scholarly journals Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Malin C. Erlandsson ◽  
Roberto Doria Medina ◽  
Sofia Töyrä Silfverswärd ◽  
Maria I. Bokarewa
Keyword(s):  
Rheumatoid Arthritis ◽  
Cigarette Smoking ◽  
Serum Levels ◽  
Negative Regulator ◽  
Lower Serum ◽  
Bivariate Correlation ◽  
Novel Association ◽  
Long Term Prognosis ◽  
Never Smokers

Objectives.Smoking is pathogenic for rheumatoid arthritis (RA) being tightly connected to the genetic and serological risk factors for this disease. This study aims to understand connections between cigarette smoking and serum levels of IGF1 and adipokines in RA.Methods.Serum levels of IGF1 and adipokines leptin, adiponectin, resistin, and visfatin were measured in two independent cohorts of RA patients from Gothenburg (n=350) and Leiden (n=193). An association of these parameters with smoking was tested in a direct comparison and proved by bivariate correlation analysis. The obtained associations were further tested in multivariate regression models where the confounders (age, gender, disease duration, and BMI) were controlled.Results.The smokers had significantly lower serum levels of IGF1, adiponectin, and leptin compared to never smokers. In regression analysis, smoking and low leptin, but not adiponectin, were associated and predicted low IGF1. Additionally, high disease activity and high BMI increased the probability of low leptin.Conclusions.The study indicates cigarette smoking as an important cause of a relative IGF1 and leptin deficiency in RA patients. This novel association between smoking and hypoleptinemia may be of importance for long-term prognosis of RA and for prediction of comorbidities.

scholarly journals Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers

2011 ◽  
Vol 13 (2) ◽  
pp. R65 ◽  
Author(s):  
Saedis Saevarsdottir ◽  
Bo Ding ◽  
Kristjan Steinsson ◽  
Gerdur Grondal ◽  
Helgi Valdimarsson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Serum Levels ◽  
Never Smokers ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Proliferative Synovitis, an Ultrasound Pattern Associated with ACPA positive Patients, Erosive Disease and Enhanced Need to Change Therapy in Rheumatoid Arthritis

2020 ◽  
Author(s):  
Julio Ramírez ◽  
Ana Belen Azuaga-Piñango ◽  
Beatriz Frade-Sosa ◽  
Roberto Gumucio-Sanguino ◽  
Katherine Cajiao-Sanchez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Power Doppler ◽  
Serum Levels ◽  
Dominant Hand ◽  
Erosive Disease ◽  
The Us ◽  
Grade Ii ◽  
Autoantibody Status ◽  
Activity Therapy

Abstract Objectives: To analyze ultrasound (US) differences between rheumatoid arthritis (RA) patients according to their autoantibody status and characterize the clinical, immunological and radiological features associated with the US pattern of seropositive patients.Methods: We collected clinical and immunological data along with bilateral hand US images of RA patients. Serum biomarkers, MRI of dominant hand and immunostaining of synovial biopsies were performed.Results: Two hundred and five RA patients were collected (84.8% seropositive). No significant differences in disease activity/therapy were found according to autoantibodies status. An extreme proliferative US pattern, encompassing synovial hypertrophy grade II-III with Power Doppler signal that we called US Proliferative Synovitis (US PS) was present in 55.5% of seropositive and 16.1% of seronegative patients, (p=0.0001). In the multivariate analysis, erosions [OR 4.90 CI 95% (2.17-11.07). p=0.0001] and ACPA [OR 3.5 CI 95% (1.39-10.7), p=0.09] but not RF status [OR 0.74 CI 95% (0.31-1.71), p=0.483] were independently associated with the presence of US PS. Ninety-four per cent of joints with US PS scored 2-3 in RAMRIS synovitis sub-index. At synovial level, US PS was significantly associated with higher density of vessels (p=0.042). Moreover, significantly higher serum levels of angiogenic and inflammatory cytokines were found in patients with US PS. After a mean of 46 months of follow-up, US PS was independently associated with change of therapy (OR 2.63, 95% CI 1.20-5.77, p=0.016).Conclusions: ACPA+ RA was associated with US PS. This US pattern significantly detected erosive disease and an enhanced need to change therapy in the long-term.

FRI0022 THE ANALYSIS OF THE INVOLVEMENT OF TRANSFORMING-GROWTH INTERACTING FACTOR POLYMORPHISMS IN THE BONE METABOLISM OF RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 583.1-583
Author(s):  
H. Tan ◽  
L. Zhang ◽  
B. Yang ◽  
L. Zhou
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Metabolism ◽  
Type I Collagen ◽  
Transforming Growth Factor ◽  
Bone Erosion ◽  
Serum Levels ◽  
Negative Regulator ◽  
Type I ◽  
Nucleotide Polymorphisms ◽  
The Relationship

Background:Rheumatoid arthritis (RA) is an autoimmune disease that mainly invades synovial membranes and further damage to articular cartilage and bone. The abnormal activation of transforming-growth factor β (TGF-β) in the subchondral bone is related to the onset of RA joint cartilage degeneration and transforming-growth interacting factor (TGIF) is a negative regulator of TGF-β signaling, while there is no literature addressing the relationship between TGIF polymorphisms and the bone metabolism of RA.Objectives:The aim of the study was to comprehensively explore the possible association for single nucleotide polymorphisms (SNPs) in the TGIF gene with serum bone metabolism markers and RA susceptibility.Methods:Three SNPs within the TGIF gene were genotyped in 155 RA patients and 168 healthy controls by high resolution melting (HRM) analysis in a case-control study. The serum levels of osteocalcin, bone alkaline phosphatase (BALP) and β type I collagen-crosslinked C telopeptide (β-CTX) were detected by electrochemical luminescence in 108 RA patients randomly selected from RA patients group.Results:Genotypes and alleles frequency analysis showed rs7362020 was associated with bone erosion in RA (P=0.012, P=0.003, respectively) and individuals carrying T allele for rs7362020 showed a decreased RA risk (OR=0.59, 95% CI = 0.42-0.84; P= 0.003). In the gender-specific analysis, rs73620203 polymorphism was associated with bone erosion of female RA patients (P values of the distribution of genotypes and alleles were 0.022 and 0.006, respectively). In addition, RA patients with CC, CT and TT genotypes at rs73620203 locus had statistically significant differences in serum osteocalcin and BALP (P=0.006, P=0.037, respectively) and the serum levels in TT genotype RA patients were significantly lower than CC and CT genotype RA patients. The serum levels of β-CTX in rs85440 AA genotype male RA patients were significantly higher than female RA patients (P=0.001), while the serum levels of osteocalcin and BALP in genotype AA, AG and GG female and male RA patients were not significantly different (P all>0.05).Conclusion:Our study provided the first evidence that rs73620203 is associated with bone erosion of RA and provided new insight into the relationship between three SNPs within TGIF gene and regulation of bone metabolism in RA patients of different genders.Acknowledgments:This work was supported by the National Natural Science Foundation of China (Nos. 81772258) and Science and Technology Agency of Sichuan Province (Nos. 2019YFS0310, 2018FZ0106).Disclosure of Interests:None declared

Abstract 053: Gene Expression Signatures of Tobacco Exposure

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Roby Joehanes ◽  
Sai-xia Ying ◽  
Andrew D Johnson ◽  
George T O’Connor ◽  
Dawn L DeMeo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cigarette Smoking ◽  
Differentially Expressed Genes ◽  
Gene Expression Analysis ◽  
Molecular Signatures ◽  
Tobacco Exposure ◽  
Heart Study ◽  
Gene Expression Signatures ◽  
Never Smokers

Introduction: Cigarette smoking is a cardinal risk factor of coronary heart disease (CHD), yet its gene expression signatures are not well characterized. Hypothesis: We hypothesized that cigarette smoking disturbs expression signatures of many genes, some of which may have long-term implications. Methods: To that end, we analyzed whole-blood gene expression of 2,446 Framingham Heart Study participants (204 current, 1,460 former, and 782 never smokers) and compared gene expression signatures of current vs. never smokers, and former vs. never smokers, adjusting for sex, age, and familial relationship. Smoking status based on self-reported longitudinal data collected over the span of 37 years of observation. P-value and false discovery rate (FDR) were computed for each gene. Results: At FDR<0.05, 1,602 genes were significant in current vs. never smokers. These genes were associated with many pathways, including immune response, response to stress, blood coagulation, platelet activation, and apoptosis. Of the differentially expressed genes, 112 were also associated with smoking in the San Antonio Family Heart Study. At FDR<0.05, 3 genes were significant in former vs. never smokers. These three genes are among the 1,602 genes for current vs. never smokers. Conclusions: Gene expression analysis of current vs. never smokers reveals molecular signatures of tobacco exposure. The differentially expressed genes reflect pathways previously implicated in CHD. Gene expression analysis of former vs. never smokers reveals long-term persisting molecular signatures of tobacco exposure. Table. Top 5 genes in current vs. never smokers and in former vs. never smokers.

Clinical implications of cigarette smoking in acute myocardial infarction: Acute angiographic findings and long-term prognosis

1997 ◽  
Vol 134 (5) ◽  
pp. 955-960 ◽  
Author(s):  
Masaharu Ishihara ◽  
Hikaru Sato ◽  
Hironobu Tateishi ◽  
Takuji Kawagoe ◽  
Yuji Shimatani ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cigarette Smoking ◽  
Clinical Implications ◽  
Long Term Prognosis ◽  
Angiographic Findings

scholarly journals Differences in Levels of Biomarkers of Potential Harm among Users of a Heat-not-burn Tobacco Product, Cigarette Smokers, and Never-Smokers in Japan: A Post-Marketing Observational Study

2021 ◽  
Author(s):  
Chikako Sakaguchi ◽  
Yasufumi Nagata ◽  
Akira Kikuchi ◽  
Yuki Takeshige ◽  
Naoki Minami
Keyword(s):  
Cigarette Smoking ◽  
Tobacco Smoke ◽  
Cigarette Smokers ◽  
Potential Harm ◽  
Actual Use ◽  
Post Marketing ◽  
Harmful Substances ◽  
Never Smokers ◽  
The Impact

Abstract Introduction Cigarette smoking is associated with the risk of certain diseases, but non-combustible products may lower these risks. The potential long-term health effects of the next-generation non-combustible products (heat-not-burn tobacco products (HNBP) or electronic vapor products) have not been thoroughly studied. The present study aimed to investigate the impact of biomarkers of potential harm (BoPH) of one of HNBP (a novel vapor product: NTV), under the conditions of actual use. Methods This study was an observational, cross-sectional, three-group, multi-center study. Exclusive NTV users (NTV, n = 259), conventional cigarette smokers (CC, n = 100) and never-smokers (NS, n=100) were enrolled. Biomarkers of tobacco smoke exposure (cotinine and total NNAL) and BoPH including parameters of physical pulmonary functions relevant to smoking-related diseases were examined, and subjects answered a questionnaire on cough-related symptoms (J-LCQ) and health-related quality of life (SF-36v2®). Results Levels of cotinine, total NNAL and BoPH (HDL-cholesterol, triglyceride, sICAM-1, WBC count, 11-DHTXB2, 2,3-d-TXB2, 8-epi-PGF2α, FEV1, %FEV1 and FEF25-75) were significantly different in the NTV group as compared to levels in CC group (p&lt;0.05). Significantly higher levels of cotinine, total NNAL, and 2,3-d-TXB2, and lower levels of FEV1 and %FEV1, were observed among NVT users compared to the NS group. Conclusion In a post-marketing study under actual use conditions, BoPH associated with smoking-related disease examined in exclusive NTV users were found to be favorably different from those of CC smokers, a finding attributable to a reduction in exposure to harmful substances of tobacco smoke. Implications Cigarette smoking is associated with increased risk of pulmonary diseases like COPD, cardiovascular diseases, and certain cancers. There is a growing body of evidence that HNBP reduces the exposure associated with smoking and that there is a favorable change in BoPH. However, long-term effects regarding the relative health risks to HNBP users compared to CC smokers have not been examined. This study provides post-marketing data under actual use conditions of the effects on biomarkers of potential harm in NTV, one of HNBP, exclusive users compared to CC smokers and never-smokers. The evidence suggests that exclusive NTV users have favorable levels of BoPH compared to CC smokers, and that is result from a sustained reduction in exposure to harmful substances of tobacco smoke.

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