scholarly journals Towards a Rational Design of Zeolite-Polymer Composite Nanofibers for Efficient Adsorption of Creatinine

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Ryo Takai ◽  
Rio Kurimoto ◽  
Yasuhiro Nakagawa ◽  
Yohei Kotsuchibashi ◽  
Koki Namekawa ◽  
...  
Keyword(s):  
Adsorption Capacity ◽  
Polymer Composite ◽  
Structural Design ◽  
Rational Design ◽  
Composite Nanofibers ◽  
Uremic Toxins ◽  
Composite Fibers ◽  
New Approach ◽  
Ethylene Content ◽  
Poly Ethylene

This report describes the compositional and structural design strategy of a zeolite-polymer composite nanofiber mesh for the efficient removal of uremic toxins towards blood purification application. The nanofiber is fabricated by electrospinning composite solution of biocompatible poly(ethylene-co-vinyl alcohol) (EVOH) and zeolite particles which are capable of selectively adsorbing uremic toxins such as creatinine. By controlling electrospinning conditions carefully, the incorporated zeolites in EVOH were found to correspond closely to the feed ratios. Elemental mapping images of Si show that zeolites were uniformly blended within the fibers. The fabricated composite fibers successfully adsorbed creatinine from solution and the adsorption capacity reached a maximum at 12 h. The crystallinity of the nanofiber was also controlled by varying the composition of ethylene content in EVOH. Less crystallinity resulted in higher creatinine adsorption capacity due to the barrier property of EVOH. Cytotoxicity assay demonstrated that the composite fibers showed less toxicity than free zeolite particles which killed more than 95% of cells. The proposed composite fibers, therefore, have the potential to be utilized as a new approach to removing creatinine selectively from the bloodstream.

Fabrication of zeolite–polymer composite nanofibers for removal of uremic toxins from kidney failure patients

2014 ◽  
Vol 2 (5) ◽  
pp. 674 ◽  
Author(s):  
Koki Namekawa ◽  
Makoto Tokoro Schreiber ◽  
Takao Aoyagi ◽  
Mitsuhiro Ebara
Keyword(s):  
Polymer Composite ◽  
Kidney Failure ◽  
Composite Nanofibers ◽  
Uremic Toxins

Fabrication and Characterization of Molybdenum Oxide Nanofibers by Electrospinning

2005 ◽  
Vol 900 ◽  
Author(s):  
Guan Wang ◽  
Xianrong Huang ◽  
Michael Dudley ◽  
Pelagia-Irene Gouma ◽  
Xiaoqing Yang
Keyword(s):  
Ethylene Oxide ◽  
Molybdenum Oxide ◽  
Composite Nanofibers ◽  
Sol Gel ◽  
Precursor Solution ◽  
Ethanol Solution ◽  
Composite Fibers ◽  
Time Dynamics ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

ABSTRACTMolybdenum oxide/ Poly (ethylene oxide) composite nanofibers were prepared by combining the sol-gel process and electrspinning technique. An ethanol solution of Poly(ethylene oxide) (PEO) was mixed with molybdenum isopropoxide to form a precursor solution. Composite nanofibers were obtained by electrspinning this viscous solution. By calcination of the composite fibers, pure molybdenum oxide nanofibers and nano-rods were obtained with diameters of 100-nanometer scale. Morphology of the fibers has been characterized by scanning electric microscopy. Components and structures of the final products have been identified by EDAX and grazing incidence XRD. Calcination process has been studied by DSC and TG analysis. The real time dynamics of the structural evolution from composite fibers to nanocrystalline metal oxide fibers has been investigated by synchrotron-based in-situ x-ray diffraction.

Effect of High Salt Concentration on Ion Clustering and Transport in Polymer Solid Electrolytes: a Molecular Dynamics Study of PEO-LiTFSI

2018 ◽  
Author(s):  
Nicola Molinari ◽  
Jonathan P. Mailoa ◽  
Boris Kozinsky
Keyword(s):  
Polymer Electrolyte ◽  
Salt Concentration ◽  
Rational Design ◽  
Material System ◽  
Ion Dynamics ◽  
High Concentration ◽  
Anion Clusters ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

<div> <div> <div> <p>The model and analysis methods developed in this work are generally applicable to any polymer electrolyte/cation-anion combination, but we focus on the currently most prominent polymer electrolyte material system: poly(ethylene) oxide/Li- bis(trifluoromethane) sulfonamide (PEO + LiTFSI). The obtained results are surprising and challenge the conventional understanding of ionic transport in polymer electrolytes: the investigation of a technologically relevant salt concentration range (1 - 4 M) revealed the central role of the anion in coordinating and hindering Li ion movement. Our results provide insights into correlated ion dynamics, at the same time enabling rational design of better PEO-based electrolytes. In particular, we report the following novel observations. 1. Strong binding of the Li cation with the polymer competes with significant correlation of the cation with the salt anion. 2. The appearance of cation-anion clusters, especially at high concentration. 3. The asymmetry in the composition (and therefore charge) of such clusters; specifically, we find the tendency for clusters to have a higher number of anions than cations.</p> </div> </div> </div>

Effect of High Salt Concentration on Ion Clustering and Transport in Polymer Solid Electrolytes: a Molecular Dynamics Study of PEO-LiTFSI

2018 ◽  
Author(s):  
Nicola Molinari ◽  
Jonathan P. Mailoa ◽  
Boris Kozinsky
Keyword(s):  
Polymer Electrolyte ◽  
Salt Concentration ◽  
Rational Design ◽  
Material System ◽  
Ion Dynamics ◽  
High Concentration ◽  
Anion Clusters ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

<div> <div> <div> <p>The model and analysis methods developed in this work are generally applicable to any polymer electrolyte/cation-anion combination, but we focus on the currently most prominent polymer electrolyte material system: poly(ethylene) oxide/Li- bis(trifluoromethane) sulfonamide (PEO + LiTFSI). The obtained results are surprising and challenge the conventional understanding of ionic transport in polymer electrolytes: the investigation of a technologically relevant salt concentration range (1 - 4 M) revealed the central role of the anion in coordinating and hindering Li ion movement. Our results provide insights into correlated ion dynamics, at the same time enabling rational design of better PEO-based electrolytes. In particular, we report the following novel observations. 1. Strong binding of the Li cation with the polymer competes with significant correlation of the cation with the salt anion. 2. The appearance of cation-anion clusters, especially at high concentration. 3. The asymmetry in the composition (and therefore charge) of such clusters; specifically, we find the tendency for clusters to have a higher number of anions than cations.</p> </div> </div> </div>

scholarly journals Interfacial Adhesion and Mechanical Properties of PET Fabric/PVC Composites Enhanced by SiO2/Tributyl Citrate Hybrid Sizing

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 898
Author(s):  
Dandan Pu ◽  
Fuyao Liu ◽  
Yubing Dong ◽  
Qingqing Ni ◽  
Yaqin Fu
Keyword(s):  
Interfacial Adhesion ◽  
Ethylene Terephthalate ◽  
Sio2 Nanoparticles ◽  
New Approach ◽  
Pet Fabric ◽  
Poly Ethylene Terephthalate ◽  
Wide Range ◽  
Peeling Strength ◽  
Poly Ethylene

Poly(ethylene terephthalate) (PET) fabric-reinforced polyvinyl chloride (PVC) composites have a wide range of applications, but the interface bonding of PET fabric/PVC composites has remained a challenge. In this work, a new in-situ SiO2/tributyl citrate sizing agent was synthesized according to the principle of “similar compatibility.” The developed sizing agent was used as a PET surface modifier to enhance the interfacial performance of PET fabric/PVC composites. The morphology and structure of the PET filaments, the wettability and tensile properties of the PET fabric, the interfacial adhesion, and the tensile and tearing properties of the PET fabric/PVC composites were investigated. Experimental results showed that many SiO2 nanoparticles were scattered on the surface of the modified PET filaments. Moreover, the surface roughness of the modified PET filaments remarkably increased in comparison with that of the untreated PET filaments. The contact angle of the modified PET filaments was also smaller than that of the untreated ones. The peeling strength of the modified PET fabrics/PVC composites was 0.663 N/mm, which increased by 62.50% in comparison with the peeling strength of the untreated ones (0.408 N/mm). This work provides a new approach to the surface modification of PET and improves the properties of PET fabric/PVC composites.

scholarly journals Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

2020 ◽  
Vol 18 (5) ◽  
pp. 348-407 ◽  
Author(s):  
Vanessa Silva Gontijo ◽  
Flávia P. Dias Viegas ◽  
Cindy Juliet Cristancho Ortiz ◽  
Matheus de Freitas Silva ◽  
Caio Miranda Damasio ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Rational Design ◽  
Brain Regions ◽  
Molecular Hybridization ◽  
Drug Candidate ◽  
New Paradigm ◽  
New Approach ◽  
Biological Targets ◽  
Drug Candidates ◽  
Biochemical Pathways

Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies related to neuronal impairment and functional loss from different brain regions. Currently, no effective treatments are available for any NDs, and this lack of efficacy has been attributed to the multitude of interconnected factors involved in their pathophysiology. In the last two decades, a new approach for the rational design of new drug candidates, also called multitarget-directed ligands (MTDLs) strategy, has emerged and has been used in the design and for the development of a variety of hybrid compounds capable to act simultaneously in diverse biological targets. Based on the polypharmacology concept, this new paradigm has been thought as a more secure and effective way for modulating concomitantly two or more biochemical pathways responsible for the onset and progress of NDs, trying to overcome low therapeutical effectiveness. As a complement to our previous review article (Curr. Med. Chem. 2007, 14 (17), 1829-1852. https://doi.org/10.2174/092986707781058805), herein we aimed to cover the period from 2008 to 2019 and highlight the most recent advances of the exploitation of Molecular Hybridization (MH) as a tool in the rational design of innovative multifunctional drug candidate prototypes for the treatment of NDs, specially focused on AD, PD, HD and ALS.

Alignment of carbon nanotubes and reinforcing effects in nylon-6 polymer composite fibers

2008 ◽  
Vol 19 (24) ◽  
pp. 245703 ◽  
Author(s):  
Vijaya K Rangari ◽  
Mohammed Yousuf ◽  
Shaik Jeelani ◽  
Merlyn X Pulikkathara ◽  
Valery N Khabashesku
Keyword(s):  
Carbon Nanotubes ◽  
Polymer Composite ◽  
Nylon 6 ◽  
Composite Fibers ◽  
Reinforcing Effects
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