scholarly journals Relationship between Daytime Sleepiness and Intrinsically Photosensitive Retinal Ganglion Cells in Glaucomatous Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Carolina P. B. Gracitelli ◽  
Gloria Liliana Duque-Chica ◽  
Ana Laura de Araújo Moura ◽  
Marina Roizenblatt ◽  
Balazs V. Nagy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Retinal Ganglion Cells ◽  
Daytime Sleepiness ◽  
Epworth Sleepiness Scale ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Pupillary Reflex

Patients with glaucoma showed to have higher daytime sleepiness measured by Epworth sleepiness scale. In addition, this symptom was associated with pupillary reflex and polysomnography parameters. These ipRGC functions might be impaired in patients with glaucoma, leading to worse quality of life.

515 Excessive daytime sleepiness: beyond the Epworth Sleepiness Scale results from a population-based study

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A202-A203
Author(s):  
Erika Treptow ◽  
Maurice Ohayon ◽  
Ronaldo Piovesan ◽  
Luciana Oliveira ◽  
Luciano Drager ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Body Composition ◽  
General Population ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Epworth Sleepiness Scale ◽  
Population Based ◽  
Factorial Structure

Abstract Introduction Excessive daytime sleepiness (EDS) is a common symptom present in several clinical, mental and sleep disorders. However, its subjective metrics have been criticized in the literature due to lack of association with disorder severity, or disagreement with objective measures. Epworth Sleepiness Scale (ESS) is a widely used questionnaire to evaluate EDS, however it may not be sufficient as a sole measure to identify cases of somnolence in the general population. Study objectives: To investigate the association between EDS with socio-demographic, body composition and PSG measures in the general population of São Paulo, Brazil. Methods 1,042 participants from a population-based epidemiological study underwent full in-lab PSG, questionnaires (ESS, fatigue, quality of life, depression and anxiety scales), bio impedance, socio-demographic and anthropometric measures at baseline and in the follow-up 9 years later. A univariate linear regression analysis including the whole sample (baseline and follow-up) was performed to analyze predictors of EDS and ESS score in the follow-up was the dependent variable. All variables with a p-value <0.15 were included in an exploratory factor analysis (principal component analysis with Varimax rotation) to assess the factorial structure of EDS. Results The results supported a five-factorial structure associated with EDS as follows: Factor 1 - Quality of life (Physical and Psychological domains of WHOQOL), Factor 2 – Fatigue (questions from Chalder Fatigue Scale concerning weakness, tiredness, lack of energy and less strength in the muscles), Factor 3 – PSG – sleep duration (wake after sleep onset, sleep efficiency, total time spent awake), Factor 4 – PSG – sleep structure (arousal index, N1 and N3 duration), Factor 5 – Body composition (body mass index). PSG variables related to sleep disordered breathing and movement disorders were not associated with EDS. Conclusion EDS measured by ESS was associated with domains other than sleep disorders in the general population. ESS metrics was significantly associated with fatigue and sleep duration. Support (if any) Associação Fundo Incentivo à Pesquisa (AFIP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES – Processo 88887.468428/2019-00).

scholarly journals Pupillary Response to Chromatic Light Stimuli as a Biomarker at the Early Stage of Glaucoma

2021 ◽  
Author(s):  
Carla Arévalo López ◽  
Samuel Madariaga Román ◽  
Ivan Plaza
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Early Stage ◽  
Open Angle Glaucoma ◽  
Visual Image ◽  
Pupillary Response ◽  
Retinal Ganglion ◽  
Irreversible Damage ◽  
Pupillary Reflex ◽  
Potential Biomarker

Abstract Glaucoma is a multifactorial neurodegenerative disease of the optic nerve currently considered a severe health problem because of its high prevalence, being the primary cause of irreversible blindness worldwide. The most common type corresponds to Primary Open-Angle Glaucoma (POAG). Glaucoma produces, among other alterations, a progressive loss of Retinal Ganglion Cells (RGC) and its axons, key to generate the action potential that reaches the visual cortex to create the visual image. It indicates a Visual Field (VF) loss whose main feature is to be painless, and this makes early detection difficult, causing a late diagnosis and delaying a timely treatment indication that slows down its progression. Intrinsically photosensitive Retinal Ganglion Cells (ipRGCs), which represent a subgroup of RGCs being sensitive to damage, are characterized by reacting to short-wave light stimulation close to 480 nm and among their non-visual function, the role in the generation of the pupillary reflex stands out. Currently, the sensitivity of clinical trials correlates to RGC damage, however the need for an early damage biomarker is still relevant. It is an urgent task to create new diagnostic approaches to detect an early stage of glaucoma in a prompt, quick, and economical manner. We suggest evaluating the pupillary response to chromatic light as a potential biomarker of disease, its diagnostic benefit, and its cost-effectiveness in clinical practice to reduce irreversible damage caused by glaucoma.

Calcium Signals Induced By Tonic Firing In Rat Retinal Ganglion Cells

2012 ◽  
Vol 3 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Kyril I. Kuznetsov ◽  
Vitaliy Yu. Maslov ◽  
Svetlana A. Fedulova ◽  
Nikolai S. Veselovsky
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Calcium Signals ◽  
Tonic Firing
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