scholarly journals Association of Serum Adropin Concentrations with Diabetic Nephropathy

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Wenchao Hu ◽  
Li Chen
Keyword(s):  
Regression Analysis ◽  
Diabetic Nephropathy ◽  
Energy Homeostasis ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Regulatory Protein ◽  
Multiple Linear Regression Analysis ◽  
Lower Serum ◽  
Urine Albumin

Objective. Adropin is a newly identified regulatory protein encoded by the Enho gene and is critically involved in energy homeostasis and insulin sensitivity. This study aims to determine the correlation of serum adropin concentrations with diabetic nephropathy (DN).Methods. This study consisted of 245 patients with type 2 diabetes mellitus (T2DM) and 81 healthy subjects. Then T2DM patients were divided into normoalbuminuria, microalbuminuria, and macroalbuminuria subgroups based on urine albumin to creatinine ratio (ACR).Results. T2DM patients showed significantly lower serum adropin concentrations than those in the controls. T2DM patients with macroalbuminuria had significantly decreased serum adropin concentrations compared with the other three groups. In addition, T2DM patients with microalbuminuria showed lower serum adropin concentrations than those in patients with normoalbuminuria. Logistic regression analysis showed that serum adropin was correlated with decreased risk of developing T2DM and DN. Pearson correlation analysis indicated that serum adropin was negatively correlated with body mass index (BMI), blood urea nitrogen, creatinine, and ACR and positively correlated with glomerular filtration rate. Furthermore, multiple linear regression analysis showed that BMI and ACR were negatively correlated with serum adropin levels.Conclusion. Serum adropin concentrations are negatively associated with renal function. Adropin may be implicated in the pathogenesis of DN development.

Elevated serum preptin concentrations in patients with diabetic nephropathy

2019 ◽  
Vol 67 (7) ◽  
pp. 1048-1052 ◽  
Author(s):  
Rui Wang ◽  
Aili Xue ◽  
Wenjian Zheng ◽  
Linchuan Wang ◽  
Fei Yan ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Diabetic Nephropathy ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Elevated Serum ◽  
Multiple Linear Regression Analysis ◽  
Urine Albumin ◽  
Acarbose Treatment ◽  
And Gender

Preptin is a peptide synthesized and secreted accompanied with insulin from pancreatic β cells. Here, we tested the hypothesis that serum preptin concentrations are correlated with diabetic nephropathy (DN). Our study was performed in a population of 234 patients with type 2 diabetes mellitus (T2DM) and 78 healthy subjects. Patients with T2DM were divided into three groups: normoalbuminuria group (DN0, n=106), microalbuminuria group (DN1, n=90), and macroalbuminuria group (DN2, n=38) according to urine albumin to creatinine ratio (ACR). Serum preptin concentrations were significantly increased in the three T2DM subgroups than those in the controls. DN2 group showed significantly higher serum preptin concentrations compared with DN0 and DN1 groups. Moreover, DN1 group had higher serum preptin concentrations than DN0 group. Serum preptin was correlated with a higher risk of T2DM and DN after logistic regression analysis. Simply linear regression analysis demonstrated a positive correlation between serum preptin and gender, body mass index (BMI), blood urea nitrogen, creatinine, ACR, and a negative correlation between serum preptin and glomerular filtration rate, metformin, acarbose treatment. Gender, BMI, and ACR were still positively correlated with serum preptin after multiple linear regression analysis. Our findings indicate that serum preptin concentrations are associated with renal function and DN.

scholarly journals The Association of Fasting C-peptide with Corneal Neuropathy in Patients with Type 2 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Anju Zuo ◽  
Chuan Wang ◽  
Lili Li ◽  
Jingru Qu ◽  
Juan Cao ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
C Peptide ◽  
Duration Of Diabetes ◽  
Corneal Nerve ◽  
And Gender ◽  
The Relationship

Purpose. Damage to corneal nerve fibers has been demonstrated in people with type 2 diabetes mellitus (T2DM) that further progresses with increasing severity of diabetic peripheral neuropathy. However, the role of C-peptide in corneal nerve damage has not been reported in T2DM. The present study investigated the relationship of fasting C-peptide levels with corneal neuropathy evaluated by corneal confocal microscopy (CCM) in patients with T2DM. Methods. 160 T2DM patients (72 females) aged 34-78 with duration ranging from 0 to 40 years underwent CCM to measure corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), and corneal nerve branch density (CNBD). Pearson correlation analysis and multiple linear regression analysis were used to explore the association of fasting C-peptide levels with corneal nerve parameters. Partial correlation analysis (adjusted for age and gender) was also conducted to analyze the correlation of metabolic indexes with these three corneal nerve parameters. The relationship between fasting C-peptide levels and duration of diabetes was also explored by Pearson correlation analysis. Results. With an increase in fasting C-peptide levels, the values of CNFL, CNFD, and CNBD also showed a corresponding trend for an increase. Partial correlation analysis revealed that fasting C-peptide levels were positively associated with CNFL ( r = 0.245 , P = 0.002 ), CNFD ( r = 0.180 , P = 0.024 ), and CNBD ( r = 0.214 , P = 0.008 ) after adjusting for age and gender. Using multiple linear regression analysis, fasting C-peptide levels were also closely associated with CNFL ( P = 0.047 ) and CNBD ( P = 0.038 ) after multiple adjustments. However, this association disappeared after further adjusting for duration of diabetes. Further analysis indicated that fasting C-peptide levels declined with duration of diabetes ( r = − 0.267 , P = 0.001 ). Conclusions. C-peptide was closely associated with corneal neuropathy and disease duration in T2DM. C-peptide levels might be both an indicator of beta-cell function and a marker of disease severity (such as diabetic corneal neuropathy) and duration.

scholarly journals Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes

2020 ◽  
Author(s):  
Melissa K Thomas ◽  
Amir Nikooienejad ◽  
Ross Bray ◽  
Xuewei Cui ◽  
Jonathan Wilson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Insulin Sensitivity ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Receptor Agonist ◽  
Cell Function ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis

Abstract Context Novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) tirzepatide demonstrated substantially greater glucose control and weight loss (WL) compared with selective GLP-1RA dulaglutide. Objective Explore mechanisms of glucose control by tirzepatide. Design Post hoc analyses of fasting biomarkers and multiple linear regression analysis. Setting Forty-seven sites in 4 countries. Patients or other Participants Three hundred and sixteen subjects with type 2 diabetes. Interventions Tirzepatide (1, 5, 10, 15 mg), dulaglutide (1.5 mg), placebo. Main Outcome Measures Analyze biomarkers of beta-cell function and insulin resistance (IR) and evaluate WL contributions to IR improvements at 26 weeks. Results Homeostatic model assessment (HOMA) 2-B significantly increased with dulaglutide and tirzepatide 5, 10, and 15 mg compared with placebo (P ≤ .02). Proinsulin/insulin and proinsulin/C-peptide ratios significantly decreased with tirzepatide 10 and 15 mg compared with placebo and dulaglutide (P ≤ .007). Tirzepatide 10 and 15 mg significantly decreased fasting insulin (P ≤ .033) and tirzepatide 10 mg significantly decreased HOMA2-IR (P = .004) compared with placebo and dulaglutide. Markers of improved insulin sensitivity (IS) adiponectin, IGFBP-1, and IGFBP-2 significantly increased by 1 or more doses of tirzepatide (P < .05). To determine whether improvements in IR were directly attributable to WL, multiple linear regression analysis with potential confounding variables age, sex, metformin, triglycerides, and glycated hemoglobin A1c was conducted. WL significantly (P ≤ .028) explained only 13% and 21% of improvement in HOMA2-IR with tirzepatide 10 and 15 mg, respectively. Conclusions Tirzepatide improved markers of IS and beta-cell function to a greater extent than dulaglutide. IS effects of tirzepatide were only partly attributable to WL, suggesting dual receptor agonism confers distinct mechanisms of glycemic control.

scholarly journals Free Triiodothyronine Levels Are Associated with Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Jingcheng Wu ◽  
Xiaohua Li ◽  
Yang Tao ◽  
Yufei Wang ◽  
Yongde Peng
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Free Triiodothyronine ◽  
Cross Sectional ◽  
Traditional Risk Factors

Objective. To investigate the association of thyroid function and diabetic nephropathy (DN) in euthyroid patients with type 2 diabetes.Methods. A total of 421 patients were included in this cross-sectional study. The following parameters were assessed: anthropometric measurements, fast plasma glucose, serum creatinine, lipid profile, HbA1c, free triiodothyronine (FT3), free thyroxine, thyroid-stimulating hormone levels, and urinary albumin-to-creatinine ratio (UACR). Patients with UACR of ≥30 mg/g were defined as those suffering from DN.Results. Of the 421 patients, 203 (48.2%) suffered from DN, and no difference was found between males and females. The patients with DN yielded significantly lower FT3 levels than those without DN (P<0.01). The prevalence of DN showed a significantly decreasing trend across the three tertiles based on FT3 levels (59.6%, 46.4%, and 38.6%,P<0.01). After adjustment for gender and age, FT3 levels were found to correlate positively with estimated glomerular filtration rate (P=0.03) and negatively with UACR (P<0.01). Multiple linear regression analysis showed that FT3 level was independently associated with UACR (β=-0.18,t=-3.70, andP<0.01).Conclusion. Serum FT3 levels are inversely associated with DN in euthyroid patients with type 2 diabetes, independent of traditional risk factors.

scholarly journals The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis Patients

2021 ◽  
Vol 11 (16) ◽  
pp. 7405
Author(s):  
An-Ting Lee ◽  
Yen-Pei Lu ◽  
Chun-Hao Chen ◽  
Chia-Hao Chang ◽  
Yuan-Hsiung Tsai ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Serum Sodium ◽  
Fluid Overload ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Hemodialysis Patients ◽  
Older Age ◽  
Lower Serum

Patients on maintenance hemodialysis are at high risk for cardiovascular morbidity and mortality. Fluid overload is generally regarded as the main cause of cardiovascular death among them. Cardiothoracic ratio (CTR) by chest plain film is routinely performed to evaluate their volumetric states and cardiac conditions. We recently reported that salivary conductivity is a reliable marker for assessing fluid status in healthy adults. This cross-sectional study aims to explore the association between salivary conductivity and CTR. Cardiomegaly is defined as a CTR greater than 0.5. A total of 129 hemodialysis patients were enrolled, 42 of whom (32.6%) had cardiomegaly. Patients with cardiomegaly had significantly lower serum osmolality, lower serum sodium, and lower salivary conductivity, but a higher percentage of underlying atrial fibrillation. In the multiple linear regression analysis, CTR was negatively associated with salivary conductivity or to the serum sodium level and positively correlated with older age. We further divided patients into low, medium, and high salivary conductivity groups according to the tertials of conductivity levels. There was a significant trend for the increment of cardiomegaly from high to low salivary conductivity groups (p for trend: 0.021). The receiver operating characteristic curves for the diagnostic ability of salivary conductivity on cardiomegaly reported the area under the curve equal to 0.626 (95% CI: 0.521–0.730, p = 0.02). Moreover, older age and higher serum osmolality were independent determinants for salivary conductivity by multiple linear regression analysis. This work has presented that salivary conductivity is a novel approach to uncover fluid overload and cardiomegaly among chronic hemodialysis patients.

scholarly journals Employees’ Perception of School Leaders’ Efficacy and its Impact on their Adaptive Performance

2020 ◽  
Vol 7 (1) ◽  
pp. 55
Author(s):  
Farhat Munir ◽  
M. Abiodullah ◽  
Faiza Aslam
Keyword(s):  
Regression Analysis ◽  
Positive Relationship ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Adaptive Performance ◽  
Significant Positive Relationship ◽  
Administrative Employees ◽  
High Level ◽  
The Relationship

The fast-paced change in schools demands high level of adaptability. Several factors have been explored through research that affects employees’ adaptability. The purpose of this study was to explore the relationship between employees’ perception of leaders’ efficacy and its impact on their adaptive performance. A sample of 266 academic & administrative employees was randomly selected from 50 private secondary schools of Lahore Pakistan. Pearson correlation and multiple linear regression analysis were run for data analysis and significant positive relationship was found between employees’ perception of leaders’ efficacy and their adaptive performance.

scholarly journals The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Xiaoyu Ma ◽  
Canlu Lu ◽  
Chuan Lv ◽  
Can Wu ◽  
Qiuyue Wang
Keyword(s):  
Diabetic Nephropathy ◽  
Transforming Growth Factor ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin ◽  
Urine Albumin Creatinine Ratio

Objective. To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients.Methods. 464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA,n=157), microalbuminuria group (MA,n=159), and large amount of albuminuria group (LA,n=148). 127 healthy persons were selected as the control group (NC,n=127). The serum miR-192 levels were detected by Real-Time PCR and transforming growth factor-β1 (TGF-β1) and fibronectin (FN) were detected by enzyme-linked immunosorbent assay. The relationships among these parameters were analyzed by Pearson correlation analysis and multiple linear regression analysis.Results. The miR-192 in the LA group was significantly lower than other groups, which was lower in the MA group than in the NA group (P<0.01). The TGF-β1 and FN in the LA group were significantly higher than other groups, which were higher in the MA group than in the NA group (P<0.01). The expression of miR-192 was negatively correlated with TGF-β1, FN, and Ln (UACR) and miR-192, TGF-β1, and FN were independent relevant factors affecting Ln (UACR) in T2DM (P<0.01).Conclusions. These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.

scholarly journals THE INVESTIGATION OF THE INFLUENCE OF PSYCHOLOGICAL CONTRACT TYPES ON ORGANIZATIONAL CITIZENSHIP BEHAVIOUR

2019 ◽  
pp. 365
Author(s):  
Ivana Simić ◽  
Biljana Đorđević ◽  
Sandra Milanović
Keyword(s):  
Regression Analysis ◽  
Organizational Citizenship ◽  
Psychological Contract ◽  
Positive Impact ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Positive Relation ◽  
The Relationship ◽  
Organizational Performances

Organizational citizenship behaviour represents the behaviour of the employees that goes beyond their duties. This type of behaviour from the perspective of employer is very desirable since it produces many positive consequences regarding individual and the overall organizational performances. However, readiness of the employees to exert this type of behaviour is influenced by many factors. One of the most important is fulfilment of employees’ psychological contract. Since that there are two basic forms of contracts, relational and transactional, the aim of this paper is to investigate the relationship between these types of psychological contract and organizational citizenship behaviour. For the purpose of testing proposed hypothesis, t-test, Pearson correlation and multiple linear regression analysis were applied. The results showed that there is a positive relation and positive impact of relational psychological contract on the organizational citizenship behaviour, which was not the case when it was about the transactional contract.

scholarly journals Association of Serum Bilirubin Levels With Sarcopenia in Patients With Type 2 Diabetes: a Cross-Sectional Study in China

2020 ◽  
Author(s):  
Chuan Wang ◽  
Chen Jin ◽  
Jidong Liu ◽  
Xiaofei Yin ◽  
Chuanlong Wu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Muscle Mass ◽  
Serum Bilirubin ◽  
Linear Regression Analysis ◽  
Multiple Logistic Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Multiple Logistic Regression

Abstract Background: The prevalence of sarcopenia increased in type 2 diabetes mellitus (T2DM). Elevated oxidative stress and inflammation played important roles in the pathogenesis of diabetic sarcopenia. Bilirubin had been confirmed to possess potential anti-oxidative activity. This study aimed to explore the relationship between bilirubin and sarcopenia in patients with T2DM. Methods: A total of 251 patients (124 men and 127 postmenopausal women) with T2DM aged ≥ 50 years were recruited. Levels of serum total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) were measured. Muscle mass was measured by dual-energy X-ray absorptiometry (DXA). The relationships between serum bilirubin levels and appendicular skeletal muscle mass index (SMI) were assessed using a Pearson correlation analysis and multiple linear regression analysis in men and women, respectively. Multiple logistic regression analysis was used to evaluate the association of the highest quartile of serum bilirubin levels with sarcopenia.Results: TBIL (r =0.211, p = 0.019) and IBIL (r =0.249, p = 0.005) were positively associated with SMI in men, but not in women. After multiple adjustment in multiple linear regression analysis, TBIL (p = 0.023) and IBIL (p = 0.012) were also significantly associated with SMI in men. In multiple logistic regression analysis, the highest quartile of IBIL showed a decreased OR for sarcopenia (OR=0.243, P = 0.009) in men. Conclusions: Both of TBIL and IBIL were positively associated with muscle mass in men with T2DM. IBIL might have a stronger protective effect on the occurrence of sarcopenia in men with T2DM.

ANALISIS PENGARUH INFLASI, KURS DAN IHSG TERHADAP RETURN REKSA DANA SAHAM PT NIKKO SECURITIES INDONESIA PERIODE 2014-2017

2019 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
Muhammad Rois Rois ◽  
Manarotul Fatati Fatati ◽  
Winda Ihda Magfiroh
Keyword(s):  
Regression Analysis ◽  
Exchange Rate ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Stock Price ◽  
Price Index ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Equity Fund ◽  
Stock Price Index

This study aims to determine the effect of Inflation, Exchange Rate and Composite Stock Price Index (IHSG) to Return of PT Nikko Securities Indonesia Stock Fund period 2014-2017. The study used secondary data obtained through documentation in the form of PT Nikko Securities Indonesia Monthly Net Asset (NAB) report. Data analysis is used with quantitative analysis, multiple linear regression analysis using eviews 9. Population and sample in this research are PT Nikko Securities Indonesia. The result of multiple linear regression analysis was the coefficient of determination (R2) showed the result of 0.123819 or 12%. This means that the Inflation, Exchange Rate and Composite Stock Price Index (IHSG) variables can influence the return of PT Nikko Securities Indonesia's equity fund of 12% and 88% is influenced by other variables. Based on the result of the research, the variables of inflation and exchange rate have a negative and significant effect toward the return of PT Nikko Securities Indonesia's equity fund. While the variable of Composite Stock Price Index (IHSG) has a negative but not significant effect toward Return of Equity Fund of PT Nikko Securities Indonesia

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