scholarly journals Imaging Findings of Plasmacytoma of Both Breasts as a Preceding Manifestation of Multiple Myeloma

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Young Mi Park
Keyword(s):  
Multiple Myeloma ◽  
Unusual Case ◽  
Extramedullary Plasmacytoma ◽  
Emission Tomography ◽  
Rare Tumor ◽  
Imaging Findings ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Positron Emission ◽  
One Year

Breast plasmacytoma is an extremely rare tumor. It can occur as a primary isolated tumor or as an extramedullary manifestation in multiple myeloma. This report describes the unusual case of a primary extramedullary plasmacytoma that progressed to multiple myeloma within 15 months in a 35-year-old woman. The patient had been initially diagnosed with a primary extramedullary plasmacytoma of the epidural soft tissue at the cervical 6-thoracic 1 spine level and the stomach. The patient had received chemotherapy and the disease had been in remission. One year later, the disease recurred, affecting both breasts, right clavicle, and orbit. Three months later, the disease had progressed to multiple myeloma. I report this case, focusing on the findings of mammography, ultrasonography, magnetic resonance imaging, and positron emission tomography of bilateral breast plasmacytoma, and provide a review of the literature.

PET Imaging of Recurrent Medullary Thyroid Cancer

1996 ◽  
Vol 35 (03) ◽  
pp. 102-104 ◽  
Author(s):  
E. U. Nitzsche ◽  
J. J. Laubenberger ◽  
Almut Einert ◽  
E. Moser ◽  
G. H. Simon
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Medullary Thyroid Cancer ◽  
Alternative Therapy ◽  
Medullary Carcinoma ◽  
Emission Tomography ◽  
Rare Tumor ◽  
Resonance Imaging ◽  
Medullary Thyroid ◽  
Positron Emission

SummaryMedullary carcinoma of the thyroid gland is a rare tumor. Its prognosis is mainly linked to surgery, because there is no valid alternative therapy to improve patients outcome. In this report, we discuss the recurrence of such a tumor in a 64-year-old female, focusing on magnetic resonance imaging and positron emission tomography evaluation of this tumor.

scholarly journals Prospective Evaluation of Magnetic Resonance Imaging and [18F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study

2017 ◽  
Vol 35 (25) ◽  
pp. 2911-2918 ◽  
Author(s):  
Philippe Moreau ◽  
Michel Attal ◽  
Denis Caillot ◽  
Margaret Macro ◽  
Lionel Karlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Multiple Myeloma ◽  
Emission Tomography ◽  
Bone Lesions ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Pet Ct ◽  
Ct And Mri

Purpose Magnetic resonance imaging (MRI) and positron emission tomography–computed tomography (PET-CT) are important imaging techniques in multiple myeloma (MM). We conducted a prospective trial in patients with MM aimed at comparing MRI and PET-CT with respect to the detection of bone lesions at diagnosis and the prognostic value of the techniques. Patients and Methods One hundred thirty-four patients received a combination of lenalidomide, bortezomib, and dexamethasone (RVD) with or without autologous stem-cell transplantation, followed by lenalidomide maintenance. PET-CT and MRI were performed at diagnosis, after three cycles of RVD, and before maintenance therapy. The primary end point was the detection of bone lesions at diagnosis by MRI versus PET-CT. Secondary end points included the prognostic impact of MRI and PET-CT regarding progression-free (PFS) and overall survival (OS). Results At diagnosis, MRI results were positive in 127 of 134 patients (95%), and PET-CT results were positive in 122 of 134 patients (91%; P = .33). Normalization of MRI after three cycles of RVD and before maintenance was not predictive of PFS or OS. PET-CT became normal after three cycles of RVD in 32% of the patients with a positive evaluation at baseline, and PFS was improved in this group (30-month PFS, 78.7% v 56.8%, respectively). PET-CT normalization before maintenance was described in 62% of the patients who were positive at baseline. This was associated with better PFS and OS. Extramedullary disease at diagnosis was an independent prognostic factor for PFS and OS, whereas PET-CT normalization before maintenance was an independent prognostic factor for PFS. Conclusion There is no difference in the detection of bone lesions at diagnosis when comparing PET-CT and MRI. PET-CT is a powerful tool to evaluate the prognosis of de novo myeloma.

scholarly journals Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
A. Romano ◽  
M. S. Marescalco ◽  
Chiara Liardo ◽  
L. Villari ◽  
C. Vetro ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Hematological Malignancy ◽  
Case Reports ◽  
Oral Lesion ◽  
Extramedullary Plasmacytoma ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Multistage Process ◽  
Solitary Bone Plasmacytoma ◽  
Magnetic Resonance Imaging Mri

Extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP) represent a disease continuum through a multistage process of cell differentiation, survival, proliferation, and dissemination, strictly related to multiple myeloma (MM), the second most common hematological malignancy. Herein, we report two cases of recurrent oral plasmacytoma progressed to MM, in which the first clinical sign of a more widespread disease was limited to the mouth. Based on our experience, we recommend a strict workup for the differential diagnosis between EMP, SBP, and MM for patients with oral plasmacytoma, including radiological exam of the skeleton, magnetic resonance imaging (MRI) of the bone, and positive emission tomography (FDG-PET). MRI and possibly PET can all be used to more sensitively detect EM plasmacytoma sites.

Triple manifestation of extramedullary plasmacytoma in the upper airway: an unusual clinical entity

2011 ◽  
Vol 125 (9) ◽  
pp. 970-972 ◽  
Author(s):  
I Morariu ◽  
P Burns ◽  
P Roche ◽  
S Hone
Keyword(s):  
Multiple Myeloma ◽  
Rare Case ◽  
Unusual Case ◽  
English Literature ◽  
Upper Airway ◽  
Extramedullary Plasmacytoma ◽  
Review Of The Literature ◽  
Close Cooperation ◽  
Disease Free ◽  
Extramedullary Plasmacytomas

AbstractObjective:We report an extremely rare case of extramedullary plasmacytoma.Method:Case report and review of the English-literature concerning extramedullary plasmacytoma and multiple myeloma.Result:We present an unusual case of multiple extramedullary plasmacytomas, which, over a protracted course of 30 years, presented on different occasions at three separate sites in the head and neck. The patient was managed surgically on all occasions, and was disease-free at the time of writing.Conclusion:Following review of the literature, we believe this to be the only case with this extremely unusual presentation. This case is noteworthy, not only because of the rarity of extramedullary plasmacytoma, but also because it highlights a number of important clinical issues. The diagnosis and management of extramedullary plasmacytoma require close cooperation between multiple disciplines.

scholarly journals IMAGING TECHNIQUES USED IN MULTIPLE MYELOMA

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Abdul Hameed ◽  
Paul Foran ◽  
Peter O'Gorman ◽  
Jonathan Ryan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Multiple Myeloma ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Skeletal Survey ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Positron Emission

Multiple myeloma (MM) is a plasma cell disorder, characterised by bone marrow infiltration with clonal plasma cells; production of monoclonal immunoglobulin (paraprotein); end-organ damage; lytic lesions in the bones; renal impairment; hypercalcaemia and anaemia. Skeleton evaluation in MM is necessary not only for staging purposes but also to detect serious complications such as fractures. Skeletal survey is an established rst-line investigation for this purpose. However, in recent years, new imaging techniques such as whole-body magnetic resonance imaging and 2- uoro-2-deoxy-D-glucose positron emission tomography computed tomography have been used widely. In this article, we review different imaging techniques used in MM and their impact on patient management. Key words: Imaging techniques, magnetic resonance imaging, multiple myeloma, osteolytic lesions, positron emission tomography/computed tomography, skeletal survey 

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