scholarly journals Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Henned Saade ◽  
María de Lourdes Guillén ◽  
Judith Cabello Romero ◽  
Jesús Cepeda ◽  
Anna Ilyna ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Methyl Methacrylate ◽  
Methacrylic Acid ◽  
Ultrafine Particles ◽  
Micellar Solution ◽  
Polymerization Kinetics ◽  
Degenerative Diseases ◽  
Product Characterization ◽  
Mean Diameter ◽  
Semicontinuous Heterophase Polymerization

Ultrafine nanoparticles, less than 10 nm in mean diameter, of the FDA approved copolymer methyl methacrylate- (MMA-)co-methacrylic acid (MAA), 2/1 (mol/mol), were prepared. The method used for the preparation of these particles stabilized in a latex containing around 11% solids includes the dosing of the monomers mixture on a micellar solution preserving monomer starved conditions. It is thought that the operation at these conditions combined with the hydrophilicity of MMA and MAA units favors the formation of ultrafine particles; the propagation reaction carried out within so small compartments renders copolymer chains rich in syndiotactic units very likely as consequence of the restricted movements of the end propagation of the chains. Because of their biocompatibility and biodegradability as well as their extremely small size these nanoparticles could be used as vehicles for improved drug delivery in the treatment of chronic-degenerative diseases.

scholarly journals Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Loaded with Aspirin

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
R. López-Muñoz ◽  
M. E. Treviño ◽  
G. Morales ◽  
J. A. Valdez-Garza ◽  
R. Díaz de León ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Methacrylic Acid ◽  
Molar Ratio ◽  
Infrared Spectrometry ◽  
Fourier Transform Infrared Spectrometry ◽  
Poly Methyl Methacrylate ◽  
Nanoparticle Surface ◽  
Transmission Electron ◽  
Eudragit S100 ◽  
Semicontinuous Heterophase Polymerization

Nanoparticles of the poly(methyl methacrylate-co-methacrylic acid) or copolymer of P(MMA-co-MAA), were prepared by semicontinuous heterophase polymerization; they show a mean diameter of 12 nm and a 1.75 MMA/MAA molar ratio determined by carbon-13 nuclear magnetic resonance. The content of MAA, greater than that of Eudragit S100, copolymer of P(MMA-co-MAA) accepted by the FDA for the preparation of tablets, ensures its biocompatibility and its metabolism without toxic effects. Loaded with up to 22 wt. % aspirin, that is, acetylsalicylic acid (ASA), these nanoparticles increase slightly their size, according to transmission electron microscopy; however, the presence of ASA on the nanoparticle surface decreases their stability, which leads to a certain aggregation of the particles in the dispersion. Fourier transform infrared spectrometry was used for demonstrating the loading of ASA in the nanoparticles.

TiO2-based Mitoxantrone Imprinted Poly (Methacrylic acid-co-polycaprolctone diacrylate) Nanoparticles as a Drug Delivery System

2017 ◽  
Vol 23 (18) ◽  
Author(s):  
Maryam Bakhshizadeh ◽  
Ameneh Sazgarnia ◽  
Mahmoud Seifi ◽  
Farzin Hadizadeh ◽  
Ghadir Rajabzadeh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Methacrylic Acid

The Synthesis of Branched Poly(methyl methacrylate)

1993 ◽  
Vol 58 (11) ◽  
pp. 2523-2534 ◽  
Author(s):  
Claudio G. Dos Santos ◽  
Aubrey D. Jenkins ◽  
David R. M. Walton ◽  
Jaroslav Stejskal ◽  
Pavel Kratochvíl
Keyword(s):  
Methyl Methacrylate ◽  
Poly Methyl Methacrylate ◽  
Product Characterization

The synthesis of branched poly(methyl methacrylate) is described. The method used is based on an anionic technique with initiation by enolate ions. details of product characterization are included.

scholarly journals Synthesis of Poly(methacrylic acid-co-butyl acrylate) Grafted onto Functionalized Carbon Nanotube Nanocomposites for Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 533 ◽  
Author(s):  
Josué A. Torres-Ávalos ◽  
Leonardo R. Cajero-Zul ◽  
Milton Vázquez-Lepe ◽  
Fernando A. López-Dellamary ◽  
Antonio Martínez-Richa ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Methacrylic Acid ◽  
Butyl Acrylate ◽  
Chemical Vapor ◽  
Vis Spectroscopy ◽  
Ir And Raman Spectroscopies ◽  
Ft Ir

Design of a smart drug delivery system is a topic of current interest. Under this perspective, polymer nanocomposites (PNs) of butyl acrylate (BA), methacrylic acid (MAA), and functionalized carbon nanotubes (CNTsf) were synthesized by in situ emulsion polymerization (IEP). Carbon nanotubes were synthesized by chemical vapor deposition (CVD) and purified with steam. Purified CNTs were analyzed by FE-SEM and HR-TEM. CNTsf contain acyl chloride groups attached to their surface. Purified and functionalized CNTs were studied by FT-IR and Raman spectroscopies. The synthesized nanocomposites were studied by XPS, 13C-NMR, and DSC. Anhydride groups link CNTsf to MAA–BA polymeric chains. The potentiality of the prepared nanocomposites, and of their pure polymer matrices to deliver hydrocortisone, was evaluated in vitro by UV–VIS spectroscopy. The relationship between the chemical structure of the synthesized nanocomposites, or their pure polymeric matrices, and their ability to release hydrocortisone was studied by FT-IR spectroscopy. The hydrocortisone release profile of some of the studied nanocomposites is driven by a change in the inter-associated to self-associated hydrogen bonds balance. The CNTsf used to prepare the studied nanocomposites act as hydrocortisone reservoirs.

Stereoassociation between poly(methyl methacrylate) and poly(methacrylic acid)

1975 ◽  
Vol 13 (12) ◽  
pp. 725-729 ◽  
Author(s):  
J. H. G. M. Lohmeyer ◽  
G. Kransen ◽  
Y. Y. Tan ◽  
G. Challa
Keyword(s):  
Methyl Methacrylate ◽  
Methacrylic Acid ◽  
Poly Methyl Methacrylate
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