scholarly journals A Case of Penicillin-ResistantVeillonellaProsthetic Joint Infection of the Knee

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Claudia R. Libertin ◽  
Joy H. Peterson ◽  
Mark P. Brodersen ◽  
Tamara Huff
Keyword(s):  
Joint Infection ◽  
Emerging Pathogens ◽  
Knee Infection ◽  
Prosthetic Knee ◽  
The Third ◽  
Procedural Approach ◽  
Prosthetic Joint ◽  
Follow Up Care ◽  
Prosthetic Knee Infection

Veillonellasp. andV. disparare emerging pathogens. This is the third case of a monomicrobialVeillonellasp. prosthetic joint infection (PJI) among knees and hips; this is the second prosthetic knee infection described. The infection was treated with a 2-stage procedural approach combined with 6 weeks of ceftriaxone with excellent clinical response. There was no relapse in 2 years of follow-up care. This case exemplifies the importance of incubating anaerobic cultures for at least 7 days to grow some anaerobic pathogens.

scholarly journals Mycobacterium mageritense Prosthetic Joint Infection

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Maria A. Caravedo Martinez ◽  
Lucas S. Blanton
Keyword(s):  
Medical Literature ◽  
Joint Infection ◽  
Mycobacterial Species ◽  
Knee Infection ◽  
Prosthetic Knee ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Prosthetic Knee Infection ◽  
Removal Of Hardware

Prosthetic joint infections (PJI) complicate up to 2% of arthroplasties and are usually caused by typical bacterial agents (e.g., staphylococci and streptococci). Although an infrequent cause of PJI, mycobacterial species are difficult to eradicate, as they adhere to hardware, form biofilms, and have high rates of antimicrobial resistance. Mycobacterium mageritense is a rapidly growing Mycobacterium that has been infrequently described as a cause of surgical and device-related infections. We herein described a case of prosthetic knee infection due to M. mageritense. The patient was treated with removal of hardware, antimicrobials, and prosthetic knee reimplantation with a good outcome. To our knowledge, M. mageritense has not been previously described as a cause of PJI in the medical literature.

The effect of patient institutional transfer during the interstage period of two-stage treatment for prosthetic knee infection

2019 ◽  
Vol 101-B (9) ◽  
pp. 1087-1092 ◽  
Author(s):  
Simon Garceau ◽  
Yaniv Warschawski ◽  
Omar Dahduli ◽  
Ibrahim Alshaygy ◽  
Jesse Wolfstadt ◽  
...  
Keyword(s):  
Joint Infection ◽  
Recurrent Infection ◽  
Porous Metal ◽  
Revision Total Knee Arthroplasty ◽  
Two Stage ◽  
Prosthetic Knee ◽  
Continuous Care ◽  
Prosthetic Joint ◽  
Total Knee ◽  
Prosthetic Knee Infection

Aims The aim of this study was to assess the effects of transferring patients to a specialized arthroplasty centre between the first and second stages (interstage) of prosthetic joint infection (PJI) of the knee. Patients and Methods A search of our institutional database was performed to identify patients having undergone two-stage revision total knee arthroplasty (TKA) for PJI. Two cohorts were created: continuous care (CC) and transferred care (TC). Baseline characteristics and outcomes were collected and compared between cohorts. Results A total of 137 patients were identified: 105 in the CC cohort (56 men, 49 women; mean age 67.9) and 32 in the TC cohort (17 men, 15 women; mean age 67.8 years). PJI organism virulence was greater in the CC cohort (36.2% vs 15.6%; p = 0.030). TC patients had a higher rate of persisting or recurrent infection (53.6% vs 13.4%; p < 0.001), soft-tissue complications (31.3 vs 14.3%; p = 0.030), and reduced requirement for porous metal augments (78.1% vs 94.3%; p = 0.006). Repeat first stage debridement after transfer led to greater need for plastic surgical procedures (58.3% vs 0.0%; p < 0.001). Conclusion Patient transfer during the interstage of treatment for infected TKA leads to poorer outcomes compared with patients receiving all their treatment at a specialized arthroplasty centre. Cite this article: Bone Joint J 2019;101-B:1087–1092.

scholarly journals Rotating Hinge Knee Arthroplasty for Revision Prosthetic-Knee Infection: Good Functional Outcomes but a Crucial Need for Superinfection Prevention

2021 ◽  
Vol 8 ◽  
Author(s):  
Florian Bourbotte-Salmon ◽  
Tristan Ferry ◽  
Mickaël Cardinale ◽  
Elvire Servien ◽  
Frédéric Rongieras ◽  
...  
Keyword(s):  
Knee Arthroplasty ◽  
Functional Outcomes ◽  
Knee Prosthesis ◽  
Implant Removal ◽  
Knee Infection ◽  
Prosthetic Knee ◽  
Rotating Hinge ◽  
Total Knee ◽  
Prosthetic Knee Infection

Introduction: Management of chronic infection following total knee arthroplasty (TKA) is challenging. Rotating hinged prostheses are often required in this setting due to severe bone loss, ligamentous insufficiency, or a combination of the two. The nature of the mechanical and septic complications occurring in this setting has not been well-described. The aim of this study was to evaluate patient outcomes using a hinge knee prosthesis for prosthetic knee infections and to investigate risk factors for implant removal.Methods: This was a retrospective cohort study that included all patients treated in our tertiary level referral center between January 2009 and December 2016 for prosthetic knee infection with a hinge knee prosthesis. Only patients with a minimum 2-year of follow-up were included. Functional evaluation was performed using international knee society (IKS) “Knee” and “Function” scores. Survival analysis comparing implant removal risks for mechanical and septic causes was performed using Cox univariate analysis and Kaplan-Meier curves. Risk factors for implant removal and septic failure were assessed.Results: Forty-six knees were eligible for inclusion. The majority of patients had satisfactory functional outcomes as determined by mean IKS scores (mean knee score: 70.53, mean function score: 46.53 points, and mean knee flexion: 88.75°). The 2-year implant survival rate was 89% but dropped to 65% at 7 years follow-up. The risk of failure (i.e., implant removal) was higher for septic etiology compared to mechanical causes. Patients with American society of anesthesiologists (ASA) score&gt;1, immunosuppression, or with peripheral arterial diseases had a higher risk for septic failure. Patients with acute infection according to the Tsukayamaclassification had a higher risk of failure. Of the 46 patients included, 19 (41.3%) had atleast one infectious event on the surgical knee and most of these were superinfections (14/19) with new pathogens isolated. Among pathogens responsible for superinfections (i) cefazolin and gentamicin were both active in six of the cases but failed to prevent the superinfection; (ii) cefazolin and/or gentamicin were not active in eight patients, leading to alternative systemic and/or local antimicrobial prophylaxis consideration.Conclusions: Patients with chronic total knee arthroplasty (TKA) infection, requiring revision using rotating hinge implant, had good functional outcomes but experienced a high rate of septic failure, mostly due to bacterial superinfection. These patients may need optimal antimicrobial systemic prophylaxis and innovative approaches to reduce the rate of superinfection.

scholarly journals Image-guided in situ detection of bacterial biofilms in a human prosthetic knee infection model: a feasibility study for clinical diagnosis of prosthetic joint infections

2020 ◽  
Author(s):  
Jorrit W. A. Schoenmakers ◽  
Marjolein Heuker ◽  
Marina López-Álvarez ◽  
Wouter B. Nagengast ◽  
Gooitzen M. van Dam ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Bacterial Species ◽  
Bacterial Biofilms ◽  
Infection Model ◽  
Knee Infection ◽  
Prosthetic Knee ◽  
Image Guided ◽  
Prosthetic Joints ◽  
Prosthetic Joint Infections ◽  
Prosthetic Knee Infection

Abstract Purpose Due to an increased human life expectancy, the need to replace arthritic or dysfunctional joints by prosthetics is higher than ever before. Prosthetic joints are unfortunately inherently susceptible to bacterial infection accompanied by biofilm formation. Accurate and rapid diagnosis is vital to increase therapeutic success. Yet, established diagnostic modalities cannot directly detect bacterial biofilms on prostheses. Therefore, the present study was aimed at investigating whether arthroscopic optical imaging can accurately detect bacterial biofilms on prosthetic joints. Methods Here, we applied a conjugate of the antibiotic vancomycin and the near-infrared fluorophore IRDye800CW, in short vanco-800CW, in combination with arthroscopic optical imaging to target and visualize biofilms on infected prostheses. Results We show in a human post-mortem prosthetic knee infection model that a staphylococcal biofilm is accurately detected in real time and distinguished from sterile sections in high resolution. In addition, we demonstrate that biofilms associated with the clinically most relevant bacterial species can be detected using vanco-800CW. Conclusion The presented image-guided arthroscopic approach provides direct visual diagnostic information and facilitates immediate appropriate treatment selection.

Outcomes of repeat two-stage exchange hip arthroplasty for prosthetic joint infection

2019 ◽  
Vol 101-B (6_Supple_B) ◽  
pp. 110-115 ◽  
Author(s):  
N. Khan ◽  
D. Parmar ◽  
M. S. Ibrahim ◽  
B. Kayani ◽  
F. S. Haddad
Keyword(s):  
Hip Arthroplasty ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Antimicrobial Treatment ◽  
Successful Outcome ◽  
Two Stage ◽  
Persistent Symptoms ◽  
Prosthetic Joint ◽  
Revision Tha

Aims The increasing infection burden after total hip arthroplasty (THA) has seen a rise in the use of two-stage exchange arthroplasty and the use of increasingly powerful antibiotics at the time of this procedure. As a result, there has been an increase in the number of failed two-stage revisions during the past decade. The aim of this study was to clarify the outcome of repeat two-stage revision THA following a failed two-stage exchange due to recurrent prosthetic joint infection (PJI). Patients and Methods We identified 42 patients who underwent a two-stage revision THA having already undergone at least one previous two stage procedure for infection, between 2000 and 2015. There were 23 women and 19 men. Their mean age was 69.3 years (48 to 81). The outcome was analyzed at a minimum follow-up of two years. Results A satisfactory control of infection and successful outcome was seen in 26 patients (57%). There therefore remained persistent symptoms that either required further surgery or chronic antibiotic suppression in 16 patients (38%). One-third of patients had died by the time of two years’ follow-up. Conclusion The rate of failure and complication rate of repeat two-stage exchange THA for PJI is high and new methods of treatment including host optimization, immunomodulation, longer periods between stages, and new and more powerful forms of antimicrobial treatment should be investigated. Cite this article: Bone Joint J 2019;101-B(6 Supple B):110–115.

scholarly journals Prosthetic Knee Septic Arthritis due toPseudomonas stutzeri

2000 ◽  
Vol 11 (6) ◽  
pp. 329-331 ◽  
Author(s):  
Jihad Bishara ◽  
Eyal Robenshtok ◽  
Zmira Samra ◽  
Silvio Pitlik
Keyword(s):  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Pseudomonas Stutzeri ◽  
Promyelocytic Leukemia ◽  
Artificial Joint ◽  
Coagulase Negative Staphylococci ◽  
Pertinent Literature ◽  
Prosthetic Knee ◽  
Prosthetic Joint ◽  
Artificial Joint Replacement

Prosthetic joint infection is usually caused byStaphylococcus aureus, coagulase-negative staphylococci and, less commonly, by Gram-negative bacilli and anaerobes. A case of prosthetic joint infection due toPseudomonas stutzeriin a 73-year-old female with acute promyelocytic leukemia is presented, and the pertinent literature is reviewed. Although the patient had prolonged neutropenia, the infection was successfully treated with antibiotics and without artificial joint replacement.

Success Rates for Initial Eradication of Peri-prosthetic Knee Infection Treated with a Two-stage Procedure

2014 ◽  
Vol 16 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Andrzej Kaminski ◽  
Mustafa Citak ◽  
Thomas Schildhauer ◽  
Tobias Fehmer
Keyword(s):  
Success Rates ◽  
Two Stage ◽  
Knee Infection ◽  
Prosthetic Knee ◽  
Prosthetic Knee Infection

Bilateral Prosthetic Knee Infection by Campylobacter fetus

2005 ◽  
Vol 20 (3) ◽  
pp. 401-405 ◽  
Author(s):  
John David ◽  
Rana M. Nasser ◽  
Jerry W. Goldberg ◽  
Kurt D. Reed ◽  
Mark D. Earll
Keyword(s):  
Knee Infection ◽  
Prosthetic Knee ◽  
Campylobacter Fetus ◽  
Prosthetic Knee Infection
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