scholarly journals Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Monika Heisig ◽  
Łukasz Łaczmański ◽  
Adam Reich ◽  
Felicja Lwow ◽  
Jacek C. Szepietowski
Keyword(s):  
Specific Treatment ◽  
Endocannabinoid System ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Chain Reactions ◽  
Uremic Pruritus ◽  
Patients With Diabetes ◽  
Bothersome Symptom ◽  
Endocannabinoid Receptor ◽  
Cnr1 Gene

Uremic pruritus (UP) is a frequent and bothersome symptom in hemodialysis patients. Its etiology is not fully understood and that is why there is no specific treatment. The endocannabinoid system plays a role in many pathological conditions. There is reliable evidence on the association between cannabinoid system and pruritus. In our study, we aimed to evaluate whether genetic variations in the endocannabinoid receptor 1 (CNR1) gene can affect UP. The rs12720071, rs806368, rs1049353, rs806381, rs10485170, rs6454674, and rs2023239 polymorphisms of the CNR1 gene were genotyped in 159 hemodialysis patients and 150 healthy controls using two multiplex polymerase chain reactions and the minisequencing technique. No statistically significant relationship was found in any of the evaluated genotypes between patients with and without UP, even after excluding patients with diabetes and dyslipidemia. There were no differences between patients with UP and the control group. However, in the group of all HD patients, a significantly higher incidence of GA genotype and lower incidence in GG genotype in the polymorphism rs806381s were revealed versus the control group (p=0.04). It seems that polymorphisms of the CNR1 gene are not associated with uremic pruritus.

scholarly journals Restless legs syndrome in end-stage renal disease patients undergoing hemodialysis

2018 ◽  
Vol 76 (12) ◽  
pp. 827-830 ◽  
Author(s):  
Sergio Andrés Castillo-Torres ◽  
Héctor Raúl Ibarra-Sifuentes ◽  
Helda Sánchez-Terán ◽  
Concepción Sánchez-Martínez ◽  
Beatriz Chávez-Luévanos ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Poor Quality ◽  
Hemodialysis Patients ◽  
Deficiency Anemia ◽  
Control Group ◽  
Restless Legs ◽  
Uremic Pruritus ◽  
Increased Risk ◽  
The Impact ◽  
Mexican Patients

ABSTRACT Restless legs syndrome (RLS) is a frequent complication of hemodialysis that has been associated with poor quality of life and increased risk for complications. Nevertheless, few studies regarding this entity exist in resource-limited settings. Objectives: To determine the prevalence of RLS among Mexican patients on hemodialysis; and compare these patients with a control group of the same population. Methods: We recruited 105 hemodialysis patients. Restless legs syndrome was diagnosed according to the updated criteria set out by the International RLS Study Group. We selected patients who did not meet the criteria, as controls. Results: We found an RLS prevalence of 18%. The RLS patients had a significantly higher prevalence of iron deficiency anemia and uremic pruritus. None of the patients reported RLS symptoms prior to hemodialysis initiation. Conclusions: Restless legs syndrome is common among Mexican patients on hemodialysis. Larger studies are required to address the impact of RLS in hemodialysis patients.

scholarly journals LEVELS ANTIINFAMMATORY CYTOKINES (ІL-4, ІL-10) IN MAINTENCE HEMODIALYSIS PATIENTS DEPENDING ON EXPRESSED ANAEMIA AND CHARACTER DEFEAT OF KIDNEY

2017 ◽  
pp. 31-36
Author(s):  
І. Dudar ◽  
V. Savchuk ◽  
I. Gonchar ◽  
V. Driyanska ◽  
E. Krasjuk ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Inflammatory Cytokines ◽  
Negative Correlation ◽  
Hemodialysis Patients ◽  
Average Level ◽  
Control Group ◽  
Diabetic Patients ◽  
Patients With Diabetes ◽  
Anti Inflammatory

Aims: The purpose of the present study was to compare the levels of anti-inflammatory cytokines in patients with chronic kidney disease, prolonged sessions of hemodialysis, depending on the severity of anemia. Materials and methods: We investigated 155 patients with chronic kidney disease, prolonged sessions of hemodialysis and anemia (mean age 46.4±12.4). Patients were divided into 4 groups depending on expressed of anemia: in the I-st (n=22) group – patients with the level of hemoglobin over 110g/l, in the II (n=66) group hemoglobin 90 - 110g/l, in the III (n=44) group hemoglobin 70-89 g/l, in the IV (n=22) group hemoglobin <70 g/l. Results: We have defined that level of IL-4 was clinically significantly lower (p <0.001) in patients, who have getting hemodialysis by comparison to control group. Levels of IL-4 had a significant differences between all of group of patients and controls (p <0.05). IL-10 had a positive correlation with the level of Hb (r=0.2405; p=0.003). ІL-4 had a negative correlation with the level of Hb (r=-0.4842; p <0.001). The average level of IL-4 was significantly increased in diabetic patients compared with non-diabetic patients 92±17.7 vs 48.3±28.1 (p <0.05). Conclusions: All of studied patients have had an increased level of anti- inflammatory cytokines. Serum IL-4 was higher in patients with diabetes. The levels of anti-inflammatory cytokines (IL-4 and IL-10) have had a significant correlation with the severity of anemia.

scholarly journals Effects of Thermotherapy on the Quality of Life and Biochemical Parameters in Hemodialysis Patients with Uremic Pruritus

2021 ◽  
Vol 15 (7) ◽  
pp. 2123-2127
Author(s):  
Hamed Zare ◽  
Majideh Heravi Karimooi ◽  
Nahid Rejeh ◽  
Hamid Sharif Nia ◽  
Nader Noori Majelan
Keyword(s):  
Quality Of Life ◽  
Biochemical Parameters ◽  
Intervention Group ◽  
Far Infrared ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Common Symptom ◽  
Uremic Pruritus ◽  
Experimental Group

Introduction and objective: Uremic pruritus is a common symptom in patients under hemodialysis. The exact cause of uremic pruritus is not yet known. Although effective treatments are available, there is not still a commonly accepted treatment for this disorder. The present study was aimed at examining the effects of thermotherapy on the quality of life (QOL) and biochemical parameters in hemodialysis patients with uremic pruritus. Patients and methods: In this experimental study, a total of 40 men under hemodialysis suffering from uremic pruritus were randomly selected and divided into an experimental group (thermotherapy) and a control group (no exposure to heat). The experimental group were exposed to far-infrared radiation (FIR) at 40 °C in 15-minute sessions, three times a week, in total for 18 sessions. The Severity of Pruritus Scale (SPS), the Kidney Disease Quality of Life Instrument (KDQOL), and the ItchyQoL were completed by the participants before the start of intervention, one month after the start of intervention, and at the end of intervention. The data were analyzed using SPSS22. Results: Significant differences were observed between the intervention and control groups in all the criteria for assessing uremic pruritus, including history of symptoms, daily activities, QOL, effects on sleep, emotional aspects, and severity of pruritus (p<0.001). In addition, significant improvements were found after the intervention in the criteria for assessing the QOL of the patients (p<0.001). Moreover, improvements in the calcium and phosphorus levels were observed in the intervention group in comparison with the control group. Conclusion: Thermotherapy is effective in reducing the severity of pruritus and increasing the QOL of patents with this problem. Therefore, it can be used as a complementary method in treating patients with uremic pruritus who also experience a reduction in their QOL. Keywords: Hemodialysis, Thermotherapy, Uremic pruritus, Quality of life, Biochemical parameters

SUPPORTIVE EDUCATIVE SYSTEM DALAM MENINGKATKAN KEMANDIRIAN MERAWAT KAKI PADA PASIEN DIABETES MELLITUS TIPE II

2019 ◽  
Vol 9 (2) ◽  
pp. 63-72
Author(s):  
Nova Nurwinda Sari ◽  
Herlina Herlina
Keyword(s):  
Diabetes Mellitus ◽  
Health Center ◽  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
P Value ◽  
Type Ii ◽  
Foot Care ◽  
Control Group Design ◽  
Patients With Diabetes

Diabetes mellitus dapat menyebabkan cukup banyak komplikasi seperti kelainan mata, kelainan ginjal, kelainan pembuluh darah dan kelainan pada kaki. Penderita diabetes mellitus yang mengalami komplikasi kronis perlu diberikan upaya preventif untuk mencegah komplikasi, salah satunya adalah kemampuan perawatan kaki. Penelitian ini dilakukan untuk menguji efektivitas supportive educative system dalam meningkatkan kemandirian perawatan kaki pada pasien dengan diabetes mellitus Tipe II di Puskesmas Permata Sukarame, Bandar Lampung. Penelitian ini menggunakan metode quasy eksperimen dengan desain pretest-posttest with control group dengan total masing-masing kelompok sebanyak 18 responden. Pengumpulan data dilakukan dengan menyebarkan kuesioner kepada responden yang memenuhi kriteria inklusi penelitian. Penelitian ini diuji menggunakan analisis univariat, bivariat dan uji T-test. Hasil penelitian menunjukkan bahwa terdapat perbedaan rata-rata dalam kemandirian perawatan kaki pada kelompok intervensi dan kelompok kontrol dengan p-value 0,000. Pendidikan dan praktik perawatan kaki harus diberikan sejak dini sebagai upaya pencegahan untuk komplikasi.   Kata kunci : Supportive educative system, kemandirian perawatan kaki   SUPPORTIVE EDUCATIVE SYSTEM IN IMPROVING INDEPENDENCE OF FOOT CARE IN PATIENTS WITH DIABETES MELLITUS TYPE II   ABSTRACT Diabetes mellitus can cause quite a lot of complications such as eye disorders, kidney disorders, vascular disorders and abnormalities in the legs. Patients with diabetes mellitus who have chronic complications need to be given a preventive effort to prevent complications, one of which is foot care ability. This research was conducted to examine the effectiveness of supportive educative systems in increasing the independence of foot care in patients with Type II diabetes mellitus in the Permata Sukarame Health Center Bandar Lampung Working Area. This study used a quasi-experimental method with pretest-posttest with control group design with a total of 18 respondents each. Data collection is done by distributing questionnaires to respondents who meet the research inclusion criteria. This study was tested using univariate, bivariate, T-Test analysis. The results showed that the mean differences in the independence of foot care in the intervention group and the control group in the Permata Sukarame Community Health Center work area with a p-value of 0,000. Education and practice of foot care should be given early as a preventative effort for complications.   Keywords: Supportive educative system, independence of foot care

Glycemic Control and Infections among U.S. Hemodialysis Patients with Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1588-P
Author(s):  
JINNIE J. RHEE ◽  
YUANCHAO ZHENG ◽  
MARIA MONTEZ-RATH ◽  
WOLFGANG WINKELMAYER
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Hemodialysis Patients ◽  
Patients With Diabetes

Good Glycemic Control for a Low Cardiovascular Risk in Children Suffering from Diabets

2017 ◽  
Vol 68 (2) ◽  
pp. 358-361
Author(s):  
Camelia Busila ◽  
Mariana Cretu Stuparu ◽  
Aurel Nechita ◽  
Camelia Ana Grigore ◽  
Gabriela Balan
Keyword(s):  
Glycosylated Hemoglobin ◽  
Control Group ◽  
Sex Distribution ◽  
Good Glycemic Control ◽  
Rural And Urban ◽  
Lipid Panel ◽  
Patients With Diabetes ◽  
Kolmogorov Smirnov ◽  
Low Cardiovascular Risk

The study is a prospective and operational one, ant its was conducted on 58 patients with diabetes type 1 and 2. The patients sex distribution was homogenious and they come from both rural and urban environment. The statistical analisys was carried out using the programme SPSS 17.0 for Windows. The distribution normality was cheked using the Kolmogorov - Smirnov Z test. he values of glycemia, glycosylated hemoglobin, lipid panel, blood pressure have been measured and compared to the ones belonging to the control group.

Diabetes-induced Alterations in HDL Subfractions Distribution

2020 ◽  
Vol 26 (27) ◽  
pp. 3341-3348 ◽  
Author(s):  
Marek Femlak ◽  
Anna Gluba-Brzozka ◽  
Beata Franczyk ◽  
Jacek Rysz
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Public Health Problem ◽  
Statin Treatment ◽  
Oxidative Modification ◽  
Control Group ◽  
Newly Diagnosed ◽  
Hdl Subfractions ◽  
Patients With Diabetes ◽  
Healthy Control

Introduction: Diabetes mellitus (DM) due to its increasing prevalence and associated morbidity and mortality has become a serious public health problem. In DM, HDL may lose its beneficial features and become proatherogenic due to its altered biological activity thus increasing cardiovascular risk. The aim of this study was to assess the influence of the presence of diabetes mellitus type 2 and its duration on the distribution of HDL subfractions. Moreover, the effect of statin treatment on HDL subfraction share was analysed in this study. Methods: The study group consisted of 50 patients with newly diagnosed DM and 50 persons with DM for longer than 10 years while the control group consisted of 50 healthy volunteers. HDL subfractions were analysed with the use of Lipoprint. Results: We demonstrated progressive worsening of heart functioning and impairment of its structure in the course of diabetes mellitus. Moreover, we observed that HDL-6 subfraction and intermediate HDL fraction are lowest in the group with advanced DMt2 compared to the group with newly diagnosed DM and a healthy control group. Finally, the results of our study indicated the effect of statin treatment on HDL subfractions that seems not to be advantageous. Conclusion: It seems that in patients with diabetes mellitus compromised antiatherogenic properties of HDL, as a result of oxidative modification and glycation of the HDL protein as well as the transformation of the HDL proteome into a proinflammatory protein, increase cardiovascular risk.

Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Type 2 Diabetes Mellitus: A Retrospective Cohort Study

2020 ◽  
Vol 20 (4) ◽  
pp. 584-590 ◽  
Author(s):  
Shima Fathi ◽  
Shiva Borzouei ◽  
Mohammad Taghi Goodarzi ◽  
Jalal Poorolajal ◽  
Fatemeh Ahmadi-Motamayel
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Type 2 Dm ◽  
Patients With Diabetes ◽  
The Difference ◽  
And Oxidative Stress

Background: Diabetes Mellitus (DM) is a progressive metabolic disorder. Objective: The aim of this study was to investigate the relationship between antioxidant and oxidative stress markers in the saliva of patients with type 2 DM and a healthy control group. Methods: In this study, 20 patients with diabetes and 20 healthy individuals were evaluated. Salivary antioxidants markers consisted of total antioxidant capacity (TAC), uric acid (UA), peroxidase and catalase. Oxidative stress markers included total oxidant status (TOS), malondealdehyde (MDA) and total thiol (SH). Sialochemical analysis was performed with spectrophotometric assay. All the statistical analyses were conducted using STATA software. Results: TAC decreased significantly in patients with diabetes. Although salivary UA and peroxidase were lower in patients with diabetes compared to the control group, the difference was not significant. Salivary catalase in patients with diabetes was significantly lower than that in the control group. MDA and TOS exhibited significantly higher levels in type 2 DM. SH levels were slightly higher in DM. Conclusions: According to the results of the present study, there were some changes in the salivary levels of some antioxidants and oxidative stress markers in patients with type 2 DM and could be measured as an indicator of serum changes..

scholarly journals The correlation between uremic pruritus and blood lead levels in prevalent hemodialysis patients and its relation to the severity of pruritus using visual analog score

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Sahar Mahmoud Shawky ◽  
Reeham Abdel Aziz Abdel Hamid ◽  
Lina Essam Khedr
Keyword(s):  
Blood Lead ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Visual Analog Score ◽  
Blood Lead Levels ◽  
Cross Sectional ◽  
Uremic Pruritus ◽  
Significant Difference ◽  
Lead Levels ◽  
Group 2

Abstract Background Pruritus is a common and often distressing symptom in patients with chronic kidney disease. Though the pathogenesis of uremic pruritus remains poorly understood, systemic inflammation has presented itself as one of the possible explanations. High blood lead levels (BLLs) have been noted to be associated with inflammation and poor nutritional status in hemodialysis patients. Our aim is to study the relation between blood lead levels and uremic pruritus. This is a cross-sectional study that enrolled 50 patients; all were on regular hemodialysis 3 times per week for at least 6 months. Patients were divided into 2 groups, group 1 (n =10) with no pruritus and group 2 (n=40) with varying degrees of pruritus. Group 2 was further divided according to intensity of pruritus by visual analog score (VAS) into mild (n=10), moderate (n=20), and severe pruritus (n=10). Results There was a significant difference in serum lead levels and ferritin levels between groups 1 and 2 (p value < 0.01 and < 0.05, respectively). There was a statistically significant difference in serum lead levels in the groups with varying intensity of pruritus, having higher serum lead levels in patients who exhibited severe pruritus (p value < 0.005) Moreover, a statistically significant relation between elevated blood lead levels and the duration of dialysis was observed in this study. Conclusion Uremic pruritus is a multi-factorial phenomenon, and our study showed that blood lead levels in hemodialysis patients might be associated with increased intensity of pruritus.

Self-Management Micro-Video Health Education Program for Hemodialysis Patients

2021 ◽  
pp. 105477382110339
Author(s):  
Qingli Ren ◽  
Suhua Shi ◽  
Chen Yan ◽  
Yang Liu ◽  
Wei Han ◽  
...  
Keyword(s):  
Health Education ◽  
Education Program ◽  
Self Efficacy ◽  
Hemodialysis Patients ◽  
Self Management ◽  
Control Group ◽  
Group Comparison ◽  
Health Education Program ◽  
Significant Group ◽  
Problem Solving Skills

Self-management in hemodialysis patients is critical; however, is generally low. This study aimed to examine the effects of a theory-based micro-video health education program on the improvement of self-management, hemodialysis knowledge, and self-efficacy in hemodialysis patients. A pre-test post-test control group quasi-experimental design was used to recruit 80 hemodialysis patients in a dialysis center. The participants were assigned in a 1:1 ratio to receive routine care or a 3-month micro-video health education program. Between-group comparison showed that patients in the intervention group had significantly greater improvement in hemodialysis knowledge than those in the control group ( p < .05). However, no significant group differences were observed in terms of self-management and self-efficacy. Within-group comparison showed that the overall self-management level of patients in both groups improved significantly, particularly in problem-solving skills and self-care dimensions. Therefore, micro-video health education can improve the self-management and hemodialysis knowledge in Chinese patients undergoing hemodialysis. Trial Registration: Registered at ClinicalTrials.gov with study number (ChiCTR1800018172; http://www.chictr.org.cn/index.aspx ).

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