scholarly journals Retracted: Leaf Rolling and Stem Fasciation in Grass Pea (Lathyrus sativusL.) Mutant Are Mediated through Glutathione-Dependent Cellular and Metabolic Changes and Associated with a Metabolic Diversion through Cysteine during Phenotypic Reversal

2016 ◽  
Vol 2016 ◽  
pp. 1-1
Keyword(s):  
Metabolic Changes ◽  
Leaf Rolling ◽  
Grass Pea ◽  
Phenotypic Reversal

scholarly journals Leaf Rolling and Stem Fasciation in Grass Pea (Lathyrus sativusL.) Mutant Are Mediated through Glutathione-Dependent Cellular and Metabolic Changes and Associated with a Metabolic Diversion through Cysteine during Phenotypic Reversal

2014 ◽  
Vol 2014 ◽  
pp. 1-21 ◽  
Author(s):  
Dibyendu Talukdar ◽  
Tulika Talukdar
Keyword(s):  
Antioxidant Defense ◽  
Imaging Study ◽  
Buthionine Sulfoximine ◽  
Mitotic Cell ◽  
Glycolate Oxidase ◽  
Leaf Rolling ◽  
Proliferating Cells ◽  
Glutathione Synthesis ◽  
Phenotypic Reversal ◽  
Rolled Leaf

ALathyrus sativusL. mutant isolated in ethylmethane sulfonate-treated M2progeny of mother variety BioL-212 and designated asrlfL-1was characterized by inwardly rolled-leaf and stem and bud fasciations. The mutant exhibited karyomorphological peculiarities in both mitosis and meiosis with origin of aneuploidy. The mitosis was vigorous with high frequency of divisional cells and their quick turnover presumably steered cell proliferations. Significant transcriptional upregulations of cysteine and glutathione synthesis and concomitant stimulations of glutathione-mediated antioxidant defense helpedrlfL-1mutant to maintain balanced reactive oxygen species (ROS) metabolisms, as deduced by ROS-imaging study. Glutathione synthesis was shut down in buthionine sulfoximine- (BSO-) treated mother plant and mutant, and leaf-rolling and stems/buds fasciations in the mutant were reversed, accompanied by normalization of mitotic cell division process. Antioxidant defense was downregulated under low glutathione-redox but cysteine-desulfurations and photorespiratory glycolate oxidase transcripts were markedly overexpressed, preventing cysteine overaccumulation but resulted in excess H2O2in BSO-treated mutant. This led to oxidative damage in proliferating cells, manifested by severe necrosis in rolled-leaf and fasciated stems. Results indicated vital role of glutathione in maintaining abnormal proliferations in plant organs, and its deficiency triggered phenotypic reversal through metabolic diversions of cysteine and concomitant cellular and metabolic modulations.

A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

1975 ◽  
Vol 33 ◽  
pp. 460-461
Author(s):  
Sidney D. Kobernick ◽  
Edna A. Elfont ◽  
Neddra L. Brooks
Keyword(s):  
Lipid Metabolism ◽  
New Zealand ◽  
Aortic Wall ◽  
Rabbit Aorta ◽  
Plaque Formation ◽  
Metabolic Changes ◽  
Atherosclerotic Plaques ◽  
Cytochemical Study ◽  
Cellular Alteration ◽  
New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

Antipsychotic Rx May Mean Metabolic Changes

2005 ◽  
Vol 35 (10) ◽  
pp. 34
Author(s):  
DIANA MAHONEY
Keyword(s):  
Metabolic Changes

Platelet Metabolism during the Interiorization of Two Different Types of Particulate Matter

1972 ◽  
Vol 27 (02) ◽  
pp. 263-271 ◽  
Author(s):  
I. A. Cooper ◽  
P Cochrane ◽  
B. G. Firkin ◽  
K. J. Pinkard
Keyword(s):  
Particulate Matter ◽  
Polymorphonuclear Leukocyte ◽  
Anaerobic Metabolism ◽  
Human Platelets ◽  
Metabolic Changes ◽  
Polystyrene Latex ◽  
Considerable Time ◽  
Difference Of Opinion ◽  
Different Types ◽  
Aerobic And Anaerobic

SummaryIt has been suggested that human platelets possess the ability to phagocytose particulate matter similar to the polymorphonuclear leukocyte. However some difference of opinion has arisen regarding this contention, particularly as differences have been demonstrated with regard to the observed metabolic changes occurring in platelets related to such a process.The experiments reported in this paper were designed to observe the aerobic and anaerobic metabolism in human platelets during and following interiorization of two different particles, viz. polystyrene latex and thorotrast. The results of these experiments show a marked difference between both types of particles with regard to observable metabolic changes despite the rapid interiorization of both types of material. Some alteration occurs in both aerobic and anaerobic metabolism a considerable time after interiorization of latex, whereas no alteration could be demonstrated after interiorization of thorotrast. It is suggested that the interiorization of particulate matter is by some process other than phagocytosis and that observed metabolic changes related to latex may be due to a release reaction.

Thyroid dysfunctions and metabolic changes in centenarians: consequence or cause of longevity?

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
M Kleinhardt ◽  
D Nicula ◽  
T Thomas ◽  
G Brabant ◽  
M Derwahl
Keyword(s):  
Metabolic Changes ◽  
Thyroid Dysfunctions

Ultra-trail marathon induces bone response in association with acute and established metabolic changes

2016 ◽  
Author(s):  
Giovanni Lombardi ◽  
Veronica Sansoni ◽  
Silvia Perego ◽  
Gianluca Vernillo ◽  
Federico Schena ◽  
...  
Keyword(s):  
Metabolic Changes ◽  
Bone Response
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