scholarly journals Bone Regeneration in Iliac Crestal Defects: An Experimental Study on Sheep

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Antonio Scarano ◽  
Felice Lorusso ◽  
Lorenzo Ravera ◽  
Carmen Mortellaro ◽  
Adriano Piattelli
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Bone Defect ◽  
Iliac Crest ◽  
Statistical Evaluation ◽  
Control Site ◽  
Routine Procedure ◽  
Oral Rehabilitation ◽  
Edentulous Patients ◽  
A Site

Background. Oral rehabilitation of partially fully edentulous patients with dental implants has become a routine procedure in clinical practice. In a site with a lack of bone GBR is a surgical procedure that provides an augmentation in terms of volume for the insertion of dental implants.Materials and Methods. In the iliac crest of six sheep 4 defects were created where an implant was inserted, three of them with different biomaterials and a control site. All animals were sacrificed after a 4-month healing period. All specimens were processed and analyzed with histomorphometry. Statistical evaluation was done to evaluate percentage of bone defect filled by new bone.Results. All experimental groups showed an increase of the new bone. Higher and highly statistically significant differences were found in the percentages of bone defect filled by new bone in group filled with corticocancellous 250–1000 microns particulate porcine bone mix.Conclusions. This study demonstrates that particulate porcine bone mix and porcine corticocancellous collagenate prehydrated bone mix when used as scaffold are able to induce bone regeneration. Moreover, these data suggest that these biomaterials have higher biocompatibility and are capable of inducing faster and greater bone formation.

scholarly journals Oral microbial profile variation during canine ligature-induced peri-implantitis development

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shichong Qiao ◽  
Dongle Wu ◽  
Mengge Wang ◽  
Shujiao Qian ◽  
Yu Zhu ◽  
...  
Keyword(s):  
Dental Implants ◽  
Keystone Species ◽  
Operational Taxonomic Unit ◽  
Canine Model ◽  
Rrna Gene ◽  
Oral Rehabilitation ◽  
Core Microbiome ◽  
Network Analyses ◽  
Microbial Profile ◽  
Edentulous Patients

Abstract Background Dental implants have become well-established in oral rehabilitation for fully or partially edentulous patients. However, peri-implantitis often leads to the failure of dental implants. The aim of this study was to understand the core microbiome associated with peri-implantitis and evaluate potential peri-implantitis pathogens based on canine peri-implantitis model. Results In this study, three beagle dogs were used to build peri-implantitis models with ligature-induced strategy. The peri-implant sulcular fluids were collected at four different phases based on disease severity during the peri-implantitis development. Microbial compositions during peri-implantitis development were monitored and evaluated. The microbes were presented with operational taxonomic unit (OTU) classified at 97% identity of the high-throughput 16S rRNA gene fragments. Microbial diversity and richness varied during peri-implantitis. At the phylum-level, Firmicutes decreased and Bacteroides increased during peri-implantitis development. At the genus-level, Peptostreptococcus decreased and Porphyromonas increased, suggesting peri-implantitis pathogens might be assigned to these two genera. Further species-level and co-occurrence network analyses identified several potential keystone species during peri-implantitis development, and some OTUs were potential peri-implantitis pathogens. Conclusion In summary, canine peri-implantitis models help to identify several potential keystone peri-implantitis associated species. The canine model can give insight into human peri-implantitis associated microbiota.

scholarly journals Interimplant Papilla Reconstruction by Using Demineralized Freeze Dried Bone Allograft Block Fixed by Titanium Screw: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Preeti Charde ◽  
M. L. Bhongade ◽  
Aniruddha Deshpande ◽  
Anendd Jadhav ◽  
Kaustubh Thakare ◽  
...  
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Dental Implants ◽  
Treatment Modality ◽  
Bone Allograft ◽  
Oral Rehabilitation ◽  
Titanium Screw ◽  
Early Loading ◽  
Freeze Dried ◽  
Edentulous Patients

Dental implants are now considered as a predictable treatment modality for the oral rehabilitation of partially or fully edentulous patients. Recently emphasis has changed towards achieving a predictable esthetic success. Creating aesthetically successful implant-supported restoration in the anterior region of oral cavity depends on the presence of interimplant papilla when multiple implants are used. The present paper reports a case of interimplant papilla reconstruction in esthetic zone of maxilla during one stage early loading multiple implant procedure using demineralized freeze dried bone allograft block fixed by titanium screw.

scholarly journals Guided bone regeneration in the anterior maxilla after tooth extraction and implant removal with sticky bone and L-PRF membrane in two surgical approaches

2021 ◽  
Vol 10 (11) ◽  
pp. e112101119456
Author(s):  
Jose Sandro Ponte ◽  
Alberto Tadeu da Frota Nogueira ◽  
Jacques Antonio Cavalcante Maciel ◽  
Igor Iuco Castro-Silva
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Case Reports ◽  
Treatment Success ◽  
Guided Bone Regeneration ◽  
Radiographic Examination ◽  
Surgical Approaches ◽  
Oral Rehabilitation ◽  
Anterior Maxilla ◽  
Main Requirement

The main requirement for the insertion of dental implants is a good bone and gum condition and guided bone regeneration (GBR) combines grafts and membranes to increase such parameters in tissue deficiencies and thus achieve treatment success. This clinical case reports the oral rehabilitation of the anterosuperior area by the association of bone graft, autologous membrane and implantodontic therapy. Female patient, 45 years old, normosystemic, reported aesthetic complaint and implant mobility in the maxilla. Upon clinical and radiographic examination, an implant was diagnosed in the region of tooth 11 with unfavorable esthetics, mobility, inadequate prosthesis and bone loss, and tooth 22 with suppuration, fracture line and periapical radiolucency. The treatment consisted of removal of the implant and tooth 22, with immediate GBR using filling with Bio-Oss® and liquid leukocyte- and platelet-rich fibrin (L-PRF) and coating with L-PRF membrane. After 7 months, the second GBR was performed with the installation of 2 dental implants. After 6 months, healers were placed and 20 days after the adaptation of the provisional implant-supported single prostheses. There was a good gain in thickness and mucogingival limit, bone dimensions in height and thickness, and the case continues to be followed up until the final prosthesis is completed. This case suggests that sticky bone and L-PRF membrane can contribute to multiple GBR in the anterior maxillary region, favoring bone gain and osseointegration.

scholarly journals Reconstruction of comminuted jaw with iliac crest graft and implant-supported prostheses – case report

2020 ◽  
Vol 9 (10) ◽  
pp. e8169109175
Author(s):  
Camila Fernanda Vasconcelos ◽  
Andressa Bolognesi Bachesk ◽  
José Henrique Santana Quinto ◽  
Willian Pecin Jacomacci ◽  
Caio Cesar Santos Patron Luiz ◽  
...  
Keyword(s):  
Bone Graft ◽  
Dental Implants ◽  
Iliac Crest ◽  
Autogenous Bone ◽  
Oral Rehabilitation ◽  
Body Fracture ◽  
Iliac Bone Graft ◽  
Fixation Techniques ◽  
Mandibular Body ◽  
Jaw Fractures

Comminuted jaw fractures represent a challenge in terms of treatment. The advancement of fixation techniques and materials has contributed to the surgeon providing faster treatment and less complication. Even so, cases that present severe mandibular fragmentation require additional therapies, such as the use of bone grafts and dental implants, in order to recover function, aesthetics and anatomy of the mandible. This work aims to report a case of comminuted mandibular body fracture, which was treated with reconstruction, initially by rigid internal fixation, and secondly, by iliac bone graft and implant-supported oral rehabilitation. Although studies in the literature demonstrate that autogenous grafts show significant resorption, they are still considered the gold standard, and allow an ideal basis for obtaining osseointegration of dental implants. Thus, we concluded that the use of the autogenous bone graft coming from the iliac crest and rehabilitation with implants can be a satisfactory option for functional and aesthetic repair of patients who presented high impact fractures, and developed significant bone defects.

scholarly journals Collagen Membrane for Guided Cortical Bone Regeneration: Characterization, Preclinical and Proof of Concept Clinical Studies

2020 ◽  
Author(s):  
Brent Allan ◽  
Rui Ruan ◽  
Euphemie Landao-Bassonga ◽  
Nicholas Gillman ◽  
Tao Wang ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Bone Regeneration ◽  
Cortical Bone ◽  
Dental Implants ◽  
Bone Defect ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Micro Ct ◽  
Proof Of Concept

Abstract Background: Treatment of cortical bone defects is a clinical challenge. Guided bone regeneration (GBR), commonly used in oral in maxillofacial dental surgery, may show promise for orthopedic application in repair of cortical defects. However, a limitation in the use of GBR for cortical bone defects is the lack of an ideal scaffold that provides sufficient mechanical support to bridge the cortical bone with minimal interference in the repair process. We have developed a new collagen membrane, CelGroTM, for use in GBR. We report the material characterisation of CelGroTM, and evaluate the performance of CelGroTM in translational preclinical and clinical studies. Methods: Scanning electron microscopy (SEM), micro computed tomography (micro-CT) and transmission electron microscopy (TEM) were used to examine the structural morphology of CelGroTM. Purity and biochemical composition of CelGroTM was evaluated by Western-blot, immunohistochemistry and confocal microscopy. Physical and chemical properties of CelGroTM were examined and compared with another commercially available collagen membrane. The pre-clinical evaluation was conducted using a cortical bone defect model in the New Zealand white rabbit. Cortical bone regeneration in defects of the femoral diaphysis were evaluated at 30 days and 60 days after intervention, by micro-CT and histology. A clinical study to evaluate the performance of CelGroTM in GBR for treatment of bone augmentation surrounding dental implants was also performed. The clinical outcomes were evaluated by semi quantitative tissue condition assessments and cone-beam computed tomography (CBCT) scan. Results: CelGroTM has a bilayer structure of different fibre alignment and is composed almost exclusively of type I collagen. CelGroTM was found to be completely acellular and a clinically significant xenoantigen, α -gal, was not detected. CelGroTM displayed less deformity and better mechanical strength as compared to Bio-Gide ® . In the preclinical study, CelGroTM demonstrated enhanced bone-modelling activity and cortical bone healing. Micro-CT evaluation showed early bony bridging over the defect area 30 days post-operatively, and nearly complete restoration of mature cortical bone at the bone defect site 60 days post- operatively. Histological analysis at day 60 after surgery further confirmed that CelGroTM enables bridging of the cortical bone defect by induction of newly-formed cortical bone. It appears that CelGroTM showed better cortical alignment and reduced porosity at the defect interface compared to Bio-Gide®. Owning the fact that selection of orthopedic patients with cortical bone defects is complex, we conducted the proof of concept clinical study in a total of 16 dental implants which were placed in 10 participants receiving GBR. The results showed that there were with no complications or adverse events observed. CBCT evidenced efficiency of the CelGroTM scaffold for GBR for the dental implants, showing significantly decreased 2 distance from the implant shoulder to first bone/implant contact (DIB) and increased horizontal thickness of facial bone wall (HT). Conclusion: The findings of our study demonstrate that CelGroTM is an ideal membrane for GBR not only in oral maxillofacial reconstructive surgery but also in orthopedic applications. Details of clinical trial registration: “Single centre, open-label, pilot study of Celgro(tm) collagen membrane for guided bone regeneration around exposed implants in patients undergoing dental implant surgery”; Registration ID: ACTRN12615000027516; Date of registration: 19/01/2015; URL: https://anzctr.org.au/ACTRN12615000027516.aspx

A STUDY ON CLINICAL AND X - RAY FEATURES OF PARTIALLY  EDENTULOUS PATIENTS WITH DENTAL IMPLANT

2011 ◽  
pp. 96-103
Author(s):  
Quang Hai Nguyen ◽  
Toai Nguyen
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Tooth Loss ◽  
Permanent Teeth ◽  
Missing Teeth ◽  
X Ray ◽  
Lower Jaw ◽  
Molar Teeth ◽  
Edentulous Patients ◽  
Missing Tooth

1. Background: Loss of permanent teeth is very common, affected chewing function, speech and aesthetics; restoration of missing teeth with dental implant has several advantages, but we need thoroughly study the clinical and X ray features at the position at missing teeth, then to select the type of implant and make the best plan for the dental implant patients. 2. Materials and method: Cross-section descriptive study. From January 2009 to November 2010, study with 56 patients with 102 implants of MIS and Megagen systems at the Faculty of Odonto-Stomatology, Hue College of Medicine and Pharmacy and Vietnam-Cuba Hospital in Ha Noi. 3. Results: Distributed equally in male and female, common ages 40 – 59 (55,4%), the majority of missing teeth occurs in the lower jaw (63,8%) and especially, the teeth 36 and 46 (25,4%). The majority of missing teeth due to dental caries, dental pulp and apical diseases (64,7%) of the molar teeth (51,9%); the most position of missing tooth have enough bone for dental implants (87,3%), time of tooth loss and bone status in the position of tooth loss are related to each other (p < 0,01). Diameter and length of implant usually used 4.0 – 6.0 mm (63,7%) and 8.5 – 13.0 mm (83,3%). 4. Conclusion: Clinical and X ray features of edentulous patients has an important role in determining the type of implants and treatment planning of dental implants. Key words: Loss of permanent teeth, X ray and clinical features, Dental implant.

scholarly journals Construction of hollow polydopamine nanoparticle based drug sustainable release system and its application in bone regeneration

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Lu Wang ◽  
Shuwei Liu ◽  
Chunxia Ren ◽  
Siyuan Xiang ◽  
Daowei Li ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Load Capacity ◽  
Good Prospect ◽  
Alizarin Red ◽  
Drug Load ◽  
Load Rate ◽  
Low Toxicity

AbstractNanomaterial-based drug sustainable release systems have been tentatively applied to bone regeneration. They, however, still face disadvantages of high toxicity, low biocompatibility, and low drug-load capacity. In view of the low toxicity and high biocompatibility of polymer nanomaterials and the excellent load capacity of hollow nanomaterials with high specific surface area, we evaluated the hollow polydopamine nanoparticles (HPDA NPs), in order to find an optimal system to effectively deliver the osteogenic drugs to improve treatment of bone defect. Data demonstrated that the HPDA NPs synthesized herein could efficiently load four types of osteogenic drugs and the drugs can effectively release from the HPDA NPs for a relatively longer time in vitro and in vivo with low toxicity and high biocompatibility. Results of qRT-PCR, ALP, and alizarin red S staining showed that drugs released from the HPDA NPs could promote osteogenic differentiation and proliferation of rat bone marrow mesenchymal stem cells (rBMSCs) in vitro. Image data from micro-CT and H&E staining showed that all four osteogenic drugs released from the HPDA NPs effectively promoted bone regeneration in the defect of tooth extraction fossa in vivo, especially tacrolimus. These results suggest that the HPDA NPs, the biodegradable hollow polymer nanoparticles with high drug load rate and sustainable release ability, have good prospect to treat the bone defect in future clinical practice.

scholarly journals Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

2021 ◽  
Vol 12 ◽  
pp. 204173142110042
Author(s):  
Rao Fu ◽  
Chuanqi Liu ◽  
Yuxin Yan ◽  
Qingfeng Li ◽  
Ru-Lin Huang
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Repair ◽  
Endochondral Ossification ◽  
Current Knowledge ◽  
Endochondral Bone ◽  
Defect Reconstruction ◽  
Hypoxic Conditions ◽  
Bone Defect Reconstruction

Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation by mimicking the embryological process of intramembranous ossification. However, the clinical translation of these clinical strategies for bone repair is hampered by limited vascularization and poor bone regeneration after implantation in vivo. An alternative strategy for overcoming these drawbacks is engineering cartilaginous constructs by recapitulating the embryonic processes of endochondral ossification (ECO); these constructs have shown a unique ability to survive under hypoxic conditions as well as induce neovascularization and ossification. Such developmentally engineered constructs can act as transient biomimetic templates to facilitate bone regeneration in critical-sized defects. This review introduces the concept and mechanism of developmental BTE, explores the routes of endochondral bone graft engineering, highlights the current state of the art in large bone defect reconstruction via ECO-based strategies, and offers perspectives on the challenges and future directions of translating current knowledge from the bench to the bedside.

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