scholarly journals Docosahexaenoic Acid Rescues Synaptogenesis Impairment and Long-Term Memory Deficits Caused by Postnatal Multiple Sevoflurane Exposures

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Guorong Tao ◽  
Yan Luo ◽  
Qingsheng Xue ◽  
Guohui Li ◽  
Yongchang Tan ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Spatial Memory ◽  
Animal Studies ◽  
Morphological Changes ◽  
Memory Deficits ◽  
Morris Water Maze Test ◽  
Long Term Memory ◽  
Term Memory ◽  
Transmission Electron

Sevoflurane exposures were demonstrated to induce neurotoxicity in the developing brain in both human and animal studies. However, there is no effective approach to reverse it. The present study aimed to evaluate the feasibility of utilizing docosahexaenoic acid (DHA) to prevent sevoflurane-induced neurotoxicity. P6 (postnatal 6 days) mice were administrated DHA after exposure to 3% sevoflurane for two hours daily in three consecutive days. Molecular expressions of synaptic makers (PSD95, synaptophysin) and synaptic morphological changes were investigated by Western blot analysis and transmission electron microscopy, respectively. Meanwhile, Morris water maze test was used to assess spatial memory of mice at P31 (postnatal 31 days). DHA restored sevoflurane-induced decreased level of PSD95 and synaptophysin expressions and increased PSD areas and also improved long-term spatial memory. These results suggest that DHA could rescue synaptogenesis impairment and long-term memory deficits in postnatal caused by multiple sevoflurane exposures.

Abstract P783: Alpha 7 -Acetylcholine Receptor Signaling Reduces Neuronal Apoptosis After Subarachnoid Hemorrhage

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Ari Dienel ◽  
Remya A Veettil ◽  
Kanako Matsumura ◽  
Peeyush Kumar T. ◽  
Spiros Blackburn ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Acetylcholine Receptor ◽  
Neuronal Apoptosis ◽  
Neuronal Survival ◽  
Memory Function ◽  
Memory Deficits ◽  
Long Term Memory ◽  
Term Memory ◽  
Receptor Knockout Mouse

Subarachnoid hemorrhage induces neuronal apoptosis which causes acute and long-term memory deficits. Ourhypothesis is that agonism of α7-acetylcholine receptors attenuates neuronal apoptosis and improves memorydeficits in SAH mice. Mice were randomly assigned into the experimental groups. One cohort was euthanizedone day after SAH to assess neuronal apoptosis and signaling pathways. A second cohort survived for 30 dayspost-SAH to test long-term memory function. Inhibitors and an α7-acetylcholine receptor knockout mouse wereused. Neurobehavioral performance was assessed on days 1-3, 5, 7, and 23-28. All outcomes were performedand all data was analyzed by a blinded investigator. The α7-acetylcholine receptor agonist prevented neuronalapoptosis and improved acute memory deficits caused by SAH via activation of the PI3K/Akt pathway in neurons.Agonism of the α7-acetylcholine receptor was beneficial in both male and female mice, although the protectionin females was significantly better than in male mice. α7-acetylcholine receptor agonism did not provide anybenefit in α7-acetylcholine receptor knockout mice subjected to SAH. Treatment with the α7-acetylcholinereceptor agonist for 3 days after SAH led to improved working memory one month after SAH suggesting thatacutely improving neuronal survival can have long-lasting benefits. The α7-acetylcholine receptor may be atherapeutic target for SAH which can promote neuronal survival acutely after SAH, but also confer long-lastingmemory benefits. The findings of this study support the α7-acetylcholine receptor as a treatment target whichmay attenuate the long-term memory deficits which SAH patients suffer from.

scholarly journals Prenatal Exposure to Cadmium During Organogenesis Impairs Memory in Young Rats

2019 ◽  
Vol 38 (4) ◽  
pp. 312-318 ◽  
Author(s):  
Fernanda Gumilar ◽  
Cristina Bras ◽  
Patricia Aggio ◽  
Sergio Domínguez ◽  
Mariana Bartos ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Radial Maze ◽  
Inhibitory Avoidance ◽  
Male Offspring ◽  
Control Group ◽  
Long Term Memory ◽  
Pregnant Rats ◽  
Term Memory ◽  
Step Down

Pregnant rats were treated with 0.3 and 0.6 mg cadmium (CdCl2)/kg injected subcutaneously on a daily basis from gestational day 7 to day 15 (organogenesis period). One control group was not injected and other received saline. The 45-day-old offspring were tested in a step-down inhibitory avoidance to evaluate short-term and long-term memory and in a radial maze for the study of spatial memory. These studies showed that gestational exposure to 0.6 mg Cd/kg produced in the male offspring a significant impairment in the retention of long-term memory evaluated 24 hours after training in the step-down inhibitory avoidance. The radial maze also demonstrated that the male offspring prenatally exposed to 0.6 mg Cd presented a significant deficit in the retention of spatial memory evaluated 42 days after training. These results demonstrate that the exposure to Cd during organogenesis may affect the retention of some types of memory.

scholarly journals Morphological changes of neurons involved in long-term memory in day-old chicks hatching from hypomagnetic field space

2012 ◽  
Vol 7 (43) ◽  
pp. 5827-5836 ◽  
Author(s):  
Wang Xuebin ◽  
Lin Guang Zhe ◽  
Li Junfeng ◽  
Zhang Xu ◽  
Xu Muling ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Long Term Memory ◽  
Term Memory ◽  
Hypomagnetic Field

Developmental exposure to methylmercury elicits early cell death in the cerebral cortex and long‐term memory deficits in the rat

2008 ◽  
Vol 27 (2) ◽  
pp. 165-174 ◽  
Author(s):  
Luca Ferraro ◽  
Maria Cristina Tomasini ◽  
Sergio Tanganelli ◽  
Roberta Mazza ◽  
Addolorata Coluccia ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Cortex ◽  
Memory Deficits ◽  
Long Term Memory ◽  
Developmental Exposure ◽  
Term Memory

PDE-7 Inhibitor BRL-50481 Reduces Neurodegeneration and Long-Term Memory Deficits in Mice Following Sevoflurane Exposure

2020 ◽  
Vol 11 (9) ◽  
pp. 1353-1358 ◽  
Author(s):  
Yingle Chen ◽  
Shunyuan Li ◽  
Xianmei Zhong ◽  
Zhenming Kang ◽  
Rulei Chen
Keyword(s):  
Memory Deficits ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Selenofuranoside improves long-term memory deficits in rats after exposure to monosodium glutamate: Involvement of Na+, K+-ATPase activity

2018 ◽  
Vol 184 ◽  
pp. 27-33 ◽  
Author(s):  
Juliana Bernera Ramalho ◽  
Aryele Pinto Izaguirry ◽  
Melina Bucco Soares ◽  
Cristiano Chiapinotto Spiazzi ◽  
Natasha Frasson Pavin ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Monosodium Glutamate ◽  
Memory Deficits ◽  
Long Term Memory ◽  
Term Memory

Long-term memory deficits in patients with malignant gliomas

1995 ◽  
Vol 25 (3) ◽  
pp. 227-238 ◽  
Author(s):  
P�r Salander ◽  
Thomas Karlsson ◽  
Tommy Bergenheim ◽  
Roger Henriksson
Keyword(s):  
Malignant Gliomas ◽  
Memory Deficits ◽  
Long Term Memory ◽  
Term Memory
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