scholarly journals Rapid Creation of Three-Dimensional, Tactile Models from Crystallographic Data

2016 ◽  
Vol 2016 ◽  
pp. 1-8
Author(s):  
Nathan B. Fisher ◽  
John C. Charbonneau ◽  
Stephanie K. Hurst
Keyword(s):  
Critical Role ◽  
Three Dimensional ◽  
Basic Research ◽  
Virtual Space ◽  
Molecular Models ◽  
Research Education ◽  
Potential Applications ◽  
Data Files ◽  
The Cost ◽  
Information Framework

A method for the conversion of crystallographic information framework (CIF) files to stereo lithographic data files suitable for printing on three-dimensional printers is presented. Crystallographic information framework or CIF files are capable of being manipulated in virtual space by a variety of computer programs, but their visual representations are limited to the two-dimensional surface of the computer screen. Tactile molecular models that demonstrate critical ideas, such as symmetry elements, play a critical role in enabling new students to fully visualize crystallographic concepts. In the past five years, major developments in three-dimensional printing has lowered the cost and complexity of these systems to a level where three-dimensional molecular models may be easily created provided that the data exists in a suitable format. Herein a method is described for the conversion of CIF file data using existing free software that allows for the rapid creation of inexpensive molecular models. This approach has numerous potential applications in basic research, education, visualization, and crystallography.

scholarly journals Potential applications of aptamers in veterinary science

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Solène Niederlender ◽  
Jean-Jacques Fontaine ◽  
Grégory Karadjian
Keyword(s):  
Veterinary Medicine ◽  
In Vitro Selection ◽  
Three Dimensional ◽  
Basic Research ◽  
High Specificity ◽  
Environmental Safety ◽  
Veterinary Science ◽  
Potential Market ◽  
Potential Applications

AbstractAptamers are small nucleic acids that fold in a three-dimensional conformation allowing them to bind specifically to a target. This target can be an organic molecule, free or carried in cells or tissues, or inorganic components, such as metal ions. Analogous to monoclonal antibodies, aptamers however have certain advantages over the latter: e.g., high specificity for their target, no to low immunogenicity and easy in vitro selection. Since their discovery more than 30 years ago, aptamers have led to various applications, although mainly restricted to basic research. This work reviews the applications of aptamers in veterinary science to date. First, we present aptamers, how they are selected and their properties, then we give examples of applications in food and environmental safety, as well as in diagnosis and medical treatment in the field of veterinary medicine. Because examples of applications in veterinary medicine are scarce, we explore the potential avenues for future applications based on discoveries made in human medicine. Aptamers may offer new possibilities for veterinarians to diagnose certain diseases—particularly infectious diseases—more rapidly or “at the patient’s bedside”. All the examples highlight the growing interest in aptamers and the premises of a potential market. Aptamers may benefit animals as well as their owners, breeders and even public health in a “One Health” approach.

Gene Therapy for Cancer - A New Dimension and Challenge for Insurers

2019 ◽  
Vol 48 (1) ◽  
pp. 58-64
Author(s):  
Achim Regenauer
Keyword(s):  
Gene Therapy ◽  
Side Effects ◽  
Molecular Targets ◽  
Basic Research ◽  
Healthcare Systems ◽  
Insurance Companies ◽  
Gene Therapies ◽  
Potential Applications ◽  
Health Insurance Companies ◽  
The Cost

Due to an increasingly better understanding of the human genome, the number of potential molecular targets, and therefore, potential applications by gene therapies is also increasing. After almost two decades of basic research, the first gene therapeutics are now entering the market. They are among the most expensive types of treatment in medicine. Over the next 10 years, the number and volume of their applications will increase significantly. So, our healthcare systems and inherently health insurance companies will face considerable challenges that will require new approaches to financial solutions. This article first describes the mode of action of the first gene therapies of cancer and their by now known side effects. Subsequently, the cost problems are dealt with and possible financing options are pointed out.

An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

2021 ◽  
Vol 21 ◽  
Author(s):  
Madhukar Garg ◽  
Anju Goyal ◽  
Sapna Kumari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayers ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Three Dimensional ◽  
Biologically Active ◽  
Potential Applications ◽  
Health Related ◽  
Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

scholarly journals A Novel Pseudomonas geniculata AGE Family Epimerase/Isomerase and Its Application in d-Mannose Synthesis

Foods ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1809
Author(s):  
Zhanzhi Liu ◽  
Ying Li ◽  
Jing Wu ◽  
Sheng Chen
Keyword(s):  
3D Structure ◽  
Three Dimensional ◽  
Optimal Temperature ◽  
Reaction Conditions ◽  
Enzymatic Production ◽  
Physiological Properties ◽  
Potential Applications ◽  
Kinetics Of ◽  
Optimal Reaction ◽  
Gene Age

d-mannose has exhibited excellent physiological properties in the food, pharmaceutical, and feed industries. Therefore, emerging attention has been applied to enzymatic production of d-mannose due to its advantage over chemical synthesis. The gene age of N-acetyl-d-glucosamine 2-epimerase family epimerase/isomerase (AGEase) derived from Pseudomonas geniculata was amplified, and the recombinant P. geniculata AGEase was characterized. The optimal temperature and pH of P. geniculata AGEase were 60 °C and 7.5, respectively. The Km, kcat, and kcat/Km of P. geniculata AGEase for d-mannose were 49.2 ± 8.5 mM, 476.3 ± 4.0 s−1, and 9.7 ± 0.5 s−1·mM−1, respectively. The recombinant P. geniculata AGEase was classified into the YihS enzyme subfamily in the AGE enzyme family by analyzing its substrate specificity and active center of the three-dimensional (3D) structure. Further studies on the kinetics of different substrates showed that the P. geniculata AGEase belongs to the d-mannose isomerase of the YihS enzyme. The P. geniculata AGEase catalyzed the synthesis of d-mannose with d-fructose as a substrate, and the conversion rate was as high as 39.3% with the d-mannose yield of 78.6 g·L−1 under optimal reaction conditions of 200 g·L−1d-fructose and 2.5 U·mL−1P. geniculata AGEase. This novel P. geniculata AGEase has potential applications in the industrial production of d-mannose.

scholarly journals Fermi gas approach to general rank theories and quantum curves

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Naotaka Kubo
Keyword(s):  
Matrix Models ◽  
Critical Role ◽  
Three Dimensional ◽  
Fermi Gas ◽  
Fermi Gases ◽  
Partition Functions ◽  
Density Matrices ◽  
General Rank ◽  
Chern Simons ◽  
The Ideal

Abstract It is known that matrix models computing the partition functions of three-dimensional $$ \mathcal{N} $$ N = 4 superconformal Chern-Simons theories described by circular quiver diagrams can be written as the partition functions of ideal Fermi gases when all the nodes have equal ranks. We extend this approach to rank deformed theories. The resulting matrix models factorize into factors depending only on the relative ranks in addition to the Fermi gas factors. We find that this factorization plays a critical role in showing the equality of the partition functions of dual theories related by the Hanany-Witten transition. Furthermore, we show that the inverses of the density matrices of the ideal Fermi gases can be simplified and regarded as quantum curves as in the case without rank deformations. We also comment on four nodes theories using our results.

scholarly journals Bio-inspired Fog Harvesting Materials: Basic Research and Bionic Potential Applications

2021 ◽  
Vol 18 (3) ◽  
pp. 501-533
Author(s):  
Kui Wan ◽  
Xuelian Gou ◽  
Zhiguang Guo
Keyword(s):  
Collection Efficiency ◽  
Basic Research ◽  
Development Trend ◽  
Water Mist ◽  
Long Distance ◽  
Biological Water ◽  
Water Collection ◽  
Transmission Area ◽  
Potential Applications ◽  
Water Transmission

AbstractWith the explosive growth of the world’s population and the rapid increase in industrial water consumption, the world’s water supply has fallen into crisis. The shortage of fresh water resources has become a global problem, especially in arid regions. In nature, many organisms can collect water from foggy water under harsh conditions, which provides us with inspiration for the development of new functional fog harvesting materials. A large number of bionic special wettable synthetic surfaces are synthesized for water mist collection. In this review, we introduce some water collection phenomena in nature, outline the basic theories of biological water harvesting, and summarize six mechanisms of biological water collection: increased surface wettability, increased water transmission area, long-distance water delivery, water accumulation and storage, condensation promotion, and gravity-driven. Then, the water collection mechanisms of three typical organisms and their synthesis are discussed. And their function, water collection efficiency, new developments in their biomimetic materials are narrated, which are cactus, spider and desert beetles. The study of multiple bionics was inspired by the discovery of Nepenthes’ moist and smooth peristome. The excellent characteristics of a variety of biological water collection structures, combined with each other, are far superior to other single synthetic surfaces. Furthermore, the main problems in the preparation and application of biomimetic fog harvesting materials and the future development trend of materials fog harvesting are prospected.

scholarly journals Simulation of Thermal and Electric Field Distribution in Packaged Sausages Heated in a Stationary Versus a Rotating Microwave Oven

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1622
Author(s):  
Wipawee Tepnatim ◽  
Witchuda Daud ◽  
Pitiya Kamonpatana
Keyword(s):  
Temperature Distribution ◽  
Electric Field ◽  
Three Dimensional ◽  
Development Stage ◽  
Microwave Oven ◽  
Computational Time ◽  
Plastic Package ◽  
Heating Uniformity ◽  
The Cost ◽  
Good Agreement

The microwave oven has become a standard appliance to reheat or cook meals in households and convenience stores. However, the main problem of microwave heating is the non-uniform temperature distribution, which may affect food quality and health safety. A three-dimensional mathematical model was developed to simulate the temperature distribution of four ready-to-eat sausages in a plastic package in a stationary versus a rotating microwave oven, and the model was validated experimentally. COMSOL software was applied to predict sausage temperatures at different orientations for the stationary microwave model, whereas COMSOL and COMSOL in combination with MATLAB software were used for a rotating microwave model. A sausage orientation at 135° with the waveguide was similar to that using the rotating microwave model regarding uniform thermal and electric field distributions. Both rotating models provided good agreement between the predicted and actual values and had greater precision than the stationary model. In addition, the computational time using COMSOL in combination with MATLAB was reduced by 60% compared to COMSOL alone. Consequently, the models could assist food producers and associations in designing packaging materials to prevent leakage of the packaging compound, developing new products and applications to improve product heating uniformity, and reducing the cost and time of the research and development stage.

scholarly journals Giant Magnetoresistance and Magneto-Thermopower in 3D Interconnected NixFe1−x/Cu Multilayered Nanowire Networks

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1133
Author(s):  
Nicolas Marchal ◽  
Tristan da Câmara Santa Clara Gomes ◽  
Flavio Abreu Araujo ◽  
Luc Piraux
Keyword(s):  
Giant Magnetoresistance ◽  
Nanowire Array ◽  
Three Dimensional ◽  
Strong Increase ◽  
Thermoelectric Effect ◽  
Heat Management ◽  
Thermoelectric Effects ◽  
Nanowire Network ◽  
Potential Applications ◽  
Nanowire Networks

The versatility of the template-assisted electrodeposition technique to fabricate complex three-dimensional networks made of interconnected nanowires allows one to easily stack ferromagnetic and non-magnetic metallic layers along the nanowire axis. This leads to the fabrication of unique multilayered nanowire network films showing giant magnetoresistance effect in the current-perpendicular-to-plane configuration that can be reliably measured along the macroscopic in-plane direction of the films. Moreover, the system also enables reliable measurements of the analogous magneto-thermoelectric properties of the multilayered nanowire networks. Here, three-dimensional interconnected NixFe1−x/Cu multilayered nanowire networks (with 0.60≤x≤0.97) are fabricated and characterized, leading to large magnetoresistance and magneto-thermopower ratios up to 17% and −25% in Ni80Fe20/Cu, respectively. A strong contrast is observed between the amplitudes of magnetoresistance and magneto-thermoelectric effects depending on the Ni content of the NiFe alloys. In particular, for the highest Ni concentrations, a strong increase in the magneto-thermoelectric effect is observed, more than a factor of 7 larger than the magnetoresistive effect for Ni97Fe3/Cu multilayers. This sharp increase is mainly due to an increase in the spin-dependent Seebeck coefficient from −7 µV/K for the Ni60Fe40/Cu and Ni70Fe30/Cu nanowire arrays to −21 µV/K for the Ni97Fe3/Cu nanowire array. The enhancement of the magneto-thermoelectric effect for multilayered nanowire networks based on dilute Ni alloys is promising for obtaining a flexible magnetic switch for thermoelectric generation for potential applications in heat management or logic devices using thermal energy.

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