scholarly journals The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Quanhui Tan ◽  
Jianjun Hu ◽  
Xiaolan Yu ◽  
Wen Guan ◽  
Huili Lu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Regeneration ◽  
Receptor Antagonist ◽  
Kupffer Cells ◽  
Liver Diseases ◽  
Close Association ◽  
Interleukin 1 ◽  
Family Members ◽  
Systemic Review

Interleukin-1 (IL-1) family and Kupffer cells are linked with liver regeneration, but their precise roles remain unclear. IL-1 family members are pleiotropic factors with a range of biological roles in liver diseases, inducing hepatitis, cirrhosis, and hepatocellular carcinoma, as well as liver regeneration. Kupffer cells are the main source of IL-1 and IL-1 receptor antagonist (IL-1Ra), the key members of IL-1 family. This systemic review highlights a close association of IL-1 family members and Kupffer cells with liver regeneration, although their specific roles are inconclusive. Moreover, IL-1 members are proposed to induce effects on liver regeneration through Kupffer cells.

Bivalent Role of LncRNA-LRAHC during Liver Regeneration and Hepatocellular Carcinoma

2018 ◽  
Author(s):  
Da-wei Li ◽  
Chen-xi Zhao ◽  
Le-chen Li ◽  
Jun-jie Zhang ◽  
Wan-dai Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Regeneration

scholarly journals The Role of Endoglin in Hepatocellular Carcinoma

2021 ◽  
Vol 22 (6) ◽  
pp. 3208
Author(s):  
Kuo-Shyang Jeng ◽  
I-Shyan Sheen ◽  
Shu-Sheng Lin ◽  
Chuen-Miin Leu ◽  
Chiung-Fang Chang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Diseases ◽  
Transforming Growth Factor ◽  
Antiangiogenic Therapy ◽  
Transforming Growth Factor Β ◽  
Postoperative Recurrence ◽  
Transmembrane Glycoprotein ◽  
Early Progression

Endoglin (CD105) is a type-1 integral transmembrane glycoprotein and coreceptor for transforming growth factor-β (TGF-β) ligands. The endoglin/TGF-β signaling pathway regulates hemostasis, cell proliferation/migration, extracellular matrix (ECM) synthesis and angiogenesis. Angiogenesis contributes to early progression, invasion, postoperative recurrence, and metastasis in hepatocellular carcinoma (HCC), one of the most widespread malignancies globally. Endoglin is overexpressed in newly formed HCC microvessels. It increases microvessel density in cirrhotic and regenerative HCC nodules. In addition, circulating endoglin is present in HCC patients, suggesting potential for use as a diagnostic or prognostic factor. HCC angiogenesis is dynamic and endoglin expression varies by stage. TRC105 (carotuximab) is an antibody against endoglin, and three of its clinical trials were related to liver diseases. A partial response was achieved when combining TRC105 with sorafenib. Although antiangiogenic therapy still carries some risks, combination therapy with endoglin inhibitors or other targeted therapies holds promise.

scholarly journals Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice

2017 ◽  
Vol 12 ◽  
pp. 62-65
Author(s):  
Yasuharu Abe ◽  
Aya Nambu ◽  
Sachiko Yamaguchi ◽  
Ayako Takamori ◽  
Hajime Suto ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Interleukin 25 ◽  
Deficient Mice

scholarly journals Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease

2018 ◽  
Vol 5 (1) ◽  
pp. 27-31
Author(s):  
Gul Dursun ◽  
Ayse Feyda Nursal ◽  
Helin Deniz Demir ◽  
Nevin Karakus ◽  
Osman Demir ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Interleukin 1 ◽  
Behcet's Disease ◽  
Interleukin 1 Receptor Antagonist

scholarly journals Role of Interleukin-1 Family Members and Signaling Pathways in KSHV Pathogenesis

2020 ◽  
Vol 10 ◽  
Author(s):  
Lindsey Barrett ◽  
Jungang Chen ◽  
Lu Dai ◽  
Karlie Plaisance-Bonstaff ◽  
Luis Del Valle ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Interleukin 1 ◽  
Family Members

scholarly journals Data on Adiponectin from 2010 to 2020: Therapeutic Target and Prognostic Factor for Liver Diseases?

2020 ◽  
Vol 21 (15) ◽  
pp. 5242 ◽  
Author(s):  
Misaq Heydari ◽  
María Eugenia Cornide-Petronio ◽  
Mónica B. Jiménez-Castro ◽  
Carmen Peralta
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Disease ◽  
Therapeutic Target ◽  
Liver Diseases ◽  
Therapeutic Strategies ◽  
Potential Therapeutic Target ◽  
Surgical Interventions ◽  
Scientific Controversies

The review describes the role of adiponectin in liver diseases in the presence and absence of surgery reported in the literature in the last ten years. The most updated therapeutic strategies based on the regulation of adiponectin including pharmacological and surgical interventions and adiponectin knockout rodents, as well as some of the scientific controversies in this field, are described. Whether adiponectin could be a potential therapeutic target for the treatment of liver diseases and patients submitted to hepatic resection or liver transplantation are discussed. Furthermore, preclinical and clinical data on the mechanism of action of adiponectin in different liver diseases (nonalcoholic fatty disease, alcoholic liver disease, nonalcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma) in the absence or presence of surgery are evaluated in order to establish potential targets that might be useful for the treatment of liver disease as well as in the practice of liver surgery associated with the hepatic resections of tumors and liver transplantation.

Sign in / Sign up

Export Citation Format

Share Document