scholarly journals Mini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of “Anticholinergic Spectrum Disorders”

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Koji Hori ◽  
Kimiko Konishi ◽  
Misa Hosoi ◽  
Hiroi Tomioka ◽  
Masayuki Tani ◽  
...  
Keyword(s):  
Lewy Body ◽  
Cholinesterase Inhibitors ◽  
Lewy Body Disease ◽  
Anticholinergic Activity ◽  
Dual Action ◽  
Spectrum Disorders ◽  
The Relationship ◽  
Pituitary Adrenal Axis ◽  
Behavioral Pathology ◽  
Inflammatory System

Given the relationship between anticholinergic activity (AA) and Alzheimer’s disease (AD), we rereview our hypothesis of the endogenous appearance of AA in AD. Briefly, because acetylcholine (ACh) regulates not only cognitive function but also the inflammatory system, when ACh downregulation reaches a critical level, inflammation increases, triggering the appearance of cytokines with AA. Moreover, based on a case report of a patient with mild AD and slightly deteriorated ACh, we also speculate that AA can appear endogenously in Lewy body disease due to the dual action of the downregulation of ACh and hyperactivity of the hypothalamic-pituitary-adrenal axis. Based on these hypotheses, we consider AA to be a behavioral pathology of Lewy body disease. We also propose the concept of “anticholinergic spectrum disorders,” which encompass a variety of conditions, including AD, Lewy body disease, and delirium. Finally, we suggest the prescription of cholinesterase inhibitors to patients in this spectrum of disorders to abolish AA by upregulating ACh.

scholarly journals A Review of the Role of Anticholinergic Activity in Lewy Body Disease and Delirium

2015 ◽  
Vol 15 (3) ◽  
pp. 162-167 ◽  
Author(s):  
Yuka Kitajima ◽  
Koji Hori ◽  
Kimiko Konishi ◽  
Masayuki Tani ◽  
Hiroi Tomioka ◽  
...  
Keyword(s):  
Lewy Body ◽  
Lewy Body Disease ◽  
Anticholinergic Activity

Delirium prior to dementia as a clinical phenotype of Lewy body disease: an autopsied case report

2016 ◽  
Vol 29 (4) ◽  
pp. 687-689 ◽  
Author(s):  
Hiroshige Fujishiro ◽  
Ito Kawakami ◽  
Kenichi Oshima ◽  
Kazuhiro Niizato ◽  
Shuji Iritani
Keyword(s):  
Lewy Body ◽  
Clinical Phenotype ◽  
Lewy Bodies ◽  
Lewy Body Disease ◽  
Japanese Woman ◽  
Visual Hallucinations ◽  
Limited Information ◽  
Lewy Body Pathology ◽  
Old Japanese ◽  
The Relationship

ABSTRACTAlthough delirium shares clinical characteristics with dementia with Lewy bodies (DLB), there is limited information regarding the relationship between delirium and Lewy body pathology. Here, we report an 89-year-old Japanese woman with an episode of delirium who was pathologically confirmed to have limbic-type Lewy body disease (LBD). Although she exhibited transient visual hallucinations during the delirium, she had no overt dementia. She developed no core clinical features of DLB and died of pneumonia at the age of 90 years. This autopsied case suggests that delirium may be one of the clinical phenotypes of LBD prior to the onset of dementia.

scholarly journals Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story

2009 ◽  
Vol 4 (2) ◽  
pp. 91 ◽  
Author(s):  
Benjamin Lam ◽  
Elizabeth Hollingdrake ◽  
James L Kennedy ◽  
Sandra E Black ◽  
Mario Masellis
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Cholinesterase Inhibitors ◽  
Spectrum Disorders

A Review of Lewy Body Disease

1998 ◽  
Vol 3 (1) ◽  
pp. 13-19
Author(s):  
Denise A. Drumm ◽  
D. Larry Sparks
Keyword(s):  
Lewy Body ◽  
Lewy Body Disease

Sleep and cognition in schizophrenia spectrum disorders: A systematic review protocol.

2020 ◽  
Author(s):  
Sean Carruthers ◽  
Gemma Brunetti ◽  
Susan Rossell
Keyword(s):  
Systematic Review ◽  
Mental Illnesses ◽  
Schizophrenia Spectrum Disorders ◽  
Systematic Review Protocol ◽  
Schizophrenia Spectrum Disorder ◽  
Schizophrenia Spectrum ◽  
Review Protocol ◽  
Spectrum Disorders ◽  
Sleep And Cognition ◽  
The Relationship

Schizophrenia spectrum disorders are chronic and debilitating mental illnesses characterised by both cognitive impairments and sleep deficits. In this systematic review protocol, we outline an approach to examine the available literature investigating the relationship between sleep and cognition in individuals with schizophrenia spectrum disorder.

Lewy Body Disease

2002 ◽  
Vol 59 (6) ◽  
pp. 1043-1043
Author(s):  
D. E. Riley
Keyword(s):  
Lewy Body ◽  
Lewy Body Disease

scholarly journals Structural connectivity networks in Alzheimer’s disease and Lewy body disease

2021 ◽  
Author(s):  
Kyoungwon Baik ◽  
Jin‐Ju Yang ◽  
Jin Ho Jung ◽  
Yang Hyun Lee ◽  
Seok Jong Chung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Structural Connectivity ◽  
Lewy Body Disease

scholarly journals Comparison of the diagnostic performance of H/M ratio between early and delayed phases for Lewy body disease

2015 ◽  
Vol 36 (5) ◽  
pp. 477-480
Author(s):  
Yasuki Maruyama ◽  
Takayuki Yamada ◽  
Kenji Murakami ◽  
Reiko Kumano
Keyword(s):  
Lewy Body ◽  
Diagnostic Performance ◽  
Lewy Body Disease
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