scholarly journals The Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implantitis

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Umberto Romeo ◽  
Gianna Maria Nardi ◽  
Fabrizio Libotte ◽  
Silvia Sabatini ◽  
Gaspare Palaia ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Test Group ◽  
Plaque Index ◽  
Adjunctive Treatment ◽  
Control Group ◽  
Antimicrobial Photodynamic Therapy ◽  
Control Groups ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Group 3

Introduction. The aim of this study is to demonstrate the effectiveness of addition of the antimicrobial photodynamic therapy to the conventional approach in the treatment of peri-implantitis.Materials and Methods. Forty patients were randomly assigned to test or control groups. Patients were assessed at baseline and at six (T1), twelve (T2), and twenty-four (T3) weeks recording plaque index (PlI), probing pocket depth (PPD), and bleeding on probing (BOP); control group received conventional periodontal therapy, while test group received photodynamic therapy in addition to it.Result. Test group showed a 70% reduction in the plaque index values and a 60% reduction in PD values compared to the baseline. BOP and suppuration were not detectable. Control group showed a significative reduction in plaque index and PD.Discussion. Laser therapy has some advantages in comparison to traditional therapy, with faster and greater healing of the wound.Conclusion. Test group showed after 24 weeks a better value in terms of PPD, BOP, and PlI, with an average pocket depth value of 2 mm, if compared with control group (3 mm). Our results suggest that antimicrobial photodynamic therapy with diode laser and phenothiazine chloride represents a reliable adjunctive treatment to conventional therapy. Photodynamic therapy should, however, be considered a coadjuvant in the treatment of peri-implantitis associated with mechanical (scaling) and surgical (grafts) treatments.

Hyperbaric oxygen therapy for the treatment of moderate to severe periodontitis: a clinical pilot study

2020 ◽  
pp. 571-580 ◽  
Author(s):  
Giorgio Lombardo ◽  
◽  
Alessia Pardo ◽  
Caterina Signoretto ◽  
Annarita Signoriello ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Chronic Periodontitis ◽  
Soft Tissues ◽  
Test Group ◽  
Clinical Parameter ◽  
Control Group ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Parallel Group ◽  
Hbo2 Therapy

Objectives: To clinically and microbiologically evaluate the effects of hyperbaric oxygen (HBO2) therapy in addition to full-mouth ultrasonic subgingival debridement (FM-UD), in the initial treatment of chronic periodontitis.  Methods: Twenty patients presenting moderate to severe generalized forms of chronic periodontitis were included in a three-month randomized, parallel-group, single-blinded, prospective study. At baseline patients were randomly assigned to two treatment groups [Test Group (FM-UD+HBO2) and Control Group (FM-UD)]. Both groups were treated with an FM-UD session. Ten HBO2 sessions (one session per day for 10 days at a pressure of 2.5 ATA) were additionally administered to the Test Group. Soft tissues parameters [probing pocket depth (PPD), bleeding on probing (BOP), clinical attachment level (CAL) and visible plaque index (VPI)] were assessed at baseline (immediately before FM-UD treatment), after two weeks, after six weeks and at three months. For each patient, a site presenting PPD ≥ 6mm and positive BOP was selected as a qualifying site (QS), to be monitored clinically (at T0, T1, T2 and T3) and microbiologically (at T0, T1 and T3). Results: There were no statistically significant differences between the two groups for any clinical parameter analyzed after three months, except for BOP, which was significantly (p < 0.05) reduced in the Test Group. Reductions in bacterial levels were detected in both groups after therapy. Faster bacterial recolonization occurred after three months in the Control Group. Conclusion: HBO2 therapy in combination with FM-UD may represent an efficacious approach to the treatment of moderate to severe forms of periodontitis.

scholarly journals Effectiveness of Antimicrobial Photodynamic Therapy in the Treatment of Periodontitis: A Systematic Review and Meta-Analysis of In Vivo Human Randomized Controlled Clinical Trials

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 836
Author(s):  
Snehal Dalvi ◽  
Stefano Benedicenti ◽  
Tudor Sălăgean ◽  
Ioana Roxana Bordea ◽  
Reem Hanna
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Meta Analysis ◽  
Cochrane Collaboration ◽  
Future Research ◽  
Antimicrobial Photodynamic Therapy ◽  
Pocket Depth ◽  
Hand Search ◽  
Probing Pocket Depth

This systematic review and meta-analysis evaluated antimicrobial photodynamic therapy (aPDT) efficacy in periodontitis. The review protocol was conducted in accordance with PRISMA statements, Cochrane Collaboration recommendations and is registered in PROSPERO (CRD 42020161516). Electronic and hand search strategies were undertaken to gather data on in vivo human RCTs followed by qualitative analysis. Differences in probing pocket depth (PPD) and clinical attachment level (CAL) were calculated with 95% confidence intervals and pooled in random effects model at three and six months. Heterogeneity was analyzed, using Q and I2 tests. Publication bias was assessed by visual examination of the funnel plot symmetry. Sixty percent of 31 eligible studies showed a high risk of bias. Meta-analysis on 18 studies showed no additional benefit in split mouth studies in terms of PPD reduction (SMD 0.166; 95% CI −0.278 to 0.611; P = 0.463) and CAL gain (SMD 0.092; 95% CI −0.013 to 0.198; P = 0.088). Similar findings noted for parallel group studies; PPD reduction (SMD 0.076; 95% CI −0.420 to 0.573; P = 0.763) and CAL gain (SMD 0.056; 95% CI −0.408 to 0.552; P = 0.745). Sensitivity analysis minimized heterogeneity for both outcome variables; however, intergroup differences were not statistically significant. Future research should aim for well-designed RCTs in order to determine the effectiveness of aPDT.

Salivary Matrix Metalloproteinase-8 (MMP-8) in Relation to Periodontal Health Status Among a Group of Hypertensive Patients

2018 ◽  
Vol 30 (3) ◽  
pp. 48-53
Author(s):  
Iman Z AlMudaris ◽  
Nadia A AlRawi
Keyword(s):  
Periodontal Disease ◽  
Plaque Index ◽  
Control Group ◽  
Study Group ◽  
Periodontal Health ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Probing Pocket Depth ◽  
Significant Difference ◽  
Attachment Level

Background: Hypertension is probably the most important public health problem around the world. People with periodontal disease may be at greater risk of hypertension. The inflammatory effects of periodontal disease help to promote endothelial dysfunction in arteries which may lead to changes in blood pressure. Salivary MMP-8 has been associated with both periodontal disease and prevalent hypertension. Aim of study: This study was conducted to measure salivary matrix metalloproteinase - 8, in relation to periodontal health condition among a group of patients with hypertension in comparison with control group. Materials and methods: Ninety subjects, aged 45-50 years old were included in this study, seeking treatment for chest pain in Ibn-AlBaytar center for cardiac surgical treatments in Baghdad, Iraq. The subjects were divided into study group (45 patient) who were diagnosed to be a hypertensive patient, and a control group (45 subject), with no hypertension. Plaque status was evaluated according to the Silness and Loe, probing pocket depth and clinical attachment level. Unstimulated saliva was collected from all subjects to analyses MMP-8. Result: A high mean value of plaque index, clinical attachment level and probing pocket depth for the study group than the control group with statistically no significant difference. In addition to that, a significant positive correlation between the plaque index and the clinical attachment level among both groups. Salivary MMP-8 level showed a higher level in the study group than in the control group, with statistically significant difference between groups, and a significant positive correlation was detected between salivary MMP-8 with plaque index, among study group, Conclusions: Higher percentage of periodontal diseases was found among patients with blood hypertension. In addition, high level of salivary MMP-8 is potentially associated with periodontal status of the study group.

scholarly journals Treatment of Peri-Implant Mucositis with Repeated Application of Chlorhexidine Chips or Gel during Supportive Therapy—A Randomized Clinical Trial

2019 ◽  
Vol 7 (4) ◽  
pp. 115
Author(s):  
Philipp Sahrmann ◽  
Cyrill Bettschart ◽  
Daniel B. Wiedemeier ◽  
Ahmed Al-Majid ◽  
Thomas Attin ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Supportive Therapy ◽  
Test Group ◽  
Group Differences ◽  
Control Group ◽  
Repeated Application ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Application Methods ◽  
Better Than

Background: To assess the effect of chlorhexidine (CHX) chip application in patients with peri-implant mucositis as compared to CHX gel application. Methods: In peri-implant sites with mucositis, CHX gel was applied in the control group (GC) and CHX chips in the test group (CC) at baseline and after three months. At baseline and after six months, peri-implant pocket depths (PPD), bleeding-on-probing (BOP) and activated matrix metalloproteinase-8 (aMMP8) were assessed. Longitudinal changes were tested for inter-group differences. Results: Thirty-two patients were treated. BOP was more reduced (p = 0.006) in CC than in GC, with means and standard deviations of 46 ± 28% and 17 ± 27%, respectively. PPD was more reduced (p = 0.002) in CC than in GC with 0.65 ± 0.40 mm and 0.18 ± 0.32 mm, respectively. Regarding BOP, the percentages of improved, unchanged and worsened sites accounted for 32%, 61% and 7% in GC and 46%, 53% and 1% in CC, respectively. For probing pocket depth, the according values were 26%, 66% and 8% (GC) versus 57%, 38% and 5% (CC). Conclusions: During supportive therapy, repeated CHX chip application might resolve marginal peri-implant inflammation in terms of bleeding better than CHX gel.

scholarly journals Lack of Correlation between Periodontitis and Renal Dysfunction in Systemically Healthy Patients

2011 ◽  
Vol 05 (01) ◽  
pp. 008-018 ◽  
Author(s):  
Renata Squariz Brotto ◽  
Regina Célia Vendramini ◽  
Iguatemy Lourenço Brunetti ◽  
Rosemary Adriana Chierici Marcantonio ◽  
Adriana Pelegrino Pinho Ramos ◽  
...  
Keyword(s):  
Kidney Function ◽  
Test Group ◽  
Severity Index ◽  
Reference Intervals ◽  
Control Group ◽  
Pocket Depth ◽  
Albumin Creatinine Ratio ◽  
Probing Pocket Depth ◽  
Severe Periodontitis ◽  
Significant Difference

ABSTRACTObjectives: The aim of this study was to assess a suggested association between periodontitis and renal insufficiency by assaying kidney disease markers. Methods: Variables used to diagnose periodontitis were: (i) probing pocket depth (PPD), (ii) attachment loss (AL), (iii) bleeding on probing (BOP), (iv) plaque index (PI) and (v) extent and severity index. Blood and urine were collected from 60 apparently healthy non-smokers (men and women), consisting of a test group of 30 subjects with periodontitis (age 46±6 yrs) and a control group of 30 healthy subjects (age 43±5 yrs). Kidney function markers (urea, creatinine, uric acid and albumin contents) were measured in the serum and urine. Also, the glomerular filtration rate was estimated from creatinine clearance, from the abbreviated Modification of Diet in Renal Disease formula and from the albumin : creatinine ratio in a 24–h sample of urine. Results: It was found that the control group had a greater mean number of teeth than the test group and that the two groups also differed in PPD, AL, BOP and PI, all these variables being higher in the test group (P=0.006). For the extent and severity index of both PPD and AL, the test group had much higher medians of both extent and severity than the control group (P=0.001). With regard to kidney function, none of the markers revealed a significant difference between the control and test groups and all measured values fell within the reference intervals. Conclusions: It is proposed that severe periodontitis is not associated with any alteration in kidney function. (Eur J Dent 2011;5:8-18)

scholarly journals Comparative Assessment of a Standard Oral Hygiene Regimen with and without Mouthwash and Related Clinical Findings over a 14-day Period

2018 ◽  
Vol 7 (1) ◽  
pp. 21-25
Author(s):  
Mahdi Kadkhodazadeh ◽  
Reza Amid ◽  
Parisa Zarnegarnia ◽  
Fatemeh Mollaverdi ◽  
Yaser Safi ◽  
...  
Keyword(s):  
Oral Hygiene ◽  
Chronic Periodontitis ◽  
Statistical Significance ◽  
Cetylpyridinium Chloride ◽  
Test Group ◽  
Clinical Findings ◽  
Control Group ◽  
Pocket Depth ◽  
Dental Floss ◽  
Probing Pocket Depth

Background and aims. The goal of this study was to evaluate the clinical efficacy of a standard oral hygiene routine (daily tooth brushing and flossing) along with cetylpyridinium chloride (CPC) mouthwash in comparison to the same protocol without mouthwash in chronic periodontitis patients during a 14-day period. Materials and methods. This comparative study was carried out or 50 non-smoking patients with chronic periodontitis; 25 patients followed an oral hygiene regimen using a toothbrush and dental floss (control group) and the remaining 25 used the mentioned protocol along with CPC mouthwash (test group) for 14 days. The plaque index (PI), modified gingival index (MGI) and probing pocket depth (PPD) were assessed. Wilcoxon and Mann-Whitney U tests were used to evaluate and compare the prevalence of indices between the two groups. Statistical significance was set at P<0.05. Results. The results showed greater improvement of MGI in the test group (P=0.001). No statistically significant differences were observed in PI (P=0.47) and PPD (P=0.43) between the two groups. Conclusion. Adding mouthwash to a standard oral hygiene regimen may improve some clinical gingival parameters when compared with an oral hygiene routine without a mouthwash

scholarly journals Evaluation of Bovine Derived Xenograft Combined with Bioresorbable Collagen Membrane in Treatment of Intrabony Defects

2020 ◽  
Vol 4 (2) ◽  
pp. 61-67
Author(s):  
Ranjita Shrestha Gorkhali ◽  
Shaili Pradhan ◽  
Rejina Shrestha ◽  
Shweta Agrawal ◽  
Krishna Lamicchane ◽  
...  
Keyword(s):  
Test Group ◽  
Control Group ◽  
Collagen Membrane ◽  
Intrabony Defects ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Probing Pocket Depth ◽  
Open Flap Debridement ◽  
Attachment Level ◽  
Depth Reduction

Introduction: Treatment of periodontal diseases done by surgical therapy depends upon extent and severity of disease. The ultimate goal of periodontal reconstructive surgery is to regenerate tissues destroyed during periodontal disease. Objective: To evaluate the effectiveness of bovine-derived xenograft with collagen membrane in treatment of intrabony defects by comparing it with open flap debridement alone. Methods: This non-randomised controlled trial was conducted after ethical clearance, at Bir hospital from 2018 March to 2019 April. The study recruited 38 patients by convenience sampling, age from 25-44 years, with chronic periodontitis, and willing to sign informed consent. Intrabony defects were treated by open flap debridement with bovine-derived xenograft and bioresorbable collagen membrane (Test group) and open flap debridement alone (Control group). Probing pocket depth, clinical attachment level, gingival recession, oral hygiene status, and gingival status were assessed at baseline and six months. Results: Six months after therapy, in Test group probing pocket depth reduction was 5.2 mm and gain in mean clinical attachment level was 4.3 mm. In Control group, mean probing pocket depth reduction was 3.8 mm and mean gain in clinical attachment level was 2.7 mm. The test treatment resulted in statistically higher probing pocket depth reduction and clinical attachment level gain than Control group. Conclusion: Both therapies resulted in significant probing pocket depth reductions and clinical attachment gains, and treatment with open flap debridement with bovine-derived xenografts and collagen membrane resulted in significantly higher probing pocket depth reduction and clinical attachment gain than treatment with open flap debridement alone.

scholarly journals Clinical and microbiological evaluation of 940-nm diode laser as an adjunct to modified Widman flap for the management of chronic periodontitis: A 6-month randomized split-mouth clinical trial

2021 ◽  
Vol 15 (2) ◽  
pp. 133-139
Author(s):  
Ashish Agarwal ◽  
Anugrah Saxena ◽  
Shiva Shankar Gummaluri ◽  
Bharti Chaudhary ◽  
karthikeyan Subramanyam S Sai ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Diode Laser ◽  
Chronic Periodontitis ◽  
Test Group ◽  
Control Group ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Colony Forming Units ◽  
Intergroup Comparison ◽  
Microbiological Parameters

Background. The present randomized clinical trial aimed to determine the additive clinical and microbiological benefits of diode laser (DL) with modified Widman flap (MWF) to manage chronic periodontitis. Methods. Seventy-two sites in 36 healthy non-smoking patients diagnosed with chronic periodontitis were randomly assigned to the test group (MWF + active DL) or control group (MWF + sham DL). Clinical (probing pocket depth [PPD], clinical attachment level [CAL]) and microbiological (colony-forming units [CFUs]) measurements were recorded at baseline and 6- and 6-month postoperative intervals. Results. Compared to baseline, 6-month results showed significant changes in clinical and microbiological parameters in both groups. However, the intergroup comparison revealed significantly lower PPD (1.90±0.48 mm vs. 2.35±0.41 mm), CAL (4.43±0.57 mm vs. 4.93±0.58 mm), and CFUs for Porphyromonas gingivalis (6.32±0.18 vs. 8.88 ±1.88), Prevotella intermedia (7.62±1.86 vs. 8.12±1.78), and Aggregatibacter actinomycetemcomitans (6.43±1.44 vs. 7.24±1.22) in the test group after six months. Conclusion. Within the limitations, the present study confirmed the useful role of DL with MWF to manage chronic periodontitis.

scholarly journals The adjunct effectiveness of diode laser gingivectomy in maintaining periodontal health during orthodontic treatment

2012 ◽  
Vol 83 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Tony N. F. To ◽  
A. Bakr M. Rabie ◽  
Ricky W. K. Wong ◽  
Colman P. McGrath
Keyword(s):  
Diode Laser ◽  
Test Group ◽  
Periodontal Treatment ◽  
Control Group ◽  
Gingival Index ◽  
Periodontal Health ◽  
Pocket Depth ◽  
Gingival Overgrowth ◽  
Probing Pocket Depth ◽  
Gingival Health

Abstract Objective: To evaluate the effectiveness of diode laser gingivectomy as an adjunct to nonsurgical periodontal treatment in the management of periodontal health among patients receiving fixed orthodontic appliance therapy (FOAT). Materials and Methods: Thirty patients undergoing FOAT with gingival enlargement were block randomized into two treatment groups. The test group received diode laser gingivectomy (940-nm diode laser, ezlase, Biolase Technology Inc) as an adjunct to nonsurgical periodontal treatment. The control group received nonsurgical periodontal treatment only. For both groups, five periodontal parameters were assessed at baseline, 1 month, 3 months, and 6 months: Plaque Index, Gingival Index, bleeding on probing, probing pocket depth, and Gingival Overgrowth Index. Intra- and intergroup variations in the periodontal parameters were determined over time. Results: Both groups showed statistically significant improvements in periodontal health over the study period (P &lt; .05). However, significant improvements in periodontal health were evident earlier among the test group subjects (P &lt; .05). The magnitude of improvement in periodontal health compared to baseline was greater in the test group than in the control group for Gingival Overgrowth Index at 1 month (P &lt; .001) and 3 months (P &lt; .05), Gingival Index at 3 months (P &lt; .05) and 6 months (P &lt; .05), and probing pocket depth at 1 month (P &lt; .05). Conclusions: Nonsurgical periodontal management with or without the adjunct use of lasers can be effective in the management of gingival health problems among patients receiving FOAT. The adjunctive use of lasers can produce an earlier and greater improvement in gingival health.

scholarly journals Short-term results in evaluating a gingiva-adhesive hydrophobic-chlorhexidine-gel for chronic periodontitis

2014 ◽  
Vol 87 (3) ◽  
pp. 186-191
Author(s):  
Ciprian Sarbu ◽  
Darian Rusu ◽  
Horia Călniceanu ◽  
Adrian Kasaj ◽  
Stefan Adrian Petrutiu ◽  
...  
Keyword(s):  
Oral Hygiene ◽  
Chronic Periodontitis ◽  
Test Group ◽  
Study Groups ◽  
Plaque Index ◽  
Control Group ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Root Planing ◽  
Chlorhexidine Gel

Background and Aims: Oral mucosa and interproximal spaces of the teeth could favor the colonization of periodontopathogenic bacteria, which could be targeted by chemical antiplaque agents such as chlorhexidine, present in different oral hygiene products, thus improving the control of biofilm growth and delaying microbial accumulation. The study aimed to evaluate whether the use of a hydrophobic gel with good gingival adhesion for 14 days after the scaling and root planing of patients with chronic periodontitis would improve the treatment outcome, when compared with the use of a regular hydrophyllic gel.Material and Methods: Patients with moderate disease were included in two study groups. At baseline and 3 months after the treatment the following parameters were recorded: pocket depth, Approximal Plaque Index, Modified Gingival Index, Simplified Oral Hygiene Index, bleeding on probing. Patients received scaling and root planing in two sessions at 24 hours interval. After the treatment, patients in the test group applied the hydrophobic adhesive chlorhexidine gel once a day, every other day, while in the control group the gel was used twice daily.Results. Both treatments resulted in significant improvement in all clinical indices, except Approximal Plaque Index, which deteriorated significantly in both groups. Three months after mechanical treatment, the mean probing depth changed in the test group from 4.16±0.45 mm to 2.80±0.42 mm, and in the control group from 4.16±0.30 to 2.69±0.19.Conclusions: Both adjunctive anti-infective therapies induced clinical improvement 3 months from baseline. The differences between the two treatments were not statistically significant.

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