scholarly journals Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yang Lin ◽  
Lijian Xu ◽  
Wei Wei ◽  
Xiaohui Zhang ◽  
Rongchao Ying
Keyword(s):  
Long Noncoding Rna ◽  
Tumor Invasion ◽  
Noncoding Rna ◽  
Digestive System ◽  
Web Of Science ◽  
Meta Analysis ◽  
Pathological Features ◽  
Oncological Outcomes ◽  
Node Metastasis ◽  
Poorly Differentiated

Long noncoding RNA (lncRNA) H19 has been reported to be upregulated in malignant digestive tumors, but its clinical relevance is not yet established. The meta-analysis was to investigate the association between H19 expression and pathological features of digestive system cancers. The databases of PubMed, EMBase, Web of Science, CNKI, and WanFang were searched for the related studies. A total of 478 patients from 6 studies were finally included. The meta-analysis showed that the patient group of high H19 expression had a higher risk of poorly differentiated grade, deep tumor invasion (T2 stage or more), lymph node metastasis, and advanced TNM stage than the group of low H19 expression, although there was no difference between them in terms of distant metastasis. Therefore, the high expression of lncRNA H19 might predict poor oncological outcomes of patients with digestive system cancers.

scholarly journals The association between long noncoding RNA H19 and pathological features in cancers: A meta-analysis

2017 ◽  
Vol 1 (4) ◽  
pp. 203-210
Author(s):  
Meng Cui ◽  
Qing Luo ◽  
Yi Zhang ◽  
Kaijiong Zhang ◽  
Jinbo Liu
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Pathological Features

scholarly journals Long noncoding RNA UCA1 as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Congmin Liu ◽  
Jing Jin ◽  
Jin Shi ◽  
Liqun Wang ◽  
Zhaoyu Gao ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Hot Spot ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Node Metastasis ◽  
Increased Risk

AbstractBackground: Urothelial carcinoma associated 1 (UCA1), a novel long noncoding RNA (lncRNA) which is first discovered in 2006 in human bladder cancer and has become a hot spot in recent years. UCA1 has been demonstrated correlated with clinical outcomes in various cancers. However, the results from each study are insufficient and not completely consistent. Therefore, we perform a systematic meta-analysis to evaluate the value for a feasible biomarker for metastasis and prognosis of cancer. Methods: Relevant English literatures were searched in PubMed, Cochrane Library, Web of science, Embase databases and Chinese literatures were searched in Chinese National Knowledge Infrastructure Wanfang from inception up to 17 April 2018. The pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) using random/fixed-effect were used to identify the relationship between UCA1 and lymph node metastasis (LNM) or overall survival (OS) of cancer patients. Subgroup analysis and sensitivity analysis were performed. The current meta-analysis was performed using Review Manager 5.3 and Stata 12.0 software. Results: A total of 3411 patients from 38 studies were finally included. Patients who with high UCA1 expression suffered from an increased risk of LNM (OR = 2.50; 95% CI: 1.93–3.25). UCA1 was also significantly associated with OS (HR = 2.05; 95% CI: 1.77–2.38). Subgroup analyses across several different variables also showed the similar results in LNM and OS of cancer patients. Conclusion: High expression of UCA1 was linked with poor clinical outcome. UCA1 can serve as a potential molecular marker for metastasis and prognosis in different types of cancers.

The prognostic potential of long noncoding RNA HOTAIR expression in human digestive system carcinomas: A meta‐analysis

2018 ◽  
Vol 234 (7) ◽  
pp. 10926-10933 ◽  
Author(s):  
Hossein Abdeahad ◽  
Amir Avan ◽  
Mehran Pashirzad ◽  
Majid Khazaei ◽  
Saman Soleimanpour ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Digestive System ◽  
Meta Analysis ◽  
Human Digestive System

scholarly journals Long noncoding RNA ANRIL as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 9 (18) ◽  
pp. 14608-14618 ◽  
Author(s):  
Han Wang ◽  
Yang Liu ◽  
Jianhua Zhong ◽  
Chenglong Wu ◽  
Yuantang Zhong ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Human Cancer ◽  
Meta Analysis ◽  
Node Metastasis

scholarly journals Elevated P-Element-Induced Wimpy-Testis-Like Protein 1 Expression Predicts Unfavorable Prognosis for Patients with Various Cancers

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Kehua Jiang ◽  
Tao Ye ◽  
Juan Du ◽  
Lanlan Tang ◽  
Xiaolong Chen ◽  
...  
Keyword(s):  
Tumor Invasion ◽  
Prognostic Value ◽  
Web Of Science ◽  
Meta Analysis ◽  
Clinical Stage ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Features ◽  
P Element ◽  
Statistical Software ◽  
Node Metastasis

Increasing evidence has shown that overexpression of P-element-induced wimpy-testis (PIWI)-like protein 1 (PIWIL1) was associated with unfavorable prognosis of patients with various types of cancers. Herein, we conducted this meta-analysis to identify the clinicopathological and prognostic value of the PIWIL1 expression in cancers. Three electronic databases (PubMed, Web of Science, and Embase) were comprehensively retrieved for relevant studies up to August 4th, 2019. RevMan 5.3 and STATA 12.0 statistical software programs were used to explore the relationships between PIWIL1 expression and the prognosis and clinicopathological features in cancer patients. A total of 13 studies recruiting 2179 patients with 9 types of solid tumors were finally included in the meta-analysis. The results indicated that patients with high PIWIL1 expression tended to have a shorter survival, and additionally deeper tumor invasion, higher clinical stage, and more lymph node metastasis. PIWIL1 could serve as a biomarker for prognosis and clinicopathological characteristics in various cancers.

scholarly journals Role of long noncoding RNA UCA1 as a common molecular marker for lymph node metastasis and prognosis in various cancers: a meta-analysis

Oncotarget ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 1937-1943 ◽  
Author(s):  
Anbang He ◽  
Rong Hu ◽  
Zhicong Chen ◽  
Xinhui Liao ◽  
Jianfa Li ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Molecular Marker ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Node Metastasis
Sign in / Sign up

Export Citation Format

Share Document