scholarly journals Association of Alanine Aminotransferase and Periodontitis: A Cross-Sectional Analysis—NHANES 2009–2012

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
R. Constance Wiener ◽  
Usha Sambamoorthi ◽  
Richard J. Jurevic

Objective. Alanine Aminotransferase is an enzyme associated with not only liver diseases, liver conditions, and metabolic syndrome, but also inflammation. Periodontitis is associated with increased cytokines and other markers of inflammation. The purpose of this study is to determine if an independent association between Alanine Aminotransferase and periodontitis exists.Methods. Data from the 2009-2010 and 2011-2012 National Health and Nutrition Surveys (NHANES) were combined. Data concerning periodontitis and Alanine Aminotransferase were extracted and analyzed with Rao Scott Chi-square and logistic regressions. Serum Alanine Aminotransferase was dichotomized at 40 units/liter, and periodontitis was dichotomized to the presence or absence of periodontitis.Results. In bivariate Chi-square analyses, periodontitis and Alanine Aminotransferase were associated (p=0.0360) and remained significant in unadjusted logistic regression (OR = 1.30 [95% CI: 1.02, 1.65]). However, when other known risk factors of periodontitis were included in the analyses, the relationship attenuated and failed to reach significance (adjusted OR = 1.17 [95% CI: 0.85, 1.60]).Conclusion. Our study adds to the literature a positive but attenuated association of serum Alanine Aminotransferase with periodontitis which failed to reach significance when other known, strong risk factors of periodontitis were included in the analysis.

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiajing Jia ◽  
Ying Yang ◽  
Fangchao Liu ◽  
Minjin Zhang ◽  
Qin Xu ◽  
...  

Abstract Background Inconsistent results were found in the association between serum alanine aminotransferase (ALT) and hypertension among population-based studies. This study evaluated the association between ALT and hypertension among Chinese reproductive-age population by utilizing registration data from National Free Pre-pregnancy Checkups Project in 2016–2017. Methods The 21,103,790 registered participants were eligible for analysis, including women who were 20–49 years old and men who were 20–59 years old with available data for ALT and blood pressure (BP). Logistic regression was conducted to estimate odds ratio (OR) for the association between ALT and hypertension as a binary outcome. Linear regression was used to examine the association between ALT and BP as a continuous outcome. Results In total, 4.21% of the participants were hypertensive, and 11.67% had elevated ALT (> 40 U/L). Hypertension prevalence was 3.63% and 8.56% among participants with normal and elevated ALT levels. A strong linear relationship was found between serum ALT levels and the odds of hypertension after adjustment for potential confounders. The multivariable-adjusted ORs for hypertension were 1, 1.22 (1.21, 1.22), 1.67 (1.65 1.68), 1.78 (1.76, 1.80), and 1.92 (1.90, 1.94) in participants with ALT levels of ≤ 20, 20.01–40, 40.01–60, 60.01–80, and > 80 U/L, respectively. Systolic and diastolic BPs rose by 1.83 and 1.20 mmHg on average, for each 20 U/L increase in ALT (P for trend < 0.001). The association was consistent among subgroups and tended to be stronger among populations who are overweight (body mass index ≥ 24 kg/m2) (χ2 = 52,228, P < 0.001), alcohol drinking (χ2 = 100,730, P < 0.001) and cigarette smoking (χ2 = 105,347, P < 0.001). Conclusions Our cross-sectional analysis suggested a linear association between serum ALT and hypertension or BP, which indicated that abnormal liver metabolism marked by elevated serum ALT could play a role in hypertension or elevated BP condition.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Svein Ivar Bekkelund

Abstract Background High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population. Methods Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP). Results Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88–1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86–0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found. Conclusion This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies.


Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1780 ◽  
Author(s):  
Alwerdt ◽  
Patterson ◽  
Sliwinski

Sex hormone changes in adults are known to play a part in aging, including cognitive aging. Dietary intake of phytoestrogens can mimic estrogenic effects on brain function. Since sex hormones differ between genders, it is important to examine gender differences in the phytoestrogen–cognition association. Therefore, the goal of this study is to examine the relationship between urinary phytoestrogens and speed of processing (SOP) and the variation of the association between genders in older adults. Participants were drawn from the 1999–2002 National Health and Nutrition Examination Survey and included 354 individuals aged 65–85 years old. General linear models (GLMs) were used to test for significant gender differences in the relationship between phytoestrogens and SOP. Results from the GLMs showed significant gender differences in the relationship between genistein and SOP. Higher levels of genistein were associated with better SOP in women. This relationship was reversed in men: higher genistein levels were associated with worse performance. Results indicate that there are distinct gender differences in the relationship between genistein and SOP. These results emphasize the importance of considering gender differences when devising dietary and pharmacologic interventions that target phytoestrogens to improve brain health.


2021 ◽  
Vol 12 (2) ◽  
pp. 487
Author(s):  
Tauseef AMAN ◽  
Mussawar SHAH ◽  
Humera JAMAL ◽  
Younas KHAN ◽  
Muhammad ARIF ◽  
...  

The major objective of this study was to measure the association between various interventions and Chitral Gole National Park (CGNP) role in preservation of bio-diversity and socio-economic uplift. A sample size of 346 respondents was randomly selected from total population of 3326 from the 4 selected villages on the basis of close proximity. A conceptual framework including dependent variable social development and independent variable tourism development were taken. The data were analyzed through frequency and percentage distribution. Moreover, Chi-square test was applied to know the relationship between dependent and independent variables at bi-variate level. In bi-variate analysis a highly significant (P=0.000) relation was found between CGNP is main source of promoting tourism in Chitral,tourists do any impacts upon local community in terms of increased business activities, local culture is safeguarded despite influx of tourists in the area, tourism produced employment opportunities, and social development. Qualitative data supported the empirical findings, however tourism brings economic opportunities at micro and macro level, but unfortunately CGNP is not as satisfactory regarding generating income since its establishment. The government should ensure to make such polices pertaining to the entrance fee, provides accommodation services on payment to the tourists and to reserve the entrance fee or any other form of taxes to ensure CGNP to spend on self-sustaining basis by ensuring refinement in the procedures as well.


2018 ◽  
Vol 6 (1) ◽  
pp. 43
Author(s):  
Desy Amanda ◽  
Santi Martini

Background: The prevalence of hypertension in Indonesia was 25,80% in 2013 found in people aged above 18 years old. One of the risk factors is obesity. Purpose: This study aimed to analyze the relationship between the demographical characteristic and central obesity with the risk of hypertension in the health center of Sidoarjo. Methods: This analytical observational study design was cross sectional. There were 50 respondents selected through accidental sampling. The independent variables of this study were respondents’ characteristic and central obesity status. However, the dependent variable was hypertension. Overall, respondents were divided into two groups based on sex (female and male) and age (> 59 years old and ≤ 59 years old). Data were analyzed with chi-square statistical analysis. Results: Respondents with central obesity had a higher risk to get hypertension, with majority male respondents aged above 59 years old. Conclusion: There was a correlation between age and hypertension (p = 0,01), sex and hypertension (p = 0,04), also between central obesity status and hypertension (p = 0,01). 


2021 ◽  
Vol 2 (1) ◽  
pp. 23
Author(s):  
Putri Ayu Anjani ◽  
Khairizka Citra Palupi ◽  
Mertien Sa’pang ◽  
Dudung Angkasa ◽  
Vitria Melani

Constipation marked by feces hard one, dry, and difficult issued. About 73.9% pregnant women experience constipation. Increase in the hormone progesterone for pregnant women resulted in drop motility gastrointestinal tract. Constipation affects psychology and causes swelling of the rectum area.To determine the relationship between the level of fiber adequacy, to consumption of Fe tablets and depression and to see the combined risk factors for depression and adherence to consumption of Fe tablets with the incidence of constipation in pregnant women. Design this research is observational analytics with Cross Sectional design. The sample of pregnant women is 55 people with purposive sampling data collection technique. Taking data done with use questionnaire. Statistic test used the chi-square test. 58.2% of pregnant women experienced constipation; 92.7% insufficient fiber sufficiency level; 40.0% adhered to consuming Fe tablets; 55.4% experienced depression; 23.6% of depression was adherent. The results of the chi-square test showed that there was no significant relationship between the level of fiber adequacy and the incidence of constipation in pregnant women (p = 0.298) and a significant relationship with the incidence of constipation in pregnant women, namely consuming Fe tablets (p = 0.039; OR = 4.080), depression (p = 0.026; OR = 4.125), risk factors for the combination of depression and adherence to consumption of Fe tablets (p = 0.005).Compliance with Fe tablet consumption and depression can increase the risk of constipation in pregnant women by 4,080 times and 4,125 times.


2021 ◽  
Vol 4 (1) ◽  
pp. 77-86
Author(s):  
Siti Arofah Siregar ◽  
Rapida Saragih

According to the World Health Organization (WHO), 15-50% of maternal deaths are caused by abortion. Data shows the possibility of a fairly high percentage, approximately 15-40% the number of known occurrences on mothers who already stated positively pregnant, and 60-75% of abortion occurs before the pregnancy reaches 12 weeks. This research investigates the relationship between the mother’s characteristics with the abortion case in the RSU Muhammadiyah. The investigation was conducted in a cross-sectional analysis. The population is 42 mothers who experienced abortion in the RSU Muhammadiyah based on medical record year 2020. Statistical analysis using chi-square with the p-value of age, parity, and education parameters are 0,002, 0.017, and 0.004 respectively. This data showed that there was a relationship between age, parity, and education with abortion cases in RSU Muhammadiyah Medan. This report might be useful for the government and stakeholders in controlling the abortion case in Medan.


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