scholarly journals The Effect of Systemic and Regional Use of Magnesium Sulfate on Postoperative Tramadol Consumption in Lumbar Disc Surgery

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Melek Demiroglu ◽  
Canan Ün ◽  
Dilsen Hatice Ornek ◽  
Oya Kıcı ◽  
Ali Erdem Yıldırım ◽  
...  
Keyword(s):  
Side Effects ◽  
Postoperative Analgesia ◽  
Lumbar Disc ◽  
Demographic Data ◽  
The Other ◽  
Lumbar Disc Surgery ◽  
Paraspinal Muscles ◽  
Pain Scores ◽  
Disc Surgery ◽  
C 30

Aim.To investigate the effect of magnesium administered to the operative region muscle and administered systemically on postoperative analgesia consumption after lumbar disc surgery.Material and Method.The study included a total of 75 ASA I-II patients aged 18–65 years. The patients were randomly allocated into 1 of 3 groups of 25: the Intravenous (IV) Group, the Intramuscular (IM) Group, and the Control (C) Group. At the stage of suturing the surgical incision site, the IV Group received 50 mg/kg MgSO4intravenously in 150 mL saline within 30 mins. In the IM Group, 50 mg/kg MgSO4in 30 mL saline was injected intramuscularly into the paraspinal muscles. In Group C, 30 mL saline was injected intramuscularly into the paraspinal muscles. After operation patients in all 3 groups were given 100 mg tramadol and 10 mg metoclopramide and tramadol solution was started intravenously through a patient-controlled analgesia device. Hemodynamic changes, demographic data, duration of anesthesia and surgery, pain scores (NRS), the Ramsay sedation score (RSS), the amount of analgesia consumed, nausea- vomiting, and potential side effects were recorded.Results.No difference was observed between the groups. Nausea and vomiting side effects occurred at a rate of 36% in Group C, which was a significantly higher rate compared to the other groups (p<0.05). Tramadol consumption in the IM Group was found to be significantly lower than in the other groups (p<0.05).Conclusion.Magnesium applied to the operative region was found to be more effective on postoperative analgesia than systemically administered magnesium.

Single low dose epidural morphine postoperative analgesia after lumbar disc surgery

2001 ◽  
Vol 18 (Supplement 21) ◽  
pp. 133-134
Author(s):  
A. Doll ◽  
V. Bonhomme ◽  
P. Y. Dewandre ◽  
J. F. Brichant ◽  
P. Hans
Keyword(s):  
Postoperative Analgesia ◽  
Epidural Morphine ◽  
Low Dose ◽  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Disc Surgery

Effect of Celecoxib and Dexamethasone on Postoperative Pain after Lumbar Disc Surgery

Neurosurgery ◽  
2003 ◽  
Vol 53 (2) ◽  
pp. 331-337 ◽  
Author(s):  
Matthias Karst ◽  
Tanja Kegel ◽  
Anne Lukas ◽  
Wolf Lüdemann ◽  
Samii Hussein ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Double Blind Study ◽  
Double Blind ◽  
Wound Area ◽  
Pain Scores ◽  
Disc Surgery ◽  
Pain At Rest ◽  
To Receive

Abstract OBJECTIVE This study was designed to assess the efficacy of perioperative administration of celecoxib (Celebrex; Pharmacia GmbH, Erlangen, Germany) in reducing pain and opioid requirements after single-level lumbar microdiscectomy. METHODS We studied 34 patients (mean age, 44.26 yr; standard deviation [SD], 13.09 yr) allocated randomly to receive celecoxib 200 mg twice a day for 72 hours starting on the evening before surgery or placebo capsules in a double-blind study. Fourteen patients received 20 to 80 mg dexamethasone intravenously during surgery (mean, 40 mg; SD, 19.22 mg) because of visible signs of compression of the affected nerve root. After lumbar disc surgery, patients were monitored for visual analog scores for pain at rest and on movement, patient-controlled analgesia (PCA) piritramide requirements, and von Frey thresholds in the wound area. RESULTS Pain scores decreased and wound von Frey thresholds increased continuously until discharge, with no intergroup differences. Mean 24-hour PCA piritramide requirements were 22.63 mg (SD, 23.72 mg) and 26.14 mg (SD, 22.57 mg) in the celecoxib and placebo groups, respectively (P = not significant). However, patients with intraoperative dexamethasone (n = 14) required only 10.29 mg (SD, 8.55 mg) 24-hour PCA piritramide, in contrast to the 34.25 mg (SD, 24.69 mg) needed in those who did not receive intraoperative dexamethasone (P = 0.001). In addition, 24 hours after the operation, pain scores on movement were significantly lower in the dexamethasone subgroup (P = 0.003). CONCLUSION Celecoxib has no effect on postoperative pain scores and PCA piritramide requirements. The intraoperative use of 20 to 80 mg dexamethasone is able to significantly decrease postoperative piritramide consumption and pain scores on the first day after surgery.

scholarly journals Challenges in the Analysis of Longitudinal Pain Data: Practical Lessons from a Randomized Trial of Annular Closure in Lumbar Disc Surgery

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Gerrit J. Bouma ◽  
Martin Barth ◽  
Larry E. Miller ◽  
Sandro Eustacchio ◽  
Charlotte Flüh ◽  
...  
Keyword(s):  
Lumbar Disc ◽  
Lumbar Discectomy ◽  
Pain Severity ◽  
Leg Pain ◽  
Lumbar Disc Surgery ◽  
Integrated Analysis ◽  
Pain Scores ◽  
Disc Surgery ◽  
Unadjusted Analysis

Purpose. To analyze leg pain severity data from a randomized controlled trial (RCT) of lumbar disc surgery using integrated approaches that adjust pain scores collected at scheduled follow-up visits for confounding clinical events occurring between visits. Methods. Data were derived from an RCT of a bone-anchored annular closure device (ACD) following lumbar discectomy versus lumbar discectomy alone (Control) in patients with large postsurgical annular defects. Leg pain was recorded on a 0 to 100 scale at 6 weeks, 3 months, 6 months, 1 year, and 2 years of follow-up. Patients with pain reduction ≥20 points relative to baseline were considered responders. Unadjusted analyses utilized pain scores reported at follow-up visits. Since symptomatic reherniation signifies clinical failure of lumbar discectomy, integrated analyses adjusted pain scores following a symptomatic reherniation by baseline observation carried forward for continuous data or classification as nonresponders for categorical data. Results. Among 550 patients (272 ACD, 278 Control), symptomatic reherniation occurred in 10.3% of ACD patients and in 21.9% of controls (p < 0.001) through 2 years. There was no difference in leg pain scores at the 2-year visit between ACD and controls (12 versus 14; p = 0.33) in unadjusted analyses, but statistically significant differences favoring ACD (19 versus 29; p < 0.001) in integrated analyses. Unadjusted nonresponder rates were 6.0% with ACD and 6.7% with controls (p = 0.89), but 15.7% and 27.8% (p = 0.001) in integrated analyses. The probability of nonresponse was 16.4% with ACD and 18.3% with controls (p = 0.51) in unadjusted analysis, and 23.7% and 31.2% (p = 0.04) in integrated analyses. Conclusion. In an RCT of lumbar disc surgery, an integrated analysis of pain severity that adjusted for the confounding effects of clinical failures occurring between follow-up visits resulted in different conclusions compared to an unadjusted analysis of pain scores reported at follow-up visits only.

Epidural Administration of Low-Dose Morphine Combined With Clonidine for Postoperative Analgesia After Lumbar Disc Surgery

2002 ◽  
Vol 14 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Vincent Bonhomme ◽  
Anne Doll ◽  
Pierre Yves Dewandre ◽  
Jean François Brichant ◽  
Keyvan Ghassempour ◽  
...  
Keyword(s):  
Postoperative Analgesia ◽  
Low Dose ◽  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Epidural Administration ◽  
Disc Surgery

Serum creatine phosphokinase activity and histological changes in the multifidus muscle: a prospective randomized controlled comparative study of discectomy with or without retraction

2007 ◽  
Vol 6 (2) ◽  
pp. 121-125 ◽  
Author(s):  
Kadir Kotil ◽  
Tamer Tunckale ◽  
Zeynep Tatar ◽  
Macit Koldas ◽  
Alev Kural ◽  
...  
Keyword(s):  
Back Pain ◽  
Muscle Injury ◽  
Creatine Phosphokinase ◽  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Pain Scores ◽  
Disc Surgery ◽  
Serum Creatine Phosphokinase ◽  
Significant Difference ◽  
Group B

Object The aim of this study was to determine the extent of muscle injury caused by continuous or intermittent muscle retraction during macro- and microdiscectomy in lumbar disc surgery. Pain scores, serum creatine phosphokinase (CPK) levels, and histological findings obtained in muscle specimens were compared. Methods Sixty patients who underwent surgery for a one-level disc herniation during a 1-year period (January 2004–January 2005) and who had similar demographic characteristics were randomly assigned to one of four groups, each consisting of 15 patients: Group A, microdiscectomy in which the retractor was never released; Group B, microdiscectomy in which the retractor was released every 15 minutes; Group C, macrodiscectomy in which the retractor was never released; and Group D, macrodiscectomy in which the retractor was released every 15 minutes. Muscle biopsy samples were acquired in each group, and biochemical studies were conducted to determine serum CPK levels. The duration of muscle retraction was 15 minutes followed by 3 minutes of relaxation in Groups B and D. In all groups, muscle degeneration and elevation in serum CPK levels were observed immediately after surgery. The overall results, however, were different. The decline of serum CPK levels started 1 week after surgery. The smallest degree of muscle injury (reflected by the lowest serum CPK level) was observed in Group B. When the pre- and postoperative CPK values were compared in all groups, the patients in Groups B and D reported the least amount of back pain (p < 0.001). No significant differences in serum CPK levels were observed between Groups A and C or between Groups B and D. The extent of back pain was evaluated using a visual analog scale, and the consumption of analgesics was also assessed. The groups exhibited significantly different responses: the lowest analgesic consumption and the lowest pain scores were demonstrated in Groups B and D. Conclusions In this prospective randomized clinical trial, the authors determined that muscle injury during lumbar disc surgery was closely related to muscle retraction and relaxation times whereas the size of the paravertebral skin incision had no effect on postoperative back pain and disability. There was no significant difference among the groups in terms of back pain during the long-term follow-up period (18–19 months).

scholarly journals Residual complaints following lumbar disc surgery: prognostic indicators of outcome

Pain ◽  
2005 ◽  
Vol 114 (1) ◽  
pp. 177-185 ◽  
Author(s):  
Raymond W.J.G. Ostelo ◽  
Johan W.S. Vlaeyen ◽  
Piet A. van den Brandt ◽  
Henrica C.W. de Vet
Keyword(s):  
Lumbar Disc ◽  
Lumbar Disc Surgery ◽  
Prognostic Indicators ◽  
Disc Surgery

Lumbar disc surgery in the third trimester – with the fetus in utero

2006 ◽  
Vol 15 (2) ◽  
pp. 182 ◽  
Author(s):  
A. Kathirgamanathan ◽  
A.D. Jardine ◽  
D.M. Levy ◽  
M.P. Grevitt
Keyword(s):  
Lumbar Disc ◽  
In Utero ◽  
Lumbar Disc Surgery ◽  
Third Trimester ◽  
The Third ◽  
Disc Surgery

scholarly journals Abdominal aortic injury due to lumbar disc surgery: A case report

2014 ◽  
Vol 29 (4) ◽  
pp. 192-196 ◽  
Author(s):  
Ramazan Yildiz ◽  
Muharrem Oztas ◽  
Mehmet Ali Sahin ◽  
Gokhan Yagci
Keyword(s):  
Case Report ◽  
Lumbar Disc ◽  
Aortic Injury ◽  
Lumbar Disc Surgery ◽  
Disc Surgery ◽  
Abdominal Aortic
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