scholarly journals The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Shengyan Xi ◽  
Lifeng Yue ◽  
Mengmeng Shi ◽  
Ying Peng ◽  
Yangxinzi Xu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Histological Change ◽  
Hepatic Function ◽  
Chronic Liver ◽  
Hepatic Tissue ◽  
Mice Model ◽  
Related Factors ◽  
Downstream Signaling ◽  
Flos Carthami

Chronic liver disease is one of the most common diseases that threaten human health. Effective treatment is still lacking in western medicine.Semen Persicae(Taoren) andFlos Carthami(Honghua) are known to relieve acute hepatic injury and inflammation, improve microcirculation, and reduce tissue fiber. The aim of our study is to investigate the potential mechanisms of Taoren-Honghua Herb Pair (THHP) in murine model of chronic liver disease caused by Carbon Tetrachloride (CCl4). Mice were randomly divided into seven groups: (1) blank, (2) model, (3) control (colchicine, 0.1 mg/kg), (4) THHP (5.53, 2.67, and 1.33 g/kg), and (5) Tao Hong Siwu Decoction (THSWD) (8.50 g/kg). Histological change and microvessels density were examined by microscopy. Hepatic function, serum fibrosis related factors, and hepatic vascular endothelial growth factor (VEGF) were measured with ELISA. VEGF, kinase insert domain-containing receptor (KDR), Flt-1, and Akt mRNA expression in hepatic tissue were determined with PCR. Tissues of Akt, pAkt, KDR, and Flt-1 were measured with western blotting. Data from this study showed that THHP improved hepatic function and restrained the hepatic inflammation and fibrosis. Its role in inhibiting pathological angiogenesis and hepatic fibrogenesis may be through affecting the angiogenesis-associated VEGF and its upstream and downstream signaling pathways.

Hepatic function and functional hepatic volumes correlate with the severity of chronic liver disease (CLD)

2000 ◽  
Vol 118 (4) ◽  
pp. A1448
Author(s):  
John C. Hoefs ◽  
Muhammad Y. Sheikh ◽  
Gary Kanel ◽  
Felix W. Wang ◽  
Norah Milne
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Hepatic Function ◽  
Chronic Liver

Association of serum glycated albumin to haemoglobin A1C ratio with hepatic function tests in patients with chronic liver disease

2009 ◽  
Vol 46 (5) ◽  
pp. 368-372 ◽  
Author(s):  
Yukihiro Bando ◽  
Hideo Kanehara ◽  
Daisyu Toya ◽  
Nobuyoshi Tanaka ◽  
Soji Kasayama ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Plasma Glucose ◽  
Glycated Albumin ◽  
Hepatic Function ◽  
Chronic Liver ◽  
Diabetic Patients ◽  
Haemoglobin A1c ◽  
Glucose Levels ◽  
The Mean

Background In patients with chronic liver disease (CLD), glycated haemoglobin (HbA1C) levels have been shown to be apparently lower than real values, whereas serum glycated albumin (GA) levels are apparently higher. The present study was aimed to examine whether both glycaemic indices are influenced by hepatic function. Methods Subjects consisted of 82 patients with CLD. Various indicators for hepatic function as well as HbA1C and GA were also measured. Estimated HbA1C values were calculated from the mean plasma glucose levels. Two hundred and two type 2 diabetic patients without CLD were studied as controls. Results Although GA was strongly correlated with HbA1C in patients with CLD as well as diabetic patients, GA levels in patients with CLD were relatively higher than those in diabetic patients. In patients with estimated HbA1C ≤5.8%, GA levels significantly increased but HbA1C levels decreased as a function of decreasing hepaplastin test (HPT). The ratio of GA/HbA1C (G/H ratio) increased as a function of decreasing HPT. In patients with estimated HbA1C >5.8%, in contrast, GA levels were independent of HPT levels. In the patients with CLD, GA and HbA1C were associated with mean plasma glucose levels and some indicators for hepatic function. The multivariate analysis revealed a significant association of G/H ratio with HPT, cholinesterase and direct bilirubin. The G/H ratio was not associated with the mean plasma glucose but with HPT and cholinesterase levels. Conclusions The G/H ratio correlates with hepatic function but not with plasma glucose levels. Therefore, CLD should be suspected for diabetic patients with an elevated G/H ratio.

scholarly journals Antipyrine clearance per unit volume liver: an assessment of hepatic function in chronic liver disease.

Gut ◽  
1979 ◽  
Vol 20 (7) ◽  
pp. 596-601 ◽  
Author(s):  
M Homeida ◽  
C J Roberts ◽  
M Halliwell ◽  
A E Read ◽  
R A Branch
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Unit Volume ◽  
Hepatic Function ◽  
Chronic Liver ◽  
Antipyrine Clearance

scholarly journals Assessment of health-related quality of life and related factors in patients with chronic liver disease

2015 ◽  
Vol 19 (6) ◽  
pp. 590-595 ◽  
Author(s):  
Neila Paula de Souza ◽  
Livia Melo Villar ◽  
Artênio José Ísper Garbin ◽  
Tânia Adas Saliba Rovida ◽  
Cléa Adas Saliba Garbin
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Health Related Quality ◽  
Related Factors ◽  
Related Quality ◽  
Health Related

scholarly journals Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Giorgos Bamias ◽  
Michalis Gizis ◽  
Ioanna Delladetsima ◽  
Eyfrosyni Laoudi ◽  
Spyros I. Siakavellas ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Elevated Serum ◽  
Liver Stiffness ◽  
Serum Levels ◽  
Chronic Liver ◽  
Decompensated Cirrhosis ◽  
Related Factors ◽  
Decoy Receptor ◽  
Decoy Receptor 3

Background. Decoy-receptor 3 (DcR3) exerts antiapoptotic and immunomodulatory function and is overexpressed in neoplastic and inflammatory conditions. Serum DcR3 (sDcR3) levels during the chronic hepatitis/cirrhosis/hepatocellular carcinoma (HCC) sequence have not been explored.Objective. To assess the levels and significance of sDcR3 protein in various stages of chronic liver disease.Methods. We compared sDcR3 levels between healthy controls and patients with chronic viral hepatitis (CVH), decompensated cirrhosis (DC), and HCC. Correlations between sDcR3 levels and various patient- and disease-related factors were analyzed.Results. sDcR3 levels were significantly higher in patients with CVH than in controls (P<0.01). sDcR3 levels were elevated in DC and HCC, being significantly higher compared not only to controls (P<0.001for both) but to CVH patients as well (P<0.001for both). In addition, DcR3 protein was detected in large quantities in the ascitic fluid of cirrhotics. In patients with CVH, sDcR3 significantly correlated to fibrosis severity, as estimated by Ishak score (P=0.019) or by liver stiffness measured with elastography (Spearmanr=0.698,P<0.001). In cirrhotic patients, significant positive correlations were observed between sDcR3 levels and markers of severity of hepatic impairment, including MELD score (r=0.653,P<0.001).Conclusions. Circulating levels of DcR3 are elevated during chronic liver disease and correlate with severity of liver damage. sDcR3 may serve as marker for liver fibrosis severity and progression to end-stage liver disease.

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