scholarly journals Adalimumab: Another Medication Related to Osteonecrosis of the Jaws?

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Andrea Cassoni ◽  
Umberto Romeo ◽  
Valentina Terenzi ◽  
Marco Della Monaca ◽  
Oriana Rajabtork Zadeh ◽  
...  

Objective.The acronym MRONJ has been created in order to identify “Medication-Related Osteonecrosis of the Jaw,” observed after the use of Bisphosphonates, RANK ligand inhibitor, and antiangiogenic medications. Only a case of osteonecrosis of the jaw in a Chron’s disease patient following a course of Bisphosphonate and Adalimumab therapy has been recently described, so that it has been supposed that also this medication could promote manifestation of osteonecrosis.Clinical Case. On August, 2014, a 63-year-old female with a history of idiopathic arthritis treated with medical treatment with Adalimumab from 2010 to 2013 presented referring pain in the right mandible.Results. This patient presented with nonexposed osteonecrosis of the jaw after placement, on September, 2010, of four titanium fixtures in the mandible.Conclusions. The authors suggest that the biologic therapy with an anti-TNF-αantibody might promote the manifestation of osteonecrosis and compromise oral healing capacity of the bone.

2022 ◽  
Vol 15 ◽  
Author(s):  
Yu Tian ◽  
Jiaming Wang ◽  
Xin Shi ◽  
Zhaohai Feng ◽  
Lei Jiang ◽  
...  

Patients requiring deep brain stimulation due to intracerebral metallic foreign substances have not been reported elsewhere in the world. Additionally, the long-term effects of metallic foreign bodies on deep brain stimulation (DBS) are unknown. A 79-year-old man with a 5-year history of Parkinson's disease (PD) reported that, 40 years ago, while playing with a pistol, a metallic bullet was accidentally discharged into the left brain through the edge of the left eye, causing no discomfort other than blurry vision in the left eye. DBS was performed due to the short duration of efficacy for oral medication. Because the bullet was on the left subthalamic nucleus (STN) electrode trajectory and the patient's right limb was primarily stiff, the patient received globus pallidus interna (GPi)-DBS implantation in the left hemisphere and STN-DBS implantation in the right hemisphere. During a 6-month postoperative follow-up, the patient's PD symptoms were effectively managed with no noticeable discomfort.


2021 ◽  
Vol 12 (1) ◽  
pp. e12-e12
Author(s):  
Marcelo Vieira da Costa Almeida ◽  
Antonio C. Moura ◽  
Lúcia Santos ◽  
Luciana Gominho ◽  
Ully Dias Nascimento Távora Cavalcanti ◽  
...  

Introduction: Medication-related osteonecrosis of the jaw (MRONJ) corresponds to an adverse effect of the use of drugs such as bisphosphonates and denosumab. This condition is often associated with pain, infection, purulent secretion, paraesthesia, tooth mobility and halitosis, decreasing the patient’s quality of life. The management of MRONJ tends to be conservative, through the guidance of oral hygiene, antibiotic therapy and mouthwashes. However, the use of antimicrobial photodynamic therapy (aPDT) has shown promise in the treatment of these injuries. The purpose of this article is to report a case of MRONJ treatment associated with aPDT. Case Report: A 75-year-old patient, with a history of breast cancer and use of intravenous Zoledronic Acid, presented with bilateral MRONJ lesions in tuberosity on the right and left sides. Treatment was conservatively instituted with the use of aPDT as an adjuvant. After 12 aPDT sessions, complete regression of the lesion was observed. However, after two weeks, the presence of a new lesion was noted, this time in the anterior region of the maxilla. The same protocol previously established was followed and after two aPDT sessions, the patient returned with complete lesion regression. Conclusion: The use of aPDT may represent an important adjuvant within a set of clinical protocols in the treatment of MRONJ.


2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
J. N. Ulrich ◽  
S. Garg ◽  
G. K. Escaravage ◽  
T. M. Meredith

Purpose. To describe a patient with Bilateral Diffuse Uveal Proliferation who presented initially with a clinical picture consistent with choroidal melanoma.Methods. Presentation of a clinical case with fundus photos, fluorescein angiography, and optical coherence tomography.Results. A 70-year-old Caucasian male with history of esophageal cancer presented with an asymptomatic pigmented choroidal lesion in his left eye initially diagnosed as choroidal nevus. This lesion enlarged over the course of a year and developed orange pigment and increased thickness. A metastatic workup was negative, and a radioactive iodine plaque was placed on the left eye. Over the next six months, the visual acuity in his left eye decreased. His clinical picture was consistent with unilateral Diffuse Uveal Proliferation. A recurrence of his esophageal carcinoma with metastasis was discovered and palliative chemotherapy was initiated. Although his visual acuity improved in the left eye, similar pigmentary changes developed in the right fundus. His visual acuity in both eyes gradually decreased to 20/200 until his death a year later.Conclusion. BDUMP should always be considered in the differential diagnosis of patients with pigmented fundus lesions and a history of nonocular tumors.


2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Gustavo Gaitan-Quintero ◽  
Loida Camargo-Camargo ◽  
Norman López-Velásquez ◽  
Miguel González

Introduction. Melkersson–Rosenthal syndrome (MRS) is a neuromucocutaneous disorder characterized by the following classic symptom triad: peripheral facial paralysis, orofacial edema, and scrotal or fissured tongue. It is rare, and since most of the patients are oligo- or monosymptomatic, it makes it difficult to diagnose. Clinical Case. We present a 26-year-old male patient with a history of sickle cell trait, untreated snoring, and left peripheral facial paralysis when he was 11 years old. This was an overall 20-day clinical profile that started with left peripheral facial paralysis, which was accompanied by moderate-intensity occipital pulsatile headaches. Additionally, the patient experienced paresthesias in the tongue and feelings of labial edema. After one week, he manifested peripheral facial paralysis on the right side. Physical examination revealed bilateral peripheral facial paralysis, mild labial edema, and a scrotal or fissured tongue. The patient received corticosteroids, which resulted in improvement of the edema and facial paralysis. Discussion. MRS is a rare disorder that predominantly affects women, typically starting in their 20s or 30s. The etiology is unknown. However, a multifactorial origin that involves environmental factors and a genetic predisposition has been proposed, which causes a dysfunction of the local immune system and autonomic nervous system (ANS) and an appearance of granulomatous inflammation in the lips and tongue. Facial paralysis usually appears later on; however, it can occur from its clinical debut. There are no curative treatments. Therapy is focused on modulating the patient's immune response, and relapses are frequent.


2019 ◽  
Vol 64 (No. 03) ◽  
pp. 138-143
Author(s):  
CF Agudelo ◽  
M Crha ◽  
B Lukač ◽  
Z Yilmaz

An intracardiac communication between the left ventricle and the right atrium (Geborde defect) was diagnosed in a 9-year Yorkshire Terrier with a history of chronic exercise intolerance. The history, clinical examination, and diagnostic imaging confirmed the diagnosis and did not reveal evidence of trauma or endocarditis which could lead to this special type of left-to-right shunting. A Gerbode defect is a very rare finding in human beings and animals. In the veterinary literature all reports about this condition were related to thoracic trauma or valvular infection. According to the authors, this would be the first clinical case of congenital Geborde defect in a dog.


2020 ◽  
Vol 46 (4) ◽  
pp. 431-437
Author(s):  
Gustavo Zanna Ferreira ◽  
Amanda Bolognesi Bachesk ◽  
Andressa Bolognesi Bachesk ◽  
Gustavo Jacobucci Farah ◽  
Liogi Iwaki Filho ◽  
...  

Osteonecrosis of the jaw is a possible oral complication resulting from antiresorptive therapies, such as bisphosphonates (Bfs). Although the etiology is not entirely clear, it has been shown to be dependent on several factors, with the traumatic stimulation caused by the placement of teeth implants indicated as one of the predisposing factors to this pathology. The indications and preventive methods for performing these procedures have been questioned, making it essential to determine the proper protocols. Thus, the present study aims to discuss the risks of the development of osteonecrosis in patients undergoing dental implant surgery who use Bfs as well as to discuss related local and systemic factors and possible methods for preventing this side effect. The study also aims to present a clinical case of an osteopenic patient who used Bfs and underwent rehabilitation through implants according to specific protocols, which resulted in successful treatment.


2005 ◽  
Vol 3 (2) ◽  
pp. 0-0
Author(s):  
Raimundas Lunevičius

Raimundas LunevičiusVilniaus universiteto Bendrosios ir plastinės chirurgijos,ortopedijos, traumatologijos klinika,Vilniaus universitetinė greitosios pagalbos ligoninė,Šiltnamių g. 29, LT-04130 VilniusEl paštas: [email protected] Įvadas / tikslas Gydant dvylikapirštės žarnos traumą patyrusį ligonį dažnai reikia parinkti vieną sprendimą iš dviejų – tik užsiūti dvylikapirštę žarną ar, užsiuvus pažeistą dvylikapirštės žarnos vietą, atlikti chirurginės prevencijos veiksmus, kurie turėtų sumažinti dvylikapirštės žarnos siūlių nelaikymo riziką. Straipsnio tikslas – pasitelkiant klinikinio atvejo aprašą ir literatūros apžvalgą išnagrinėti ypatybes, kurios lemia chirurginio gydymo metodo pasirinkimą, ir tuo remiantis iš naujo įvertinti aprašytosios ligonės gydymo taktiką. Klinikinis atvejis Ligonei diagnozuotas uždaras smūginis izoliuotas dvylikapirštės žarnos trečiosios dalies III laipsnio plyšimas. Dvylikapirštė žarna užsiūta, jos siūlės padengtos storąja skersine žarna, suformuota choledochostoma. Po šios operacijos ryškėjo intoksikacija, išsivystė dešiniosios kojos giliųjų venų tromboflebitas, susidarė retroperitoninio tarpo pūlinys. Antrosios operacijos metu pūlinys buvo drenuotas. Storąja žarna padengta siūlė nerevizuota, kompleksinės operacijos nuspręsta nedaryti. Po šios operacijos greitai išryškėjo dvylikapirštės žarnos fistulė. Po nesėkmingo konservatyvaus gydymo buvo padaryta trečioji, kompleksinė, operacija, tačiau ji buvo neveiksminga ir ligonė mirė. Išvada Sunkus dvylikapirštės žarnos trauminis sužalojimas yra indikacija atlikti kompleksinę dvylikapirštės žarnos operaciją. Reikšminiai žodžiai: dvylikapirštės žarnos uždara trauma, plyšimas, chirurginis gydymas, užsiuvimas, kompleksinė operacija Traumatic duodenal rupture: a case report and review Raimundas LunevičiusVilnius University, Clinic of General and Plastic Surgery,Orthopaedics, Traumatology,Vilnius University Emergency Hospital,Šiltnamių str. 29, LT-04130 Vilnius, LithuaniaE-mail: [email protected] Background / objective Treating the patient with duodenal trauma, a surgeon is often confronted with the dilemma of either doing primary simple repair or after primary duodenal repair aditionally performing a procedure of surgical prevention aimed at minimizing the postoperative risk of duodenal suture leak. The objective of the article is to describe a clinical case and in the light of review of the literature to re-evaluate the management of the patient described. Clinical case A history of a female patient with isolated grade III rupture of the D3 part of the duodenum due to a blunt trauma is described. During the first operation, a primary duodenal stitch repair with additional use of a transverse colon serosal patch and T-tube drainage of the common bile duct has been performed. After this operation, severe signs of intoxication, thrombophlebitis of deep veins of the right leg and an abscess in the right retroperitoneal space developed. During the second operation, a drainage of the abscess was basically done. The duodenum was strongly closed by the transverse colon and was not revised. The idea of performing a duodenum diversion procedure was rejected. Soon after the second operation an obvious external duodenal fistula was diagnosed. After the failure of conservative treatment a third operation – pyloric exclusion procedure – was perfomed. However, it was ineffective. The patient died. Conclusion For high-risk duodenal injuries, a complex decompressive repair (duodenal diversion procedure) of the duodenum is indicated. Keywords: blunt duodenal trauma, traumatic duodenal rupture, surgery, primary simple repair, complex repair, duodenal diversion, pyloric exclusion


2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Raimund HM Preidl ◽  
Tobias Ebker ◽  
Martin Raithel ◽  
Falk Wehrhan ◽  
Friedrich W Neukam ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Jesse M. Jakubowski ◽  
Ines Velez ◽  
Shawn A. McClure

A 49-year-old male with known history of end-stage renal disease (ESRD) presents with an intraoral exophytic mass of the right mandible. This lesion was given a histologic diagnosis of a Brown tumor.Purpose. To allow physicians to include this lesion in a differential diagnosis when evaluating patients with primary, secondary, or tertiary hyperparathyroidism.


Author(s):  
Melinda L. Estes ◽  
Samuel M. Chou

Many muscle diseases show common pathological features although their etiology is different. In primary muscle diseases a characteristic finding is myofiber necrosis. The mechanism of myonecrosis is unknown. Polymyositis is a primary muscle disease characterized by acute and subacute degeneration as well as regeneration of muscle fibers coupled with an inflammatory infiltrate. We present a case of polymyositis with unusual ultrastructural features indicative of the basic pathogenetic process involved in myonecrosis.The patient is a 63-year-old white female with a one history of proximal limb weakness, weight loss and fatigue. Examination revealed mild proximal weakness and diminished deep tendon reflexes. Her creatine kinase was 1800 mU/ml (normal < 140 mU/ml) and electromyography was consistent with an inflammatory myopathy which was verified by light microscopy on biopsy muscle. Ultrastructural study of necrotizing myofiber, from the right vastus lateralis, showed: (1) degradation of the Z-lines with preservation of the adjacent Abands including M-lines and H-bands, (Fig. 1), (2) fracture of the sarcomeres at the I-bands with disappearance of the Z-lines, (Fig. 2), (3) fragmented sarcomeres without I-bands, engulfed by invading phagocytes, (Fig. 3, a & b ), and (4) mononuclear inflammatory cell infiltrate in the endomysium.


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