scholarly journals Ophthalmic Manifestations of Hematopoietic Malignancy

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Natsuyo Yoshida-Hata ◽  
Naomichi Katai ◽  
Toshiyuki Oshitari

Purpose. To report the ocular findings in patients with hematopoietic malignancy with optic nerve involvement and abducens nerve palsy.Methods. The medical records of all cases of hematopoietic cancer with ophthalmic involvements seen in the Department of Ophthalmology of the National Center for Global Health and Medicine between 2009 and 2014 were reviewed.Results. Eight patients with hematopoietic cancer with optic nerve invasion or abducens nerve palsy were studied. The primary diseases were 3 cases of multiple myeloma, 1 case of acute lymphocytic leukemia, 1 case of follicular lymphoma, and 3 cases of AIDS-related lymphoma. Six cases had optic nerve invasion, 2 cases had abducens nerve palsy, and 1 case had optic nerve invasion of both eyes. The median visual acuity of eyes with optic nerve invasion was 0.885 logarithm of the minimum angle of resolution (logMAR) units. The final visual acuity of eyes with optic nerve invasion was 1.25 logMAR units, and that of those with sixth-nerve palsy was −0.1 logMAR units. Six cases died during the five-year follow-up period. An ophthalmic involvement in patients with hematopoietic cancer, especially AIDS-related lymphoma, was associated with poor prognosis.Conclusion. Because ophthalmic involvement in patients with hematopoietic malignancy has a poor prognosis, an early diagnosis of the cancers by the ophthalmologic findings by ophthalmologists could improve the prognosis.

2020 ◽  
Vol 13 (3) ◽  
pp. e231889 ◽  
Author(s):  
Michael S Lundin ◽  
Sherri L Sandel ◽  
Corina M Suciu ◽  
Debra A Spicehandler

2009 ◽  
Vol 22 (4) ◽  
pp. 381-385 ◽  
Author(s):  
A. Viglianesi ◽  
M. Messina ◽  
R. Chiaramonte ◽  
G.A. Meli ◽  
L. Meli ◽  
...  

Magnetic resonance imaging disclosed both optic nerve tortuosity and kinking in a 64-year-old man with orbital pain and monolateral abducens nerve palsy. The association between optic nerve tortuosity and abducens nerve palsy is often described in literature reports of idiopathic intracranial hypertension. However the diagnosis of idiopathic intracranial hypertension was excluded in our patient because of the absence of other signs such as papilledema (universally present in the cases of idiopathic intracranial hypertension), visual loss, headache and flattening of the posterior sclera. Other possible diagnoses to be considered when looking at a case of optic nerve tortuosity are neurofibromatosis and/or optic nerve glioma. Tortuosity of both optic nerves seems to be isolated in our patient and not associated with other diseases or disorders. We suggest that in some patients optic nerve tortuosity could be correlated with an aberrant anatomical development of the optic nerve. Further studies are necessary to confirm this hypothesis which currently remains conjectural.


2021 ◽  
pp. 1-5
Author(s):  
Ritwik Ghosh ◽  
Subhrajyoti Biswas ◽  
Arnab Mandal ◽  
Kaustav De ◽  
Srijit Bandyopadhyay ◽  
...  

Author(s):  
Aishwarya Anilkumar ◽  
Elizabeth Tan ◽  
Jonathan Cleaver ◽  
Hamish D Morrison

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