scholarly journals Preparation and Characterization of Modified Polyethyleneimine Magnetic Nanoparticles for Cancer Drug Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Sedighe Arabi ◽  
Hamid Akbari Javar ◽  
Mehdi Khoobi
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Amphiphilic Polymer ◽  
Polymeric Coating ◽  
Cancer Drug ◽  
X Ray Diffraction ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Cancer Drug Delivery ◽  
Cancerous Cells

Magnetic nanoparticles with polymeric coating have great significance in drug delivery purpose. We intended to prepare a modified amphiphilic polymer with targeting susceptibility to reduce side effects to normal cells. In this study polyethyleneimine (PEI) as a polycationic polymer reacted with sebacoyl chloride to make a new amphiphilic polymer and folic acid as a targeting agent to reduce cytotoxicity of polymer and increase specific entrance of nanoparticles to cancerous cells. The obtained polymer (PEI-Sb-FA) was then coated on magnetic nanoparticles (MNPs) to stabilize them. The core-shell nanoparticles were characterized by different methods such as scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Curcumin was finally loaded on PEI-Sb-FA-MNPs and the release behavior was studied in different pH. Curcumin loading of 28.2% was obtained and released drug in acidic pH = 4.5 was more than pH = 7.4, showing drug release sensitivity toward pH of media.

scholarly journals Nanotechnology in Cancer Drug Delivery and Selective Targeting

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Kumar Bishwajit Sutradhar ◽  
Md. Lutful Amin
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Treatment ◽  
Direct Access ◽  
Cancer Drug ◽  
Proliferating Cells ◽  
Selective Targeting ◽  
Traditional Drug ◽  
Cancer Drug Delivery ◽  
Cancerous Cells

Nanoparticles are rapidly being developed and trialed to overcome several limitations of traditional drug delivery systems and are coming up as a distinct therapeutics for cancer treatment. Conventional chemotherapeutics possess some serious side effects including damage of the immune system and other organs with rapidly proliferating cells due to nonspecific targeting, lack of solubility, and inability to enter the core of the tumors resulting in impaired treatment with reduced dose and with low survival rate. Nanotechnology has provided the opportunity to get direct access of the cancerous cells selectively with increased drug localization and cellular uptake. Nanoparticles can be programmed for recognizing the cancerous cells and giving selective and accurate drug delivery avoiding interaction with the healthy cells. This review focuses on cell recognizing ability of nanoparticles by various strategies having unique identifying properties that distinguish them from previous anticancer therapies. It also discusses specific drug delivery by nanoparticles inside the cells illustrating many successful researches and how nanoparticles remove the side effects of conventional therapies with tailored cancer treatment.

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