scholarly journals A 33-Year-Old Man with Gynaecomastia and Galactorrhea as the First Symptoms of Graves Hyperthyroidism

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Somdul Khoohaphatthanakul ◽  
Apiradee Sriwijitkamol
Keyword(s):  
Physical Examination ◽  
Male Patient ◽  
Successful Treatment ◽  
Hormone Level ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
The Third ◽  
Rare Manifestation ◽  
Laboratory Investigations ◽  
Male Patients

Graves’ hyperthyroidism has a various number of well-recognized manifestations. Galactorrhea is a rare manifestation in this disease. We describe a 33-year-old man who presented with the symptoms of hyperthyroidism, gynaecomastia, and galactorrhea for 2 months. Physical examination revealed goitre, gynaecomastia, and galactorrhea, bilaterally. Laboratory investigations demonstrated high free thyroxine with suppressed thyroid-stimulating hormone level together with elevated anti-TSH receptor; therefore, the diagnosis of Graves’ disease was confirmed. Other investigations to elucidate the etiology of galactorrhea were normal, so the galactorrhea was hypothesized to be caused by Graves’ disease. The gynaecomastia and galactorrhea resolved with the successful treatment of hyperthyroidism. Although the galactorrhea is extremely rare in thyrotoxicosis male patients, to the best of our knowledge, this is the third case which reported gynaecomastia and galactorrhea in male patient who presented with thyrotoxicosis.

scholarly journals Successful Treatment of Generalized Pustular Psoriasis of Pregnancy with Oral Cyclosporine

2020 ◽  
Vol 4 (3) ◽  
pp. 252
Author(s):  
Hamid Khederlou ◽  
Zahra Najmi ◽  
Narges Mohammadi ◽  
Shahla Atrak ◽  
Nader Ghaffari
Keyword(s):  
Successful Treatment ◽  
Male Infant ◽  
Pustular Psoriasis ◽  
Third Trimester ◽  
The Third ◽  
Generalized Pustular Psoriasis ◽  
Laboratory Investigations

Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatosis that usually occurs during the third trimester of pregnancy. The diagnosis is primarily clinical, confirmed by laboratory investigations and histopathological typical findings. Here we report, a 26-year-old, gravida one woman, in 37 weeks of pregnancy, presenting with extensive erythematous, pruritic plaques with peripheral scaling and pustules. Patient was induced at 37+4 weeks and delivered a healthy 2900g male infant. GPPP was eventually controlled with oral cyclosporine.  

scholarly journals THYROID ACROPACHY: A RARE MANIFESTATION OF GRAVES DISEASE IN JOINTS

2019 ◽  
Vol 5 (6) ◽  
pp. e369-e371 ◽  
Author(s):  
Nicolas Perini ◽  
Roberto Bernardo Santos ◽  
João Hamilton Romaldini ◽  
Danilo Villagelin
Keyword(s):  
Elevated Serum ◽  
Clinical Signs ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Free T4 ◽  
Tissue Edema ◽  
Rare Manifestation ◽  
Small Joint ◽  
History Of ◽  
Hands And Feet

Objective: The objective of this report was to describe a patient with Graves acropachy, a rare manifestation of Graves disease (GD) that is clinically defined by skin tightness, digital clubbing, small-joint pain, and soft tissue edema progressing over months or years with gradual curving and enlargement of the fingers. Methods: The patient was evaluated regarding thyroid function (serum free T4 [FT4] and thyroid-stimulating hormone [TSH] quantifications) and autoimmunity biomarkers (thyroid receptor antibody [TRAb]) as well as radiographic investigation of the extremities. Results: A 52-year-old man presented with a history of thyrotoxicosis and clinical signs of Graves orbitopathy. Laboratory tests showed suppressed TSH (0.01 UI/L; normal, 0.4 to 4.5 UI/L) and elevated serum FT4 (7.77 ng/dL; normal, 0.93 to 1.7 ng/dL), with high TRAb levels (40 UI/L; normal, <1.75 UI/L). A diagnosis of thyrotoxicosis due to GD was made and the patient was treated with methimazole. After the patient complained of swelling in hands and feet, X-ray evaluation was conducted and established the thyroid acropachy. Conclusion: We present a case of a patient with GD associated with worsening extrathyroid manifestations during orbitopathy, dermopathy, and developed acropachy in hands and feet.

CUSHING'S SYNDROME FOLLOWING PARTIAL ADRENALECTOMY AND COMPLETE HYPOPHYSECTOMY

1965 ◽  
Vol 48 (4) ◽  
pp. 565-568 ◽  
Author(s):  
W. A. Sullivan ◽  
Jerrold D. Hydovitz ◽  
H. Rosomoff ◽  
T. S. Danowski
Keyword(s):  
Cushing’S Syndrome ◽  
Adult Male ◽  
Successful Treatment ◽  
Cushing's Syndrome ◽  
Partial Adrenalectomy ◽  
The Third ◽  
Subtotal Adrenalectomy ◽  
Pituitary Ablation ◽  
Acth Secreting

ABSTRACT A third episode of Cushing's syndrome developed in an adult male who had undergone subtotal adrenalectomy and then complete hypophysectomy in temporarily successful treatment of two earlier episodes. Judging from necropsy findings, this final recurrence was not the result of incomplete pituitary ablation or regeneration of pituitary remnants. Extrasellar pituitary or other ACTH secreting tissue could not be identified, but the patient's marked melanosis suggested its presence with consequent excesses of ACTH or MSH. However, irrespective of whether such excesses did or did not exist, it is clear that the third episode of Cushing's syndrome resulted from hyperfunction of the small adrenal remnant.

Serum thyroid stimulating hormone level for predicting utility of thyroid uptake and scan

2020 ◽  
pp. 1-4
Author(s):  
Lauren Buehler ◽  
Alireza Movahed ◽  
Keren Zhou ◽  
M. Cecilia Lansang
Keyword(s):  
Hormone Level ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Uptake ◽  
Stimulating Hormone

scholarly journals Spontaneous Pneumomediastinum, Pneumothorax, Pneumopericardium and Subcutaneous Emphysema—Not So Uncommon Complications in Patients with COVID-19 Pulmonary Infection—A Series of Cases

2021 ◽  
Vol 10 (7) ◽  
pp. 1346
Author(s):  
Talida Georgiana Cut ◽  
Cristina Tudoran ◽  
Voichita Elena Lazureanu ◽  
Adelina Raluca Marinescu ◽  
Raluca Dumache ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Subcutaneous Emphysema ◽  
Diffuse Alveolar Damage ◽  
Demographic Data ◽  
Pathophysiological Mechanism ◽  
Spontaneous Pneumomediastinum ◽  
Intensive Care Stay ◽  
Laboratory Investigations ◽  
Male Patients ◽  
Pulmonary Pathology

(1) Background: Spontaneous pneumomediastinum (PM), pneumothorax (PT), and pneumopericardium (PP) were recently reported as rare complications in patients with severe COVID-19 pneumonia, and our study aims to follow the evolution of these involvements in 11 cases. The presumed pathophysiological mechanism is air leak due to extensive diffuse alveolar damage followed by alveolar rupture. (2) Methods: We followed the occurrence of PM, PN, PP, and subcutaneous emphysema (SE) in 1648 patients hospitalized during the second outbreak of COVID-19 (October 2020–January 2021) in the main hospital of infectious diseases of our county and recorded their demographic data, laboratory investigations and clinical evolution. (3) Results: Eleven patients (0.66%) developed PM, with eight of them having associated PT, one PP, and seven SE, in the absence of mechanical ventilation. Eight patients (72.72%) died and only three (27.27%) survived. All subjects were nonsmokers, without known pulmonary pathology or risk factors for such complications. (4) Conclusions: pneumomediastinum, pneumothorax, and pneumopericardium are not so uncommon complications of SARS-CoV2 pneumonia, being observed mostly in male patients with severe forms and associated with prolonged hospitalization and poor prognosis. In some cases, with mild forms and reduced pulmonary injury, the outcome is favorable, not requiring surgical procedures, mechanical ventilation, or intensive care stay.

Successful Treatment of Graves Disease in Pregnancy with Lugol's Iodine

2000 ◽  
Vol 45 (1) ◽  
pp. 20-21 ◽  
Author(s):  
A. Jamieson ◽  
C.G. Semple
Keyword(s):  
Drug Therapy ◽  
Successful Treatment ◽  
Surgical Intervention ◽  
Antithyroid Drug ◽  
Primary Treatment ◽  
Graves Disease ◽  
Lugol’S Iodine ◽  
Organic Iodine ◽  
Antithyroid Drug Therapy ◽  
In Pregnancy

We report a case of Grave's disease in pregnancy complicated by intolerance of standard antithyroid drug therapy. We describe the success of prolonged use of organic iodine as a primary treatment prior to surgical intervention.

A case of Graves’ disease associated with membranoproliferative glomerulonephritis and leukocytoclastic vasculitis

2018 ◽  
Vol 31 (10) ◽  
pp. 1165-1168 ◽  
Author(s):  
Werner Keenswijk ◽  
Eva Degraeuwe ◽  
Anne Hoorens ◽  
Jo Van Dorpe ◽  
Johan Vande Walle
Keyword(s):  
Renal Function ◽  
Membranoproliferative Glomerulonephritis ◽  
Leukocytoclastic Vasculitis ◽  
White Cell Count ◽  
Gastrointestinal Symptoms ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Complement Factor ◽  
Gradual Improvement ◽  
Complement Factor C3

Abstract Background The association of hyperthyroidism with renal disease is very rare and the importance of timely clinical recognition cannot be overemphasized. Case presentation An 11-year-old girl presented with gastrointestinal symptoms while hypertension, edema and abdominal pain were noticed on clinical examination. Laboratory investigation revealed: hemoglobin 9.4 (11.5–15.5) g/dL, total white cell count 16 (4.5–12)×109/L, platelets 247 (150–450)×109/L, C-reactive protein (CRP) 31.8 (<5) mg/L, blood urea nitrogen (BUN) 126 (13–43) mg/dL, creatinine 0.98 (0.53–0.79) mg/dL, albumin 25 (35–52) g/dL, complement factor C3 0.7 (0.9–1.8) g/L, complement factor C4 0.1 (0.1–0.4) g/L, tri-iodothyronine 6.5 (2.5–5.2) pg/mL, free thyroxine 2.4 (1–1.7) ng/dL, thyroid stimulating hormone (TSH) <0.02 (0.5–4.3) mU/L. Urinalysis showed nephrotic range proteinuria. Renal function deteriorated necessitating hemodialysis (HD). A renal biopsy revealed an immune complex-mediated membranoproliferative glomerulonephritis (MPGN). Elevated thyroid hormones and suppressed TSH levels with elevated thyroperoxidase antibodies and thyroid stimulating immunoglobulins confirmed the diagnosis of Graves’ disease. Corticosteroids were commenced and eventually thiamazole was added with gradual improvement of renal function, cessation of HD and discharge from the hospital. Conclusions Graves’ disease complicated by MPGN is extremely rare, but can cause life-threatening complications.

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