered saline (PBS) was added as a control (PBS-control). HIFU (Pac=150 W,t=5/10 s) exposures were performed in both phantoms with various duty cycles (DC). US images, temperature, and cavitation emissions were recorded during HIFU exposure. HIFU-induced lesions were measured and calculated.Results.Compared to PBS-control, MSNC-PFH nanoemulsion could significantly increase the volume of HIFU-induced lesion (P<0.01). Peak temperatures were 78.16 ± 5.64°C at a DC of 100%, 70.17 ± 6.43°C at 10%, 53.17 ± 4.54°C at 5%, and 42.00 ± 5.55°C at 2%, respectively. Inertial cavitation was much stronger in the pulsed-HIFU than that in the continuous-wave HIFU exposure. Compared to 100%-DC exposure, the mean volume of lesion induced by 5 s exposure at 10%-DC was significantly larger, but smaller at 2%-DC.Conclusions.MSNC-PFH nanoemulsion can significantly enhance HIFU ablation. Appropriate pulsed-HIFU exposure could significantly increase the volume of lesion and reduce total US energy required for HIFU ablation.

scholarly journals Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating

2018 ◽  
Vol 10 (43) ◽  
pp. 36786-36795 ◽  
Author(s):  
Adem Yildirim ◽  
Dennis Shi ◽  
Shambojit Roy ◽  
Nicholas T. Blum ◽  
Rajarshi Chattaraj ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Acoustic Cavitation ◽  
High Intensity Focused Ultrasound ◽  
Tissue Heating ◽  
Ultrasound Ablation ◽  
Focused Ultrasound Ablation

scholarly journals Neutrophil-mediated clinical nanodrug for treatment of residual tumor after focused ultrasound ablation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jian Shen ◽  
Junnian Hao ◽  
Yini Chen ◽  
Hairong Liu ◽  
Jianrong Wu ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Therapeutic Potential ◽  
Malignant Tumors ◽  
Residual Tumor ◽  
High Intensity Focused Ultrasound ◽  
Drug Uptake ◽  
Integrated Method ◽  
Hifu Ablation ◽  
Inflammatory Stimuli ◽  
Ultrasound Ablation

Abstract Background The risk of local recurrence after high-intensity focused ultrasound (HIFU) is relatively high, resulting in poor prognosis of malignant tumors. The combination of HIFU with traditional chemotherapy continues to have an unsatisfactory outcome because of off-site drug uptake. Results Herein, we propose a strategy of inflammation-tendency neutrophil-mediated clinical nanodrug targeted therapy for residual tumors after HIFU ablation. We selected neutrophils as carriers and PEGylated liposome doxorubicin (PLD) as a model chemotherapeutic nanodrug to form an innovative cell therapy drug (PLD@NEs). The produced PLD@NEs had a loading capacity of approximately 5 µg of PLD per 106 cells and maintained the natural characteristics of neutrophils. The targeting performance and therapeutic potential of PLD@NEs were evaluated using Hepa1-6 cells and a corresponding tumor-bearing mouse model. After HIFU ablation, PLD@NEs were recruited to the tumor site by inflammation (most in 4 h) and released PLD with inflammatory stimuli, leading to targeted and localized postoperative chemotherapy. Conclusions This effective integrated method fully leverages the advantages of HIFU, chemotherapy and neutrophils to attract more focus on the practice of improving existing clinical therapies. Graphical Abstract

scholarly journals Neutrophil-Mediated Clinical Nanodrug for Treatment of Residual Tumor After Focused Ultrasound Ablation

2021 ◽  
Author(s):  
Jian Shen ◽  
Junnian Hao ◽  
Yini Chen ◽  
Hairong Liu ◽  
Jianrong Wu ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Therapeutic Potential ◽  
Malignant Tumors ◽  
Residual Tumor ◽  
High Intensity Focused Ultrasound ◽  
Drug Uptake ◽  
Targeting Therapy ◽  
Hifu Ablation ◽  
Inflammatory Stimuli ◽  
Ultrasound Ablation

Abstract Background: The risk of local recurrence of high intensity focused ultrasound (HIFU) is relatively high, resulting in poor prognosis of malignant tumors. Combination of HIFU with traditional chemotherapy still remains the unsatisfactory outcome because of off-site drug uptake.Results: Herein, we proposed the strategy of inflammation-tendency neutrophil-mediated clinical nanodrug targeting therapy for residual tumor of HIFU ablation. Neutrophils as a carrier, and PEGylated liposome doxorubicin (PLD) as a nanodrug model of chemotherapy, were selected to form an innovative cell therapy drug (PLD@NEs). The targeting performance and therapeutic potential of PLD@NEs were evaluated using hepa1-6 cells and corresponding tumor-bearing mouse model. After HIFU ablation, PLD@NEs were recruited to the tumor site by inflammation, and released PLD with inflammatory stimuli, leading to targeted and localized postoperative chemotherapy.Conclusion: This effective integration takes full use of the advantages of both HIFU, chemotherapy and neutrophil, attracting more focus on the practice of improving the existing clinical therapeutics.

scholarly journals The feasibility of a noise elimination method using continuous wave response of therapeutic ultrasound signals for ultrasonic monitoring of high-intensity focused ultrasound treatment

2021 ◽  
Author(s):  
Ryo Takagi ◽  
Toshikatsu Washio ◽  
Yoshihiko Koseki
Keyword(s):  
Noise Reduction ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Continuous Wave ◽  
High Intensity Focused Ultrasound ◽  
Hifu Treatment ◽  
Noise Elimination ◽  
Tissue Samples ◽  
Wave Response ◽  
Failure Conditions

Abstract Purpose In this study, the robustness and feasibility of a noise elimination method using continuous wave response of therapeutic ultrasound signals were investigated when tissue samples were moved to simulate the respiration-induced movements of the different organs during actual high-intensity focused ultrasound (HIFU) treatment. In addition to that, the failure conditions of the proposed algorithm were also investigated. Methods The proposed method was applied to cases where tissue samples were moved along both the lateral and axial directions of the HIFU transducer to simulate respiration-induced motions during HIFU treatment, and the noise reduction level was investigated. In this experiment, the speed of movement was increased from 10 to 40 mm/s to simulate the actual movement of the tissue during HIFU exposure, with the intensity and driving frequency of HIFU set to 1.0–5.0 kW/cm2 and 1.67 MHz, respectively. To investigate the failure conditions of the proposed algorithm, the proposed method was applied with the HIFU focus located at the boundary between the phantom and water to easily cause cavitation bubbles. The intensity of HIFU was set to 10 kW/cm2. Results Almost all HIFU noise was constantly able to be eliminated using the proposed method when the phantom was moved along the lateral and axial directions during HIFU exposure. The noise reduction level (PRL in this study) at an intensity of 1.0, 3.0, and 5.0 kW/cm2 was in the range of 28–32, 38–40, and 42–45 dB, respectively. On the other hand, HIFU noise was not basically eliminated during HIFU exposure after applying the proposed method in the case of cavitation generation at the HIFU focus. Conclusions The proposed method can be applicable even if homogeneous tissues or organs move axially or laterally to the direction of HIFU exposure because of breathing. A condition under which the proposed algorithm failed was when instantaneous tissue changes such as cavitation bubble generation occurred in the tissue, at which time the reflected continuous wave response became less steady.

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