scholarly journals The Utility of Endoscopic Biopsies in Patients with Normal Upper Endoscopy

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Anouar Teriaky ◽  
Abdullah AlNasser ◽  
Carolyn McLean ◽  
James Gregor ◽  
Brian Yan

Background and Aims. Upper endoscopy is a valuable tool in the workup of gastrointestinal (GI) complaints. The purpose of this study is to determine cost and yield of taking biopsies in a normal upper GI tract.Methods. This is a retrospective study where all upper GI biopsies were identified between May 2012 and April 2013, at a tertiary care center. Clinical, procedural, and pathology reports were reviewed to identify patient demographics, procedure information, and pathology diagnosis.Results. Biopsies of the upper GI tract were taken in 1297 patients with normal upper endoscopies. In patients with normal upper endoscopy, 22% of esophageal, 44% of gastric, and 12% of duodenal biopsies were abnormal. The most frequent abnormality was reflux esophagitis in 16% of esophageal biopsies, chronic gastritis in 23% of gastric biopsies, and increased intraepithelial lymphocytes in 6% of duodenal biopsies. The additional cost for taking biopsies in a normal upper GI tract for a diagnosis of eosinophilic esophagitis was $2963 Canadian (CAD),H. pyloriassociated gastritis was $1404 CAD, and celiac disease was $3024 CAD.Conclusions. The yield of biopsy in normal upper endoscopy varied with location, but the additional expense can be costly and should be tailored to appropriate clinical situations.

2021 ◽  
Vol 8 (6) ◽  
pp. A158-163
Author(s):  
Anjana M.L ◽  
Kavitha Yevoor

Background: Upper GI endoscopy is an established procedure for investigating a wide range of upper GI conditions especially inflammatory and malignant diseases of stomach and esophagus. A good correlation in diagnosis can be achieved by complementing endoscopic findings with histopathology of biopsy specimens. Methods: Both retrospective and prospective study of upper GI endoscopic biopsy was carried out at department of pathology, KIMS, Hubli during January 2016 to December 2018. Samples were received in 10% formalin; routine processing was followed with H & E staining. Special stain like Giemsa was done for detection of H. Pylori. 396 endoscopic mucosal biopsies were analyzed and evaluated. Result: Out of 396 cases, 250 cases were esophageal biopsies, 104 cases were gastric biopsies & 42 cases were duodenal biopsies. The male: female ratio was 1:9:1. The highest number of cases was seen between 61 to 70 years. Dyspepsia was the common symptom seen in 61.3%. The most common lesions encountered in the esophagus were carcinomas (67%) followed by esophagitis (16%). The commonly encountered gastric lesion was chronic gastritis in 54.8% with H. pylori gastritis being positive in 38.18%. Among the duodenal biopsies, non-neoplastic lesions were most common (59.5%) followed by neoplastic lesions (26%). Conclusion: Upper GI endoscopy is an effective and appropriate preliminary investigation to assess patients with dysphagia, dyspepsia, vomiting. Endoscopy without biopsy is incomplete and that the combination of methods offers a strong diagnostic tool for better patient care.


Gut ◽  
2016 ◽  
Vol 67 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Christian Schulz ◽  
Kerstin Schütte ◽  
Nadine Koch ◽  
Ramiro Vilchez-Vargas ◽  
Melissa L Wos-Oxley ◽  
...  

ObjectivePatients infected with Helicobacter pylori develop chronic gastritis with a subgroup progressing to further complications. The role of microbiota from the oral cavity swallowed with saliva and either transiting the stomach or persisting in the gastric mucosa is uncertain. It is also not known whether the bacterial community differs in luminal and mucosal niches. A key question is whether H. pylori influences the bacterial communities of gastroduodenal niches.DesignSaliva, gastric and duodenal aspirates as well as gastric and duodenal biopsies were collected during oesophagogastroduodenoscopy from 24 patients (m:9, f:15, mean age 52.2±SD 14.5 years). RNA was extracted and the V1–V2 region of the retrotranscribed bacterial 16S rRNA amplified and sequenced on the Illumina MiSeq platform.ResultsOverall, 687 bacterial phylotypes that belonged to 95 genera and 11 phyla were observed. Each individual comprised a unique microbiota composition that was consistent across the different niches. However, the stomach fluid enriched for specific microbiota components. Helicobacter spp were shown to dominate the mucosa-associated community in the stomach, and to significantly influence duodenal and oral communities.ConclusionsThe detailed analysis of the active global bacterial communities from the five distinct sites of the upper GI tract allowed for the first time the differentiation between host effects and the influence of sampling region on the bacterial community. The influence of Helicobacter spp on the global community structures is striking.


2013 ◽  
Vol 108 ◽  
pp. S18
Author(s):  
Srikala Meda ◽  
Varun Vemulapalli ◽  
Krishna Ayyagari ◽  
Tejaswi Vemuru ◽  
Karthik Raja ◽  
...  

VideoGIE ◽  
2021 ◽  
Author(s):  
Yuan-Chen Wang ◽  
Jun Pan ◽  
Bin Jiang ◽  
Yang-Yang Qian ◽  
Xiao-Ou Qiu ◽  
...  

2006 ◽  
Vol 63 (5) ◽  
pp. AB246
Author(s):  
Pierre Eisendrath ◽  
Michel Cremer ◽  
Olivier Le Moine ◽  
Jacques Himpens ◽  
Guy-Bernard Cadiere ◽  
...  

Endoscopy ◽  
1990 ◽  
Vol 22 (S 1) ◽  
pp. 9-12 ◽  
Author(s):  
M. de Reuck ◽  
B. Ramdani ◽  
C. Jonas ◽  
J. F. Nyst ◽  
M. van Gossum ◽  
...  

2015 ◽  
Vol 148 (4) ◽  
pp. S-579
Author(s):  
Osman O. Ahsen ◽  
Hsiang-Chieh Lee ◽  
Kaicheng Liang ◽  
Michael G. Giacomelli ◽  
Zhao Wang ◽  
...  

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