scholarly journals Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Anna Papazoglou ◽  
Julien Soos ◽  
Andreas Lundt ◽  
Carola Wormuth ◽  
Varun Raj Ginde ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Primary Motor Cortex ◽  
Seizure Activity ◽  
Cortical Excitability ◽  
Memory Loss ◽  
Fast Fourier Transformation ◽  
Model Of Alzheimer’S Disease ◽  
Eeg Recordings ◽  
Gender Specific

Alzheimer’s disease (AD) is a multifactorial disorder leading to progressive memory loss and eventually death. In this study an APPswePS1dE9 AD mouse model has been analyzed using implantable video-EEG radiotelemetry to perform long-term EEG recordings from the primary motor cortex M1 and the hippocampal CA1 region in both genders. Besides motor activity, EEG recordings were analyzed for electroencephalographic seizure activity and frequency characteristics using a Fast Fourier Transformation (FFT) based approach. Automatic seizure detection revealed severe electroencephalographic seizure activity in both M1 and CA1 deflection in APPswePS1dE9 mice with gender-specific characteristics. Frequency analysis of both surface and deep EEG recordings elicited complex age, gender, and activity dependent alterations in the theta and gamma range. Females displayed an antithetic decrease in theta (θ) and increase in gamma (γ) power at 18-19 weeks of age whereas related changes in males occurred earlier at 14 weeks of age. In females, theta (θ) and gamma (γ) power alterations predominated in the inactive state suggesting a reduction in atropine-sensitive type II theta in APPswePS1dE9 animals. Gender-specific central dysrhythmia and network alterations in APPswePS1dE9 point to a functional role in behavioral and cognitive deficits and might serve as early biomarkers for AD in the future.

scholarly journals Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer’s Disease

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1802
Author(s):  
Enrique Armijo ◽  
George Edwards ◽  
Andrea Flores ◽  
Jorge Vera ◽  
Mohammad Shahnawaz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Symptoms ◽  
Memory Loss ◽  
Amyloid Β ◽  
Cerebral Atrophy ◽  
Brain Inflammation ◽  
Neural Precursors ◽  
Model Of Alzheimer’S Disease ◽  
Induced Pluripotent

Alzheimer’s disease (AD) is the most common type of dementia in the elderly population. The disease is characterized by progressive memory loss, cerebral atrophy, extensive neuronal loss, synaptic alterations, brain inflammation, extracellular accumulation of amyloid-β (Aβ) plaques, and intracellular accumulation of hyper-phosphorylated tau (p-tau) protein. Many recent clinical trials have failed to show therapeutic benefit, likely because at the time in which patients exhibit clinical symptoms the brain is irreversibly damaged. In recent years, induced pluripotent stem cells (iPSCs) have been suggested as a promising cell therapy to recover brain functionality in neurodegenerative diseases such as AD. To evaluate the potential benefits of iPSCs on AD progression, we stereotaxically injected mouse iPSC-derived neural precursors (iPSC-NPCs) into the hippocampus of aged triple transgenic (3xTg-AD) mice harboring extensive pathological abnormalities typical of AD. Interestingly, iPSC-NPCs transplanted mice showed improved memory, synaptic plasticity, and reduced AD brain pathology, including a reduction of amyloid and tangles deposits. Our findings suggest that iPSC-NPCs might be a useful therapy that could produce benefit at the advanced clinical and pathological stages of AD.

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Nature ◽  
2000 ◽  
Vol 408 (6815) ◽  
pp. 982-985 ◽  
Author(s):  
Dave Morgan ◽  
David M. Diamond ◽  
Paul E. Gottschall ◽  
Kenneth E. Ugen ◽  
Chad Dickey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Memory Loss ◽  
Aβ Peptide ◽  
Peptide Vaccination ◽  
Model Of Alzheimer’S Disease

scholarly journals Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-17 ◽  
Author(s):  
Magdalena Elisabeth Siwek ◽  
Ralf Müller ◽  
Christina Henseler ◽  
Astrid Trog ◽  
Andreas Lundt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
Cortical Excitability ◽  
Theta Oscillations ◽  
Dark Phase ◽  
Model Of Alzheimer’S Disease ◽  
Cortical Hyperexcitability ◽  
5Xfad Mice ◽  
Hippocampal Theta

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by impairment of memory function. The 5XFAD mouse model was analyzed and compared with wild-type (WT) controls for aberrant cortical excitability and hippocampal theta oscillations by using simultaneous video-electroencephalogram (EEG) monitoring. Seizure staging revealed that 5XFAD mice exhibited cortical hyperexcitability whereas controls did not. In addition, 5XFAD mice displayed a significant increase in hippocampal theta activity from the light to dark phase during nonmotor activity. We also observed a reduction in mean theta frequency in 5XFAD mice compared to controls that was again most prominent during nonmotor activity. Transcriptome analysis of hippocampal probes and subsequent qPCR validation revealed an upregulation of Plcd4 that might be indicative of enhanced muscarinic signalling. Our results suggest that 5XFAD mice exhibit altered cortical excitability, hippocampal dysrhythmicity, and potential changes in muscarinic signaling.

scholarly journals Erratum: correction: Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Nature ◽  
2001 ◽  
Vol 412 (6847) ◽  
pp. 660-660 ◽  
Author(s):  
Dave Morgan ◽  
David M. Diamond ◽  
Paul E. Gottschall ◽  
Kenneth E. Ugen ◽  
Chad Dickey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Memory Loss ◽  
Aβ Peptide ◽  
Peptide Vaccination ◽  
Model Of Alzheimer’S Disease

scholarly journals Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

2002 ◽  
Vol 22 (15) ◽  
pp. 6331-6335 ◽  
Author(s):  
Linda A. Kotilinek ◽  
Brian Bacskai ◽  
Marcus Westerman ◽  
Takeshi Kawarabayashi ◽  
Linda Younkin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Loss ◽  
Transgenic Model ◽  
Model Of Alzheimer’S Disease
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