scholarly journals Evaluation of Peripapillary Nerve Fiber Layer after Dexamethasone Implantation (Ozurdex) in Branch Retinal Vein Occlusions

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Muhammed Nurullah Bulut ◽  
Yusuf Özertürk ◽  
Ümit Çallı ◽  
Güzide Akçay ◽  
Ulviye Kıvrak ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Vein Occlusion ◽  
Corrected Visual Acuity ◽  
Baseline Values ◽  
The Mean ◽  
Inferior Quadrant

Purpose. To evaluate the peripapillary retinal nerve fiber layer (RNFL) thicknesses of patients treated with intravitreal Ozurdex implant due to branch retinal vein occlusion (BRVO) related macular edema (ME). Methods. Thirty-three eyes of 33 patients treated with Ozurdex implant due to ME associated with BRVO were included in the study. Ophthalmic examinations including determination of best corrected visual acuity (BCVA), measurement of intraocular pressure (IOP), and central macular thickness (CMT) and peripapillary RNFL assessment with optical coherence tomography (OCT) were performed before the injection of Ozurdex implant and during the 6-month follow-up period after the injection. Results. The mean age was 55.2 ± 7.4 (range: 40–68) years. The BCVAs were significantly increased and CMTs were significantly decreased at month 3 and month 6 visits compared to baseline values. The mean IOP was significantly increased from baseline at day 1, week 1, and month 1 visits (p1=0.008, p2=0.018, and p3=0.022, resp.). The average and inferior quadrant peripapillary RNFL thicknesses were significantly reduced at month 6 control visit compared to baseline values (both p<0.001). Conclusions. Ozurdex implant improved the BCVA and reduced the CMT in the eyes with RVO related ME. However, IOP elevations occurred within the first month after the injection and the average and inferior quadrant RNFL thinning was found six months after the injection. Further controlled studies are warranted.

scholarly journals Retinal Nerve Fiber Layer Alterations After Photocoagulation: A Prospective Spectral-Domain OCT Study

2014 ◽  
Vol 8 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Sıtkı Eren ◽  
Taylan Ozturk ◽  
Aylin Yaman ◽  
Hakan Oner ◽  
Osman Saatci A
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Control Groups ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
The Third ◽  
Baseline Values

Purpose : To evaluate the effect of panretinal photocoagulation (PRP) on retinal nerve fiber layer thickness (RNFLT) in treatment-naive patients with proliferative diabetic retinopathy (PDR). Methods : Fifty eight previously untreated eyes of 30 patients with PDR who underwent PRP treatment were enrolled prospectively. All patients had at least six months of follow-up. Detailed ophthalmologic examinations including macular thickness and RNFLT assessments with spectral-domain type optic coherence tomography were performed at baseline as well as the third and sixth posttreatment months. Initial RNFLT and macular thickness of laser administered patients were compared with two separate control groups that were consisted of either nondiabetic patients or diabetics without PDR. Results : The mean age of study patients was 52.4±7.1 years (Range, 32-66 years) and 16 of them (53.3%) were female. At the sixth post-PRP month, visual stabilization or improvement was achieved in 54 eyes (93.1%). No significant difference was demonstrated in initial RNFLT measurements between the study patients and two control groups (p=0.478). Mean RNFLT was measured as 108.5±17.5µm, 115.8±17.6µm, and 103.0±16.4µm at baseline, third and sixth months of the follow-up, respectively. Although RNFLT increase noted at the third post-laser month was statistically significant compared to its baseline values (p<0.001), there was a significant reduction in RNFLT at the sixth post-laser month compared to its baseline values (p<0.001). Conclusion : RNFLT increase in the third month of follow-up may be related to ensuing axonal edema. Significant RNLFT decrease at the sixth month of follow-up may be attributed to axonal loss secondary to the laser treatment.

Effects of Panretinal Laser Photocoagulation on the Corneal Nerve Plexus and Retinal Nerve Fiber Layer in Retinal Vein Occlusion

2017 ◽  
Vol 27 (5) ◽  
pp. 591-595 ◽  
Author(s):  
Gulfidan Bitirgen ◽  
Selman Belviranli ◽  
Rayaz A. Malik ◽  
Hurkan Kerimoglu ◽  
Ahmet Ozkagnici
Keyword(s):  
Nerve Fiber ◽  
Retinal Vein Occlusion ◽  
Retinal Nerve Fiber Layer ◽  
Nerve Plexus ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Vein Occlusion ◽  
Rnfl Thickness ◽  
The Mean ◽  
Fellow Eyes

Purpose To determine the effects of panretinal photocoagulation (PRP) on corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with unilateral central retinal vein occlusion (CRVO) who had previously undergone PRP treatment. Methods Sixty-four eyes of 32 patients (19 male, 13 female) with unilateral ischemic type CRVO who had undergone PRP treatment at least 6 months previously were included in this cross-sectional study. The laser scanning in vivo corneal confocal microscope was used to determine corneal SBNP parameters. The peripapillary RNFL thickness was assessed with spectral-domain optical coherence tomography. Data obtained from the PRP-treated eyes were compared with those of the fellow unaffected eyes. Results The mean age of patients was 63.5 ± 10.7 years (range 45-85 years). The mean nerve fiber density (NFD), nerve branch density, and nerve fiber length (NFL) were significantly lower in PRP-treated eyes compared with fellow eyes (p<0.001 for all). Average peripapillary RNFL thickness was significantly lower in PRP-treated eyes than in fellow eyes (p = 0.007). The NFD and NFL showed a modest but significant positive correlation with average peripapillary RNFL thickness (r = 0.310, p = 0.013 and r = 0.272, p = 0.030, respectively). Conclusions Significant reductions in corneal SBNP parameters and average peripapillary RNFL thickness were observed in the eyes of patients receiving PRP for the treatment of ischemic CRVO.

scholarly journals Comparison of optical coherence tomography measurements between high hyperopic and low hyperopic children

2020 ◽  
Vol 12 ◽  
pp. 251584141989981
Author(s):  
Funda Dikkaya ◽  
Sevil Karaman Erdur
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Control Group ◽  
Study Group ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
The Mean ◽  
Inferior Quadrant ◽  
Retinal Nerve Fiber

Purpose: To identify the peripapillary retinal nerve fiber layer, total macular, ganglion cell layer, and inner plexiform layer thicknesses in children with high hyperopia using spectral domain optical coherence tomography. Methods: Twenty-one children with high hyperopia and 20 controls were enrolled in this study. Subjects with spherical equivalent +5.0 D or higher were evaluated in the study group and subject with spherical equivalent between +0.25 and +2.0 D in the control group. The retinal nerve fiber layer thickness, macular thickness, macular ganglion cell layer and inner plexiform layer thicknesses were measured using a spectral domain optical coherence tomography, and results were compared between groups. Results: The nasal and inferior quadrant and the global retinal nerve fiber layer thickness were significantly thicker in the study group. The mean thickness of inferior quadrant of the inner macula was significantly thicker in the study group than those in the control group. The mean thickness of the ganglion cell layer in nasal, temporal and inferior quadrant of outer macula was significantly thinner in the study group than the control group. The mean thickness of the inner plexiform layer in the inferior quadrant of the inner macula and nasal and inferior quadrant of the outer macula were significantly higher in study group than those in control group. Conclusion: High hyperopic children had thicker retinal nerve fiber layer when compared to the controls. This difference should be taken into account when evaluating children with glaucoma or other optic disc disorders.

Changes in Intraocular Pressure and Corneal and Retinal Nerve Fiber Layer Thicknesses in Hypothyroidism

2005 ◽  
Vol 15 (5) ◽  
pp. 556-561 ◽  
Author(s):  
U.A. Bahçeci ◽  
Ş. Özdek ◽  
Z. Pehlivanli ◽  
I. Yetkin ◽  
M. Önol
Keyword(s):  
Intraocular Pressure ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Scanning Laser ◽  
Fiber Layer ◽  
Serum Free ◽  
Correlation Test ◽  
Nerve Fiber Layer ◽  
The Mean ◽  
Spearman’S Correlation

Purpose To evaluate the changes in intraocular pressure (IOP), corneal thickness (CT), and retinal nerve fiber layer thickness (RNFLT) in patients with hypothyroidism before and after treatment. Methods A complete ophthalmic examination including visual acuity, IOP, anterior segment, and fundus examination together with CT and RNFLT measurements were performed for each patient with newly diagnosed hypothyroidism, at the initial diagnosis and the third and ninth months of the L-thyroxine treatment. Wilcoxon signed rank test and Spearman's correlation test were used for statistical evaluation of the results. Results A total of 56 eyes of 28 patients were included in the study. The mean IOP and CT values were found to decrease with medical treatment (p=0.000). There was no significant change in any of the RNFLT parameters measured with scanning laser Polarimeter after L-thyroxine treatment (Wilcoxon, p>0.05). The change in IOP levels was not correlated with the change in thyroid hormone levels (Spearman's correlation test, p>0.05). The mean increase in serum free T3 and serum free T4 levels and the mean decrease in serum TSH levels at the ninth month of the therapy were found to be correlated with the decrease in CT in the left eyes (Spearman's correlation test, R>0.4 and p<0.05). Conclusions Hypothyroidism seems to cause a reversible increase in CT and IOP. IOP changes may be secondary to CT changes. RNFLT parameters measured with scanning laser Polarimeter do not seem to be affected by hypothyroidism. When the CT is taken into account and the IOPs corrected for CT, the prevalence of glaucoma in hypothyroidism may not be as high as previously reported. This issue should be taken into account while assessing glaucoma in patients with hypothyroidism.

Comparative Analysis of Retinal Nerve Fiber Layer Thickness between Normal and Mild to Moderately Myopic Eyes

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Gul Nasreen ◽  
Shaheer Suhail Sarwar ◽  
Irfana Bibi ◽  
Muhammad Arslan Ashraf
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Rnfl Thickness ◽  
The Mean ◽  
Retinal Nerve Fiber

Purpose:  To determine the difference between mean retinal nerve fiber layer (RNFL) thickness in myopic eyes (up to -6.00D) and normal eyes. Study Design:  Descriptive observational study. Place and Duration of the Study:  Eye department of Mayo hospital Lahore, from February 2019 to April 2019. Methods:  We compared the mean RNFL between 58 myopic eyes (up to -6.00 D) and age matched 60 normal eyes. The age of the participants was between 12 to 42 years. Complete ocular examination was done and RNFL thickness was measured by using Optical coherence tomography (NIDEX RS-33.0, software-ex 1.5.2).Data was analyzed by independent sample t-test by using SPSS; with P < .05 as significant. Results:  The mean difference among these groups was 5.852 µm with (SE: 1.929). Mean RNFL thickness in myopic group was (95.93 ± 10.158µm) with (SE: 1.334). The result for mean RNFL thickness in myopic eyes was distributed normally as P < .03. Mean RNFL in normal group was (101.78 ± 10.774 µm) with (SE: 1.391), and the result of mean RNFL thickness measured in normal eyes was not distributed normally as P < .20. The results showed that there is a statistically significant difference between mean RNFL thickness measured in normal versus myopic eyes as (P < .003). Conclusion:  There is a significance difference between mean RNFL thickness between myopic eyes and normal eyes as measured by OCT. Careful interpretation of RNFL data in myopic eyes is recommended to avoid misdiagnosis with glaucoma. Key Words:  Retinal Nerve Fiber Layer thickness, Myopia, Optical Coherence Tomography.

Long-term follow-up of retinal nerve fiber layer cleavages in glaucoma patients and suspects

2018 ◽  
Vol 256 (10) ◽  
pp. 1945-1952 ◽  
Author(s):  
Yun Hsia ◽  
Chien-Chia Su ◽  
Tsing-Hong Wang ◽  
Chung-May Yang ◽  
Jehn-Yu Huang
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Long Term Follow Up ◽  
Retinal Nerve Fiber

scholarly journals Choroidal thickness and retinal nerve fiber layer analysis in acute systemic brucellosis

2021 ◽  
Vol 19 ◽  
pp. 205873922110406
Author(s):  
Kürşad Ramazan Zor ◽  
Tuğba Arslan Gülen ◽  
Gamze Yıldırım Biçer ◽  
Erkut Küçük ◽  
Ayfer İmre ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Control Group ◽  
Fiber Layer ◽  
Subfoveal Choroidal Thickness ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean ◽  
Retinal Nerve Fiber

Introduction This study aims to detect changes in choroidal thickness and retinal nerve fiber layer (RNFL) thickness in acute stage brucellosis. Methods Fnewly diagnosed patients with acute brucellosis and 19 healthy individuals as control group were included in the study. Choroidal thickness and RNFL thickness were measured using the Spectral Domain Cirrus OCT Model 400 (Carl Zeiss Meditec, Jena, Germany) for each participant in the patient and control group. Results In the brucella group, in the right eyes, the mean nasal choroidal thickness was 272.77 ± 50.26 μm ( p = 0.689), the mean subfoveal choroidal thickness was 321.14 ± 33.08 μm ( p = 0.590), the mean temporal choroidal thickness was 278.86 ± 48.84 μm ( p = 0.478), and the mean RNFL thickness was 90.43 ± 8.93 μm ( p = 0.567). In the left eyes, the mean nasal choroidal thickness was 282.29 ± 48.93 μm ( p = 0.715), the mean subfoveal choroidal thickness was 316.79 ± 39.57 μm ( p = 0.540), the mean temporal choroidal thickness was 284.93 ± 50.57 μm ( p = 0.392), and the mean RNFL thickness was 92.64 ± 8.95 μm ( p = 0.813). Conclusion No difference was found between the control and the brucella groups regarding to all choroidal regions and RNFL thickness.

scholarly journals DETERMINATION OF FACTORS ASSOCIATED WITH PERIPAPILLARY RETINAL NERVE FIBER LAYER AND MACULAR THICKNESS USING OPTICAL COHERENCE TOMOGRAPHY

2021 ◽  
Vol 32 (6) ◽  
pp. 448-457
Author(s):  
Hadi Ostadimoghaddam ◽  
Neda Nakhjavanpour ◽  
Abolfazl Payandeh ◽  
Mohammad-Reza Mohammad-Reza Sedaghat ◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Macular Thickness ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Factors Associated ◽  
Retinal Nerve Fiber

Early retinal and retinal nerve fiber layer effects of hydroxychloroquine: a follow up study by sdOCT

2013 ◽  
Vol 32 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Fatma Yülek ◽  
Nagihan Uğurlu ◽  
Emine Akçay ◽  
Sücattin İlker Kocamıs¸ ◽  
Sıdıka Gerçeker ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Follow Up Study ◽  
Retinal Nerve Fiber
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