scholarly journals Solitary Plasmacytoma in the Mandible Resembling an Odontogenic Cyst/Tumor

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Fatemeh Rezaei ◽  
Hesamedin Nazari ◽  
Babak Izadi
Keyword(s):  
Multiple Myeloma ◽  
Third Molar ◽  
Panoramic Radiograph ◽  
Final Diagnosis ◽  
Chief Complaint ◽  
Solitary Plasmacytoma ◽  
Oral Medicine ◽  
Bony Lesion ◽  
The Right ◽  
Rule Out

A 46-year-old male patient referred to Department of Oral Medicine, with the primary chief complaint of a painless swelling in the right side of mandibular. A panoramic radiograph revealed a well-defined, multilocular radiolucent bony lesion with thin and straight septa in the right side of mandible extending from distal of canine to mesial of third molar. Histological examination showed a solid proliferation of atypical plasmacytoid cells, which was indicative of plasmacytoma. A systemic workup for the final diagnosis was performed to rule out multiple myeloma.

scholarly journals Abducens Nerve Palsy as Initial Presentation of Multiple Myeloma and Intracranial Plasmacytoma

2018 ◽  
Vol 7 (9) ◽  
pp. 253
Author(s):  
Elochukwu Ibekwe ◽  
Neil Horsley ◽  
Lan Jiang ◽  
Nadine-Stella Achenjang ◽  
Azubuogu Anudu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Multiple Myeloma ◽  
Nervous System ◽  
Case Report ◽  
Nerve Palsy ◽  
Abducens Nerve ◽  
Initial Presentation ◽  
Solitary Plasmacytoma ◽  
Cns Involvement ◽  
The Right

Central Nervous System (CNS) involvement in multiple myeloma and/or multifocal solitary plasmacytoma is rare. Although they are unique entities, multiple myeloma (MM) and plasmacytoma represent a spectrum of plasma cell neoplastic diseases that can sometimes occur concurrently. Plasmacytomas very often present as late-stage sequelae of MM. In this case report, we report a 53-year-old female presenting with right abducens cranial nerve (CN) VI palsy as an initial presentation secondary to lesion of the right clivus.

scholarly journals Inion Bony Solitary Plasmocytoma: A Case Report

2020 ◽  
Vol 6 (2) ◽  
pp. 83-88
Author(s):  
Vivek Agrawal ◽  
◽  
Kunal M.Ch Dholakia ◽  
Keyword(s):  
Multiple Myeloma ◽  
Brain Mri ◽  
Residual Tumor ◽  
Myeloma Cell ◽  
Venous Sinus ◽  
Solitary Plasmacytoma ◽  
Systemic Involvement ◽  
Bony Lesion ◽  
One Year

ackground and Importance: Plasma Cell Dyscrasias (PCD) are a heterogeneous group of diseases having a spectrum from multiple myeloma to solitary plasmacytoma, a rare subtype, which constitutes 2 to 5% of all PCD. It typically involves axial bones but the involvement of skull bone is very rare. Case Presentation: We are reporting a case of inion bony lesion with venous sinus infiltration in a 55-year-old male patient, presented with pain, imbalance in walking, and swelling in the occipital region. Brain MRI suggested an extra-axial lesion with skull involvement and venous sinus infiltration. The tumor was infiltrating into the sinus with patent torcular venous confluence. Tumor decompression followed by radiosurgery of residual lesion was considered in pre-operative surgical planning. It was diagnosed as a case of myeloma cell disease on histopathology. Postoperative myeloma work-up confirmed the absence of any systemic involvement. The patient was given a course of radiotherapy. Conclusion: One-year follow-up with repeated MRI and myeloma investigations in the 3rd month, 6th months, and 1 year did not show any finding suggestive of progression to multiple myeloma. The follow-up of brain MRI showed a complete resolution of the residual tumor.

scholarly journals Mandibular Metastasis of a Recurrent Poorly Differentiated Urothelial Bladder Carcinoma

2020 ◽  
Vol 10 ◽  
pp. 27
Author(s):  
Georges Aoun ◽  
Elie Hayek ◽  
Ibrahim Nasseh
Keyword(s):  
Bladder Carcinoma ◽  
Panoramic Radiograph ◽  
Final Diagnosis ◽  
Metastatic Lesion ◽  
Radiographic Images ◽  
Urothelial Bladder Carcinoma ◽  
Multiple Imaging ◽  
Oral Neoplasms ◽  
Urothelial Bladder ◽  
The Right

Metastatic lesions to the oral cavity are uncommon; they represent between 1 and 3% of all malignant oral neoplasms. In this article, we report a rare case of metastatic urothelial bladder carcinoma in the mandible detected on oral radiographic images and confirmed with multiple imaging modalities. A 67-year-old woman presented to our clinic suffering from pain in the right side of the mandible with a mild swelling. Panoramic radiograph revealed an ill-defined relatively radiolucent lesion in the right mandibular premolar-canine region presenting with permeative changes. Cone-beam computed tomography showed a relatively hypodense lesion with demineralization, interruption of the buccal cortices, and slight thickening and sclerosis of the buccal cortical bone. The patient was referred for further evaluation including additional advanced imaging radiographic techniques (MRI and PET scan) and clinical and histopathological examinations that lead to a final diagnosis of metastatic lesion from an underlying urothelial bladder carcinoma.

scholarly journals Isolated hyperphosphatemia as an early manifestation in asymptomatic multiple myeloma

2014 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
Monica Gupta ◽  
Pritam Singh
Keyword(s):  
Multiple Myeloma ◽  
Tumor Lysis Syndrome ◽  
Final Diagnosis ◽  
Solitary Plasmacytoma ◽  
Diagnostic Challenge ◽  
Renal Functions ◽  
Laboratory Error ◽  
Laboratory Investigations ◽  
Spurious Results ◽  
High Disease Burden

Usual presentation of multiple myeloma with symptoms like bone pains, renal failure or recurrent infections do not pose much of a diagnostic challenge, but difficulties arise when symptoms are vague and spurious results of laboratory investigations complicate the clinical picture. Hyperphosphatemia is usually observed in cases that have high disease burden (tumor lysis syndrome) or impaired renal functions; however its occurrence with solitary plasmacytoma or early stages (low burden) with preserved renal functions is unlikely and probably best explicable on account of pseudohyperphosphatemia- a laboratory error that results from interference in colorimetric estimation of serum phosphate because of existence of paraproteins in these patients. We, hereby, report a case where evaluation of asymptomatic hyperphosphatemia led to the final diagnosis of multiple myeloma. 

scholarly journals Correlation between mandibular length and third molar maturation based on their radiography appearances

2018 ◽  
Vol 30 (2) ◽  
pp. 109
Author(s):  
Berty Pramatika ◽  
Azhari Azhari ◽  
Lusi Epsilawati
Keyword(s):  
Strong Correlation ◽  
Third Molar ◽  
Strong Relationship ◽  
Panoramic Radiograph ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mandibular Third Molar ◽  
The Right ◽  
Cervical Vertebral Maturation

Introduction: Growth and development is a dynamic process that is influenced by many factors, this is why children of the same age do not have the same growth rate, therefore growth can not  be evaluated only by chronological age, but also by maturation skeletal and dental. Previous research has shown a strong relationship between mandibular length and Cervical Vertebral Maturation (CVM). The aim of the present study was to determine the correlation between mandibular length and mandibular third molar maturation using panoramic radiograph. Methods: This research is an observational analytic cross sectional study. Total 412 panoramic radiographs of 207 male and 205 female aged 9-25 years were evaluated. The mandibular length measured from the point of condylion (Co) to menton (Me). M3 maturation of the mandible was evaluated by Demirjian methods. Results: Spearman non-parametric correlation was used for analysis. A strong correlation was found between mandibular length and third molar development (in males: r=0.705 on the right side and are=0.729 on the left side; in females: are=0.755 on the right side and are=0.707 on the left side) Conclusion: There is a strong correlation between mandibular length and mandibular third molar maturation in both male and female.

scholarly journals Ossifying Fibroma pada mandibula pasien anak

2020 ◽  
Vol 4 (2) ◽  
pp. 21
Author(s):  
Ratih Trikusumadewi Lubis ◽  
Fadhlil Ulum Abdul Rahman ◽  
Muhammad Adri Nurrahim ◽  
Lusi Epsilawati ◽  
Eka Marwansyah Oli'i
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Panoramic Radiograph ◽  
Chief Complaint ◽  
Odontogenic Tumor ◽  
Ossifying Fibroma ◽  
Adenomatoid Odontogenic Tumor ◽  
Panoramic Radiographs ◽  
Internal Structures ◽  
The Right

Objectives: To view a case report of mandibular ossifying fibroma (OF) in pediatric male. Case Report: A 12 year old child came to RSHS with a panoramic radiograph with the chief complaint of swelling in the right mandible. Panoramic radiograph shows well-defined mixed lesions with radiolucent content and snowflake-like opaque. MDCT shows a superior-inferior and bucco-lingual extension of the lesion. The suspicion of this case leads to Ossifying Fibroma with differential diagnosis of Adenomatoid Odontogenic Tumor (AOT) and Calcifiying Ephitelial Odontogenic Tumor (CEOT). Conclusion: OF cases in children, especially mandibular, are very rare, where the characteristics of the lesion can be well defined through the help of panoramic radiographs and MDCT. OF is a lesion that has benign characteristics with well-defined borders, and the most important lies in the presence of wrapping capsules and mixed internal structures accompanied by snowflake-like calcification.

scholarly journals Diagnóstico e tratamento do plasmocitoma solitário ósseo em mandíbula / Diagnosis and treatment of solitary bone plasmacytoma in mandible

2020 ◽  
Vol 65 (1) ◽  
pp. 1
Author(s):  
Dayane Mendonça dos Santos ◽  
Claudia Rebecca Costa Cavalcante Silva ◽  
Ney Morgado Vieira Filho ◽  
Luiz Felipe Lins de Sousa Santos ◽  
Valtuir Barbosa Felix
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Clinical Characteristics ◽  
Plasma Cells ◽  
Solitary Plasmacytoma ◽  
Plasma Cell Disorders ◽  
Accurate Treatment ◽  
Solitary Bone Plasmacytoma ◽  
The Right

Introdução: O plasmocitoma solitário pertence a um conjunto de desordens de células plasmáticas. É representado por uma massa lítica que pode ser encontrada nos ossos, sendo classificado como plasmocitoma solitário ósseo. O seu diagnóstico precoce é fundamental de modo a prevenir a progressão da doença para mieloma múltiplo. Relato de caso: Paciente do sexo feminino, de raça branca, com 81 anos, diagnosticada com plasmocitoma solitário ósseo em mandíbula à direita e tratada com radioterapia de 45Gy. Resultados: Dois anos após a conclusão do tratamento, a paciente continua em acompanhamento odontológico e hematológico, não demonstrando a evidência de transformação para mieloma múltiplo. Conclusão: Devido as características clínicas inespecíficas do plasmocitoma solitário ósseo, a correta utilização dos recursos atuais disponíveis para investigação da lesão possibilita um diagnóstico diferencial, assim como um acurado tratamento e uma proservação contínua da doença.Palavras Chave: Plasmócitos, Mandíbula, Mieloma múltiploABSTRACTIntroduction: Solitary plasmacytoma belongs to a set of plasma cell disorders. It is represented by a lytic mass that can be found in the bones, being classified as solitary bone plasmacytoma. Its precocious diagnosis is essential in order to prevent the progression of the disease for multiple myeloma. Case report: Female patient, Caucasian, 81 years old, diagnosed with solitary bone plasmacytoma in the right mandible and treated with 45Gy radiotherapy. Results: Two years after completion of treatment, the patient continues in dental and hematological follow-up, showing no evidence of transformation for multiple myeloma. Conclusion: Due the not specific clinical characteristics of solitary bone plasmacytoma, the correct use of available resources for investigation of injuries enables for a differential diagnosis, as well as an accurate treatment and a continuous disease preservation.Keywords: Plasma cells, Mandible, Multiple myeloma

scholarly journals Multiple Myeloma in a Dog

2016 ◽  
Vol 44 (1) ◽  
pp. 5
Author(s):  
Claudine Botelho De Abreu ◽  
Rodrigo Bernardes Nogueira ◽  
Luiz Eduardo Duarte De Oliveira ◽  
Flávia Dada Paiva ◽  
Antônio Carlos Cunha Lacreta Junior ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Plasma Cells ◽  
Final Diagnosis ◽  
Initial Assessment ◽  
Radiographic Examination ◽  
Cardiac Murmur ◽  
Left Femur ◽  
The Right ◽  
Bence Jones Proteinuria

Background: The multiple myeloma is a neoplasia characterized by the uncontrolled proliferation of plasma cells (plasmacytes) in the bone marrow and in other tissues. The infiltration of the neoplasia cells associated to the high level of anomalous immunoglobulin production (M protein) results in a variety of clinic-pathologic anomalies. It is a rare disease in dogs, corresponding to 0.3% of all malignant neoplasia and 2% of the hematopoietic, with few literature descriptions. So, the present paper aims at properly report a multiple myeloma in a dog of non-defined breed, emphasizing the clinic, laboratorial, radiographic and pathologic aspects.Case: In a Veterinary Teaching Hospital, an 11-year-old dog of non-defined breed was admitted, weighing 10.8 kg of body mass. The clinic history was claudication of the right thoracic member, hyporexia and lethargy in the past 20 days. The main abnormalities in the physical examination were holosystolic cardiac murmur III/VI on mitral focus, and high sensibility to touch in the right humerus. Laboratory tests showed pancytopenia, serum hypercalcemia and Bence-Jones proteinuria. Radiographic examination confirmed polyostotic punctate osteolysis on the right humerus; pelvic, femurs and vertebrae bones from L2 to L7, on generalized condition. Cytology by aspiration puncture from the left femur marrow bone did not confirm neoplasia cells. The clinic condition of the referred animal was progressively getting worse and euthanasia was performed. At the dog’s necropsy it was spotted tumor infiltrations on the femur, the humerus and the vertebrae canal. Histopathological exam of the bone marrow revealed diffuse occupation by distinguished plasmacytes, in some áreas reaching around 100% of cell population. Metastases on the primary tumor were found on the liver, kidney and spleen.Discussion: The diagnosis of multiple myeloma in this dog was confirmed by bone marrow histopathological exam. It is confirmed when there is more than 20% of plasmacytes in the examined structure. In this report, certain areas were spotted with 100% occupation of neoplasia cells. On the other hand, the first cytological assess did not reveal any abnormalities, suggesting that the place which received the puncture (aspiration) was not infiltrated by tumor cells. It is described that in the bone marrow may occur grouping of plasmacytes, as it was observed the animal’s necropsy of this report. This aspect point out that the diagnosis cannot be discarded only with a negative cytological exam from the bone marrow; especially if there are clinic, laboratorial and radiographic signs compatible to the illness. The spotted clinic signs by this patient are frequent in dogs with multiple myeloma, as well as the laboratory results, except to the monoclonal gammopathy. Due to a no realization of electrophoresis, this abnormality cannot be confirmed. At the initial assessment of the disease, the radiographic exam is considered golden standard as it was observed in this dog. The radiographic abnormalities were determinant, once they conducted the diagnosis towards the suspected neoplasia. According to current diagnosis criteria, on this present case, the pancytopenia, serum hypercalcemia and Bence-Jones proteinuria also helped towards the suspicion of multiple myeloma. However, the evaluation of the bone marrow was decisive to the final diagnosis; and a special attention was given to puncture more than one place in the bone marrow, which improved/enhanced the diagnosis possibility in this patient.Keywords: plasma cells, bone marrow, pancytopenia, osteolysis, radiography.

Synchronous presentation of Gaucher disease and solitary plasmacytoma with progression to multiple myeloma

2011 ◽  
Vol 56 (4) ◽  
pp. 1-4 ◽  
Author(s):  
M P H Hawkesford ◽  
A J Bowey ◽  
J Rao ◽  
N J Meara
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Gaucher Disease ◽  
Weight Bearing ◽  
Lytic Lesion ◽  
Solitary Plasmacytoma ◽  
Lytic Lesions ◽  
Magnetic Resonance Imaging Mri ◽  
The Right

A 37-year-old Polish immigrant presented with unilateral hip pain and difficulty weight-bearing. Plain radiography and magnetic resonance imaging (MRI) revealed a lytic lesion in the acetabulum, with abnormal serum electrophoresis and bone marrow biopsy. The patient was diagnosed with two rare conditions presenting synchronously – Gaucher disease and plasmacytoma. He was treated with enzyme therapy and radiotherapy, but subsequently developed a recurrence of plasmacytoma in the right femur, confirmed with bone marrow biopsy. This was also treated with radiotherapy, followed by a retrograde femoral nail to reduce the risk of pathological fracture. The patient went on to develop multiple lytic lesions in the ribs and vertebra, seen on MRI. Further bone marrow biopsy confirmed dissemination of the plasmacytoma into multiple myeloma, for which he was treated with systemic chemotherapy. In patients presenting with refractory bone or joint pain, haematological and histological investigations should be considered to exclude less common diagnoses.

The massive nodular cutaneous and soft tissues lesions of the right shoulder and the arm as the extramedullary manifestation of the advanced stage of multiple myeloma

Oncoreview ◽  
2017 ◽  
Vol 7 (4) ◽  
pp. 180-183
Author(s):  
Arkadiusz Drobiecki ◽  
Marcin Pasiarski ◽  
Agnieszka Stelmach-Gołdyś ◽  
Bartosz Garus
Keyword(s):  
Multiple Myeloma ◽  
Soft Tissues ◽  
Advanced Stage ◽  
The Right
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