scholarly journals Antinociceptive Activity ofZanthoxylum piperitumDC. Essential Oil

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Graciela Rocha Donald ◽  
Patrícia Dias Fernandes ◽  
Fabio Boylan
Keyword(s):  
Animal Models ◽  
Essential Oil ◽  
Medicinal Plant ◽  
Antinociceptive Effect ◽  
Leukocyte Migration ◽  
Antinociceptive Activity ◽  
Hot Plate ◽  
Air Pouch ◽  
Zanthoxylum Piperitum ◽  
Inflammatory Effect

Zanthoxylum piperitumDC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO). The major component present in the essential oil was beta-phellandrene (29.39%). Its antinociceptive activity was tested through animal models (formalin-, capsaicin-, and glutamate-induced paw licking and hot plate). The anti-inflammatory effect was evaluated through the carrageenan-induced leukocyte migration into the subcutaneous air pouch (SAP), with measurement of cytokines. The results showed antinociceptive effect for ZPEO for the first phase of the formalin-induced licking, glutamate, and hot plate tests. However, ZPEO had no effect on reducing paw licking induced by capsaicin. Finally, ZPEO had no effect against inflammation induced by carrageenan.

Antinociceptive and Antiedematogenic Activities of Andrographolide Isolated From Andrographis paniculata in Animal Models

2009 ◽  
Vol 11 (3) ◽  
pp. 293-301 ◽  
Author(s):  
M.R. Sulaiman ◽  
Z.A. Zakaria ◽  
A. Abdul Rahman ◽  
A.S. Mohamad ◽  
M.N. Desa ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Animal Models ◽  
Motor Coordination ◽  
Human Studies ◽  
Andrographis Paniculata ◽  
Antinociceptive Activity ◽  
Paw Edema ◽  
Hot Plate ◽  
Experimental Animals

The current study was performed to evaluate the antinociceptive and antiedematogenic properties of andrographolide isolated from the leaves of Andrographis paniculata using two animal models. Antinociceptive activity was evaluated using the acetic acid— induced writhing and the hot-plate tests, while antiedematogenic activity was measured using the carrageenan-induced paw edema test. Subcutaneous (s.c.) administration of andrographolide (10, 25, and 50 mg/kg) did not affect the motor coordination of the experimental animals but produced significant (p < .05) antinociceptive activity when assessed using both tests. However, 2 mg/kg naloxone failed to affect the 25 mg/kg andrographolide activity in both tests, indicating that the activity was modulated via nonopioid mechanisms. Furthermore, andrographolide showed significant (p < .05) antiedematogenic activity. In conclusion, the results obtained suggest that andrographolide has antinociceptive and antiedematogenic activities; it may be useful for treating pain and inflammation once human studies are conducted.

scholarly journals Chemical composition and antinociceptive activity of volatile fractions of the aerial parts of Solidago chilensis (Compositae)

Rodriguésia ◽  
2020 ◽  
Vol 71 ◽  
Author(s):  
Simone Sacramento Valverde ◽  
Stefânia Priscilla de Souza ◽  
Temistocles Barroso de Oliveira ◽  
Andressa Maia Kelly ◽  
Nathalia Ferreira Costa ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Antinociceptive Effect ◽  
Antinociceptive Activity ◽  
Gas Chromatography Mass Spectrometry ◽  
Aerial Parts ◽  
Germacrene D ◽  
Solidago Chilensis

Abstract Thirty-six compounds were identified from aerial parts of Solidago chilensis cultivated at PAF/FIOCRUZ campus in Rio de Janeiro city (RJ) using solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) analysis. These compounds are mainly non-oxygenated mono and sesquiterpenes. Germacrene D is the major compound of two the essential oil analyzed samples (12 to 23%) and of two of the volatiles samples analyzed by SPME (central stems and dry inflorescences samples). Limonene is the major compound in the fresh inflorescences sample (about 21%). The bornil acetate is present in both volatile fractions (16%) and essential oils (7-8%). All the essential oils samples evaluated shown a great antinociceptive activity, considering the used dose of the samples (1 mg/kg) and the standard substance (50 mg/kg). Solidago chilensis is one of Brazil arnicas and it is a medicinal plant widely used by the brazilian population. Other plants of the genus Solidago are also used in traditional medicine in North America and Europe. This is the first report of SPME analysis from Solidago genus and of the antinociceptive effect from Solidago chilensis essential oil.

scholarly journals Characterization of the Antinociceptive Activity from Stevia serrata Cav

Biomedicines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 79
Author(s):  
Millena S. Cordeiro ◽  
Daniel L. R. Simas ◽  
Juan F. Pérez-Sabino ◽  
Max S. Mérida-Reyes ◽  
Manuel A. Muñoz-Wug ◽  
...  
Keyword(s):  
Essential Oil ◽  
Mechanism Of Action ◽  
Enzyme Inhibitor ◽  
Antinociceptive Effect ◽  
Area Under The Curve ◽  
Treated Group ◽  
Hot Plate ◽  
Gastrointestinal Problems ◽  
Higher Doses

Background: Stevia serrata Cav. (Asteraceae), widely found in Guatemala, is used to treat gastrointestinal problems. The aim of this study was to demonstrate the antinociceptive and anti-inflammatory effects of the essential oil (EO) and the mechanism of action. Methods: EO was tested in chemical (capsaicin- and glutamate-induced licking response) or thermal (hot plate) models of nociception at 10, 30 or 100 mg/kg doses. The mechanism of action was evaluated using two receptor antagonists (naloxone, atropine) and an enzyme inhibitor (L-NAME). The anti-hyperalgesic effect was evaluated using carrageenan-induced nociception and evaluated in the hot plate. Results: All three doses of EO reduced licking response induced by glutamate, and higher doses reduced capsaicin-induced licking. EO also increased area under the curve, similar to the morphine-treated group. The antinociceptive effect induced by EO was reversed by pretreatment of mice with naloxone (1 mg/kg, ip), atropine (1 mg/kg, ip) or L-NAME (3 mg/kg, ip). EO also demonstrated an anti-hyperalgesic effect. The 100 mg/kg dose increased the latency time, even at 1 h after oral administration and this effect has been maintained until the 96th hour, post-administration. Conclusions: Our data suggest that essential oil of S. serrata presents an antinociceptive effect mediated, at least in part, through activation of opioid, cholinergic and nitrergic pathways.

scholarly journals Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex

2021 ◽  
Vol 20 (2) ◽  
pp. 162-176
Author(s):  
Renan Marinho Braga ◽  
◽  
Humberto Hugo Nunes de Andrade ◽  
Humberto de Carvalho Aragao Neto ◽  
Ryldene Marques Duarte da Cruz ◽  
...  
Keyword(s):  
Essential Oil ◽  
Inclusion Complex ◽  
Antinociceptive Effect ◽  
Experimental Models ◽  
Complex Formulation ◽  
Cyclodextrin Inclusion ◽  
Leucocyte Migration ◽  
Prevalence Of Pain ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Lippia pedunculosa Hayek (EOLp) presents tripanocid and amebicid effects. However essential oil needs to be further studied in experimental models of analgesia and inflammation once the prevalence of pain in the population generates great suffering and disability and the drugs most often used have undesirable side effects. We also evaluated whether the inclusion complex formulation EOLp/β-cyclodextrin (β-CD) was able to improve the antinociceptive activity of the EOLp alone. Data were evaluated by analysis of variance (ANOVA), followed by Tukey’s test. Differences were considered significant if p<0.05. EOLp presented better antinociceptive effect when compared to the EOLp/β-CD inclusion complex. Thus, cyclodextrins appear not to be efficient for essential oils with peroxide substances. However, in peritonitis, EOLp reduced total leucocyte migration and IL-1β levels in the peritoneal fluid, which confirmed its anti-inflammatory effect. The observed effects suggest that EOLp is the best promising option for the treatment of inflammation and pain-related disorders.

scholarly journals Analgesic and anti-inflammatory activity of 5,7-diacyl-3-H(alkіl)-6- aryl-5H-[1,2,4]triazol[3,4-b][1,3,4]tіadiazin derivaties

2015 ◽  
Vol 17 (2) ◽  
Author(s):  
O. Ye. Yadlovskyi ◽  
А. Ya. Koval ◽  
N. M. Seredynska ◽  
T. A. Bukhtiarova ◽  
T. A. Bershova ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Specific Activity ◽  
Reference Product ◽  
Antinociceptive Effect ◽  
Antinociceptive Activity ◽  
Hot Plate ◽  
Carrageenan Edema ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Derivatives Of

The search for new analgesic and anti-inflammatory drugs, exceeding by efficacy and/or safety the existing<br />analogues is very important and relevant. The nitrogenous heterocycles are promising in this respect, in particular,<br />the compounds containing an imidazole triazol and tіadiazin moiety. The aim of the current study was to investigate<br />the antiexudative and antinociceptive activity of new derivatives of 5,7-diacyl-3-H(alkyl)-6-aryl-5H[1,2,4]triazol[3,4-b]<br />[1,3,4]thiadiazine.<br />The antinociceptive and antiexudative activity studies were carried out on the white nonlinear mice. The<br />experimental evaluation of specific activity was carried out on the models “Hot plate”, acetic acid induced writhing<br />(antinociceptive action) and carrageenan edema (antiexudative action). The substance was used in a single oral rout<br />administration in a dose of 25 mg/kg. Ketorolac was used as a reference product in the dose of 25 mg/kg (models<br />“Hot plate”, acetic acid induced writhing). Diclofenac was used as a reference product in the dose of 25 mg/kg on<br />the model carrageenan edema. The experimental study showed the antinociceptive and antiexudative effects of the<br />derivatives. The antinociceptive activity of 5,7-diacyl-3-H(alkіl)-6-aryl-5H[1,2,4]triazol[3,4-b][1,3,4]tіadiazin derivaties<br />related to the modification structure in the para position of benzene ring. The antiexudative activity is associated with<br />acetyl groups thiadiazine ring. The most promising compound IFT_247 showed a significant antinociceptive effect,<br />which is comparable to an active comparator ketorolac: “Hot plate” +232.46 % and +112.71 %; acetic acid induced<br />writhing -66.67 % and -61.02 %, respectively.

scholarly journals Composition and Antinociceptive Activity of the Essential Oil from Protium Heptaphyllum Resin

2007 ◽  
Vol 2 (12) ◽  
pp. 1934578X0700201 ◽  
Author(s):  
Vietla S. Rao ◽  
Juliana L. Maia ◽  
Francisco A. Oliveira ◽  
Thelma L.G. Lemos ◽  
Mariana H. Chaves ◽  
...  
Keyword(s):  
Essential Oil ◽  
Radiant Heat ◽  
Antinociceptive Activity ◽  
Tail Flick ◽  
Hot Plate ◽  
Thermal Tests ◽  
Hot Plate Test ◽  
Thermal Pain ◽  
Tail Flick Latency ◽  
Latency Response

The chemical composition of the essential oil from Protium heptaphyllum resin was analyzed by GC/MS and the oil examined for antinociceptive activity in chemical and thermal tests. Fourteen compounds were characterized, representing 95.8% of the total essential oil, with the monoterpenes α-phellandrene (10.4%), α-terpinene (13.7%) and 1,8-cineole (58.7%) as major components. Oral administration of the essential oil (50 and 100 mg/kg) significantly inhibited chemical nociception induced by capsaicin and formalin in mice. In rats, the oil also effectively enhanced the radiant heat-induced tail-flick latency response at a dose of 100 mg/kg. However, the essential oil, at either dose, was ineffective against thermal pain in the hot-plate test.

Denudatin A, a Dimeric Acylphloroglucinol from Hypericum denudatum Presents an Antinociceptive Effect in Mice

Planta Medica ◽  
2017 ◽  
Vol 83 (17) ◽  
pp. 1329-1334 ◽  
Author(s):  
Henrique Bridi ◽  
Gabriela Meirelles ◽  
Sérgio Bordignon ◽  
Stela Rates ◽  
Gilsane von Poser
Keyword(s):  
Antinociceptive Effect ◽  
Motor Impairment ◽  
2D Nmr ◽  
Antinociceptive Activity ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Plate Test ◽  
Reported Data

AbstractA new dimeric acylphloroglucinol, denudatin A (1), was isolated from the flowering aerials parts of Hypericum denudatum, along with the known phloroglucinols selancin A (2), hyperbrasilol A (3), uliginosin B (4), and isouliginosin B (5). The structure of 1 was elucidated using 1D, 2D NMR, and MS experiments, and by comparison with previously reported data for Hypericum dimeric acylphloroglucinols. Denudatin A (1) and selancin A (2) were administered orally to mice displaying antinociceptive activity in the hot plate test. The compounds did not induce motor impairment in the rotarod apparatus.

scholarly journals Effect of the Croton rhamnifolioides Essential Oil and the Inclusion Complex (OEFC/β-CD) in Antinociceptive Animal Models

Macromol ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 94-111
Author(s):  
Anita Oliveira Brito Pereira Bezerra Martins ◽  
Maria Rayane Correia de Oliveira ◽  
Isabel Sousa Alcântara ◽  
Lindaiane Bezerra Rodrigues ◽  
Francisco Rafael Alves Santana Cesário ◽  
...  
Keyword(s):  
Essential Oil ◽  
Inclusion Complex ◽  
Antinociceptive Effect ◽  
Hot Plate ◽  
Cyclodextrin Inclusion ◽  
Antinociceptive Effects ◽  
Plate Models ◽  
Leaf Essential Oil ◽  
The Central Nervous System ◽  
Therapy Of Pain

This study aims to evaluate the antinociceptive effect of the C. rhamnifolioides leaf essential oil (OEFC) and the β-cyclodextrin inclusion complex (COEFC) and investigate the pain signaling pathways involved in the antinociceptive response. The effects of the OEFC and COEFC on the central nervous system (CNS) were determined by open field and rota-rod assays, and the antinociceptive effect was evaluated via the acetic acid-induced abdominal contortions, formalin, and hot plate models. Swiss (Mus musculus) male mice (20–30 g) were used in both trials. The OEFC (200 mg/kg/v.o-orally) and COEFC (83.5 mg/kg/v.o.) did not present alterations in the CNS. The OEFC (25, 50, 100, and 200 mg/kg/vo.) and COEFC (8.35, 41.75, and 83.5 mg/kg/v.o.) demonstrated antinociceptive effects in the abdominal contortions, formalin, and hot plate tests. The OEFC (25 mg/kg/v.o.) and COEFC (8.35 mg/kg/v.o.) doses showed that the antinociceptive effect involves the activation of the opioid, cholinergic, and vanilloid systems, as well as the L-arginine/NO and α-2 adrenergic receptor pathways. The antinociceptive potential the OEFC and COEFC demonstrate possible alternatives for the therapy of pain. However, the COEFC presented more significant effects at lower doses than the isolated OEFC, where this action may be justified by the properties and advantages of the complexation.

Contribution of spinal 5-HT5A receptors to the antinociceptive effects of systemically administered cannabinoid agonist WIN 55,212-2 and morphine

2018 ◽  
Vol 96 (6) ◽  
pp. 618-623 ◽  
Author(s):  
Ahmet Goktan Aksu ◽  
Ozgur Gunduz ◽  
Ahmet Ulugol
Keyword(s):  
Receptor Antagonist ◽  
Motor Coordination ◽  
Antinociceptive Effect ◽  
Antinociceptive Activity ◽  
Tail Flick ◽  
Hot Plate ◽  
Rotarod Test ◽  
Antinociceptive Effects ◽  
Cb2 Agonist ◽  
Cannabinoid Agonist

The antinociceptive effects of cannabinoids and opioids have been known for centuries. Serotonin and its receptors are also known to play important roles in nociception. However, the contribution of spinal 5-HT5A receptors in antinociceptive effects of cannabinoids and opioids has not been studied. We conducted this study to clarify spinal mechanisms of the actions of the antinociceptive effects of cannabinoids and opioids. Hot plate and tail flick tests were used to assess the antinociceptive activity in Balb/c mice. WIN 55,212-2, a nonselective CB1 and CB2 agonist, and morphine exerted significant antinociceptive effects at 1, 3, and 10 mg/kg doses administered intraperitoneally in both hot plate and tail flick tests. The selective 5-HT5A receptor antagonist SB-699551 (10 nmol/mouse) was administered intrathecally 10 min before the agonists. SB-699551 significantly reduced the antinociceptive effect of both WIN 55,212-2 and morphine. In the rotarod test, WIN 55,212-2 disrupted the motor coordination at a dose of 10 mg/kg, while morphine did not affect this function at any dose. Our findings show that spinal 5-HT5A receptors are involved in the antinociceptive effects of WIN 55,212-2 and morphine.

scholarly journals Antinociceptive Effect of the Essential Oil Obtained from the Leaves ofCroton cordiifoliusBaill. (Euphorbiaceae) in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Lenise de Morais Nogueira ◽  
Monalisa Ribeiro da Silva ◽  
Simone Maria dos Santos ◽  
Julianna Ferreira Cavalcanti de Albuquerque ◽  
Igor Cavalcanti Ferraz ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Essential Oil ◽  
Antinociceptive Effect ◽  
Antinociceptive Activity ◽  
Opioid Antagonist ◽  
Gas Chromatography Mass Spectrometry ◽  
Semiarid Region ◽  
Ethnobotanical Survey ◽  
Chemically Induced ◽  
Central Nervous Systems

Croton cordiifoliusBaill. is a shrub known as “quebra-faca” and is used to treat inflammation, pain, wounds, and gastrointestinal disturbances in the semiarid region in the northeast of Brazil. In an ethnobotanical survey in the state of Pernambuco, “quebra-faca” use was cited in 33% of the interviews. Thus, we decided to evaluate the antinociceptive effects of the essential oil fromC. cordiifolius(CcEO). Chemical analysis by gas chromatography-mass spectrometry revealed 1,8-cineole (25.09%) andα-phellandrene (15.43%) as major constituents. Antinociceptive activity was evaluated using murine models of chemically induced pain (writhing induced by acetic acid, formalin, capsaicin, and glutamate tests). Opioid and central nervous systems (CNS) involvement were also investigated. Regarding antinociceptive activity, CcEO (50 and 100 mg/kg) reduced the number of writhing responses induced by acetic acid and decreased the licking times in both phases of the formalin test. CcEO also was evaluated in capsaicin- and glutamate-induced nociception. While no effect was observed in the capsaicin test, CcEO (100 mg/kg) was effective in the glutamate test. Naloxone, an opioid antagonist, did not affect the antinociceptive activity of CcEO in writhing test. In conclusion, the antinociceptive effect of CcEO could be explained, at least in part, by inhibition of the glutamatergic system.

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