scholarly journals Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Se Won Kim ◽  
Seung-Eun Lee ◽  
Young Lyun Oh ◽  
Seokhwi Kim ◽  
Sun Hee Park ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Level ◽  
Paraneoplastic Syndrome ◽  
Adrenocortical Carcinoma ◽  
Exceptional Case ◽  
Cell Tumor ◽  
Factor Ii ◽  
Igf I ◽  
Tumor Hypoglycemia ◽  
Recurrent Hypoglycemia

Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient’s serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.

scholarly journals A Rapid Method for Analyzing Serum Pro-Insulin-Like Growth Factor-II in Patients with Non-Islet Cell Tumor Hypoglycemia

2005 ◽  
Vol 90 (7) ◽  
pp. 3819-3823 ◽  
Author(s):  
Farideh Miraki-Moud ◽  
Ashley B. Grossman ◽  
Michael Besser ◽  
John P. Monson ◽  
Cecilia Camacho-Hübner
Keyword(s):  
Growth Factor ◽  
Rapid Method ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Tumor Hypoglycemia

Hypoglycemia in a dog with a leiomyoma of the gastric wall producing an insulin-like growth factor II-like peptide

1995 ◽  
Vol 132 (6) ◽  
pp. 744-750 ◽  
Author(s):  
Andrea Boari ◽  
Antonina Barreca ◽  
Gilberto E Bestetti ◽  
Francesco Minuto ◽  
Massimiliano Venturoli
Keyword(s):  
Growth Factor ◽  
Tumor Tissue ◽  
Tissue Concentration ◽  
Molecular Form ◽  
Islet Cell Tumor ◽  
Gastric Wall ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Igf I ◽  
Tumor Hypoglycemia

Boari A, Barreca A, Bestetti GE, Minuto F, Venturoli M. Hypoglycemia in a dog with a leiomyoma of the gastric wall producing an insulin-like growth factor II-like peptide. Eur J Endocrinol 1995;132:744–50. ISSN 0804–4643 A 12-year-old mixed-breed male dog was referred to the Clinica Medica Veterinaria of Bologna University for recurrent episodes of seizures due to hypoglycemia with abnormally low plasma insulin levels (18 pmol/l), Resection of a large leiomyoma (780 g) of the gastric wall resulted in a permanent resolution of the hypoglycemic episodes. Insulin-like growth factors I and II (IGF-I and -II) were measured by RIA in serum before and after surgery and in tumor tissue. Results were compared to the serum concentration of 54 normal and to the tissue concentration observed in eight non-hypoglycemic dog gastric wall extracts. Before surgery, circulating immunoreactive IGF-I was 0.92 nmol/l, which is significantly lower than the control values (16.92 ± 8.44 nmol/l, range 3.53–35.03), while IGF-II was 152 nmol/l, which is significantly higher than the control values (42.21 ± 3.75. range 31.99–50.74). After surgery, IGF-I increased to 6.80 nmol/l while IGF-II decreased to 45.52 nmol/l, Tumor tissue IGF-II concentration was higher than normal (5.66 nmol/kg tissue as compared to a range in normal gastric wall tissue of 1.14–3.72 nmol/kg), while IGF-I was 0.08 nmol/kg tissue, which is close to the lowest normal value (range in controls, 0.08–1.18 nmol/kg). Partial characterization of IGF-II immunoreactivity extracted from tissue evidenced a molecular weight similar to that of mature IGF-II thus excluding that peptide released by the tumor is a precursor molecule. In agreement with these data, at variance with samples of normal dog gastric wall, IGF-II immunostaining was positive and in situ hybridization evidenced the expression of IGF-II mRNA in tumor tissue specimen. Evaluation of the molecular distribution of the IGFs in the circulation evidenced that IGF-II immunoreactivity was predominantly in the 3 5–65 kD region and barely detectable in the other regions. These results show that in dog, non-islet cell tumor hypoglycemia, as demonstrated in humans, can be ascribed to overproduction of IGF-II circulating in a molecular form that can more easily cross the capillary wall, thus exerting its insulin-like effects on target tissues. Andrea Boari, Istituto di Clinica Medical Veterinaria di Bologna, Via Tolara di Sopra, 40064 Ozzano Emilia (BO), Italy

scholarly journals Characterization of Insulin-Like Growth Factor II(IGF-II) and IGF Binding Proteins in Patients with Non-Islet-Cell Tumor Hypoglycemia.

1993 ◽  
Vol 40 (1) ◽  
pp. 111-119 ◽  
Author(s):  
IZUMI FUKUDA ◽  
NAOMI HIZUKA ◽  
KAZUE TAKANO ◽  
KUMIKO ASAKAWA-YASUMOTO ◽  
KAZUO SHIZUME ◽  
...  
Keyword(s):  
Growth Factor ◽  
Islet Cell ◽  
Binding Proteins ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Igf Binding Proteins ◽  
Factor Ii ◽  
Igf Binding ◽  
Tumor Hypoglycemia

A case of gastric cancer with non-islet cell tumor hypoglycemia detected by insulin-like growth factor II

2010 ◽  
Vol 60 (8) ◽  
pp. 595-597 ◽  
Author(s):  
Hiroshi Maruyama ◽  
Mitsutoshi Tatsumi ◽  
Hitoshi Kitayama ◽  
Yasunori Enomoto ◽  
Hiroki Kuniyasu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Growth Factor ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Tumor Hypoglycemia

scholarly journals Serum Insulin-Like Growth Factor II in 44 Patients with Non-Islet Cell Tumor Hypoglycemia

1998 ◽  
Vol 45 (Suppl) ◽  
pp. S61-S65 ◽  
Author(s):  
NAOMI HIZUKA ◽  
IZUMI FUKUDA ◽  
KAZUE TAKANO ◽  
YUMIKO OKUBO ◽  
KUMIKO ASAKAWA-YASUMOTO ◽  
...  
Keyword(s):  
Growth Factor ◽  
Islet Cell ◽  
Serum Insulin ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Tumor Hypoglycemia

Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia

2006 ◽  
Vol 16 (4) ◽  
pp. 211-216 ◽  
Author(s):  
Izumi Fukuda ◽  
Naomi Hizuka ◽  
Yukiko Ishikawa ◽  
Kumiko Yasumoto ◽  
Yuko Murakami ◽  
...  
Keyword(s):  
Growth Factor ◽  
Clinical Features ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Tumor Hypoglycemia
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