scholarly journals The Score Model Containing Chinese Medicine Syndrome Element of Blood Stasis Presented a Better Performance Compared to APRI and FIB-4 in Diagnosing Advanced Fibrosis in Patients with Chronic Hepatitis B

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Xiao-Ling Chi ◽  
Mei-Jie Shi ◽  
Huan-Ming Xiao ◽  
Yu-Bao Xie ◽  
Gao-Shu Cai
Keyword(s):  
Blood Stasis ◽  
Advanced Fibrosis ◽  
Yin Deficiency ◽  
Syndrome Element ◽  
Qi Stagnation ◽  
Independent Risk Factors ◽  
Logistical Regression ◽  
Score Model ◽  
Tcm Syndrome ◽  
Logistical Regression Analysis

This study aims to explore a useful noninvasive assessment containing TCM syndrome elements for liver fibrosis in CHB patients. The demographic, clinical, and pathological data were retrospectively collected from 709 CHB patients who had ALT less than 2 times the upper limit of normal from April 2009 to October 2012. Logistical regression and area under receiver-operator curve (AUROC) were used to determine the diagnostic performances of simple tests for advanced fibrosis (Scheuer stage, F ≥ 3). Results showed that the most common TCM syndrome element observed in this CHB population was dampness and Qi stagnation, followed by blood stasis, by heat, and less by Qi deficiency and Yin deficiency. The logistical regression analysis identified AST ≥ 35 IU/L, PLT ≤ 161 × 109/L, and TCM syndrome element of blood stasis as the independent risk factors for advanced fibrosis. Therefore, a score model containing these three factors was established and tested. The score model containing blood stasis resulted in a higher AUC (AUC = 0.936) compared with APRI (AUC = 0.731) and FIB-4 (AUC = 0.709). The study suggested that the score model containing TCM syndrome element of blood stasis could be used as a useful diagnostic tool for advanced fibrosis in CHB patients and presented a better performance compared to APRI and FIB-4.

scholarly journals Meta-Analysis of the Correlation between TCM Syndromes of Lung Cancer and CT through Data Mining and Computer Software

2021 ◽  
Vol 2138 (1) ◽  
pp. 012017
Author(s):  
Yifan Su ◽  
Dehui Li ◽  
Huanfang Fan
Keyword(s):  
Lung Cancer ◽  
Data Mining ◽  
Meta Analysis ◽  
Blood Stasis ◽  
Cochrane Library ◽  
Treatment Level ◽  
Yin Deficiency ◽  
Significant Difference ◽  
Qi Stagnation ◽  
Deficiency Type

Abstract To systematically evaluate the correlation between the traditional Chinese medicine (TCM) syndromes of lung cancer and the imaging manifestations of CT. Computer search of CNKI, Cochrane Library, PubMed, Springer, CBM, VIP, Wanfang database, Baidu library and other major databases. Collect the relevant literature on the TCM syndromes of lung cancer and CT imaging manifestation since the database was built until September 1, 2021. Two researchers collected literature and evaluated the quality of the literature, conducted data mining on the literature, and used the computer Revman 5.3 software to conduct a Meta-analysis of the included literature. The results showed that the phlegm dampness type lobular sign was higher than the burr sign, and there was no significant difference between vacuole sign and cavity sign; In Qi-Yin deficiency type, lobular sign was higher than burr sign, vacuole sign was higher than cavity sign; In Qi stagnation blood stasis type, lobular sign is higher than burr sign. The CT lobular sign of lung cancer are mainly phlegm dampness type, Qi-Yin deficiency type and Qi stagnation blood stasis type. Vacuole sign is mainly Qi-Yin deficiency type. Burr sign and cavity sign are less in the above three types. In this study, the combination of computer and meta-analysis technology has promoted the development of lung cancer micro-differentiation theory and assisted in improving the treatment level of lung cancer clinical syndrome differentiation.

scholarly journals Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Gaosong Wu ◽  
Jing Zhao ◽  
Jing Zhao ◽  
Nixue Song ◽  
Ningning Zheng ◽  
...  
Keyword(s):  
Blood Stasis ◽  
Underlying Mechanism ◽  
Network Pharmacology ◽  
Syndrome Differentiation ◽  
Integrated Analysis ◽  
Glutamate Metabolism ◽  
Biological Basis ◽  
Metabolomics Study ◽  
Qi Stagnation ◽  
Tcm Syndrome

Abstract Background Traditional Chinese Medicine (TCM) is distinguished by Syndrome differentiation, which prescribes various formulae for different Syndromes of same disease. This study aims to investigate the underlying mechanism. Methods Using a strategy which integrated proteomics, metabolomics study for clinic samples and network pharmacology for six classic TCM formulae, we systemically explored the biological basis of TCM Syndrome differentiation for two typical Syndromes of CHD: Cold Congealing and Qi Stagnation (CCQS), and Qi Stagnation and Blood Stasis (QSBS). Results Our study revealed that CHD patients with CCQS Syndrome were characterized with alteration in pantothenate and CoA biosynthesis, while more extensively altered pathways including D-glutamine and D-glutamate metabolism; alanine, aspartate and glutamate metabolism, and glyoxylate and dicarboxylate metabolism, were present in QSBS patients. Furthermore, our results suggested that the down-expressed PON1 and ADIPOQ might be potential biomarkers for CCQS Syndrome, while the down-expressed APOE and APOA1 for QSBS Syndrome in CHD patients. In addition, network pharmacology and integrated analysis indicated possible comorbidity differences between the two Syndromes, that is, CCQS or QSBS Syndrome was strongly linked to diabetes or ischemic stroke, respectively, which is consistent with the complication disparity between the enrolled patients with two different Syndromes. These results confirmed our assumption that the molecules and biological processes regulated by the Syndrome-specific formulae could be associated with dysfunctional objects caused by the Syndrome of the disease. Conclusion This study provided evidence-based strategy for exploring the biological basis of Syndrome differentiation in TCM, which sheds light on the translation of TCM theory in the practice of precision medicine.

scholarly journals Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiaofen Ruan ◽  
Yiping Li ◽  
Yuanlong Sun ◽  
Meijun Jia ◽  
Xiaowen Xu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Research ◽  
Stable Angina ◽  
Conventional Therapy ◽  
Blood Stasis ◽  
Chronic Stable Angina ◽  
Blood Stasis Syndrome ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Qi Stagnation

Abstract Background Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interventions for stable angina, none of them can significantly reduce mortality. Both basic and clinical research have shown that Suxiao Jiuxin Pill (SJP) can relieve the symptoms of angina pectoris and improve the clinical efficacy, but there is a lack of high-quality clinical research to provide research-based evidence. We design a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of SJP for stable angina. Methods/design This is a prospective, randomized, double-blind, placebo-controlled, and multicenter trial. The trial will enroll 324 participants with chronic stable angina (Qi Stagnation and Blood Stasis syndrome). All participants will have received the conventional therapy of chronic stable angina. Participants will be randomized into two groups, conventional therapy plus SJP group and conventional therapy plus placebo group. Eligible participants will receive either SJP or placebo (five pills administered orally, three times daily) in addition to conventional treatment for 24 weeks. The primary outcomes are the symptom improvement rate of angina from baseline to 4 weeks after inclusion and major adverse cardiovascular events (MACE). The secondary outcomes are angina classification (CCS), improvement of traditional Chinese medicine (TCM) syndromes, Seattle Angina Scale score, the dosage of emergency drugs and the stopping rate, and electrocardiogram (EKG) efficacy. Adverse events will be monitored throughout the trial. Discussion Integrated traditional Chinese and Western Medicine is commonly used for angina in China. This study will evaluate the clinical effectiveness and safety of SJP for angina. The results of the trial will provide high-level clinical research-based evidence for the application of SJP instable angina. Trial registration This study protocol was registered on 14 March 2019. The registration number is ChiCTR1900021876 on the Chinese Clinical Trial Registry.

Analysis of Gut Microbiota Composition in Lung Adenocarcinoma Patients with TCM Qi-Yin Deficiency

2021 ◽  
pp. 1-16
Author(s):  
Jiabin Chen ◽  
Sheng Wang ◽  
Jianfei Shen ◽  
Qinqin Hu ◽  
Yongjun Zhang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lung Adenocarcinoma ◽  
Deficiency Syndrome ◽  
Diagnostic Model ◽  
Linear Discriminant ◽  
Yin Deficiency ◽  
16S Rna ◽  
Stool Samples ◽  
Tcm Syndrome ◽  
Gut Microbiota Composition

In Lung adenocarcinoma (ADC), Qi-Yin deficiency syndrome (QY) is the most common Traditional Chinese medicine (TCM) syndrome. This study aimed to investigate the diversity and composition of gut microbiota in ADC patients with QY syndrome. 90 stool samples, including 30 healthy individuals (H), 30 ADC patients with QY syndrome, and 30 ADC patients with another syndrome (O) were collected. Then, 16s-RNA sequencing was used to analyze stool samples to clarify the structure of gut microbiota, and linear discriminant analysis (LDA) effect size (LEfSe) was applied to identify biomarkers for ADC with QY syndrome. Logistic regression analysis was performed to establish a diagnostic model for the diagnosis of QY syndrome in ADC patients, which was assessed with the AUC. Finally, 20 fecal samples (QY: 10; O: 10) were analyzed with Metagenomics to validate the diagnostic model. The [Formula: see text] diversity and [Formula: see text] diversity demonstrated that the structure of gut microbiota in the QY group was different from that of the H group and O group. In the QY group, the top 3 taxonomies at phylum level were Firmicutes, Bacteroidetes, and Proteobacteria, and at genus level were Faecalibacterium, Prevotella_9, and Bifidobacterium. LEfSe identified Prevotella_9 and Streptococcus might be the biomarkers for QY syndrome. A diagnostic model was constructed using those 2 genera with the AUC = 0.801, similar to the AUC based on Metagenomics (0.842). The structure of gut microbiota in ADC patients with QY syndrome was investigated, and a diagnostic model was developed for the diagnosis of QY syndrome in ADC patients, which provides a novel idea for the understanding and diagnosis of TCM syndrome.

scholarly journals Relationships between Pathological Patterns and Quality of Life: Pathway Analysis

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Shin-Woong Cho ◽  
Young-Jae Park ◽  
Sang-Chul Lee ◽  
Jaemin Ryu ◽  
Young-Bae Park ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pathway Analysis ◽  
Early Stage ◽  
General Health Questionnaire ◽  
Blood Stasis ◽  
Health Questionnaire ◽  
Pathway Model ◽  
Middle Stage ◽  
Yin Deficiency

Purpose.The purpose of our study was to examine the relationships between pathological patterns and self-rated quality of life (QoL).Methods.A total of 426 Korean subjects participated in this study (male : female = 154 : 272). The subjects were asked to complete Yin Deficiency (YD), Qi Deficiency (QD), Food Stagnation (FS), Blood Stasis (BS), Phlegm, and Seven Emotions Impairment (SEI) pattern Questionnaires and the General Health Questionnaire (GHQ). We formed a pathway model consisting of pathological patterns and QoL questionnaire scores and examined which pathological patterns resulted in decreased QoL using path analysis.Results.Our pathway model had satisfactory fitness levels (GFI = 0.975, NFI = 0.984, and CFI = 0.984) and showed that Phlegm and SEI patterns directly resulted in decreased QoL, whereas QD, YD, FD, and BS indirectly resulted in decreased QoL. The pathway model suggested that the severity or stage of decreased QoL may be estimated by pathological patterns: QD and YD patterns are associated with the early stage; FS and BS patterns are associated with the middle stage; Phlegm and SEI are associated with the later stage of decreased QoL.Conclusion.Our results suggest that pathological patterns directly or indirectly affect decreases in QoL.

scholarly journals A Nomogram Based on Preoperative Inflammatory Indices and ICG-R15 for Prediction of Liver Failure After Hepatectomy in HCC Patients

2021 ◽  
Vol 11 ◽  
Author(s):  
Tongdi Fang ◽  
Guo Long ◽  
Dong Wang ◽  
Xudong Liu ◽  
Liang Xiao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Failure ◽  
Validation Cohort ◽  
Meld Score ◽  
Decision Curve Analysis ◽  
Independent Risk Factors ◽  
Icg R15 ◽  
Score Model ◽  
End Stage ◽  
Central South

ObjectiveTo establish a nomogram based on inflammatory indices and ICG-R15 for predicting post-hepatectomy liver failure (PHLF) among patients with resectable hepatocellular carcinoma (HCC).MethodsA retrospective cohort of 407 patients with HCC hospitalized at Xiangya Hospital of Central South University between January 2015 and December 2020, and 81 patients with HCC hospitalized at the Second Xiangya Hospital of Central South University between January 2019 and January 2020 were included in the study. Totally 488 HCC patients were divided into the training cohort (n=378) and the validation cohort (n=110) by random sampling. Univariate and multivariate analysis was performed to identify the independent risk factors. Through combining these independent risk factors, a nomogram was established for the prediction of PHLF. The accuracy of the nomogram was evaluated and compared with traditional models, like CP score (Child-Pugh), MELD score (Model of End-Stage Liver Disease), and ALBI score (albumin-bilirubin) by using receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA).ResultsCirrhosis (OR=2.203, 95%CI:1.070-3.824, P=0.030), prothrombin time (PT) (OR=1.886, 95%CI: 1.107-3.211, P=0.020), tumor size (OR=1.107, 95%CI: 1.022-1.200, P=0.013), ICG-R15% (OR=1.141, 95%CI: 1.070-1.216, P<0.001), blood loss (OR=2.415, 95%CI: 1.306-4.468, P=0.005) and AST-to-platelet ratio index (APRI) (OR=4.652, 95%CI: 1.432-15.112, P=0.011) were independent risk factors of PHLF. Nomogram was built with well-fitted calibration curves on the of these 6 factors. Comparing with CP score (C-index=0.582, 95%CI, 0.523-0.640), ALBI score (C-index=0.670, 95%CI, 0.615-0.725) and MELD score (C-ibasedndex=0.661, 95%CI, 0.606-0.716), the nomogram showed a better predictive value, with a C-index of 0.845 (95%CI, 0.806-0.884). The results were consistent in the validation cohort. DCA confirmed the conclusion as well.ConclusionA novel nomogram was established to predict PHLF in HCC patients. The nomogram showed a strong predictive efficiency and would be a convenient tool for us to facilitate clinical decisions.

Conjuctivitis Sicca: A Comparison of Traditional Chinese and Western Medical Symptoms

1994 ◽  
Vol 12 (2) ◽  
pp. 88-92 ◽  
Author(s):  
Johannes Nepp ◽  
A Wedrich
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Medical Doctors ◽  
Autonomic Nervous ◽  
Yin Deficiency ◽  
Tcm Syndrome ◽  
Medical Symptoms ◽  
Conjunctivitis Sicca

In traditional Chinese medicine (TCM) three syndromes are said to be associated with conjunctivitis sicca: Liver-Yin deficiency, Liver-Yang excess and Liver fire. The diagnosis of one of these syndromes requires the use of a specific combination of points for acupuncture. We used an extensive questionnaire of autonomic nervous system disturbances to suggest points that should be treated on a western medical basis. This prospective study was performed to answer two questions: i. Is it possible to associate the complaints of our patients with a TCM syndrome? ii. Is there any difference between the results using a TCM combination of points and those selected with our western method? Thirty seven patients with conjunctivitis sicca were enrolled in the study and asked to complete two questionnaires. In one, autonomic nervous system complaints were evaluated; in the second, the symptoms of the three relevant TCM syndromes were specifically asked for. The results of both questionnaires were compared. Our “western medical” combination of points for therapy consisted of local points, and points related to the autonomic nervous system complaints and to the five Chinese elements. In total we recorded 29 different symptoms associated with conjunctivitis sicca. According to the TCM questionnaire, 21 patients had a deficit of Liver-Yin, 5 had a Liver-Yang excess and 10 suffered from Liver fire. One patient had symptoms of Liver-Yin and Liver-Yang. Yet all patients had symptoms of more than one Chinese syndrome. Only 4 out of 37 patients seemed to belong clearly to only one TCM syndrome. So the evaluation of symptoms according to the TCM system proved to be inadequate compared with the western “autonomic” system. Points for therapy resulting from the western system were similar to the points proposed by the TCM system. We conclude that the points proposed by both methods are similar for the treatment of conjunctivitis sicca, but we believe that for western medical doctors it is easier to find a successful combination of points with the western method asking about complaints of the autonomic nervous system.

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