scholarly journals Body Composition in Adult Patients with Thalassemia Major

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Marianna Vlychou ◽  
Evangelos Alexiou ◽  
Paschalis Thriskos ◽  
Ioannis Fezoulidis ◽  
Katerina Vassiou
Keyword(s):  
Body Composition ◽  
Adult Male ◽  
Lean Mass ◽  
Thalassemia Major ◽  
Dual Energy ◽  
Adult Patients ◽  
Whole Body ◽  
Male And Female ◽  
X Ray ◽  
Male Patients

Objective. To assess body composition in adult male and female patients with thalassemia major by dual-energy X-ray absorptiometry (DXA) and to compare the findings with a group of healthy age-matched controls. Methods. Our study group included sixty-two patients (27 males, mean age 36 years, and 35 females, mean age 36.4 years) and fifteen age-matched healthy controls. All patients had an established diagnosis of thalassemia major and followed a regular blood transfusion scheme since childhood and chelation treatment. Fat, lean, and bone mineral density (BMD) were assessed with dual-energy X-ray absorptiometry. Ferritin levels and body mass index of all patients and controls were also recorded. Student t-test and Wilcoxon test were performed and statistical significance was set at p<0.05. Results. BMD and whole body lean mass are lower in both male and female adult patients compared with controls (p<0.01 in both groups), whereas whole body fat mass was found to have no statistically significant difference compared to controls. Regional trunk fat around the abdomen was found to be lower in male patients compared to controls (p=0.02). Conclusion. Severe bone loss and diminished lean mass are expected in adult male and female patients with thalassemia major. Fat changes seem to affect mainly male patients.

Body Composition, Dietary Intake, and Iron Status of Female Collegiate Swimmers and Divers

2006 ◽  
Vol 16 (3) ◽  
pp. 281-295 ◽  
Author(s):  
Heidi L. Petersen ◽  
C. Ted Peterson ◽  
Manju B. Reddy ◽  
Kathy B. Hanson ◽  
James H. Swain ◽  
...  
Keyword(s):  
Body Composition ◽  
Dietary Intake ◽  
Body Fat ◽  
Lean Mass ◽  
Iron Status ◽  
Dietary Quality ◽  
Whole Body ◽  
Vitamin B ◽  
Percentage Body Fat ◽  
X Ray

This study determined the effect of training on body composition, dietary intake, and iron status of eumenorrheic female collegiate swimmers (n = 18) and divers (n = 6) preseason and after 16 wk of training. Athletes trained on dryland (resistance, strength, fexibility) 3 d/wk, 1.5 h/d and in-water 6 d/wk, nine, 2-h sessions per week (6400 to 10,000 kJ/d). Body-mass index (kg/m2; P = 0.05), waist and hip circumferences (P ≤ 0.0001), whole body fat mass (P = 0.0002), and percentage body fat (P ≤ 0.0001) decreased, whereas lean mass increased (P = 0.028). Using dual-energy X-ray absorptiometry, we found no change in regional lean mass, but fat decreased at the waist (P = 0.0002), hip (P = 0.0002), and thigh (P = 0.002). Energy intake (10,061 ± 3617 kJ/d) did not change, but dietary quality improved with training, as refected by increased intakes of fber (P = 0.036), iron (P = 0.015), vitamin C (P = 0.029), vitamin B-6 (P = 0.032), and fruit (P = 0.003). Iron status improved as refected by slight increases in hemoglobin (P = 0.046) and hematocrit (P = 0.014) and decreases in serum transferrin receptor (P ≤ 0.0001). Studies are needed to further evaluate body composition and iron status in relation to dietary intake in female swimmers.

MO047COMPARISON BETWEEN DUAL-ENERGY X-RAY ABSORPTIOMETRY AND BIOELECTRICAL IMPEDANCE FOR BODY COMPOSITION MEASUREMENTS IN ADULTS WITH CHRONIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Natália Tomborelli Bellafronte ◽  
Lorena Vega-Piris ◽  
Paula Garcia Chiarello ◽  
Guillermina Barril Cuadrado
Keyword(s):  
Chronic Kidney Disease ◽  
Body Composition ◽  
Peritoneal Dialysis ◽  
Renal Transplantation ◽  
Bioelectrical Impedance ◽  
Total Sample ◽  
Dual Energy ◽  
Error Tolerance ◽  
Whole Body ◽  
X Ray

Abstract Background and Aims Chronic kidney disease (CKD) patients frequently have an altered body composition driven by metabolic disorders from the uremic syndrome that usually leads to increased protein catabolism, with obesity and muscle impairment being common conditions associated with worse clinical prognosis and high mortality rates. Therefore, with increased mortality and disability rates of CKD patients in the last quarter of a century and the association of a poor body composition with low survival, routine and longitudinal assessment of body composition could improve clinical outcomes. Due to limited availability of reference methods to assess nutritional status, alternative methods are used. In view of the above, our goal was to evaluate the agreement between multifrequency bioelectrical impedance spectroscopy (BIS) and Dual-energy X-ray Absorptiometry (DXA) for assessment of body composition in CKD. Method Cross-sectional and prospective analyses by DXA (Hologic, GE®) and BIS (BCM, Fresenius Medical Care®) in whole-body (BISWB) and segmental (BISSEG) protocols were performed in CKD non-dialysis-dependent, hemodialysis and peritoneal dialysis (for at least 3 months), and renal transplantation (for at least 6 months) adult (18 ≤ age ≤ 60 years old) patients. Measurements were performed consecutively by the same professional after an 8-hour fast, drainage of the peritoneal dialysate and just after the midweek hemodialysis session. Intraclass correlation coefficient (ICC) and Bland-Altman plots were evaluated for agreement analysis in group and individual levels, respectively; linear regression analysis was performed for bias assessment and development of new equations; ROC curve was constructed for diagnosis of inadequate error tolerance (DXA - BIS &gt; ± 2kg). Results A total of 266 patients were included: 137 men (M) and 129 women (W); 81 were in non-dialysis-dependent treatment, 83 in hemodialysis, 24 in peritoneal dialysis, and 80 had renal transplantation. Total sample had a mean age of 47 ± 10 years old. CKD was secondary to systemic arterial hypertension in 29% of the total sample, to glomerulonephritis in 25%, to diabetes mellitus in 10%, to polycystic kidney in 7%, to glomerulosclerosis and systemic syndromes in 8%, and to other causes and unknown etiology in 20%. Fourteen patients (4 M and 10 W) were in automated and 9 (4 M and 5 W) in continuous ambulatory PD. KTx was by living donor in 18 (14 M and 4 W) and by deceased donor in 63 (34 M and 29 W) patients. The agreement with DXA was greater for BISWB than BISSEG; for fat mass (FM) (ICC in M = 0.89; ICC in W = 0.93) than for fat free mass (FFM) (ICC in M = 0.57; ICC in W = 0.52). Bland-Altman plots showed high limits of agreement (FFM: from -9.51 to 15.64kg; FM: from -7.71 to 7.32kg) with greater bias for FFM as muscular mass increases and for FM in extremes of body fat. The agreement was lower when using the prospective data (body change analysis) (ICC for FFM in M = 0.20; ICC for FFM in W = 0.49; ICC for FM in M = 0.46; ICC for FM in W = 0.58). The factors that interfered in bias between methods were extra to intracellular water ratio (ECW/ICW), body mass index, fat mass index, waist circumference, resistance and reactance (adjusted r2 for FFM = 0.90; r2 for FM = 0.87). FFM had poorer agreement in the last tertile of ECW/ICW sample (ICC in M = 0.69, 0.68 and 0.51; ICC in W = 0.71, 0.74 and 0.38 for first, second and third tertiles, respectively). An ECW/ICW cut-off point of &gt; 0.725 for inadequate error tolerance was determined. New prediction equations for FFM (r2 = 0.91) and FM (r2 = 0.89) presented adequate error tolerance in 55% and 63% in the validation sample compared to 30% and 39% of the original equation, respectively. Conclusion For body composition evaluation in CKD, BIS applied using the whole-body protocol, in normal hydration CKD patients is as reliable as DXA; BIS must be used with caution among overhydrated patients with ECW/ICW &gt; 0.725. The newly developed equations are indicated for greater precision.

DUAL-ENERGY X-RAY ABSORPTIOMETRY FOR REGIONAL AND WHOLE-BODY COMPOSITION: THE NEW GOLD STANDARD? 481

1996 ◽  
Vol 28 (Supplement) ◽  
pp. 81
Author(s):  
A D Martin ◽  
S B Heymsfield ◽  
W M Kohrt ◽  
T G Lohman
Keyword(s):  
Body Composition ◽  
Gold Standard ◽  
Dual Energy ◽  
Whole Body ◽  
X Ray

Assessment of whole-body composition with dual-energy x-ray absorptiometry.

Radiology ◽  
1992 ◽  
Vol 185 (2) ◽  
pp. 593-598 ◽  
Author(s):  
D O Slosman ◽  
J P Casez ◽  
C Pichard ◽  
T Rochat ◽  
F Fery ◽  
...  
Keyword(s):  
Body Composition ◽  
Dual Energy ◽  
Whole Body ◽  
X Ray

Reproducibility of Pediatric Whole Body Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry Using the GE Lunar Prodigy

2005 ◽  
Vol 8 (3) ◽  
pp. 298-304 ◽  
Author(s):  
Lauren Margulies ◽  
Mary Horlick ◽  
John C. Thornton ◽  
Jack Wang ◽  
Elli Ioannidou ◽  
...  
Keyword(s):  
Body Composition ◽  
Dual Energy ◽  
Whole Body ◽  
X Ray ◽  
Body Bone

scholarly journals Investigating the level of agreement of two positioning protocols when using dual energy X-ray absorptiometry in the assessment of body composition

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3880 ◽  
Author(s):  
Flinn Shiel ◽  
Carl Persson ◽  
Vini Simas ◽  
James Furness ◽  
Mike Climstein ◽  
...  
Keyword(s):  
Body Composition ◽  
Correlation Coefficient ◽  
Dual Energy ◽  
Mean Difference ◽  
Whole Body ◽  
Confidence Limits ◽  
X Ray ◽  
Change In Mean ◽  
Very High ◽  
Level Of Agreement

Background Dual energy X-ray absorptiometry (DXA) is a commonly used instrument for analysing segmental body composition (BC). The information from the scan guides the clinician in the treatment of conditions such as obesity and can be used to monitor recovery of lean mass following injury. Two commonly used DXA positioning protocols have been identified—the Nana positioning protocol and the National Health and Nutrition Examination Survey (NHANES). Both protocols have been shown to be reliable. However, only one study has assessed the level of agreement between the protocols and ascertained the participants’ preference of protocol based upon comfort. Given the paucity of research in the field and the growing use of DXA in both healthy and pathological populations further research determining the most appropriate positioning protocol is warranted. Therefore, the aims of this study were to assess the level of agreement between results from the NHANES protocol and Nana protocol, and the participants’ preference of protocol based on comfort. Methods Thirty healthy participants (15 males, 15 females, aged 23–59 years) volunteered to participate in this study. These participants underwent two whole body DXA scans in a single morning (Nana positioning protocol and NHANES positioning protocol), in a randomised order. Each participant attended for scanning wearing minimal clothing and having fasted overnight, refrained from exercise in the past 24 h and voided their bladders. Level of agreement, comparing NAHNES to Nana protocol was assessed using an intra-class correlation coefficient (ICC), concordance correlation coefficient (CCC) and percentage change in mean. Limit of agreement comparing the two protocols were assessed using plots, mean difference and confidence limits. Participants were asked to indicate the protocol they found most comfortable. Results When assessing level of agreement between protocols both the ICC and CCC scores were very high and ranged from 0.987 to 0.997 for whole body composition, indicating excellent agreement between the Nana and NHANES protocols. Regional analysis (arms, legs, trunk) ICC scores, ranged between 0.966 and 0.996, CCC ranged between 0.964 and 0.997, change in mean percentage ranged between −0.58% and 0.37% which indicated a very high level of agreement. Limit of agreement analysis using mean difference ranged between −0.223 and 0.686 kg and 95% CL produced results ranging between −1.262 kg and 1.630 kg. The majority (80%) of participants found the NHANES positioning protocol more comfortable. Discussion This study reveals a strong level of agreement as illustrated by high ICC’s and CCC’s between the positioning protocols, however systematic bias within limit of agreement plot and a large difference in 95% confidence limits indicates that the protocols should not be interchanged when assessing an individual. The NHANES protocol affords greater participant comfort.

scholarly journals Sarcopenic obesity in rheumatoid arthritis: prevalence and impact on physical functioning

Rheumatology ◽  
2021 ◽  
Author(s):  
Joshua F Baker ◽  
Jon T Giles ◽  
David Weber ◽  
Michael D George ◽  
Mary B Leonard ◽  
...  
Keyword(s):  
Body Composition ◽  
Lean Mass ◽  
Physical Functioning ◽  
Reference Population ◽  
Dual Energy ◽  
Sarcopenic Obesity ◽  
Whole Body ◽  
Z Scores ◽  
Composition Changes

Abstract Objective We determined the prevalence of sarcopenic obesity in patients with RA using multiple methods and assessed associations with physical functioning. Methods This study evaluated data from three RA cohorts. Whole-body dual-energy absorptiometry (DXA) measures of appendicular lean mass index (ALMI, kg/m2) and fat mass index (FMI) were converted to age, sex and race-specific Z-Scores and categorized using a recently validated method and compared it to a widely-used existing method. The prevalence of body composition abnormalities in RA was compared with two reference populations. In the RA cohorts, associations between body composition and change in the HAQ and the Short Physical Performance Battery (SPPB) in follow-up were assessed using linear and logistic regression, adjusting for age, sex, race and study. Results The prevalence of low lean mass and sarcopenic obesity was higher in patients with RA (14.2; 12.6%, respectively) compared with the reference population cohorts (7–10%; 4–4.5%, respectively, all P &lt;0.05). There was only moderate agreement among methods of sarcopenic obesity categorization (Kappa 0.45). The recently validated method categorized fewer subjects as obese, and many of these were categorized as low lean mass only. Low lean mass, obesity and sarcopenic obesity were each associated with higher HAQ and lower SPPB at baseline and numerically greater worsening. Conclusion RA patients had higher rates of low lean mass and sarcopenic obesity than the general population. The recently validated methods characterized body composition changes differently from traditional methods and were more strongly associated with physical function.

Techniques for Undertaking Dual-Energy X-Ray Absorptiometry Whole-Body Scans to Estimate Body Composition in Tall and/or Broad Subjects

2012 ◽  
Vol 22 (5) ◽  
pp. 313-322 ◽  
Author(s):  
Alisa Nana ◽  
Gary J. Slater ◽  
Will G. Hopkins ◽  
Louise M. Burke
Keyword(s):  
Body Composition ◽  
Dual Energy ◽  
The Body ◽  
Whole Body ◽  
Whole Body Scan ◽  
Body Scan ◽  
Physically Active ◽  
X Ray ◽  
Scanning Area ◽  
Dxa Scans

Dual-energy X-ray absorptiometry (DXA) is becoming a popular tool to measure body composition, owing to its ease of operation and comprehensive analysis. However, some people, especially athletes, are taller and/or broader than the active scanning area of the DXA bed and must be scanned in sections. The aim of this study was to investigate the reliability of DXA measures of whole-body composition summed from 2 or 3 partial scans. Physically active young adults (15 women, 15 men) underwent 1 whole-body and 4 partial DXA scans in a single testing session under standardized conditions. The partial scanning areas were head, whole body from the bottom of the chin down, and right and left sides of the body. Body-composition estimates from whole body were compared with estimates from summed partial scans to simulate different techniques to accommodate tall and/or broad subjects relative to the whole-body scan. Magnitudes of differences in the estimates were assessed by standardization. In simulating tall subjects, summation of partial scans that included the head scan overestimated whole-body composition by ~3 kg of lean mass and ~1 kg of fat mass, with substantial technical error of measurement. In simulating broad subjects, summation of right and left body scans produced no substantial differences in body composition than those of the whole-body scan. Summing partial DXA scans provides accurate body-composition estimates for broad subjects, but other strategies are needed to accommodate tall subjects.

Sign in / Sign up

Export Citation Format

Share Document