scholarly journals Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
B. V. Nagpure ◽  
Jin-Song Bian
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Cardiovascular System ◽  
Chemical Interaction ◽  
New Family ◽  
Pathophysiological Role ◽  
Effective Role ◽  
No Signaling ◽  
The Individual ◽  
Heart Contractility

Historically acknowledged as toxic gases, hydrogen sulfide (H2S) and nitric oxide (NO) are now recognized as the predominant members of a new family of signaling molecules, “gasotransmitters” in mammals. While H2S is biosynthesized by three constitutively expressed enzymes (CBS, CSE, and 3-MST) from L-cysteine and homocysteine, NO is generated endogenously from L-arginine by the action of various isoforms of NOS. Both gases have been transpired as the key and independent regulators of many physiological functions in mammalian cardiovascular, nervous, gastrointestinal, respiratory, and immune systems. The analogy between these two gasotransmitters is evident not only from their paracrine mode of signaling, but also from the identical and/or shared signaling transduction pathways. With the plethora of research in the pathophysiological role of gasotransmitters in various systems, the existence of interplay between these gases is being widely accepted. Chemical interaction between NO and H2S may generate nitroxyl (HNO), which plays a specific effective role within the cardiovascular system. In this review article, we have attempted to provide current understanding of the individual and interactive roles of H2S and NO signaling in mammalian cardiovascular system, focusing particularly on heart contractility, cardioprotection, vascular tone, angiogenesis, and oxidative stress.

scholarly journals An Update on Hydrogen Sulfide and Nitric Oxide Interactions in the Cardiovascular System

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Dan Wu ◽  
Qingxun Hu ◽  
Deqiu Zhu
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Cardiovascular System ◽  
Posttranslational Modification ◽  
Chemical Interaction ◽  
Protein Activity ◽  
Wide Range ◽  
Gaseous Transmitters ◽  
Heart Injury ◽  
Regulatory Functions

Hydrogen sulfide (H2S) and nitric oxide (NO) are now recognized as important regulators in the cardiovascular system, although they were historically considered as toxic gases. As gaseous transmitters, H2S and NO share a wide range of physical properties and physiological functions: they penetrate into the membrane freely; they are endogenously produced by special enzymes, they stimulate endothelial cell angiogenesis, they regulate vascular tone, they protect against heart injury, and they regulate target protein activity via posttranslational modification. Growing evidence has determined that these two gases are not independent regulators but have substantial overlapping pathophysiological functions and signaling transduction pathways. H2S and NO not only affect each other’s biosynthesis but also produce novel species through chemical interaction. They play a regulatory role in the cardiovascular system involving similar signaling mechanisms or molecular targets. However, the natural precise mechanism of the interactions between H2S and NO remains unclear. In this review, we discuss the current understanding of individual and interactive regulatory functions of H2S and NO in biosynthesis, angiogenesis, vascular one, cardioprotection, and posttranslational modification, indicating the importance of their cross-talk in the cardiovascular system.

scholarly journals Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications

2017 ◽  
Vol 312 (1) ◽  
pp. C3-C15 ◽  
Author(s):  
Csaba Szabo
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Soluble Guanylate Cyclase ◽  
Specific Activity ◽  
Cardiovascular Effects ◽  
Biologically Active ◽  
Reduced Form ◽  
No Production ◽  
Nitric Oxide Signaling ◽  
No Signaling

Nitric oxide (NO) vascular signaling has long been considered an independent, self-sufficient pathway. However, recent data indicate that the novel gaseous mediator, hydrogen sulfide (H2S), serves as an essential enhancer of vascular NO signaling. The current article overviews the multiple levels at which this enhancement takes place. The first level of interaction relates to the formation of biologically active hybrid S/N species and the H2S-induced stimulation of NO release from its various stable “pools” (e.g., nitrite). The next interactions occur on the level of endothelial calcium mobilization and PI3K/Akt signaling, increasing the specific activity of endothelial NO synthase (eNOS). The next level of interaction occurs on eNOS itself; H2S directly interacts with the enzyme: sulfhydration of critical cysteines stabilizes it in its physiological, dimeric state, thereby optimizing eNOS-derived NO production and minimizing superoxide formation. Yet another level of interaction, further downstream, occurs at the level of soluble guanylate cyclase (sGC): H2S stabilizes sGC in its NO-responsive, physiological, reduced form. Further downstream, H2S inhibits the vascular cGMP phosphodiesterase (PDE5), thereby prolonging the biological half-life of cGMP. Finally, H2S-derived polysulfides directly activate cGMP-dependent protein kinase (PKG). Taken together, H2S emerges an essential endogenous enhancer of vascular NO signaling, contributing to vasorelaxation and angiogenesis. The functional importance of the H2S/NO cooperative interactions is highlighted by the fact that H2S loses many of its beneficial cardiovascular effects when eNOS is inactive.

Old and New Gasotransmitters in the Cardiovascular System: Focus on the Role of Nitric Oxide and Hydrogen Sulfide in Endothelial Cells and Cardiomyocytes

2011 ◽  
Vol 12 (9) ◽  
pp. 1406-1415 ◽  
Author(s):  
Daniele Mancardi ◽  
Alessandra Florio Pla ◽  
Francesco Moccia ◽  
Franco Tanzi ◽  
Luca Munaron
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Hydrogen Sulfide ◽  
Cardiovascular System ◽  
System Focus

scholarly journals Exogenous hydrogen sulfide alleviates surgery-induced neuroinflammatory cognitive impairment in adult mice by inhibiting NO signaling

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Lijun Yin ◽  
Shunli Gao ◽  
Changkun Li
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Cognitive Dysfunction ◽  
Calcium Binding ◽  
Interleukin 1 ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Tunel Staining ◽  
Necrosis Factor Alpha ◽  
Western Blots ◽  
No Signaling

Abstract Background To investigate the effect and mechanisms of exogenous hydrogen sulfide in surgery-induced neuroinflammatory cognitive dysfunction. Methods C57BL/6 J male mice (n = 140) were used and randomly divided into seven groups: the sham group, surgery group, GYY4137 group, L-NAME group, surgery+GYY4137 group, surgery +L-NAME group, and surgery+GYY4137 + L-NAME group. After the interventions, open field tests (OFT) and the Morris water maze (MWM) test were conducted to evaluate learning and memory abilities in the mice. ELISAs, nitrate reductase assays, and Western blots (WB) were conducted to evaluate interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), nitric oxide (NO), inducible nitric oxide synthase (iNOS), malondialdehyde (MDA), and antioxidant enzyme superoxide dismutase (SOD) levels. Furthermore, the expression level of microglial marker ionized calcium binding adaptor molecule 1 (IBA) in the hippocampal CA1 and CA3 areas was detected by an immunohistochemical (IHC) assay and apoptotic cells were observed using terminal deoxynucleotidyl transferase dUTP end-labeling (TUNEL) staining kits. Results We found that surgery induced neuroinflammatory cognitive dysfunction, oxidative stress, microglial activation, and cell apoptosis in the hippocampus. Moreover, following surgery, NO and iNOS levels were elevated in the hippocampus. Notably, all the effects caused by surgery were reversed by the H2S donor GYY4137 or the iNOS inhibitor N(gamma)-nitro-L-arginine methyl ester (L-NAME). However, the combined application of GYY4137 and L-NAME was not superior to treatment with either agent alone and the effect of GYY4137 was similar to that of L-NAME. Conclusion The long-acting hydrogen sulfide donor GYY4137 had an ability to reversed the cognitive deficits and inflammation caused by carotid artery exposure surgery. This implies that NO signaling pathways might participate in this process. These results indicate that exogenous H2S may be a promising therapy for POCD.

scholarly journals The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 748
Author(s):  
Nicole Denoix ◽  
Oscar McCook ◽  
Sarah Ecker ◽  
Rui Wang ◽  
Christiane Waller ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Cardiovascular System ◽  
Signaling Pathways ◽  
Indirect Evidence ◽  
Psychological Trauma ◽  
Cardiovascular Regulation ◽  
Physical Trauma ◽  
Fluid Regulation ◽  
Available Information

The purpose of this review is to explore the parallel roles and interaction of hydrogen sulfide (H2S) and oxytocin (OT) in cardiovascular regulation and fluid homeostasis. Their interaction has been recently reported to be relevant during physical and psychological trauma. However, literature reports on H2S in physical trauma and OT in psychological trauma are abundant, whereas available information regarding H2S in psychological trauma and OT in physical trauma is much more limited. This review summarizes recent direct and indirect evidence of the interaction of the two systems and their convergence in downstream nitric oxide-dependent signaling pathways during various types of trauma, in an effort to better understand biological correlates of psychosomatic interdependencies.

scholarly journals An Overview of NO Signaling Pathways in Aging

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4533
Author(s):  
Ali Mohammad Pourbagher-Shahri ◽  
Tahereh Farkhondeh ◽  
Marjan Talebi ◽  
Dalia M. Kopustinskiene ◽  
Saeed Samarghandian ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular System ◽  
Signaling Pathways ◽  
Cellular Aging ◽  
No Production ◽  
Cellular Mechanisms ◽  
Muscle Disorders ◽  
Reproduction System ◽  
No Signaling ◽  
Endothelial Nitric Oxide

Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. The aging-related decline in NO levels and bioavailability is also discussed in this review. The decreased NO production by endothelial nitric oxide synthase (eNOS) was revealed in the aged cardiovascular system. In the CNS, the decline of the neuronal (n)NOS production of NO was related to the impairment of memory, sleep, and cognition. NO played an important role in the aging of oocytes and aged-induced erectile dysfunction. Aging downregulated NO signaling pathways in endothelial cells resulting in skin, kidney, thyroid, and muscle disorders. Putative therapeutic agents (natural/synthetic) affecting NO signaling mechanisms in the aging process are discussed in the present study. In summary, all of the studies reviewed demonstrate that NO plays a crucial role in the cellular aging processes.

Ameliorative effects of hydrogen sulfide (NaHS) on chronic kidney disease-induced brain dysfunction in rats: implication on role of nitric oxide (NO) signaling

2018 ◽  
Vol 33 (6) ◽  
pp. 1945-1954 ◽  
Author(s):  
Hassan Askari ◽  
Mohammad Foad Abazari ◽  
Pegah Ghoraeian ◽  
Sepehr Torabinejad ◽  
Maryam Nouri Aleagha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Kidney Disease ◽  
Hydrogen Sulfide ◽  
Kidney Disease ◽  
Brain Dysfunction ◽  
No Signaling

Age-Dependence in Alterations in Nitric Oxide Synthesis in Cardiovascular System during Adaptation to Physical Training

2010 ◽  
Vol 1 (4) ◽  
pp. 345-356 ◽  
Author(s):  
O. V. Bazilyuk ◽  
Anatolii V. Kotsuruba ◽  
Lyubov. G. Stepanenko ◽  
Sergey A. Talanov ◽  
Yu. P. Korchak ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular System ◽  
Physical Training ◽  
Nitric Oxide Synthesis ◽  
Age Dependence
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