scholarly journals High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Raul D. Bernabe-Dones ◽  
Maria Gonzalez-Pons ◽  
Alejandro Villar-Prados ◽  
Mercedes Lacourt-Ventura ◽  
Heriberto Rodríguez-Arroyo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Hpv Infection ◽  
Case Control ◽  
Colorectal Carcinogenesis ◽  
Colorectal Tumors ◽  
Hpv 16 ◽  
High Prevalence ◽  
Control Study

The role of Human Papillomavirus (HPV) in colorectal carcinogenesis remains elusive. Based on the high incidence of HPV-associated malignancies among Puerto Rican Hispanics, this study aimed to assess the prevalence of HPV infection and viral integration in colorectal tissues in order to evaluate its putative role in colorectal cancer (CRC). In this case-control study, the prevalence of HPV infection in CRC (casesn= 45) and normal colon mucosa from cancer-free subjects (controlsn= 36) was assessed by a nested PCR strategy. HPV-16 genotyping was performed in HPV-positive tissues and the physical status of the HPV-16 genome was determined by E2 detection. HPV was detected in 19 of 45 (42.2%) CRC cases (mean age 61.1 ± 10.7 years, 24 males) and in 1 of 36 (2.8%) controls (mean age 60.9 ± 9.6 years, 24 males) with an OR = 25.58 (95% CI 3.21 to 203.49). HPV-16 was detected in 63.2% of the HPV-positive colorectal tumors; genome integration was observed in all HPV-16 positive cases. This is the first report showing the high prevalence of HPV infections in Caribbean Hispanic colorectal tumors. Despite evidence of HPV integration into the host genome, further mechanistic analysis examining HPV oncoprotein expression and the putative role of these oncoproteins in colorectal carcinogenesis is warranted.

To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Reetu Hooda ◽  
Neeru Baghla ◽  
Nisha Malik ◽  
Samander Kaushik
Keyword(s):  
Case Control Study ◽  
Perinatal Outcomes ◽  
Preterm Births ◽  
Placental Tissue ◽  
Hpv Infection ◽  
Case Control ◽  
Full Term ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Control Study

Abstract Objectives i) To compare the placental human papilloma virus (HPV) deoxynucleic acid (DNA) status of preterm deliveries with full term deliveries and to identify high risk (HR) genotypes (HPV 16 and 18); and ii) To compare the perinatal outcomes of HPV positive with HPV negative pregnant women. Methods A case control study was carried out on 100 antenatal women with singleton live pregnancies admitted in labor ward of a tertiary care teaching hospital from April 2017 to March 2018. The two study groups were i) spontaneous preterm deliveries between 24 and 36 + 6 weeks (n=50) and ii) full term deliveries ≥37 weeks (n=50). The placental tissue was analysed for HPV DNA and HR HPV genotypes were detected by type specific primers. A comparative analysis of perinatal outcomes between HPV positive and negative women was done. Results An overall placental tissue HPV prevalence of 12% (12/100) was observed in study cohort which was not significantly different between preterm and full term deliveries (16 vs. 8%, p=0.218). HPV 16 was significantly associated with preterm births (p=0.04). Both HPV affected and non-affected women were comparable in terms of mode of delivery and neonatal outcomes. However, a statistically significant association of preterm neonatal intensive care admissions with HR HPV 16 genotype was observed (p=0.04). Conclusions Spontaneous preterm births can be attributed to placental HPV infection, specifically HR HPV 16 genotype. This association identifies a potentially preventable cause of prematurity and its associated complications, in wake of availability of an effective vaccine.

scholarly journals Role of β1-Integrin in Colorectal Cancer: Case-Control Study

2017 ◽  
Vol 40 (2) ◽  
pp. 77
Author(s):  
Bo Young Oh ◽  
Kwang Ho Kim ◽  
Soon Sup Chung ◽  
Kyoung Sook Hong ◽  
Ryung-Ah Lee
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Cancer Case ◽  
Β1 Integrin ◽  
Colorectal Cancer Case ◽  
Control Study

scholarly journals The Role of Dietary and Lifestyle Factors in the Development of Colorectal Cancer: Case Control Study in Minia, Egypt

2014 ◽  
Vol 22 (4) ◽  
pp. 215-222 ◽  
Author(s):  
Eman Mohamed Mahfouz ◽  
Refaat Raouf Sadek ◽  
Wafaa Mohamed Abdel-Latief ◽  
Fadia Abdel-Hamed Mosallem ◽  
Ebtesam Esmail Hassan
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Lifestyle Factors ◽  
Cancer Case ◽  
Colorectal Cancer Case ◽  
Control Study

Interaction Between Retinol Intake and ISX rs5755368 Polymorphism in Colorectal Cancer Risk: A Case-control Study Among the Korean Population

2021 ◽  
Author(s):  
Anh Quynh Bui ◽  
Madhawa Gunathilake ◽  
Jeonghee Lee ◽  
Jae Hwan Oh ◽  
Hee Jin Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Regression Models ◽  
Case Control Study ◽  
Protective Role ◽  
Case Control ◽  
Total Study Population ◽  
Logistic Regression Models ◽  
Study Population ◽  
Control Study

Abstract There is limited evidence about the interaction between retinol intake and the intestine-specific homeobox (ISX) rs5755368 polymorphism in colorectal cancer (CRC) risk. We conducted a hospital-based case-control study to examine whether the ISX rs5755368 genotypes are associated with the effect of dietary retinol consumption on CRC risk. First, to identify the association between dietary retinol and CRC risk, we recruited 923 CRC patients and 1846 controls. Dietary retinol intake was assessed using a semiquantitative food frequency questionnaire. For genetic analysis, genotype data were available for 1419 patients (600 cases and 819 controls) out of the total study population. ISX rs5755368 genotyping was performed using an Illumina MEGA-Expanded Array. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression models. Retinol intake was inversely associated with the development of CRC (OR = 0.49; 95% CI = 0.37–0.63) after adjusting for confounders. Patients with homozygous AA genotype of the ISX rs5755368 polymorphism were less likely to have CRC risk than subjects carrying the G allele (AG+GG) (OR = 0.76; 95% CI = 0.58–0.99). Additionally, a 68% reduced risk of CRC was related to the highest retinol intake among those carrying the rs5755368 AA genotype compared to the risk of participants carrying the G allele consumed the lowest retinol intake (OR = 0.32; 95% CI = 0.20–0.53; P interaction=0.026). In conclusion, our study confirmed a protective role of retinol intake in CRC risk reduction. Moreover, this association was strengthened significantly among individuals carrying the homozygous AA genotype of the ISX rs5755368 polymorphism.

scholarly journals Role of β1-Integrin in Colorectal Cancer: Case-Control Study

2014 ◽  
Vol 30 (2) ◽  
pp. 61 ◽  
Author(s):  
Bo-Young Oh ◽  
Kwang Ho Kim ◽  
Soon Sup Chung ◽  
Kyoung Sook Hong ◽  
Ryung-Ah Lee
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Cancer Case ◽  
Β1 Integrin ◽  
Colorectal Cancer Case ◽  
Control Study

Gene-diet interactions in the aetiology of colorectal cancer: results from a population-based case-control study in north-east Scotland

Endoscopy ◽  
2006 ◽  
Vol 37 (12) ◽  
Author(s):  
L Sharp ◽  
LF Masson ◽  
J Little ◽  
NT Brockton ◽  
SC Cotton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
North East ◽  
Control Study

scholarly journals Systemic and tumor level iron regulation in men with colorectal cancer: a case control study

2014 ◽  
Vol 11 (1) ◽  
pp. 21 ◽  
Author(s):  
Cenk K Pusatcioglu ◽  
Elizabeta Nemeth ◽  
Giamila Fantuzzi ◽  
Xavier Llor ◽  
Sally Freels ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Iron Regulation ◽  
Tumor Level ◽  
Control Study
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