scholarly journals Comment on “Biomarkers as Potential Treatment Targets in Inflammatory Bowel Disease: A Systematic Review”

2016 ◽  
Vol 2016 ◽  
pp. 1-2
Author(s):  
Nicholas-Paul Delicata ◽  
Neville Azzopardi ◽  
Pierre Ellul
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Potential Treatment ◽  
Treatment Targets ◽  
Inflammatory Bowel

scholarly journals Biomarkers as Potential Treatment Targets in Inflammatory Bowel Disease: A Systematic Review

2015 ◽  
Vol 29 (4) ◽  
pp. 203-208 ◽  
Author(s):  
Travis B Murdoch ◽  
Sarah O’Donnell ◽  
Mark S Silverberg ◽  
Remo Panaccione
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Fecal Calprotectin ◽  
Treat To Target ◽  
Radiographic Evaluation ◽  
Clinical Relapse ◽  
Treatment Targets ◽  
Inflammatory Bowel ◽  
Noninvasive Biomarkers

There is increasing interest in the concept of ‘treat-to-target’ in inflammatory bowel disease as a mechanism to standardize management and prevent complications. While clinical, radiographic and endoscopic treatment end points will figure prominently in this promising management paradigm, the role that noninvasive biomarkers will play is currently undefined. The goal of the present systematic review was to investigate the potential value of biomarkers as treatment targets in inflammatory bowel disease, with particular focus on those best studied: serum C-reactive protein (CRP) and fecal calprotectin. In Crohn disease, elevated CRP levels at baseline predict response to anti-tumour necrosis factor agents, and normalization is usually associated with clinical and endoscopic remission. CRP and hemoglobin levels can be used to help predict clinical relapse in the context of withdrawal of therapy. Ultimately, the authors conclude that currently available biomarkers should not be used as treatment targets in inflammatory bowel disease because they have inadequate operational characteristics to make them safe surrogates for clinical, endoscopic and radiographic evaluation. However, CRP and fecal calprotectin are important adjunctive measures that help alert the clinician to pursue further investigation.

Fr546 INTERVENTIONS TO INCREASE VACCINATIONS RATES WITH INFLAMMATORY BOWEL DISEASE AND RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Vol 160 (6) ◽  
pp. S-357
Author(s):  
Jalpa Patel ◽  
Dina Fakhouri ◽  
Mohamed Noureldin ◽  
Iris Kovar-Gough ◽  
Francis A. Farraye ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel

scholarly journals A Systematic Review of Monogenic Inflammatory Bowel Disease

2021 ◽  
Author(s):  
Ryusuke Nambu ◽  
Neil Warner ◽  
Daniel J. Mulder ◽  
Daniel Kotlarz ◽  
Dermot P.B. McGovern ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Bowel

Sa1727 - Chromoendoscopy Versus High Definition White Light Endoscopy for Dysplasia Detection in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 154 (6) ◽  
pp. S-371
Author(s):  
Ramprasad Jegadeesan ◽  
Madhav Desai ◽  
Tharani Sundararajan ◽  
Venkata Subhash Gorrepati ◽  
Viveksandeep Thogulva Chandrasekar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
White Light ◽  
Bowel Disease ◽  
Meta Analysis ◽  
High Definition ◽  
White Light Endoscopy ◽  
Inflammatory Bowel
Sign in / Sign up

Export Citation Format

Share Document