scholarly journals Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Valeria Muller ◽  
Ksenia Ob’edkova ◽  
Inna Krikheli ◽  
Igor Kogan ◽  
Irina Fedorova ◽  
...  
Keyword(s):  
Immunoglobulin Therapy ◽  
Effective Management ◽  
Recurrent Implantation Failure ◽  
Successful Pregnancy ◽  
Intravenous Immunoglobulin Therapy ◽  
Efficient Treatment ◽  
Novel Approach ◽  
Ivf Failure ◽  
History Of ◽  
Recurrent Ivf Failure

We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects were observed; all cases resulted in pregnancy and subsequent life births. In order to be given an adequate efficient treatment, women with recurrent implantation failure should be suspected for autoimmune factor of infertility and its possible association with anti-hCG autoimmunity.

scholarly journals Kawasaki Disease with Retropharyngeal Edema following a Blackfly Bite

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Toru Watanabe
Keyword(s):  
Kawasaki Disease ◽  
Subcutaneous Tissue ◽  
Systemic Reaction ◽  
Immunoglobulin Therapy ◽  
Hypersensitive Reaction ◽  
Retropharyngeal Abscess ◽  
Cervical Lymph Nodes ◽  
Intravenous Immunoglobulin Therapy ◽  
Left Neck ◽  
History Of

We describe a patient with Kawasaki disease (KD) and retropharyngeal edema following a blackfly bite. An 8-year-old boy was referred to our hospital because of a 3-day-history of fever and left neck swelling and redness after a blackfly bite. Computed tomography of the neck revealed left cervical lymph nodes swelling with edema, increased density of the adjacent subcutaneous tissue layer, and low density of the retropharyngeum. The patient was initially presumed to have cervical cellulitis, lymphadenitis, and retropharyngeal abscess. He was administered antibiotics intravenously, which did not improve his condition. The patient subsequently exhibited other signs of KD and was diagnosed with KD and retropharyngeal edema. Intravenous immunoglobulin therapy and oral flurbiprofen completely resolved the symptoms and signs. A blackfly bite sometimes incites a systemic reaction in humans due to a hypersensitive reaction to salivary secretions, which may have contributed to the development of KD in our patient.

scholarly journals Atypical Kawasaki Disease after COVID-19 Vaccination: A New Form of Adverse Event Following Immunization

Vaccines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 126
Author(s):  
Ana Lilia Peralta-Amaro ◽  
Melina Ivone Tejada-Ruiz ◽  
Karen Lilian Rivera-Alvarado ◽  
Orestes de Jesús Cobos-Quevedo ◽  
Patricia Romero-Hernández ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Viral Vector ◽  
Case Reports ◽  
Previous History ◽  
Immunoglobulin Therapy ◽  
Adult Patients ◽  
Intravenous Immunoglobulin Therapy ◽  
American College Of Rheumatology ◽  
Liver And Kidney ◽  
History Of

Kawasaki disease (KD) is a medium-vessel vasculitis that is typically presented during childhood; fewer than 100 cases of KD have been reported worldwide in adult patients who met the criteria according to the American College of Rheumatology. This study presents the case of an 18-year-old patient with no previous history of any disease, who presented atypical KD with liver and kidney dysfunction, with a good response to intravenous immunoglobulin therapy. The symptoms began 22 days after the application of the COVID-19 vaccine (nonreplicating viral vector Vaxzevria), and other conditions were ruled out. The term Adverse Events Following Immunization (AEFI)encompasses all the reactions that follow the application of any vaccine with no necessary causal relationship and can be due to the vaccine product, quality of the vaccine, immunization errors, or anxiety or just happen to be coincident events. These reactions should be reported so that clinicians can identify compatible cases and consider that the presentation of this disease, despite being atypical, can be manifested in adult patients. Likewise, case reports are an important basis for the pharmacovigilance of vaccines.

Passively Acquired Treponemal Antibody From Intravenous Immunoglobulin Therapy in aPregnant Patient

2002 ◽  
Vol 126 (10) ◽  
pp. 1237-1238 ◽  
Author(s):  
Karen Q. Rossi ◽  
James R. Nickel ◽  
Mary E. Wissel ◽  
Richard W. O'Shaughnessy
Keyword(s):  
Intravenous Immunoglobulin ◽  
Immunoglobulin Therapy ◽  
Absorption Test ◽  
Rapid Plasma Reagin ◽  
Syphilis Infection ◽  
Intravenous Immunoglobulin Therapy ◽  
Antibody Absorption ◽  
History Of ◽  
Fluorescence Antibody ◽  
Alloimmune Thrombocytopenia

Abstract Intravenous immunoglobulin is purified, concentrated immunoglobulin G antibodies pooled from human blood donors. The passive transmission of various antibodies from intravenous immunoglobulin has been reported. However, to the best of our knowledge, there are no reports of acquisition of treponemal antibody from immunoglobulin therapy. A woman with a pregnancy complicated by neonatal alloimmune thrombocytopenia was treated with intravenous immunoglobulin to manage her fetal thrombocytopenia. The patient had no history of a syphilis infection. The patient's blood was screened for syphilis antibodies regularly and routinely because she donated platelets for transfusion to her fetus. During her intravenous immunoglobulin treatments, a positive result on a fluorescence antibody absorption test was confirmed, but the result on a rapid plasma reagin test was negative. Eleven weeks after her final dose, results of the fluorescence antibody absorption test were negative, with a negative rapid plasma reagin test result, suggesting passive acquisition of the treponemal antibody. Clinicians and pathologists must be aware of the possible acquisition of this antibody during the treatment and counseling of patients receiving intravenous immunoglobulin.

Multiphasic acute disseminated encephalomyelitis associated with atypical rubella virus infection

2014 ◽  
Vol 21 (2) ◽  
pp. 252-254 ◽  
Author(s):  
Koji Shinoda ◽  
Hideaki Asahara ◽  
Taira Uehara ◽  
Katsue Miyoshi ◽  
Satoshi O Suzuki ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rubella Virus ◽  
Immunoglobulin Therapy ◽  
Acute Disseminated Encephalomyelitis ◽  
Pulse Therapy ◽  
Unknown Etiology ◽  
Intravenous Immunoglobulin Therapy ◽  
First Case ◽  
History Of ◽  
Rubella Virus Infection

We report the first case of an occurrence of multiphasic acute disseminated encephalomyelitis (ADEM) associated with atypical rubella virus infection with no rash and long-term increased titers of serum anti-rubella IgM in a 17-year-old male who had no history of rubella vaccination. He suffered from at least six clinical exacerbations with disseminated hyperintense lesions on FLAIR MR images during the course of 18 months. Repeated methylprednisolone pulse therapy and intravenous immunoglobulin therapy resolved the exacerbations. In patients with multiphasic ADEM of unknown etiology, clinicians should also consider the possibility of preceding infection with rubella virus.

P079 Multi-systemic inflammatory syndrome in children: skin tropism

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_5) ◽  
Author(s):  
Rahma Guedri ◽  
Mariem Glai ◽  
Zohra Fitouri ◽  
Saayda Ben Becher
Keyword(s):  
Diagnostic Criteria ◽  
Immunoglobulin Therapy ◽  
Clinical Aspects ◽  
High Dose ◽  
Conjunctival Hyperemia ◽  
Intravenous Immunoglobulin Therapy ◽  
Dermatological Disease ◽  
The Face ◽  
History Of ◽  
Inflammatory Syndrome

Abstract Background Multisystem inflammatory syndrome in children (MIS-C) is a severe immune-mediated syndrome that occurs after COVID-19 infection. It mainly affects children and presents several clinical aspects. The cutaneous and mucous signs are very much part of the diagnostic criteria. The aimisto describe the clinical and evolutionary aspects of the muco-cutaneous signs during MIS-C Patients and methods It was a descriptive retrospective study conducted over a period of 9 months (March 1, 2020 - December 31, 2020) including children admitted to COVID isolation unit with suspicion of MIS-C syndrome. Results We included 17 patients. The average age was 7 years (1–11 years). The sex ratio was 2.2 (11 boys and 6 girls). There was o history of dermatological disease has been reported. Fever was present in all patients. Mucosal signs were present in 13 patients. Conjunctival hyperemia without purulent secretions was noted in 12 patients. Conjunctivitis was bilateral in 11 cases. A rash was found in 10 cases. It was macular (6 cases), maculopapular (2 cases) and vesicular cluster in one 1 case. It was itchy in 2 cases. It was located in the limbs (7 cases), thorax and/or abdomen (5 cases), pelvis (4 cases), palms and/or soles (3 cases) and the face in one case. Cheilitis was found in 6 cases and stomatitis or glossitis in 5 cases. oEdema of the extremities was present in three patients and oedema of the face was noted in one patient. All children received intravenous immunoglobulin therapy combined with high-dose corticosteroids and acetylsalicylic acid at anti-aggregating doses. The course was marked by the disappearance of the muco-cutaneous signs without recurrence in all cases. Conclusion Mucocutaneous involvement is a characteristic manifestation of multisystem inflammatory syndrome. It is one of the various diagnostic criteria for this syndrome.

scholarly journals Crystalline-Like Keratopathy after Intravenous Immunoglobulin Therapy with Incomplete Kawasaki Disease: Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Elif Erdem ◽  
Emine Kocabas ◽  
Hande Taylan Sekeroglu ◽  
Özlem Özgür ◽  
Meltem Yagmur ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Topical Steroid ◽  
Immunoglobulin Therapy ◽  
Incomplete Kawasaki Disease ◽  
Intravenous Immunoglobulin Therapy ◽  
Unexplained Fever ◽  
Disease Case ◽  
History Of ◽  
Immunoglobulin Treatment

A 7-year-old girl had presented with high body temperature and joint pain which continued for 3 days. Because of the prolonged history of unexplained fever, rash, bilateral nonpurulent conjunctival injection, oropharyngeal erythema, strawberry tongue, and extreme of age, incomplete Kawasaki disease was considered and started on an intravenous immunoglobulin infusion. Six days after this treatment, patient was referred to eye clinic with decreased vision and photophobia. Visual acuity was reduced to 20/40 in both eyes. Slit-lamp examination revealed bilateral diffuse corneal punctate epitheliopathy and anterior stromal haze. Corneal epitheliopathy seemed like crystal deposits. One day after presentation, mild anterior uveitis was added to clinical picture. All ocular findings disappeared in one week with topical steroid and unpreserved artificial tear drops. We present a case who was diagnosed as incomplete Kawasaki disease along with bilateral diffuse crystalline-like keratopathy. We supposed that unusual ocular presentation may be associated with intravenous immunoglobulin treatment.

scholarly journals Testosterone Use and Adrenal Hemorrhage

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A160-A160
Author(s):  
Moin U Sattar ◽  
Priyanka L Mahali ◽  
Natalia Chamorro-Pareja ◽  
Nisha Suda ◽  
Noah Bloomgarden
Keyword(s):  
Adrenal Insufficiency ◽  
Antiphospholipid Syndrome ◽  
Immunoglobulin Therapy ◽  
Dehydroepiandrosterone Sulfate ◽  
International Normalized Ratio ◽  
Adrenal Hemorrhage ◽  
Critically Ill Patient ◽  
Primary Adrenal Insufficiency ◽  
Intravenous Immunoglobulin Therapy ◽  
History Of

Abstract Background: Testosterone supplementation has been associated with a variety of side effects, such as polycythemia, and can potentially increase the risk of cardiovascular disease. Testosterone use has also been associated with increased thrombotic events, especially in patients with underlying hypercoagulable state. Clinical Case: A 57-year-old man presented with abdominal pain and distention. He had history of previous intramuscular (IM) and oral testosterone use for ten years. For 8 weeks prior to initial presentation, he reported using weekly IM 500mg Testosterone injections. Computed Tomography (CT) of the abdomen and pelvis revealed multiple thrombi of the portal, splenic, superior mesenteric and inferior mesenteric veins. He was started on Warfarin and discharged home. A few weeks later, he presented with similar symptoms with labs now showing an International Normalized Ratio (INR) of 10.2. Repeat CT was significant for presence of bilateral adrenal hemorrhage, measuring 2.9cm on the right and 2.4cm on the left, which were not seen on previous imaging done one week prior. During the hospital course, he was found to be hypotensive with low platelet count so Intravenous Immunoglobulin therapy was initiated for suspected catastrophic antiphospholipid syndrome (CAPS). Morning cortisol was 5.82 ug/dL (6.2–29.0) so this critically-ill patient was started on stress dose hydrocortisone, which was subsequently tapered to physiological dose after clinical improvement. Cosyntropin stimulation test was performed after withholding the prior dose of hydrocortisone. The baseline cortisol was 0.88 ug/dL (6.20–29.00ug/dL), after administration of 250mcg of Cosyntropin 30- and 60-minute cortisol levels were 1.5 ug/dL (4.3–22.4ug/dL) and 1.6 ug/dL (4.3–22.4ug/dL) respectively. Baseline ACTH of 121.0 pg/mL (7.2–63.3pg/mL), consistent with primary adrenal insufficiency. Dehydroepiandrosterone Sulfate (DHEA-S) level was 15.7 ug/dL (80.0–560.0ug/dL). Hypercoagulability workup was significant for the presence of lupus anticoagulant and antibodies positive for heparin induced thrombocytopenia, so patient was diagnosed with Antiphospholipid syndrome. Conclusion: This is a case of hypercoagulability in a patient with history of anabolic steroid misuse who developed extensive intraabdominal venous thrombosis, adrenal hemorrhage, and primary adrenal insufficiency. Adrenal vein thrombosis and hemorrhage can be life threatening sequalae of testosterone misuse and should be considered in the differential for patients with history of testosterone misuse and adrenal insufficiency.

scholarly journals Intravenous Immunoglobulin Therapy Administered Early after Narcolepsy Type 1 Onset in Three Patients Evaluated by Clinical and Polysomnographic Follow-Up

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Elisabeth Ruppert ◽  
Hélène Zagala ◽  
Juliette Chambe ◽  
Henri Comtet ◽  
Ulker Kilic-Huck ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Daytime Sleepiness ◽  
Muscle Tone ◽  
Disease Onset ◽  
Immunoglobulin Therapy ◽  
Retrospective Case ◽  
Intravenous Immunoglobulin Therapy ◽  
Efficient Treatment

Narcolepsy type 1 is a rare disabling sleep disorder mainly characterized by excessive daytime sleepiness and cataplexy, an emotion-triggered sudden loss of muscle tone. Patients have a selective degeneration of hypocretin-producing neurons in the dorsolateral posterior hypothalamus with growing evidence supporting the hypothesis of an autoimmune mechanism. Few case studies that reported intravenous immunoglobulin therapy (IVIg) suggest the efficacy of IVIg when administered early after disease onset, but the results are controversial. In these retrospective case observations, IVIg cycles were initiated within one to four months after cataplexy onset in a twenty-seven-year-old man, a ten-year-old girl, and a seven-year-old boy, all three with early onset typical narcolepsy type 1. Efficacy of treatment (three IVIg cycles of 1 g/kg administered at four-week intervals) was evaluated based on clinical, polysomnographic, and multiple sleep latency test (mean latency and SOREM) follow-up. Two patients reported decreased cataplexy frequency and ameliorated daytime sleepiness, but no significant amelioration of polysomnographic parameters was observed. Given the possibility of spontaneous improvement of cataplexy frequency with self-behavioral adjustments, these observations would need to be confirmed by larger controlled studies. Based on the present study and current literature, proof of concept is still missing thus prohibiting the consideration of IVIg as an efficient treatment option.

scholarly journals Turning walking pneumonia into recurrent abscesses: a curious case of CVID and review of the literature

2021 ◽  
Author(s):  
David X. Gao ◽  
Habiba Hussain ◽  
Brianna Bobber ◽  
Peter Phan
Keyword(s):  
Immunoglobulin Therapy ◽  
Autoimmune Disorders ◽  
Symptom Presentation ◽  
Primary Immunodeficiency Disorder ◽  
Intravenous Immunoglobulin Therapy ◽  
Allergy And Immunology ◽  
Immunodeficiency Disorder ◽  
Mycoplasma Pneumonia ◽  
History Of ◽  
Antibody Titers

Abstract Background: common variable immunodeficiency (CVID) is a primary immunodeficiency disorder associated with a broad symptom presentation that is still being characterized. We report a rare case of recurrent mycoplasma skin abscesses in a patient with a history of autoimmune disorders and prolonged mycoplasma pneumonia who was diagnosed with CVID.Case presentation: a 34-year-old woman presented with a history of recurrent abscesses previously confirmed positive for Mycoplasma pneumoniae. Her past medical history of recurrent mycoplasma abscesses, prolonged mycoplasma pneumonia, and autoimmune disorders (mixed connective tissue disease and immune thrombocytopenia) raised suspicion of CVID. Workup included negative anti-mycoplasma antibody titers, hypogammaglobulinemia, and negative anti-pneumococcal antibody titers despite prior vaccination, solidifying the diagnosis of CVID. The patient was discharged on antibiotic and intravenous immunoglobulin therapy with improvement and now follows allergy and immunology long-term for treatment.Conclusions: her diagnostic history underscores the importance of considering the various criteria of CVID for diagnosis, and her unique presentation of M. pneumoniae skin abscesses highlights the broad sequelae patients with CVID can manifest.

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